Author: Jun Liu

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Preprints

The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I

• Downloaded 13,148 times
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  • Site-wide: 505
  • In microbiology: 57
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  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Teicoplanin potently blocks the cell entry of 2019-nCoV

• Downloaded 7,273 times
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  • Site-wide: 1,123
  • In microbiology: 102
• Year to date:
  • Site-wide: 6,580
• Since beginning of last month:
  • Site-wide: 6,580

Genomic epidemiology of SARS-CoV-2 in Guangdong Province, China

• Downloaded 3,461 times
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  • Site-wide: 3,149
  • In infectious diseases: 583
• Year to date:
  • Site-wide: 5,138
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  • Site-wide: 5,138

Molecular Detection of SARS-CoV-2 in Formalin Fixed Paraffin Embedded Specimens

• Downloaded 3,297 times
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  • Site-wide: 3,368
  • In microbiology: 218
• Year to date:
  • Site-wide: 4,629
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  • Site-wide: 4,629

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 7,927
  • In genetics: 385
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Spike-timing pattern operates as gamma-distribution across cell types, regions and animal species and is essential for naturally-occurring cognitive states

• Downloaded 1,134 times
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  • Site-wide: 16,237
  • In neuroscience: 2,016
• Year to date:
  • Site-wide: 27,981
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  • Site-wide: 27,981

Using a bar-coded AAV capsid library to select for novel clinically relevant gene therapy vectors

• Downloaded 1,043 times
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  • Site-wide: 18,420
  • In genetics: 925
• Year to date:
  • Site-wide: 22,920
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  • Site-wide: 22,920

Morphology of Mitochondria in Spatially Restricted Axons Revealed by Cryo-Electron Tomography

• Downloaded 1,016 times
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  • Site-wide: 19,153
  • In neuroscience: 2,450
• Year to date:
  • Site-wide: 43,309
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  • Site-wide: 43,309

Model-based analysis of positive selection significantly expands the list of cancer driver genes, including RNA methyltransferases

• Downloaded 996 times
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  • Site-wide: 19,722
  • In genomics: 2,008
• Year to date:
  • Site-wide: 91,777
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  • Site-wide: 91,777

MBIR: A Cryo-electron Tomography 3D Reconstruction Method that Effectively Minimizes Missing Wedge Artifacts and Restores Missing Information

• Downloaded 947 times
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  • Site-wide: 21,164
  • In biophysics: 580
• Year to date:
  • Site-wide: 48,760
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  • Site-wide: 48,760

Structure of mycobacterial ATP synthase with the TB drug bedaquiline

• Downloaded 937 times
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  • Site-wide: 21,467
  • In biochemistry: 484
• Year to date:
  • Site-wide: 15,171
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  • Site-wide: 15,171

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

• Downloaded 895 times
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  • Site-wide: 23,010
  • In microbiology: 1,298
• Year to date:
  • Site-wide: 14,311
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  • Site-wide: 14,311

Solvent quality and chromosome folding in Escherichia coli

• Downloaded 882 times
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  • Site-wide: 23,488
  • In biophysics: 655
• Year to date:
  • Site-wide: 15,991
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  • Site-wide: 15,991

High-resolution view of the type III secretion export apparatus in situ reveals membrane remodeling and a secretion pathway

• Downloaded 849 times
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  • Site-wide: 24,748
  • In microbiology: 1,417
• Year to date:
  • Site-wide: 90,553
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  • Site-wide: 90,553

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 794 times
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  • Site-wide: 27,133
  • In genetics: 1,353
• Year to date:
  • Site-wide: 26,531
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  • Site-wide: 26,531

Structure of a novel dimeric SET domain methyltransferase that regulates cell motility

• Downloaded 743 times
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  • Site-wide: 29,788
  • In biochemistry: 705
• Year to date:
  • Site-wide: 35,392
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  • Site-wide: 35,392

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 711 times
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  • Site-wide: 31,724
  • In genetics: 1,576
• Year to date:
  • Site-wide: 13,774
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  • Site-wide: 13,774

