Author: Yong Wang

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Preprints

Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2

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  • Site-wide: 1,818
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The cross-sectional study of hospitalized coronavirus disease 2019 patients in Xiangyang, Hubei province

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  • Site-wide: 3,699
  • In infectious diseases: 636
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Ultra-low input single tube linked-read library method enables short-read NGS systems to generate highly accurate and economical long-range sequencing information for de novo genome assembly and haplotype phasing

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  • Site-wide: 4,073
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AC-PCA: simultaneous dimension reduction and adjustment for confounding variation

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  • Site-wide: 4,887
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Feedback Regulation between Initiation and Maturation Networks Orchestrates the Chromatin Dynamics of Epidermal Lineage Commitment

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  • Site-wide: 25,841
  • In cell biology: 961
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Development of photoactivatable drugs enables nicotinic optopharmacology

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  • Site-wide: 31,560
  • In neuroscience: 4,367
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Integrative analysis of single cell genomics data by coupled nonnegative matrix factorizations

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  • Site-wide: 32,522
  • In bioinformatics: 3,683
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Molecular Mapping Of YrTZ2, A Stripe Rust Resistance Gene In Wild Emmer Accession TZ-2 And Its Comparative Analyses With Aegilops tauschii

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  • Site-wide: 34,278
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Ancestry Inference Using Reference Labeled Clusters of Haplotypes

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  • In genomics: 3,020
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Multiple Measures Reveal The Value of Both Race And Geographic Ancestry For Self-Identification

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  • Site-wide: 41,082
  • In genetics: 1,978
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Architecture and subunit dynamics of the mitochondrial TIM9·10·12 chaperone

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  • In biophysics: 1,381
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Integrating distal and proximal information to predict gene expression via a densely con-nected convolutional neural network

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  • Site-wide: 42,273
  • In bioinformatics: 4,556
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  • Site-wide: 70,208
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  • Site-wide: 70,208

ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming

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  • Site-wide: 42,952
  • In cancer biology: 1,196
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  • Site-wide: 42,943
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Structural basis of client specificity in mitochondrial membrane-protein chaperones

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  • Site-wide: 44,647
  • In biophysics: 1,508
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Order and disorder - an integrative structure of the full-length human growth hormone receptor

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  • Site-wide: 46,754
  • In biophysics: 1,578
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Robust nonparametric descriptors for clustering quantification in single-molecule localization microscopy

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  • Site-wide: 47,625
  • In biophysics: 1,613
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  • Site-wide: 82,815

Novel COVID-19 phenotype definitions reveal phenotypically distinct patterns of genetic association and protective effects

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  • Site-wide: 50,213
  • In genetic and genomic medicine: 144
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  • Site-wide: 1,120
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  • Site-wide: 1,120

PSX: Protein-Solvent Exchange - Software for calculation of deuterium-exchange effects in SANS measurements from protein coordinates

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  • Site-wide: 51,140
  • In biophysics: 1,767
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  • Site-wide: 101,087
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  • Site-wide: 101,087

COVID-19 in China: Risk Factors and R0 Revisited

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  • Site-wide: 53,248
  • In public and global health: 653
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  • Site-wide: 89,381
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  • Site-wide: 89,381

Augmenting Vascular Disease Diagnosis by Vasculature-aware Unsupervised Learning

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  • Site-wide: 54,442
  • In bioengineering: 996
• Year to date:
  • Site-wide: 51,136
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Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution

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  • Site-wide: 54,755
  • In biophysics: 1,913
• Year to date:
  • Site-wide: 62,671
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Phylogenomics of expanding uncultured environmental Tenericutes provides insights into their pathogenicity and evolutionary relationship with Bacilli

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  • Site-wide: 55,572
  • In microbiology: 3,621
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  • Site-wide: 34,539
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  • Site-wide: 34,539

Charge Interactions in a Highly Charge-depleted Protein

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  • Site-wide: 55,787
  • In biochemistry: 1,465
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  • Site-wide: 29,002
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Deep sea sediments associated with cold seeps are a subsurface reservoir of viral diversity

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  • Site-wide: 57,403
  • In microbiology: 3,745
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  • Site-wide: 25,345

Monte Carlo Sampling of Protein Folding by Combining an All-Atom Physics-Based Model with a Native State Bias

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  • Site-wide: 60,454
  • In biophysics: 2,169
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OPENANNO: annotating genomic regions with chromatin accessibility

