Author: Jun Liu

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Preprints

Interplay of Human Metabolome and Gut Microbiome in Major Depression

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The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I

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Glycopeptide antibiotic teicoplanin inhibits cell entry of SARS-CoV-2 by suppressing the proteolytic activity of cathepsin L

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Genomic epidemiology of SARS-CoV-2 in Guangdong Province, China

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Molecular Detection of SARS-CoV-2 in Formalin Fixed Paraffin Embedded Specimens

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Aerosol Exposure of Cynomolgus Macaques to SARS-CoV-2 Results in More Severe Pathology than Existing Models

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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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Structure of mycobacterial ATP synthase with the TB drug bedaquiline

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Spike-timing pattern operates as gamma-distribution across cell types, regions and animal species and is essential for naturally-occurring cognitive states

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Using a bar-coded AAV capsid library to select for novel clinically relevant gene therapy vectors

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Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B

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Solvent quality and chromosome folding in Escherichia coli

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Morphology of Mitochondria in Spatially Restricted Axons Revealed by Cryo-Electron Tomography

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The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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MBIR: A Cryo-electron Tomography 3D Reconstruction Method that Effectively Minimizes Missing Wedge Artifacts and Restores Missing Information

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Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

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An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria

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The bone microenvironment invigorates metastatic seeds for further dissemination

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Model-based analysis of positive selection significantly expands the list of cancer driver genes, including RNA methyltransferases

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High-resolution view of the type III secretion export apparatus in situ reveals membrane remodeling and a secretion pathway

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Genome-wide association study of plasma triglycerides, phospholipids and relation to cardio-metabolic risk factors

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Structure of a novel dimeric SET domain methyltransferase that regulates cell motility

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Molecular Mechanism for Rotational Switching of the Bacterial Flagellar Motor

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Nuclear m6A reader Ythdc1 regulates the scaffold function of LINE1 in mouse ESCs

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Homologous or Heterologous Booster of Inactivated Vaccine Reduces SARS-CoV-2 Omicron Variant Escape from Neutralizing Antibodies

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A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers

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Non-canonical immune response to the inhibition of DNA methylation via stabilization of endogenous retrovirus dsRNAs

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Neural code uses self-information principle to organize the brain's universal cell-assembly coding

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SCOAT-Net: A Novel Network for Segmenting COVID-19 Lung Opacification from CT Images

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Stability and function of a putative microtubule organizing center in the human parasite Toxoplasma gondii

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Loss of a doublecortin (DCX) domain containing protein causes structural defects in a tubulin-based organelle of Toxoplasma gondii and impairs host cell invasion.

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Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks

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An asymmetric sheath controls flagellar supercoiling and motility in the Leptospira spirochete

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Association between comorbidities and the risk of death in patients with COVID-19: sex-specific differences

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A Self-Immobilizing NIR Probe for Non-invasive Imaging of Senescence

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Ex vivo dynamics of human glioblastoma cells in a microvasculature-on-a-chip system correlates with tumor heterogeneity and subtypes

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Establishing Rod-Shape from Spherical, Peptidoglycan-Deficient Bacterial Spores

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Synergistic effect: a common theme in mixed-species litter decomposition

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Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

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A CRISPR interference platform for selective downregulation of gene expression in Borrelia burgdorferi

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Inhibition of Intracellular Lipolysis Promotes Cancer Cell Adaptation to Hypoxia

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Intranasal HD-Ad Vaccine Protects the Upper and Lower Respiratory Tracts of hACE2 Mice against SARS-CoV-2

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Deletion of Lats 1 and 2 in mouse pancreatic acinar cells induces pancreatic fibrosis and inflammation

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Encoding Fear of Heights by Basolateral Amygdala Neurons

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TgCentrin2 is required for invasion and replication in the human parasite Toxoplasma gondii

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Regulation by HSP70/90 in the different tissues and testis development of male cattle (Cattle-yak and Yak)

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A systems approach to refine disease taxonomy by integrating phenotypic and molecular networks

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methylSCOPA and META-methylSCOPA: software for the analysis and aggregation of epigenome-wide association studies of multiple correlated phenotypes

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In situ 3D comparison of Chlorella pyrenoidosa with nuclear-irradiated mutagenic strains by using focused ion beam milling and cryo-electron tomography

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Ultrasensitive small molecule fluorogenic probe for human heparanase

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A Conformation-specific Nanobody Targeting the NMN-activated State of SARM1

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Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

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Profiling tumor immune microenvironment of non-small cell lung cancer using multiplex immunofluorescence

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Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha

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RNA Polymerase II Independent Recruitment of SPT6 at Transcription Start Sites in Arabidopsis

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Trans-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

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IMCC: Quantitative Analysis of the Inter-module Connectivity for Bio-network

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Effect of inbreeding on type 2 diabetes-related metabolites in a Dutch genetic isolate

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A de novo protein structure prediction by iterative partition sampling, topology adjustment, and residue-level distance deviation optimization

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The C. elegans SMOC-1 protein acts cell non-autonomously to promote bone morphogenetic protein signaling

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Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brain

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The Vibrio H-ring facilitates the outer membrane penetration of polar-sheathed flagellum

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Distance-guided protein folding based on generalized descent direction

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Recessive genetic effects on type 2 diabetes-related metabolites in a consanguineous population

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Internally quenched fluorogenic probe provides selective and rapid detection of cathepsin L activity

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DeepUMQA: Ultrafast Shape Recognition-based Protein Model Quality Assessment using Deep Learning

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Eastern Equine Encephalitis Virus Rapidly Infects and Disseminates in the Brain and Spinal Cord of Infected Cynomolgus Macaques Following Aerosol Challenge

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MMpred: a distance-assisted multimodal conformation sampling for de novo protein structure prediction

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Quantitative investigation of factors relevant to the T cell spot test for tuberculosis infection in active tuberculosis

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A self-immolative linker for heparanase activatable probe

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A Versatile Linker for Probes Targeting Hydrolases via In Situ labeling

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ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of liver cells

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Repulsive Guidance Molecule Acts in Axon Branching in Caenorhabditis elegans

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A multi-omics study of circulating phospholipid markers of blood pressure

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The Unconventional Self-Cleavage of Selenoprotein K

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Characterization of the flagellar collar reveals structural plasticity essential for spirochete motility

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Aberrant epigenetic and transcriptional events associated with breast cancer risk

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Transcriptome analysis of Fenneropenaeus chinensis (Decapoda: Penaeidae) after low-salinity exposure identifies differentially expressed genes in pathways potentially related to osmoregulation

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Construct a variable-length fragment library for de novo protein structure prediction

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Predicting Axillary Lymph Node Metastasis in Early Breast Cancer Using Deep Learning on Primary Tumor Biopsy Slides

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DomBpred: protein domain boundary predictor using inter-residue distance and domain-residue level clustering

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Composition and Biophysical Properties of the Sorting Platform Pods in the Shigella Type III Secretion System

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Phylogenetic and protein prediction analysis reveals the taxonomically diverse distribution of virulence factors in the Bacillus cereus group

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