Genome-wide association study of plasma triglycerides, phospholipids and relation to cardio-metabolic risk factors

• Downloaded 701 times
• Download rankings, all-time:
  • Site-wide: 32,286
  • In epidemiology: 1,600
• Year to date:
  • Site-wide: 35,739
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  • Site-wide: 35,739

A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers

• Downloaded 683 times
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  • Site-wide: 33,454
  • In cell biology: 1,340
• Year to date:
  • Site-wide: 84,493
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  • Site-wide: 84,493

Molecular Mechanism for Rotational Switching of the Bacterial Flagellar Motor

• Downloaded 680 times
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  • Site-wide: 33,658
  • In microbiology: 1,993
• Year to date:
  • Site-wide: 32,098
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  • Site-wide: 32,098

Discovery of an essential mycobacterial polar growth factor involved in cell envelope integrity and lipomannan and lipoarabinomannan transport

• Downloaded 656 times
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  • Site-wide: 35,348
  • In microbiology: 2,103
• Year to date:
  • Site-wide: 30,030
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  • Site-wide: 30,030

Neural code uses self-information principle to organize the brain's universal cell-assembly coding

• Downloaded 591 times
• Download rankings, all-time:
  • Site-wide: 40,389
  • In neuroscience: 5,814
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Stability and function of a putative microtubule organizing center in the human parasite Toxoplasma gondii

• Downloaded 572 times
• Download rankings, all-time:
  • Site-wide: 42,038
  • In cell biology: 1,769
• Year to date:
  • Site-wide: 62,163
• Since beginning of last month:
  • Site-wide: 62,163

Loss of a doublecortin (DCX) domain containing protein causes structural defects in a tubulin-based organelle of Toxoplasma gondii and impairs host cell invasion.

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 43,960
  • In cell biology: 1,893
• Year to date:
  • Site-wide: 96,685
• Since beginning of last month:
  • Site-wide: 96,685

Establishing Rod-Shape from Spherical, Peptidoglycan-Deficient Bacterial Spores

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 49,387
  • In microbiology: 3,126
• Year to date:
  • Site-wide: 116,180
• Since beginning of last month:
  • Site-wide: 116,180

Ex vivo dynamics of human glioblastoma cells in a microvasculature-on-a-chip system correlates with tumor heterogeneity and subtypes

• Downloaded 486 times
• Download rankings, all-time:
  • Site-wide: 51,141
  • In bioengineering: 935
• Year to date:
  • Site-wide: 72,284
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  • Site-wide: 72,284

An asymmetric sheath controls flagellar supercoiling and motility in the Leptospira spirochete

• Downloaded 462 times
• Download rankings, all-time:
  • Site-wide: 54,114
  • In biophysics: 1,890
• Year to date:
  • Site-wide: 36,010
• Since beginning of last month:
  • Site-wide: 36,010

Non-canonical immune response to the inhibition of DNA methylation via stabilization of endogenous retrovirus dsRNAs

• Downloaded 449 times
• Download rankings, all-time:
  • Site-wide: 55,770
  • In molecular biology: 1,609
• Year to date:
  • Site-wide: 18,696
• Since beginning of last month:
  • Site-wide: 18,696

TgCentrin2 is required for invasion and replication in the human parasite Toxoplasma gondii

• Downloaded 442 times
• Download rankings, all-time:
  • Site-wide: 56,744
  • In cell biology: 2,493
• Year to date:
  • Site-wide: 113,565
• Since beginning of last month:
  • Site-wide: 113,565

Association between comorbidities and the risk of death in patients with COVID-19: sex-specific differences

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 59,347
  • In respiratory medicine: 109
• Year to date:
  • Site-wide: 76,211
• Since beginning of last month:
  • Site-wide: 76,211

Inhibition of Intracellular Lipolysis Promotes Cancer Cell Adaptation to Hypoxia

• Downloaded 419 times
• Download rankings, all-time:
  • Site-wide: 59,878
  • In biochemistry: 1,610
• Year to date:
  • Site-wide: 117,199
• Since beginning of last month:
  • Site-wide: 117,199

