Author: Deborah A Lawlor

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Preprints

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

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  • Site-wide: 6,692
  • In genetics: 293
• Year to date:
  • Site-wide: 40,794
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  • Site-wide: 44,001

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

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  • Site-wide: 8,896
  • In epidemiology: 699
• Year to date:
  • Site-wide: 87,291
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  • Site-wide: 25,026

Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

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  • Site-wide: 9,080
  • In epidemiology: 712
• Year to date:
  • Site-wide: 22,664
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  • Site-wide: 75,007

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 14,197
  • In genetics: 652
• Year to date:
  • Site-wide: 104,260
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  • Site-wide: 62,175

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 17,323
  • In genomics: 1,697
• Year to date:
  • Site-wide: 114,934
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  • Site-wide: 42,620

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

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  • Site-wide: 18,130
  • In genetics: 843
• Year to date:
  • Site-wide: 105,736
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  • Site-wide: None

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

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  • Site-wide: 19,453
  • In epidemiology: 1,215
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  • Site-wide: 35,660
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  • Site-wide: None

Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 20,204
  • In sexual and reproductive health: 15
• Year to date:
  • Site-wide: 2,598
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  • Site-wide: 2,181

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

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  • Site-wide: 25,548
  • In genetic and genomic medicine: 102
• Year to date:
  • Site-wide: 8,564
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  • Site-wide: 26,333

Is death from Covid-19 a multistep process?

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  • Site-wide: 40,178
  • In infectious diseases: 2,719
• Year to date:
  • Site-wide: 44,871
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  • Site-wide: 113,914

The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

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  • Site-wide: 42,031
  • In genetics: 1,886
• Year to date:
  • Site-wide: 147,882
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  • Site-wide: 38,669

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

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  • Site-wide: 42,457
  • In epidemiology: 2,078
• Year to date:
  • Site-wide: 130,937
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  • Site-wide: None

Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

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  • Site-wide: 44,501
  • In epidemiology: 2,155
• Year to date:
  • Site-wide: 136,072
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  • Site-wide: None

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

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  • Site-wide: 44,507
  • In genomics: 3,550
• Year to date:
  • Site-wide: 119,561
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  • Site-wide: 61,750

Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

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  • Site-wide: 46,787
  • In epidemiology: 2,231
• Year to date:
  • Site-wide: 117,335
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  • Site-wide: None

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

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  • Site-wide: 50,318
  • In epidemiology: 2,345
• Year to date:
  • Site-wide: 132,758
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  • Site-wide: 68,293

Metabolic signatures of birth weight in 18288 adolescents and adults

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  • Site-wide: 53,071
  • In systems biology: 1,169
• Year to date:
  • Site-wide: 133,044
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  • Site-wide: None

Exploring and mitigating potential bias when genetic instrumental variables are associated with multiple non-exposure traits in Mendelian randomization

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  • Site-wide: 56,010
  • In epidemiology: 2,544
• Year to date:
  • Site-wide: 45,941
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  • Site-wide: 109,107

The Parkinsons Disease Mendelian Randomization Research Portal

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  • Site-wide: 58,017
  • In neuroscience: 8,499
• Year to date:
  • Site-wide: 135,186
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  • Site-wide: 84,694

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

• Downloaded 521 times
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  • Site-wide: 58,297
  • In genetics: 2,566
• Year to date:
  • Site-wide: 142,908
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  • Site-wide: 80,803

Night Shift Work Increases the Risk of Asthma

• Downloaded 507 times
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  • Site-wide: 60,096
  • In epidemiology: 2,686
• Year to date:
  • Site-wide: 54,534
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  • Site-wide: 32,903

GLU: A tool for analysing continuously measured glucose in epidemiology

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  • Site-wide: 63,500
  • In epidemiology: 2,802
• Year to date:
  • Site-wide: 76,795
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  • Site-wide: 64,225

Exploiting collider bias to apply two-sample summary data Mendelian randomization methods to one-sample individual level data

• Downloaded 473 times
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  • Site-wide: 64,985
  • In epidemiology: 2,857
• Year to date:
  • Site-wide: 18,003
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  • Site-wide: 29,407

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts

• Downloaded 458 times
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  • Site-wide: 67,175
  • In genomics: 4,741
• Year to date:
  • Site-wide: 147,033
• Since beginning of last month:
  • Site-wide: 70,835

The effect of pre-analytical conditions on blood metabolomics in epidemiological studies

• Downloaded 457 times
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  • Site-wide: 67,368
  • In epidemiology: 2,948
• Year to date:
  • Site-wide: 136,580
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  • Site-wide: None

Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

• Downloaded 446 times
• Download rankings, all-time:
  • Site-wide: 69,099
  • In epidemiology: 3,005
• Year to date:
  • Site-wide: 113,814
• Since beginning of last month:
  • Site-wide: 61,254

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

• Downloaded 404 times
• Download rankings, all-time:
  • Site-wide: 76,279
  • In epidemiology: 3,264
• Year to date:
  • Site-wide: 70,117
• Since beginning of last month:
  • Site-wide: 107,202

Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

• Downloaded 392 times
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  • Site-wide: 78,507
  • In epidemiology: 3,340
• Year to date:
  • Site-wide: 83,046
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  • Site-wide: None

The effect of a lifestyle intervention in obese pregnant women on change in gestational metabolic profiles: findings form the UK Pregnancies Better Eating and Activity Trial (UPBEAT) RCT.

