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Author: Ian A. Wilson

Rankings

  • All-time downloads: 70,745 (rank: 3,391 )
  • Categories:
    • biochemistry: 583 (rank: 16,309 (tie) )
    • bioengineering: 810 (rank: 8,250 (tie) )
    • biophysics: 338 (rank: 22,568 (tie) )
    • immunology: 21,067 (rank: 787 )
    • infectious diseases: 1,785 (rank: 25,746 (tie) )
    • microbiology: 32,910 (rank: 669 )
    • molecular biology: 368 (rank: 26,933 (tie) )
    • neuroscience: 472 (rank: 70,200 (tie) )
    • synthetic biology: 7,642 (rank: 157 (tie) )

Downloads per author, site-wide

Preprints

Robust de novo design of protein binding proteins from target structural information alone

synthetic biology more details view paper
  • Downloaded 7,849 times
  • Download rankings, all-time:
    • Site-wide: 1,850
    • In synthetic biology: 16
  • Year to date:
    • Site-wide: 1,270
  • Since beginning of last month:
    • Site-wide: 7,258

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

microbiology more details view paper
  • Downloaded 6,140 times
  • Download rankings, all-time:
    • Site-wide: 2,590
    • In microbiology: 201
  • Year to date:
    • Site-wide: 92,136
  • Since beginning of last month:
    • Site-wide: 29,276

Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

microbiology more details view paper
  • Downloaded 5,481 times
  • Download rankings, all-time:
    • Site-wide: 3,017
    • In microbiology: 226
  • Year to date:
    • Site-wide: 66,289
  • Since beginning of last month:
    • Site-wide: 106,672

A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV

microbiology more details view paper
  • Downloaded 4,269 times
  • Download rankings, all-time:
    • Site-wide: 4,246
    • In microbiology: 283
  • Year to date:
    • Site-wide: 132,822
  • Since beginning of last month:
    • Site-wide: 106,946

Structural basis of a public antibody response to SARS-CoV-2

microbiology more details view paper
  • Downloaded 2,679 times
  • Download rankings, all-time:
    • Site-wide: 8,394
    • In microbiology: 586
  • Year to date:
    • Site-wide: 11,786
  • Since beginning of last month:
    • Site-wide: 35,939

A protective broadly cross-reactive human antibody defines a conserved site of vulnerability on beta-coronavirus spikes

immunology more details view paper
  • Downloaded 2,601 times
  • Download rankings, all-time:
    • Site-wide: 8,746
    • In immunology: 330
  • Year to date:
    • Site-wide: 7,048
  • Since beginning of last month:
    • Site-wide: 34,940

Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates

microbiology more details view paper
  • Downloaded 2,397 times
  • Download rankings, all-time:
    • Site-wide: 9,899
    • In microbiology: 587
  • Year to date:
    • Site-wide: 22,984
  • Since beginning of last month:
    • Site-wide: 28,410

A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model

immunology more details view paper
  • Downloaded 2,336 times
  • Download rankings, all-time:
    • Site-wide: 10,323
    • In immunology: 377
  • Year to date:
    • Site-wide: 71,360
  • Since beginning of last month:
    • Site-wide: 54,138

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

immunology more details view paper
  • Downloaded 1,900 times
  • Download rankings, all-time:
    • Site-wide: 14,093
    • In immunology: 524
  • Year to date:
    • Site-wide: 19,217
  • Since beginning of last month:
    • Site-wide: 24,476

Dynamics of B-cell repertoires and emergence of cross-reactive responses in COVID-19 patients with different disease severity

infectious diseases more details view paper
  • Downloaded 1,824 times
  • Download rankings, all-time:
    • Site-wide: 15,003
    • In infectious diseases: 1,951
  • Year to date:
    • Site-wide: 17,549
  • Since beginning of last month:
    • Site-wide: 108,598

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

microbiology more details view paper
  • Downloaded 1,699 times
  • Download rankings, all-time:
    • Site-wide: 16,707
    • In microbiology: 926
  • Year to date:
    • Site-wide: 24,168
  • Since beginning of last month:
    • Site-wide: 135,706

Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses

immunology more details view paper
  • Downloaded 1,532 times
  • Download rankings, all-time:
    • Site-wide: 19,664
    • In immunology: 1,041
  • Year to date:
    • Site-wide: 3,718
  • Since beginning of last month:
    • Site-wide: 7,501

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease

immunology more details view paper
  • Downloaded 1,479 times
  • Download rankings, all-time:
    • Site-wide: 20,814
    • In immunology: 896
  • Year to date:
    • Site-wide: 1,854
  • Since beginning of last month:
    • Site-wide: 9,049

Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

microbiology more details view paper
  • Downloaded 1,351 times
  • Download rankings, all-time:
    • Site-wide: 24,032
    • In microbiology: 1,338
  • Year to date:
    • Site-wide: 78,914
  • Since beginning of last month:
    • Site-wide: None

Broadly neutralizing antibodies target the coronavirus fusion peptide

immunology more details view paper
  • Downloaded 1,234 times
  • Download rankings, all-time:
    • Site-wide: 27,796
    • In immunology: 1,046
  • Year to date:
    • Site-wide: 2,466
  • Since beginning of last month:
    • Site-wide: 22,304

An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain

microbiology more details view paper
  • Downloaded 1,231 times
  • Download rankings, all-time:
    • Site-wide: 27,869
    • In microbiology: 1,564
  • Year to date:
    • Site-wide: 89,800
  • Since beginning of last month:
    • Site-wide: 141,437

Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

immunology more details view paper
  • Downloaded 1,078 times
  • Download rankings, all-time:
    • Site-wide: 34,263
    • In immunology: 1,146
  • Year to date:
    • Site-wide: 189,130
  • Since beginning of last month:
    • Site-wide: None

HIV-1 vaccine design through minimizing envelope metastability

microbiology more details view paper
  • Downloaded 1,060 times
  • Download rankings, all-time:
    • Site-wide: 35,178
    • In microbiology: 1,954
  • Year to date:
    • Site-wide: 166,125
  • Since beginning of last month:
    • Site-wide: 154,748

A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection

microbiology more details view paper
  • Downloaded 1,012 times
  • Download rankings, all-time:
    • Site-wide: 37,747
    • In microbiology: 2,134
  • Year to date:
    • Site-wide: 36,317
  • Since beginning of last month:
    • Site-wide: 169,322

Super-immunity by broadly protective nanobodies to sarbecoviruses

microbiology more details view paper
  • Downloaded 990 times
  • Download rankings, all-time:
    • Site-wide: 39,034
    • In microbiology: 2,233
  • Year to date:
    • Site-wide: 5,523
  • Since beginning of last month:
    • Site-wide: None

A large-scale systematic survey of SARS-CoV-2 antibodies reveals recurring molecular features

immunology more details view paper
  • Downloaded 917 times
  • Download rankings, all-time:
    • Site-wide: 43,933
    • In immunology: 1,472
  • Year to date:
    • Site-wide: 14,588
  • Since beginning of last month:
    • Site-wide: 94,553

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

immunology more details view paper
  • Downloaded 880 times
  • Download rankings, all-time:
    • Site-wide: 46,744
    • In immunology: 1,523
  • Year to date:
    • Site-wide: 54,748
  • Since beginning of last month:
    • Site-wide: 119,685

Broadening a SARS-CoV-1 neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution

bioengineering more details view paper
  • Downloaded 871 times
  • Download rankings, all-time:
    • Site-wide: 47,491
    • In bioengineering: 960
  • Year to date:
    • Site-wide: 20,204
  • Since beginning of last month:
    • Site-wide: 34,377

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

microbiology more details view paper
  • Downloaded 839 times
  • Download rankings, all-time:
    • Site-wide: 50,323
    • In microbiology: 2,851
  • Year to date:
    • Site-wide: 158,105
  • Since beginning of last month:
    • Site-wide: None

SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies

immunology more details view paper
  • Downloaded 800 times
  • Download rankings, all-time:
    • Site-wide: 54,019
    • In immunology: 1,747
  • Year to date:
    • Site-wide: 55,670
  • Since beginning of last month:
    • Site-wide: 119,846

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

immunology more details view paper
  • Downloaded 759 times
  • Download rankings, all-time:
    • Site-wide: 58,314
    • In immunology: 1,847
  • Year to date:
    • Site-wide: 43,599
  • Since beginning of last month:
    • Site-wide: None

Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago

microbiology more details view paper
  • Downloaded 748 times
  • Download rankings, all-time:
    • Site-wide: 59,536
    • In microbiology: 3,474
  • Year to date:
    • Site-wide: 130,198
  • Since beginning of last month:
    • Site-wide: 185,580

A broad and potent neutralization epitope in SARS-related coronaviruses

microbiology more details view paper
  • Downloaded 724 times
  • Download rankings, all-time:
    • Site-wide: 62,482
    • In microbiology: 3,927
  • Year to date:
    • Site-wide: 5,852
  • Since beginning of last month:
    • Site-wide: 34,525