A systems approach to refine disease taxonomy by integrating phenotypic and molecular networks

• Downloaded 407 times
• Download rankings, all-time:
  • Site-wide: 61,726
  • In bioinformatics: 6,073
• Year to date:
  • Site-wide: 97,974
• Since beginning of last month:
  • Site-wide: 97,974

Deletion of Lats 1 and 2 in mouse pancreatic acinar cells induces pancreatic fibrosis and inflammation

• Downloaded 399 times
• Download rankings, all-time:
  • Site-wide: 62,931
  • In molecular biology: 1,841
• Year to date:
  • Site-wide: 109,334
• Since beginning of last month:
  • Site-wide: 109,334

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

• Downloaded 385 times
• Download rankings, all-time:
  • Site-wide: 65,100
  • In physiology: 460
• Year to date:
  • Site-wide: 92,167
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  • Site-wide: 92,167

Encoding Fear of Heights by Basolateral Amygdala Neurons

• Downloaded 364 times
• Download rankings, all-time:
  • Site-wide: 68,494
  • In neuroscience: 10,516
• Year to date:
  • Site-wide: 45,049
• Since beginning of last month:
  • Site-wide: 45,049

Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks

• Downloaded 359 times
• Download rankings, all-time:
  • Site-wide: 69,430
  • In systems biology: 1,689
• Year to date:
  • Site-wide: 60,518
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  • Site-wide: 60,518

SCOAT-Net: A Novel Network for Segmenting COVID-19 Lung Opacification from CT Images

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 70,314
  • In radiology and imaging: 99
• Year to date:
  • Site-wide: 30,889
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  • Site-wide: 30,889

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

• Downloaded 344 times
• Download rankings, all-time:
  • Site-wide: 71,941
  • In genomics: 4,969
• Year to date:
  • Site-wide: 121,644
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  • Site-wide: 121,644

Regulation by HSP70/90 in the different tissues and testis development of male cattle (Cattle-yak and Yak)

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 72,421
  • In biochemistry: 2,004
• Year to date:
  • Site-wide: 109,408
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  • Site-wide: 109,408

A CRISPR interference platform for selective downregulation of gene expression in Borrelia burgdorferi

• Downloaded 320 times
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  • Site-wide: 76,367
  • In microbiology: 5,298
• Year to date:
  • Site-wide: 27,662
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  • Site-wide: 27,662

Ultrasensitive small molecule fluorogenic probe for human heparanase

• Downloaded 314 times
• Download rankings, all-time:
  • Site-wide: 77,472
  • In biochemistry: 2,194
• Year to date:
  • Site-wide: 81,387
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  • Site-wide: 81,387

methylSCOPA and META-methylSCOPA: software for the analysis and aggregation of epigenome-wide association studies of multiple correlated phenotypes

• Downloaded 313 times
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  • Site-wide: 77,708
  • In bioinformatics: 7,164
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  • Site-wide: None
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  • Site-wide: None

Synergistic effect: a common theme in mixed-species litter decomposition

• Downloaded 298 times
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  • Site-wide: 80,522
  • In ecology: 2,499
• Year to date:
  • Site-wide: 40,198
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  • Site-wide: 40,198

A Self-Immobilizing NIR Probe for Non-invasive Imaging of Senescence

• Downloaded 295 times
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  • Site-wide: 81,132
  • In biochemistry: 2,331
• Year to date:
  • Site-wide: 44,066
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  • Site-wide: 44,066

RNA Polymerase II Independent Recruitment of SPT6 at Transcription Start Sites in Arabidopsis

• Downloaded 291 times
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  • Site-wide: 81,990
  • In molecular biology: 2,427
• Year to date:
  • Site-wide: 67,901
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  • Site-wide: 67,901

The Vibrio H-ring facilitates the outer membrane penetration of polar-sheathed flagellum

• Downloaded 283 times
• Download rankings, all-time:
  • Site-wide: 83,719
  • In microbiology: 5,918
• Year to date:
  • Site-wide: 116,381
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  • Site-wide: 116,381