• Downloaded 390 times
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  • Site-wide: 78,848
  • In clinical trials: 92
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  • Site-wide: None
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Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study

• Downloaded 353 times
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  • Site-wide: 86,061
  • In epidemiology: 3,621
• Year to date:
  • Site-wide: 77,934
• Since beginning of last month:
  • Site-wide: 33,029

Physical Activity Phenotyping With Activity Bigrams, And Their Association With BMI

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  • Site-wide: 85,919
  • In epidemiology: 3,618
• Year to date:
  • Site-wide: 137,338
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  • Site-wide: None

Association of changing physical activity intensity and bout length with mortality: a study of 79,507 participants in UK Biobank

• Downloaded 318 times
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  • Site-wide: 93,500
  • In epidemiology: 3,927
• Year to date:
  • Site-wide: 83,954
• Since beginning of last month:
  • Site-wide: 103,907

Maternal and fetal genetic contribution to gestational weight gain

• Downloaded 300 times
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  • Site-wide: 97,709
  • In genetics: 4,191
• Year to date:
  • Site-wide: 136,310
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  • Site-wide: None

'When will this end? Will it end?' The impact of the March-June 2020 UK Covid-19 lockdown response on mental health: a longitudinal survey of mothers in the Born in Bradford study.

• Downloaded 290 times
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  • Site-wide: 100,055
  • In public and global health: 1,254
• Year to date:
  • Site-wide: 33,784
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  • Site-wide: 34,343

Age at period cessation and trajectories of cardiovascular risk factors across mid and later life: a prospective cohort study

• Downloaded 255 times
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  • Site-wide: 108,401
  • In epidemiology: 4,516
• Year to date:
  • Site-wide: 140,264
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  • Site-wide: None

Metabolic characterization of menopause: cross-sectional and longitudinal evidence

• Downloaded 241 times
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  • Site-wide: 111,670
  • In epidemiology: 4,659
• Year to date:
  • Site-wide: 150,890
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  • Site-wide: None

The impact of lung function on cardiovascular diseases and cardiovascular risk factors: a two sample bi-directional Mendelian randomization study

• Downloaded 232 times
• Download rankings, all-time:
  • Site-wide: 114,130
  • In epidemiology: 4,755
• Year to date:
  • Site-wide: 76,518
• Since beginning of last month:
  • Site-wide: 33,305

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

• Downloaded 226 times
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  • Site-wide: 115,544
  • In genetic and genomic medicine: 595
• Year to date:
  • Site-wide: 97,576
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  • Site-wide: None

The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

• Downloaded 211 times
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  • Site-wide: 119,284
  • In epidemiology: 4,997
• Year to date:
  • Site-wide: 114,386
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  • Site-wide: None

Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study

• Downloaded 203 times
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  • Site-wide: 121,338
  • In epidemiology: 5,073
• Year to date:
  • Site-wide: 38,821
• Since beginning of last month:
  • Site-wide: 34,834

Trajectories of child emotional and behavioural difficulties before and during the COVID-19 pandemic in a longitudinal UK cohort

• Downloaded 194 times
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  • Site-wide: 123,538
  • In psychiatry and clinical psychology: 568
• Year to date:
  • Site-wide: 31,255
• Since beginning of last month:
  • Site-wide: 52,531

EXTERNAL VALIDATION OF THE IMPROVING PARTIAL RISK ADJUSTMENT IN SURGERY (PRAIS2) MODEL FOR 30-DAY MORTALITY AFTER PEDIATRIC CARDIAC SURGERY

• Downloaded 182 times
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  • Site-wide: 126,346
  • In cardiovascular medicine: 324
• Year to date:
  • Site-wide: 125,411
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  • Site-wide: 105,287

Vulnerabilities in child wellbeing among primary school children: a cross-sectional study in Bradford, UK

• Downloaded 177 times
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  • Site-wide: 127,615
  • In public and global health: 1,629
• Year to date:
  • Site-wide: 35,023
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  • Site-wide: 106,995

Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents

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  • Site-wide: 132,906
  • In epidemiology: 5,514
• Year to date:
  • Site-wide: 69,301
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  • Site-wide: 47,323

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

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  • Site-wide: 133,541
  • In genetics: 5,422
• Year to date:
  • Site-wide: 124,821
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  • Site-wide: None

Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? A Mendelian randomization study.

• Downloaded 122 times
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  • Site-wide: 139,625
  • In epidemiology: 5,754
• Year to date:
  • Site-wide: 52,262
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  • Site-wide: 19,995

metaboprep: an R package for pre-analysis data description and processing.

• Downloaded 99 times
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  • Site-wide: 143,918
  • In bioinformatics: 11,114
• Year to date:
  • Site-wide: 64,019
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  • Site-wide: 46,579

Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study

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  • Site-wide: 147,932
  • In epidemiology: 6,088
• Year to date:
  • Site-wide: 83,491
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  • Site-wide: 105,262

Sex-specific trajectories of molecular cardiometabolic trait concentrations through childhood, adolescence and young adulthood: a cohort study

• Downloaded 19 times
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  • Site-wide: 151,728
  • In epidemiology: 6,257
• Year to date:
  • Site-wide: 148,784
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  • Site-wide: 101,184