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  • Site-wide: 60,695
  • In bioinformatics: 6,000
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  • Site-wide: 57,232
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  • Site-wide: 57,232

Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission

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  • Site-wide: 63,859
  • In neuroscience: 9,751
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  • Site-wide: 96,438
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  • Site-wide: 96,438

Establishing cell-intrinsic limitations in cell cycle progression controls graft growth and promotes differentiation of pancreatic endocrine cells

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  • Site-wide: 66,696
  • In cell biology: 3,037
• Year to date:
  • Site-wide: 13,894
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Antimicrobial silver inhibits bacterial movement and stalls flagellar motor

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  • Site-wide: 66,680
  • In biophysics: 2,443
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  • Site-wide: 74,805
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  • Site-wide: 74,805

Genome-wide identification and expression analysis of the FAR gene family in hexaploid wheat (Triticum aestivum L.)

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  • Site-wide: 71,302
  • In plant biology: 1,909
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  • Site-wide: 84,528
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  • Site-wide: 84,528

Computational Studies of Substrate Transport and Specificity in a Phospholipid Flippase

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  • Site-wide: 71,283
  • In biophysics: 2,653
• Year to date:
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  • Site-wide: 55,679

NIHBA: A Network Interdiction Approach with Hybrid Benders Algorithm for Strain Design

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  • Site-wide: 81,353
  • In bioengineering: 1,511
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Verify Hub Genes of expression profile in aortic dissection

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  • Site-wide: 86,185
  • In bioinformatics: 7,699
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Abortion and various associated risk factors in dairy cow and sheep in Ili, China

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  • Site-wide: 90,044
  • In zoology: 375
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  • Site-wide: 31,892
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DEER-PREdict: Software for Efficient Calculation of Spin-Labeling EPR and NMR Data from Conformational Ensembles

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  • Site-wide: 90,197
  • In biophysics: 3,480
• Year to date:
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  • Site-wide: 38,183

Bent DNA bows as amplifiers and biosensors for detecting DNA-interacting salts and molecules

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  • Site-wide: 92,072
  • In biophysics: 3,555
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HIV protease inhibitor Saquinavir inhibits toll-like receptor 4 activation by targeting receptor dimerization

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  • Site-wide: 92,000
  • In immunology: 2,526
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  • Site-wide: 81,494
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  • Site-wide: 81,494

Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules

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  • Site-wide: 93,871
  • In cell biology: 4,384
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Biased Auditory Nerve Central Synaptopathy Exacerbates Age-related Hearing Loss

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  • Site-wide: 94,718
  • In neuroscience: 14,819
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Retinoid X receptor alpha is a spatiotemporally-specific therapeutic target for doxorubicin-induced cardiomyopathy in adult zebrafish

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  • Site-wide: 96,191
  • In genetics: 4,385
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Faster diffusive dynamics of histone-like nucleoid structuring proteins in live bacteria caused by silver ions

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  • Site-wide: 96,787
  • In biophysics: 3,744
• Year to date:
  • Site-wide: 119,324
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  • Site-wide: 119,324

Aglycone polyether ionophores as broad-spectrum agents inhibit multiple enveloped viruses including SARS-CoV-2 in vitro and successfully cure JEV infected mice

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  • Site-wide: 101,402
  • In microbiology: 7,513
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Characterization of Isoforms of the Ovine Granulocyte Colony Stimulating Factor

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  • Site-wide: 108,346
  • In genetics: 4,820
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Evolutionarily conserved chaperone-mediated proteasomal degradation of a disease-linked aspartoacylase variant

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  • Site-wide: 112,315
  • In biochemistry: 3,358
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Staging and typing of chest CT images: A quantitative analysis based on an ambispective observational cohort study of 125 patients with COVID-19 in Xiangyang, China

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  • Site-wide: 112,959
  • In radiology and imaging: 226
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GuidingNet: revealing transcriptional cofactor and predicting binding for DNA methyltransferase by network regularization

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  • Site-wide: 114,072
  • In bioinformatics: 9,373
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Electrophysiological characterization of human atria: the understated role of temperature

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  • Site-wide: 115,343
  • In biophysics: 4,472
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Properdin oligomers adopt rigid extended conformations supporting function

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  • Site-wide: 120,756
  • In immunology: 3,417
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Phylogenomic insights into distribution and adaptation of Bdellovibrionota in marine waters

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  • Site-wide: 122,747
  • In microbiology: 9,486
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