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

immunology more details view paper
  • Downloaded 711 times
  • Download rankings, all-time:
    • Site-wide: 64,087
    • In immunology: 2,014
  • Year to date:
    • Site-wide: 137,934
  • Since beginning of last month:
    • Site-wide: 67,061

HIV-1 Envelope and MPER antibody structures in lipid assemblies

immunology more details view paper
  • Downloaded 710 times
  • Download rankings, all-time:
    • Site-wide: 64,189
    • In immunology: 2,026
  • Year to date:
    • Site-wide: 164,939
  • Since beginning of last month:
    • Site-wide: 114,886

Sequence signatures of two IGHV3-53/3-66 public clonotypes to SARS-CoV-2 receptor binding domain

microbiology more details view paper
  • Downloaded 688 times
  • Download rankings, all-time:
    • Site-wide: 67,109
    • In microbiology: 4,098
  • Year to date:
    • Site-wide: 63,827
  • Since beginning of last month:
    • Site-wide: 145,058

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

immunology more details view paper
  • Downloaded 653 times
  • Download rankings, all-time:
    • Site-wide: 72,209
    • In immunology: 2,258
  • Year to date:
    • Site-wide: 200,301
  • Since beginning of last month:
    • Site-wide: 62,478

Influenza H3 and H1 hemagglutinins have different genetic barriers for resistance to broadly neutralizing stem antibodies

microbiology more details view paper
  • Downloaded 643 times
  • Download rankings, all-time:
    • Site-wide: 73,676
    • In microbiology: 4,496
  • Year to date:
    • Site-wide: 140,276
  • Since beginning of last month:
    • Site-wide: 163,599

Bacterial Glycosyltransferase-mediated Cell-surface Chemoenzymatic Glycan Editing: Methods and Applications

biochemistry more details view paper
  • Downloaded 611 times
  • Download rankings, all-time:
    • Site-wide: 78,643
    • In biochemistry: 2,085
  • Year to date:
    • Site-wide: 136,807
  • Since beginning of last month:
    • Site-wide: 48,997

Probing Affinity, Avidity, Anti-Cooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass Analyses

immunology more details view paper
  • Downloaded 601 times
  • Download rankings, all-time:
    • Site-wide: 80,254
    • In immunology: 2,532
  • Year to date:
    • Site-wide: 93,712
  • Since beginning of last month:
    • Site-wide: 121,398

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

immunology more details view paper
  • Downloaded 601 times
  • Download rankings, all-time:
    • Site-wide: 80,331
    • In immunology: 2,516
  • Year to date:
    • Site-wide: 183,077
  • Since beginning of last month:
    • Site-wide: 154,119

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

immunology more details view paper
  • Downloaded 588 times
  • Download rankings, all-time:
    • Site-wide: 82,593
    • In immunology: 2,569
  • Year to date:
    • Site-wide: 167,807
  • Since beginning of last month:
    • Site-wide: 156,553

Rational design of hepatitis C virus E2 core nanoparticle vaccines

microbiology more details view paper
  • Downloaded 563 times
  • Download rankings, all-time:
    • Site-wide: 87,187
    • In microbiology: 5,436
  • Year to date:
    • Site-wide: 196,553
  • Since beginning of last month:
    • Site-wide: 84,359

Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2

immunology more details view paper
  • Downloaded 561 times
  • Download rankings, all-time:
    • Site-wide: 87,698
    • In immunology: 3,093
  • Year to date:
    • Site-wide: 8,951
  • Since beginning of last month:
    • Site-wide: 71,773

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike

biochemistry more details view paper
  • Downloaded 557 times
  • Download rankings, all-time:
    • Site-wide: 88,312
    • In biochemistry: None
  • Year to date:
    • Site-wide: 9,062
  • Since beginning of last month:
    • Site-wide: 4,782

Breathing and Tilting: Mesoscale simulations illuminate influenza glycoprotein vulnerabilities

biophysics more details view paper
  • Downloaded 554 times
  • Download rankings, all-time:
    • Site-wide: 88,877
    • In biophysics: None
  • Year to date:
    • Site-wide: 9,141
  • Since beginning of last month:
    • Site-wide: 9,276

A recurring YYDRxG pattern in broadly neutralizing antibodies to a conserved site on SARS-CoV-2, variants of concern, and related viruses

immunology more details view paper
  • Downloaded 522 times
  • Download rankings, all-time:
    • Site-wide: 95,583
    • In immunology: 2,993
  • Year to date:
    • Site-wide: 27,375
  • Since beginning of last month:
    • Site-wide: None

