Author: Terho Lehtimäki

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Preprints

Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

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  • Site-wide: 685
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  • Site-wide: 2,279
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  • Site-wide: 2,258

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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  • Site-wide: 775
  • In genomics: 67
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  • Site-wide: None
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  • Site-wide: 3,327

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 3,236
  • In genetics: 144
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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,510
  • In genetics: 165
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Integrative approaches for large-scale transcriptome-wide association studies

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  • Site-wide: 3,794
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  • Site-wide: 17,416
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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • Site-wide: 4,659
  • In genetics: 229
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  • Site-wide: 110,358

Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

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  • Site-wide: 5,997
  • In genetics: 304
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The Polygenic and Monogenic Basis of Blood Traits and Diseases

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  • Site-wide: 6,910
  • In genetic and genomic medicine: 17
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  • Site-wide: 9,915

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 8,259
  • In genetics: 425
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  • Site-wide: 56,191
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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 37,292
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  • Site-wide: 26,510

metaCCA: Summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis

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  • Site-wide: 9,239
  • In bioinformatics: 1,163
• Year to date:
  • Site-wide: 41,759
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  • Site-wide: 88,906

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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  • Site-wide: 9,483
  • In genomics: 1,079
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  • Site-wide: 57,727

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 11,165
  • In genetics: 580
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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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  • Site-wide: 14,414
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  • Site-wide: 57,690

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

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  • Site-wide: 19,098
  • In epidemiology: 1,071
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  • Site-wide: 49,885
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  • Site-wide: 29,131

An epigenome-wide association study of educational attainment (n = 10,767)

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  • Site-wide: 19,310
  • In genetics: 985
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  • Site-wide: 99,740

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

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  • Site-wide: 20,453
  • In genomics: 2,089
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  • Site-wide: 97,954

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 23,361
  • In genetics: 1,188
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Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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  • Site-wide: 25,659
  • In genetics: 1,308
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  • Site-wide: 90,457

Lower hemoglobin levels associate with lower body mass index and healthier metabolic profile

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  • Site-wide: 25,931
  • In epidemiology: 1,312
• Year to date:
  • Site-wide: 40,731
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  • Site-wide: 16,193

Genetic Association Study of Childhood Aggression across raters, instruments and age

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  • Site-wide: 27,427
  • In genomics: 2,589
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  • Site-wide: 45,885

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

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  • Site-wide: 27,416
  • In genomics: 2,591
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  • Site-wide: 112,390

Genetic and environmental perturbations lead to regulatory decoherence

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  • Site-wide: 28,308
  • In genomics: 2,642
• Year to date:
  • Site-wide: 60,905
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  • Site-wide: 60,892

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 28,644
  • In genomics: 2,659
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  • Site-wide: 107,381

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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  • Site-wide: 37,895
  • In genetics: 1,877
• Year to date:
  • Site-wide: 41,182
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  • Site-wide: 46,664

Metabolic Effects Of Risk Alleles In PNPLA3, TM6SF2, GCKR, And LYPLAL1 Inform About Heterogeneity Of Non-Alcoholic Fatty Liver Disease

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  • Site-wide: 38,292
  • In epidemiology: 1,766
• Year to date:
  • Site-wide: 37,856
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  • Site-wide: 71,706

Metabolic profiling of alcohol consumption in 9778 young adults

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  • Site-wide: 39,421
  • In systems biology: 940
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  • Site-wide: None
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  • Site-wide: 107,913

Discovering patterns of pleiotropy in genome-wide association studies

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  • Site-wide: 40,069
  • In genetics: 1,978
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  • Site-wide: None
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  • Site-wide: 113,057

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

• Downloaded 548 times
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  • Site-wide: 41,241
  • In genetics: 2,041
• Year to date:
  • Site-wide: 61,821
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  • Site-wide: 74,691

Metabolic signatures of birth weight in 18288 adolescents and adults

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  • Site-wide: 42,523
  • In systems biology: 1,020
• Year to date:
  • Site-wide: 57,241
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  • Site-wide: 79,268

Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

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  • Site-wide: 44,785
  • In genomics: 3,666
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  • Site-wide: None
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  • Site-wide: 111,356

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 491 times
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  • Site-wide: 46,968
  • In genomics: 3,791
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  • Site-wide: 112,771

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 460 times
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  • Site-wide: 50,563
  • In genetics: 2,470
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  • Site-wide: None
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  • Site-wide: 106,922

The landscape of incident disease risk for the biomarker GlycA and its mortality stratification in angiography patients

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  • Site-wide: 52,988
  • In epidemiology: 2,225
• Year to date:
  • Site-wide: 38,529
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  • Site-wide: 83,474

Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

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  • Site-wide: 58,671
  • In genetics: 2,837
• Year to date:
  • Site-wide: 65,103
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  • Site-wide: 40,319

Consortium genome-wide meta-analysis for childhood dental caries traits

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  • Site-wide: 62,155
  • In genetics: 2,986
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 89,992

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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  • Site-wide: 66,222
  • In genetics: 3,158
• Year to date:
  • Site-wide: 52,571
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  • Site-wide: 91,156

Secondary Vulvodynia Patients Show Reduced Bacterial Diversity in Vestibular Microbiome

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  • Site-wide: 67,336
  • In obstetrics and gynecology: 38
• Year to date:
  • Site-wide: 22,276
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  • Site-wide: 28,997

Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease

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  • Site-wide: 72,795
  • In epidemiology: 2,944
• Year to date:
  • Site-wide: 44,096
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  • Site-wide: 98,508

Genome-wide association meta-analysis of childhood and adolescent internalising symptoms

• Downloaded 304 times
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  • Site-wide: 74,557
  • In psychiatry and clinical psychology: 218
• Year to date:
  • Site-wide: 17,617
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  • Site-wide: 12,200

A genome-wide association study of total child psychiatric problems scores

• Downloaded 265 times
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  • Site-wide: 82,227
  • In psychiatry and clinical psychology: 247
• Year to date:
  • Site-wide: 22,824
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  • Site-wide: 43,570

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

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  • Site-wide: 90,487
  • In genetics: 4,206
• Year to date:
  • Site-wide: 14,995
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  • Site-wide: 34,775

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 183 times
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  • Site-wide: 99,251
  • In genomics: 5,897
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  • Site-wide: None
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  • Site-wide: 90,070

Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two European cohort studies

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  • Site-wide: 107,338
  • In epidemiology: 4,303
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  • Site-wide: 103,770

Genetic study of circulating cytokines offers insight into the determinants, cascades and effects of systemic inflammation

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  • Site-wide: 108,588
  • In epidemiology: 4,346
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  • Site-wide: 35,815

Elevated glycoprotein acetyl levels in adolescence and early adulthood predict adverse cardiometabolic profiles and risk of metabolic syndrome in up to 10 year follow-up

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  • Site-wide: 109,655
  • In cardiovascular medicine: 247
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  • Site-wide: 31,296
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  • Site-wide: 52,659