Author: Debbie A Lawlor

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Preprints

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

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  • Site-wide: 5,718
  • In genetics: 273
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  • Site-wide: 29,340
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  • Site-wide: 29,340

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

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  • Site-wide: 7,359
  • In epidemiology: 567
• Year to date:
  • Site-wide: 106,785
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  • Site-wide: 106,785

Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

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  • Site-wide: 8,403
  • In epidemiology: 627
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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 11,803
  • In genetics: 593
• Year to date:
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  • Site-wide: 83,558

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 14,247
  • In genomics: 1,514
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  • Site-wide: 62,809
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  • Site-wide: 62,809

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

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  • Site-wide: 15,038
  • In genetics: 773
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  • Site-wide: 59,474
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Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

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  • Site-wide: 19,335
  • In epidemiology: 1,130
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The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

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  • Site-wide: 34,736
  • In genetics: 1,703
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  • Site-wide: 109,678

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

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  • Site-wide: 35,786
  • In epidemiology: 1,715
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  • Site-wide: 93,416
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  • Site-wide: 93,416

Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

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  • Site-wide: 37,512
  • In epidemiology: 1,790
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  • Site-wide: 104,867
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  • Site-wide: 104,867

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

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  • Site-wide: 37,886
  • In genomics: 3,239
• Year to date:
  • Site-wide: 77,665
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  • Site-wide: 77,665

Is death from Covid-19 a multistep process?

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  • Site-wide: 38,658
  • In infectious diseases: 2,207
• Year to date:
  • Site-wide: 22,235
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  • Site-wide: 22,235

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

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  • Site-wide: 39,452
  • In genetic and genomic medicine: 112
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  • Site-wide: 7,467
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  • Site-wide: 7,467

Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

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  • Site-wide: 40,286
  • In epidemiology: 1,899
• Year to date:
  • Site-wide: 91,571
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  • Site-wide: 91,571

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

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  • Site-wide: 42,305
  • In epidemiology: 1,977
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  • Site-wide: 85,086
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  • Site-wide: 85,086

Metabolic signatures of birth weight in 18288 adolescents and adults

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  • Site-wide: 44,954
  • In systems biology: 1,050
• Year to date:
  • Site-wide: 101,156
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  • Site-wide: 101,156

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

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  • Site-wide: 48,723
  • In genetics: 2,334
• Year to date:
  • Site-wide: 100,534
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  • Site-wide: 100,534

The Parkinsons Disease Mendelian Randomization Research Portal

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  • Site-wide: 48,986
  • In neuroscience: 7,257
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  • Site-wide: 93,319
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  • Site-wide: 93,319

Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 53,019
  • In sexual and reproductive health: 20
• Year to date:
  • Site-wide: 1,270
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  • Site-wide: 1,270

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts

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  • Site-wide: 56,665
  • In genomics: 4,285
• Year to date:
  • Site-wide: 118,179
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  • Site-wide: 118,179

The effect of pre-analytical conditions on blood metabolomics in epidemiological studies

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  • Site-wide: 57,537
  • In epidemiology: 2,452
• Year to date:
  • Site-wide: 105,917
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  • Site-wide: 105,917

Exploring and mitigating potential bias when genetic instrumental variables are associated with multiple non-exposure traits in Mendelian randomization

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  • Site-wide: 59,805
  • In epidemiology: 2,537
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  • Site-wide: 57,977
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  • Site-wide: 57,977

Night Shift Work Increases the Risk of Asthma

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  • Site-wide: 60,670
  • In epidemiology: 2,578
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  • Site-wide: 49,551
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  • Site-wide: 49,551

GLU: A tool for analysing continuously measured glucose in epidemiology

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  • Site-wide: 61,466
  • In epidemiology: 2,602
• Year to date:
  • Site-wide: 109,222
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  • Site-wide: 109,222

Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

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  • Site-wide: 62,608
  • In epidemiology: 2,645
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  • Site-wide: None
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The effect of a lifestyle intervention in obese pregnant women on change in gestational metabolic profiles: findings form the UK Pregnancies Better Eating and Activity Trial (UPBEAT) RCT.

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  • Site-wide: 64,238
  • In clinical trials: 89
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  • Site-wide: None
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Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

• Downloaded 345 times
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  • Site-wide: 71,833
  • In epidemiology: 2,979
• Year to date:
  • Site-wide: 39,816
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  • Site-wide: 39,816

Physical Activity Phenotyping With Activity Bigrams, And Their Association With BMI

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  • Site-wide: 74,854
  • In epidemiology: 3,082
• Year to date:
  • Site-wide: 121,708
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  • Site-wide: 121,708

Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

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  • Site-wide: 75,000
  • In epidemiology: 3,096
• Year to date:
  • Site-wide: 108,392
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  • Site-wide: 108,392

Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study

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  • Site-wide: 80,854
  • In epidemiology: 3,311
• Year to date:
  • Site-wide: 53,345
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  • Site-wide: 53,345

Maternal and fetal genetic contribution to gestational weight gain

• Downloaded 275 times
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  • Site-wide: 85,246
  • In genetics: 3,915
• Year to date:
  • Site-wide: 120,664
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  • Site-wide: 120,664

Association of changing physical activity intensity and bout length with mortality: a study of 79,507 participants in UK Biobank

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  • Site-wide: 87,374
  • In epidemiology: 3,548
• Year to date:
  • Site-wide: 60,423
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  • Site-wide: 60,423

Age at period cessation and trajectories of cardiovascular risk factors across mid and later life: a prospective cohort study

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  • Site-wide: 93,589
  • In epidemiology: 3,787
• Year to date:
  • Site-wide: 110,296
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  • Site-wide: 110,296

Metabolic characterization of menopause: cross-sectional and longitudinal evidence

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  • Site-wide: 94,271
  • In epidemiology: 3,812
• Year to date:
  • Site-wide: 109,182
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  • Site-wide: 109,182

The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

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  • Site-wide: 105,305
  • In epidemiology: 4,302
• Year to date:
  • Site-wide: 75,641
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  • Site-wide: 75,641

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

• Downloaded 177 times
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  • Site-wide: 106,335
  • In genetic and genomic medicine: 430
• Year to date:
  • Site-wide: 102,935
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  • Site-wide: 102,935

The impact of lung function on cardiovascular diseases and cardiovascular risk factors: a two sample bi-directional Mendelian randomization study

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  • Site-wide: 109,275
  • In epidemiology: 4,443
• Year to date:
  • Site-wide: 94,496
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  • Site-wide: 94,496

EXTERNAL VALIDATION OF THE IMPROVING PARTIAL RISK ADJUSTMENT IN SURGERY (PRAIS2) MODEL FOR 30-DAY MORTALITY AFTER PEDIATRIC CARDIAC SURGERY

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  • Site-wide: 111,299
  • In cardiovascular medicine: 249
• Year to date:
  • Site-wide: 115,724
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  • Site-wide: 115,724

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

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  • Site-wide: 115,559
  • In genetics: 5,037
• Year to date:
  • Site-wide: 70,212
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  • Site-wide: 70,212

Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study

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  • Site-wide: 120,232
  • In epidemiology: 4,818
• Year to date:
  • Site-wide: 19,054
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  • Site-wide: 19,054

Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents

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  • Site-wide: 123,918
  • In epidemiology: 4,944
• Year to date:
  • Site-wide: 68,941
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  • Site-wide: 68,941

Vulnerabilities in child wellbeing among primary school children: a cross-sectional study in Bradford, UK

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  • Site-wide: 124,005
  • In public and global health: 1,389
• Year to date:
  • Site-wide: 14,335
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  • Site-wide: 14,335