Author: Jaakko Kaprio

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Preprints

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

• Downloaded 8,714 times
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  • Site-wide: 1,150
  • In genetics: 27
• Year to date:
  • Site-wide: 52,965
• Since beginning of last month:
  • Site-wide: 55,264

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,352 times
• Download rankings, all-time:
  • Site-wide: 4,221
  • In genetics: 155
• Year to date:
  • Site-wide: 44,744
• Since beginning of last month:
  • Site-wide: 22,621

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,711 times
• Download rankings, all-time:
  • Site-wide: 5,679
  • In genetics: 238
• Year to date:
  • Site-wide: 23,987
• Since beginning of last month:
  • Site-wide: 12,279

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

• Downloaded 2,301 times
• Download rankings, all-time:
  • Site-wide: 7,280
  • In genetics: 320
• Year to date:
  • Site-wide: 24,689
• Since beginning of last month:
  • Site-wide: 14,053

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

• Downloaded 1,935 times
• Download rankings, all-time:
  • Site-wide: 9,364
  • In genetics: 396
• Year to date:
  • Site-wide: 77,690
• Since beginning of last month:
  • Site-wide: 26,652

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,755 times
• Download rankings, all-time:
  • Site-wide: 10,830
  • In genetics: 478
• Year to date:
  • Site-wide: 90,449
• Since beginning of last month:
  • Site-wide: 47,961

Within-sibship GWAS improve estimates of direct genetic effects

• Downloaded 1,414 times
• Download rankings, all-time:
  • Site-wide: 14,923
  • In genetics: 686
• Year to date:
  • Site-wide: 2,098
• Since beginning of last month:
  • Site-wide: 67,476

EpiSmokEr: A robust classifier to determine smoking status from DNA methylation data

• Downloaded 1,207 times
• Download rankings, all-time:
  • Site-wide: 18,901
  • In bioinformatics: 2,154
• Year to date:
  • Site-wide: 45,720
• Since beginning of last month:
  • Site-wide: 70,899

Haplotype sharing provides insights into fine-scale population history and disease in Finland

• Downloaded 1,152 times
• Download rankings, all-time:
  • Site-wide: 20,272
  • In genetics: 932
• Year to date:
  • Site-wide: 93,104
• Since beginning of last month:
  • Site-wide: 120,260

Genetic Association Study of Childhood Aggression across raters, instruments and age

• Downloaded 1,146 times
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  • Site-wide: 20,398
  • In genomics: 1,960
• Year to date:
  • Site-wide: 13,552
• Since beginning of last month:
  • Site-wide: 12,916

Polygenic risk, susceptibility genes, and breast cancer over the life course

• Downloaded 916 times
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  • Site-wide: 28,291
  • In oncology: 36
• Year to date:
  • Site-wide: 49,298
• Since beginning of last month:
  • Site-wide: 82,913

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

• Downloaded 862 times
• Download rankings, all-time:
  • Site-wide: 30,859
  • In genetics: 1,416
• Year to date:
  • Site-wide: 106,433
• Since beginning of last month:
  • Site-wide: None

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 796 times
• Download rankings, all-time:
  • Site-wide: 34,487
  • In genetics: 1,573
• Year to date:
  • Site-wide: 25,503
• Since beginning of last month:
  • Site-wide: 26,478

Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.

• Downloaded 741 times
• Download rankings, all-time:
  • Site-wide: 38,145
  • In genomics: 3,149
• Year to date:
  • Site-wide: 41,764
• Since beginning of last month:
  • Site-wide: 133,084

Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

• Downloaded 666 times
• Download rankings, all-time:
  • Site-wide: 43,900
  • In genomics: 3,498
• Year to date:
  • Site-wide: 81,590
• Since beginning of last month:
  • Site-wide: 47,776

Genome-wide association meta-analysis of childhood and adolescent internalising symptoms

• Downloaded 621 times
• Download rankings, all-time:
  • Site-wide: 48,061
  • In psychiatry and clinical psychology: 170
• Year to date:
  • Site-wide: 17,334
• Since beginning of last month:
  • Site-wide: 3,978

Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium

• Downloaded 605 times
• Download rankings, all-time:
  • Site-wide: 49,638
  • In genomics: 3,828
• Year to date:
  • Site-wide: 80,922
• Since beginning of last month:
  • Site-wide: 123,057

Metabolic signatures of birth weight in 18288 adolescents and adults

• Downloaded 569 times
• Download rankings, all-time:
  • Site-wide: 53,685
  • In systems biology: 1,191
• Year to date:
  • Site-wide: 133,395
• Since beginning of last month:
  • Site-wide: 80,130

Variants in regulatory elements of PDE4D associate with Major Mental Illness in the Finnish population