IMCC: Quantitative Analysis of the Inter-module Connectivity for Bio-network

• Downloaded 256 times
• Download rankings, all-time:
  • Site-wide: 89,447
  • In systems biology: 2,124
• Year to date:
  • Site-wide: 119,380
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  • Site-wide: 119,380

The C. elegans SMOC-1 protein acts cell non-autonomously to promote bone morphogenetic protein signaling

• Downloaded 251 times
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  • Site-wide: 90,490
  • In genetics: 4,133
• Year to date:
  • Site-wide: 85,196
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  • Site-wide: 85,196

Effect of inbreeding on type 2 diabetes-related metabolites in a Dutch genetic isolate

• Downloaded 247 times
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  • Site-wide: 91,406
  • In genetics: 4,180
• Year to date:
  • Site-wide: 121,154
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  • Site-wide: 121,154

Recessive genetic effects on type 2 diabetes-related metabolites in a consanguineous population

• Downloaded 222 times
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  • Site-wide: 96,634
  • In genetics: 4,399
• Year to date:
  • Site-wide: 118,344
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  • Site-wide: 118,344

Quantitative investigation of factors relevant to the T cell spot test for tuberculosis infection in active tuberculosis

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 97,551
  • In epidemiology: 3,961
• Year to date:
  • Site-wide: 97,483
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  • Site-wide: 97,483

Nuclear m6A reader Ythdc1 regulates the scaffold function of LINE1 in mouse ESCs

• Downloaded 218 times
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  • Site-wide: 97,514
  • In cell biology: 4,529
• Year to date:
  • Site-wide: 3,746
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  • Site-wide: 3,746

In situ 3D comparison of Chlorella pyrenoidosa with nuclear-irradiated mutagenic strains by using focused ion beam milling and cryo-electron tomography

• Downloaded 213 times
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  • Site-wide: 98,723
  • In microbiology: 7,248
• Year to date:
  • Site-wide: 46,831
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  • Site-wide: 46,831

Repulsive Guidance Molecule Acts in Axon Branching in Caenorhabditis elegans

• Downloaded 182 times
• Download rankings, all-time:
  • Site-wide: 105,255
  • In developmental biology: 2,867
• Year to date:
  • Site-wide: 109,872
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  • Site-wide: 109,872

The bone microenvironment invigorates metastatic seeds for further dissemination

• Downloaded 176 times
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  • Site-wide: 106,523
  • In cancer biology: 3,275
• Year to date:
  • Site-wide: 31,067
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  • Site-wide: 31,067

Internally quenched fluorogenic probe provides selective and rapid detection of cathepsin L activity

• Downloaded 164 times
• Download rankings, all-time:
  • Site-wide: 108,975
  • In biochemistry: 3,227
• Year to date:
  • Site-wide: 81,379
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  • Site-wide: 81,379

MMpred: a distance-assisted multimodal conformation sampling for de novo protein structure prediction

• Downloaded 130 times
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  • Site-wide: 115,442
  • In bioinformatics: 9,471
• Year to date:
  • Site-wide: 7,591
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  • Site-wide: 7,591

Eastern Equine Encephalitis Virus Rapidly Infects and Disseminates in the Brain and Spinal Cord of Infected Cynomolgus Macaques Following Aerosol Challenge

• Downloaded 122 times
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  • Site-wide: 116,868
  • In microbiology: 8,915
• Year to date:
  • Site-wide: 41,664
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  • Site-wide: 41,664

Transcriptome analysis of Fenneropenaeus chinensis (Decapoda: Penaeidae) after low-salinity exposure identifies differentially expressed genes in pathways potentially related to osmoregulation

• Downloaded 92 times
• Download rankings, all-time:
  • Site-wide: 122,123
  • In physiology: 1,482
• Year to date:
  • Site-wide: 108,254
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  • Site-wide: 108,254

A multi-omics study of circulating phospholipid markers of blood pressure

• Downloaded 92 times
• Download rankings, all-time:
  • Site-wide: 122,064
  • In cardiovascular medicine: 317
• Year to date:
  • Site-wide: 55,578
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  • Site-wide: 55,578