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

immunology more details view paper
  • Downloaded 502 times
  • Download rankings, all-time:
    • Site-wide: 99,936
    • In immunology: 3,065
  • Year to date:
    • Site-wide: 201,886
  • Since beginning of last month:
    • Site-wide: 132,600

Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities

neuroscience more details view paper
  • Downloaded 496 times
  • Download rankings, all-time:
    • Site-wide: 101,290
    • In neuroscience: 14,461
  • Year to date:
    • Site-wide: 176,376
  • Since beginning of last month:
    • Site-wide: 79,782

Evidence of antigenic imprinting in sequential Sarbecovirus immunization

immunology more details view paper
  • Downloaded 487 times
  • Download rankings, all-time:
    • Site-wide: 103,326
    • In immunology: 3,223
  • Year to date:
    • Site-wide: 138,213
  • Since beginning of last month:
    • Site-wide: 109,984

Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection

microbiology more details view paper
  • Downloaded 452 times
  • Download rankings, all-time:
    • Site-wide: 111,458
    • In microbiology: 9,090
  • Year to date:
    • Site-wide: 12,788
  • Since beginning of last month:
    • Site-wide: 87,127

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

immunology more details view paper
  • Downloaded 404 times
  • Download rankings, all-time:
    • Site-wide: 123,994
    • In immunology: 3,777
  • Year to date:
    • Site-wide: 178,315
  • Since beginning of last month:
    • Site-wide: 131,902

Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

microbiology more details view paper
  • Downloaded 399 times
  • Download rankings, all-time:
    • Site-wide: 125,562
    • In microbiology: 8,164
  • Year to date:
    • Site-wide: 113,292
  • Since beginning of last month:
    • Site-wide: 144,287

N-glycolylneuraminic acid binding of avian H7 influenza A viruses

molecular biology more details view paper
  • Downloaded 391 times
  • Download rankings, all-time:
    • Site-wide: 127,683
    • In molecular biology: 3,678
  • Year to date:
    • Site-wide: 120,832
  • Since beginning of last month:
    • Site-wide: 108,792

An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen.

biophysics more details view paper
  • Downloaded 355 times
  • Download rankings, all-time:
    • Site-wide: 138,339
    • In biophysics: 5,097
  • Year to date:
    • Site-wide: 191,594
  • Since beginning of last month:
    • Site-wide: 113,022

Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

microbiology more details view paper
  • Downloaded 353 times
  • Download rankings, all-time:
    • Site-wide: 138,818
    • In microbiology: 9,147
  • Year to date:
    • Site-wide: 208,043
  • Since beginning of last month:
    • Site-wide: 183,082

Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates

microbiology more details view paper
  • Downloaded 335 times
  • Download rankings, all-time:
    • Site-wide: 144,072
    • In microbiology: 13,577
  • Year to date:
    • Site-wide: 20,980
  • Since beginning of last month:
    • Site-wide: 173,435

Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9

immunology more details view paper
  • Downloaded 274 times
  • Download rankings, all-time:
    • Site-wide: 162,480
    • In immunology: None
  • Year to date:
    • Site-wide: 28,831
  • Since beginning of last month:
    • Site-wide: None

Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2

immunology more details view paper
  • Downloaded 273 times
  • Download rankings, all-time:
    • Site-wide: 162,729
    • In immunology: 5,026
  • Year to date:
    • Site-wide: 107,911
  • Since beginning of last month:
    • Site-wide: 119,123

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

immunology more details view paper
  • Downloaded 252 times
  • Download rankings, all-time:
    • Site-wide: 168,808
    • In immunology: 5,367
  • Year to date:
    • Site-wide: 32,671
  • Since beginning of last month:
    • Site-wide: 122,326

Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infection

immunology more details view paper
  • Downloaded 198 times
  • Download rankings, all-time:
    • Site-wide: 182,643
    • In immunology: None
  • Year to date:
    • Site-wide: 46,267
  • Since beginning of last month:
    • Site-wide: 17,652

Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual

immunology more details view paper
  • Downloaded 170 times
  • Download rankings, all-time:
    • Site-wide: 188,792
    • In immunology: None
  • Year to date:
    • Site-wide: 56,422
  • Since beginning of last month:
    • Site-wide: 7,143

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct omicron SARS-CoV-2 subvariants

immunology more details view paper
  • Downloaded 161 times
  • Download rankings, all-time:
    • Site-wide: 190,643
    • In immunology: None
  • Year to date:
    • Site-wide: 60,205
  • Since beginning of last month:
    • Site-wide: 650

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