Author: Terho Lehtimäki

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Preprints

Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

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  • Site-wide: 11,067

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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  • Site-wide: 805
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  • Site-wide: 1,353
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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,975
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Integrative approaches for large-scale transcriptome-wide association studies

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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • Site-wide: 5,343
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Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

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The Polygenic and Monogenic Basis of Blood Traits and Diseases

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  • In genetic and genomic medicine: 25
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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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metaCCA: Summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis

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  • Site-wide: 10,505
  • In bioinformatics: 1,279
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  • Site-wide: 55,209

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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  • Site-wide: 10,607
  • In genomics: 1,152
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  • Site-wide: 89,263

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 6,231
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Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

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  • In epidemiology: 1,223
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  • Site-wide: 65,129
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An epigenome-wide association study of educational attainment (n = 10,767)

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  • In genetics: 1,012
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  • Site-wide: 62,438
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  • Site-wide: 61,290

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

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  • Site-wide: 22,335
  • In genomics: 2,193
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Genetic Association Study of Childhood Aggression across raters, instruments and age

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  • Site-wide: 24,513
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Lower hemoglobin levels associate with lower body mass index and healthier metabolic profile

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  • Site-wide: 26,556
  • In epidemiology: 1,439
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Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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An interaction map of circulating metabolites, immune gene networks and their genetic regulation

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  • Site-wide: 30,592
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  • Site-wide: 110,610
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  • Site-wide: 90,763

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 31,472
  • In genomics: 2,814
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  • Site-wide: 108,316

Genetic and environmental perturbations lead to regulatory decoherence

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  • Site-wide: 129,039

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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  • Site-wide: 41,204
  • In genetics: 1,953
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  • Site-wide: 77,047
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  • Site-wide: 71,094

Metabolic profiling of alcohol consumption in 9778 young adults

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  • Site-wide: 41,828
  • In systems biology: 955
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  • Site-wide: 69,032
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  • Site-wide: 105,334

Metabolic Effects Of Risk Alleles In PNPLA3, TM6SF2, GCKR, And LYPLAL1 Inform About Heterogeneity Of Non-Alcoholic Fatty Liver Disease

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  • Site-wide: 42,399
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  • Site-wide: 95,480
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  • Site-wide: 94,389

Discovering patterns of pleiotropy in genome-wide association studies

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  • Site-wide: 44,238
  • In genetics: 2,073
• Year to date:
  • Site-wide: 115,324
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  • Site-wide: 97,468

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

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  • Site-wide: 45,109
  • In genetics: 2,121
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  • Site-wide: 93,053
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  • Site-wide: 79,064

Metabolic signatures of birth weight in 18288 adolescents and adults

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  • Site-wide: 46,812
  • In systems biology: 1,087
• Year to date:
  • Site-wide: 100,865
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  • Site-wide: 96,416

Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

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  • Site-wide: 49,571
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  • Site-wide: 125,818
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  • Site-wide: 131,587

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

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  • Site-wide: 52,036
  • In genomics: 4,036
• Year to date:
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  • Site-wide: 116,900

Meta-analysis of exome array data identifies six novel genetic loci for lung function

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  • Site-wide: 55,735
  • In genetics: 2,588
• Year to date:
  • Site-wide: 118,304
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  • Site-wide: 130,812

The landscape of incident disease risk for the biomarker GlycA and its mortality stratification in angiography patients

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  • Site-wide: 58,494
  • In epidemiology: 2,522
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  • Site-wide: 112,791

Genome-wide association meta-analysis of childhood and adolescent internalising symptoms

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  • Site-wide: 65,259
  • In psychiatry and clinical psychology: 207
• Year to date:
  • Site-wide: 22,099
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  • Site-wide: 25,013

Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

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  • Site-wide: 65,528
  • In genetics: 3,023
• Year to date:
  • Site-wide: 128,165
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  • Site-wide: 118,499

Consortium genome-wide meta-analysis for childhood dental caries traits

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  • Site-wide: 68,915
  • In genetics: 3,166
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  • Site-wide: 130,607
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  • Site-wide: 131,003

Secondary Vulvodynia Patients Show Reduced Bacterial Diversity in Vestibular Microbiome

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  • Site-wide: 69,225
  • In obstetrics and gynecology: 45
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Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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  • Site-wide: 72,194
  • In genetics: 3,295
• Year to date:
  • Site-wide: 103,164
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  • Site-wide: 89,148

Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease

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  • Site-wide: 80,353
  • In epidemiology: 3,331
• Year to date:
  • Site-wide: 115,095
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  • Site-wide: 118,366

A genome-wide association study of total child psychiatric problems scores

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  • Site-wide: 82,299
  • In psychiatry and clinical psychology: 273
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  • Site-wide: 28,622

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

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  • Site-wide: 83,546
  • In genetic and genomic medicine: 299
• Year to date:
  • Site-wide: 5,898
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  • Site-wide: 21,669

Genetic study of circulating cytokines offers insight into the determinants, cascades and effects of systemic inflammation

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  • Site-wide: 92,970
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  • Site-wide: 19,363

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

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  • Site-wide: 113,839

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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  • Site-wide: 104,866
  • In genomics: 6,130
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  • Site-wide: 98,746
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  • Site-wide: 75,307

Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two European cohort studies

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Elevated glycoprotein acetyl levels in adolescence and early adulthood predict adverse cardiometabolic profiles and risk of metabolic syndrome in up to 10 year follow-up

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