• Downloaded 498 times
• Download rankings, all-time:
  • Site-wide: 62,742
  • In genetics: 2,770
• Year to date:
  • Site-wide: 69,909
• Since beginning of last month:
  • Site-wide: 22,478

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 483 times
• Download rankings, all-time:
  • Site-wide: 64,862
  • In genetics: 2,855
• Year to date:
  • Site-wide: 150,511
• Since beginning of last month:
  • Site-wide: None

The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

• Downloaded 448 times
• Download rankings, all-time:
  • Site-wide: 70,362
  • In epidemiology: 3,096
• Year to date:
  • Site-wide: 140,696
• Since beginning of last month:
  • Site-wide: 56,660

Identification of Slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour

• Downloaded 446 times
• Download rankings, all-time:
  • Site-wide: 70,725
  • In genetics: 3,108
• Year to date:
  • Site-wide: 110,331
• Since beginning of last month:
  • Site-wide: 50,197

Teacher-rated aggression and co-occurring problems and behaviors among schoolchildren: A comparison of four population-based European cohorts

• Downloaded 424 times
• Download rankings, all-time:
  • Site-wide: 74,378
  • In epidemiology: 3,229
• Year to date:
  • Site-wide: 69,494
• Since beginning of last month:
  • Site-wide: 87,493

Polygenic Risk for Alcohol Misuse is Moderated by Romantic Partnerships: Primarily in Men

• Downloaded 367 times
• Download rankings, all-time:
  • Site-wide: 85,167
  • In epidemiology: 3,625
• Year to date:
  • Site-wide: 143,246
• Since beginning of last month:
  • Site-wide: 47,648

An integrative machine learning approach to discovering multi-level molecular mechanisms of obesity using data from monozygotic twin pairs

• Downloaded 360 times
• Download rankings, all-time:
  • Site-wide: 86,641
  • In epidemiology: 3,680
• Year to date:
  • Site-wide: 104,262
• Since beginning of last month:
  • Site-wide: 126,375

Polygenic score for physical activity provides odds for multiple common diseases

• Downloaded 322 times
• Download rankings, all-time:
  • Site-wide: 94,675
  • In sports medicine: 65
• Year to date:
  • Site-wide: 17,708
• Since beginning of last month:
  • Site-wide: 88,270

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

• Downloaded 276 times
• Download rankings, all-time:
  • Site-wide: 105,574
  • In genetics: 4,477
• Year to date:
  • Site-wide: 100,865
• Since beginning of last month:
  • Site-wide: 53,540

Long-Term Leisure-Time Physical Activity and Other Health Habits as Predictors of Objectively Monitored Late-Life Physical Activity: A 40-Year Twin Study

• Downloaded 269 times
• Download rankings, all-time:
  • Site-wide: 107,216
  • In epidemiology: 4,507
• Year to date:
  • Site-wide: 133,563
• Since beginning of last month:
  • Site-wide: 62,600

Ketone body 3-hydroxybutyrate: a biomarker of aggression?

• Downloaded 262 times
• Download rankings, all-time:
  • Site-wide: 108,943
  • In epidemiology: 4,590
• Year to date:
  • Site-wide: 80,685
• Since beginning of last month:
  • Site-wide: 32,933

Genetic variant in SPDL1 reveals novel mechanism linking pulmonary fibrosis risk and cancer protection

• Downloaded 221 times
• Download rankings, all-time:
  • Site-wide: 119,318
  • In genetic and genomic medicine: 638
• Year to date:
  • Site-wide: 29,410
• Since beginning of last month:
  • Site-wide: 16,425

BMI is positively associated with accelerated epigenetic aging in twin pairs discordant for BMI

• Downloaded 138 times
• Download rankings, all-time:
  • Site-wide: 138,906
  • In genetic and genomic medicine: 781
• Year to date:
  • Site-wide: 50,787
• Since beginning of last month:
  • Site-wide: 21,548

Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

• Downloaded 128 times
• Download rankings, all-time:
  • Site-wide: 141,026
  • In epidemiology: 5,818
• Year to date:
  • Site-wide: 54,975
• Since beginning of last month:
  • Site-wide: 134,213

Do epigenetic clocks provide explanations for sex differences in lifespan? A cross-sectional twin study

• Downloaded 124 times
• Download rankings, all-time:
  • Site-wide: 141,765
  • In epidemiology: 5,846
• Year to date:
  • Site-wide: 56,518
• Since beginning of last month:
  • Site-wide: 98,749

Risk of dementia after hospitalization due to traumatic brain injury: a longitudinal, population-based study

• Downloaded 45 times
• Download rankings, all-time:
  • Site-wide: 152,740
  • In neurology: 899
• Year to date:
  • Site-wide: 122,028
• Since beginning of last month:
  • Site-wide: 104,747