Author: Yong Wang

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Preprints

Mesenchymal stromal cells and alpha-1 antitrypsin have a strong synergy in modulating inflammation

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Central extended amygdala neurons in the development of activity-based anorexia

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Mechanisms of ion selectivity and rotor coupling in the bacterial flagellar sodium-driven stator unit

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Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2

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Ultra-low input single tube linked-read library method enables short-read NGS systems to generate highly accurate and economical long-range sequencing information for de novo genome assembly and haplotype phasing

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The cross-sectional study of hospitalized coronavirus disease 2019 patients in Xiangyang, Hubei province

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AC-PCA: simultaneous dimension reduction and adjustment for confounding variation

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Ancestry Inference Using Reference Labeled Clusters of Haplotypes

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Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules

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Architecture and subunit dynamics of the mitochondrial TIM9·10·12 chaperone

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Novel COVID-19 phenotype definitions reveal phenotypically distinct patterns of genetic association and protective effects

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Augmenting Vascular Disease Diagnosis by Vasculature-aware Unsupervised Learning

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Feedback Regulation between Initiation and Maturation Networks Orchestrates the Chromatin Dynamics of Epidermal Lineage Commitment

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Integrating distal and proximal information to predict gene expression via a densely con-nected convolutional neural network

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Development of photoactivatable drugs enables nicotinic optopharmacology

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Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity

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Multiple Measures Reveal The Value of Both Race And Geographic Ancestry For Self-Identification

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Molecular Mapping Of YrTZ2, A Stripe Rust Resistance Gene In Wild Emmer Accession TZ-2 And Its Comparative Analyses With Aegilops tauschii

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Computational Studies of Substrate Transport and Specificity in a Phospholipid Flippase

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Integrative analysis of single cell genomics data by coupled nonnegative matrix factorizations

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Order and disorder - an integrative structure of the full-length human growth hormone receptor

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PSX: Protein-Solvent Exchange - Software for calculation of deuterium-exchange effects in SANS measurements from protein coordinates

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Deep sea sediments associated with cold seeps are a subsurface reservoir of viral diversity

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OpenAnnotate: a web server to annotate the chromatin accessibility of genomic regions

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Charge Interactions in a Highly Charge-depleted Protein

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  • In biochemistry: 1,730
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Structural basis of client specificity in mitochondrial membrane-protein chaperones

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  • Site-wide: 66,121
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ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming

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  • In cancer biology: 1,934
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Phylogenomics of expanding uncultured environmental Tenericutes provides insights into their pathogenicity and evolutionary relationship with Bacilli

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  • Site-wide: 70,721
  • In microbiology: 4,147
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COVID-19 in China: Risk Factors and R0 Revisited

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  • Site-wide: 71,262
  • In public and global health: 1,173
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Robust nonparametric descriptors for clustering quantification in single-molecule localization microscopy

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Monte Carlo Sampling of Protein Folding by Combining an All-Atom Physics-Based Model with a Native State Bias

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Establishing cell-intrinsic limitations in cell cycle progression controls graft growth and promotes differentiation of pancreatic endocrine cells

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  • In cell biology: 3,911
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Local SARS-CoV-2 peptide-specific Immune Responses in Lungs of Convalescent and Uninfected Human Subjects

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Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution

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  • In biophysics: 3,112
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Antimicrobial silver inhibits bacterial movement and stalls flagellar motor

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Influence of age on functional memory T cell diversity

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Precision Diffusion Imaging

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Genome-wide identification and expression analysis of the FAR gene family in hexaploid wheat (Triticum aestivum L.)

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  • In plant biology: 2,826
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Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission

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Human genetic variants associated with COVID-19 severity are enriched in immune and epithelium regulatory networks

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Aglycone polyether ionophores as broad-spectrum agents inhibit multiple enveloped viruses including SARS-CoV-2 in vitro and successfully cure JEV infected mice

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  • Site-wide: 108,093
  • In microbiology: 7,197
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Abortion and various associated risk factors in dairy cow and sheep in Ili, China

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Mesenchymal Stromal Cell Aging Impairs the Self-Organizing Capacity of Lung Alveolar Epithelial Stem Cells

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NIHBA: A Network Interdiction Approach with Hybrid Benders Algorithm for Strain Design

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DEER-PREdict: Software for Efficient Calculation of Spin-Labeling EPR and NMR Data from Conformational Ensembles

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Biased Auditory Nerve Central Synaptopathy Exacerbates Age-related Hearing Loss

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Verify Hub Genes of expression profile in aortic dissection

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HIV protease inhibitor Saquinavir inhibits toll-like receptor 4 activation by targeting receptor dimerization

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Retinoid X receptor alpha is a spatiotemporally-specific therapeutic target for doxorubicin-induced cardiomyopathy in adult zebrafish

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Mispatterned motile cilia beating causes flow blockage in the epileptic brain

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NMR structures and functional roles of two related chitin-binding domains of a lytic polysaccharide monooxygenase from Cellvibrio japonicus

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Faster diffusive dynamics of histone-like nucleoid structuring proteins in live bacteria caused by silver ions

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Bent DNA bows as amplifiers and biosensors for detecting DNA-interacting salts and molecules

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Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

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Staging and typing of chest CT images: A quantitative analysis based on an ambispective observational cohort study of 125 patients with COVID-19 in Xiangyang, China

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Evolutionary ecology of microbial populations inhabiting deep sea sediments associated with cold seeps

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Evolutionarily conserved chaperone-mediated proteasomal degradation of a disease-linked aspartoacylase variant

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Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Pancreatic Islets

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Electrophysiological characterization of human atria: the understated role of temperature

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Characterization of Isoforms of the Ovine Granulocyte Colony Stimulating Factor

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Phylogenomic insights into distribution and adaptation of Bdellovibrionota in marine waters

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A Multidisciplinary Prematurity Research Cohort Study

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Interpreting ruminant specific conserved non-coding elements by developmental gene regulatory network

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Predictive and analysis of COVID-19 cases cumulative total;ARIMA model based on machine learning

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GuidingNet: revealing transcriptional cofactor and predicting binding for DNA methyltransferase by network regularization

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Integrative analysis of the hydroxypyruvate reductases revealing their distinct roles in photorespiration of Chlamydomonas

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Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast

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Truncated suPAR simultaneously causes kidney disease and autoimmune diabetes mellitus

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Properdin oligomers adopt rigid extended conformations supporting function

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PHB3 Regulates Lateral Root Primordia Formation via NO-mediated Degradation of AUX/IAAs

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Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification

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Does Tesla valve work for microscale active swimmers? - a computational study

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From motor protein to toxin: Mutations in the zonula occludens toxin (Zot) of Vibrio cholerae phage CTXΦ suggest a loss of phage assembly function

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Bacterial mobility and motility in porous media mimicked by microspheres

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Drought and flooding resistances of maize germplasm are compared and evaluated using a multivariate analysis method

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