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Author: Phillip L. De Jager

Rankings

  • All-time downloads: 57,484 (rank: 3,198 )
  • Categories:
    • bioinformatics: 1,158 (rank: 14,999 (tie) )
    • cell biology: 1,805 (rank: 4,678 (tie) )
    • genetic and genomic medicine: 815 (rank: 4,915 (tie) )
    • genetics: 19,323 (rank: 768 )
    • genomics: 11,072 (rank: 1,938 )
    • immunology: 2,063 (rank: 6,352 (tie) )
    • neurology: 213 (rank: 6,424 (tie) )
    • neuroscience: 12,748 (rank: 1,065 )
    • pathology: 4,490 (rank: 301 (tie) )
    • systems biology: 3,797 (rank: 1,126 )

Downloads per author, site-wide

Preprints

Genetic determinants of co-accessible chromatin regions in T cell activation across humans

genomics more details view paper
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A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brain

neuroscience more details view paper
  • Downloaded 4,562 times
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    • Site-wide: 2,906
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    • Site-wide: 26,161
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    • Site-wide: 34,768

EXCEPTIONALLY LOW LIKELIHOOD OF ALZHEIMER'S DEMENTIA IN APOE2 HOMOZYGOTES

pathology more details view paper
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A Bayesian approach to mediation analysis predicts 206 causal target genes in Alzheimer's disease

genetics more details view paper
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    • Site-wide: 4,062
    • In genetics: 140
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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

genetics more details view paper
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    • Site-wide: 4,482
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A Consensus Proteomic Analysis of Alzheimer’s Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation

systems biology more details view paper
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    • Site-wide: 42,130

Integrative analyses of splicing in the aging brain: role in susceptibility to Alzheimer's Disease

genomics more details view paper
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    • Site-wide: 10,561
    • In genomics: 1,054
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Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

genetics more details view paper
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    • Site-wide: 11,211
    • In genetics: 478
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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
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    • Site-wide: 11,392
    • In genetics: 487
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BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 implicated in Tau pathology

cell biology more details view paper
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    • Site-wide: 12,595
    • In cell biology: 333
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Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer's Disease: An Emerging Role for Gut Microbiome

neuroscience more details view paper
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    • Site-wide: 14,124
    • In neuroscience: 1,536
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A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the Central Nervous System

immunology more details view paper
  • Downloaded 1,336 times
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    • Site-wide: 17,380
    • In immunology: 602
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Genetic control of the human brain proteome

genetics more details view paper
  • Downloaded 1,258 times
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    • Site-wide: 19,005
    • In genetics: 856
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Multi-cellular communities are perturbed in the aging human brain and with Alzheimer's disease

neuroscience more details view paper
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    • Site-wide: 19,011
    • In neuroscience: 2,270
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Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

genetics more details view paper
  • Downloaded 1,243 times
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    • Site-wide: 19,326
    • In genetics: 866
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Epigenome-wide study uncovers tau pathology-driven changes of chromatin organization in the aging human brain

neuroscience more details view paper
  • Downloaded 1,241 times
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    • Site-wide: 19,367
    • In neuroscience: 2,316
  • Year to date:
    • Site-wide: 111,393
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    • Site-wide: 75,522

Systems genetics identifies modifiers of Alzheimer's disease risk and resilience

genetics more details view paper
  • Downloaded 1,240 times
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    • Site-wide: 19,382
    • In genetics: 872
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A cortical immune network map identifies a subset of human microglia involved in Tau pathology

neuroscience more details view paper
  • Downloaded 1,196 times
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    • Site-wide: 20,443
    • In neuroscience: 2,451
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    • Site-wide: 56,238
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Shared effect modeling reveals that a fraction of autoimmune disease associations are consistent with eQTLs in three immune cell types

genetics more details view paper
  • Downloaded 1,146 times
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    • Site-wide: 21,797
    • In genetics: 969
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Deconvolving the contributions of cell-type heterogeneity on cortical gene expression

neuroscience more details view paper
  • Downloaded 1,097 times
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    • Site-wide: 23,272
    • In neuroscience: 2,846
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    • Site-wide: 113,188
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A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex

genomics more details view paper
  • Downloaded 1,090 times
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    • Site-wide: 23,472
    • In genomics: 2,194
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    • Site-wide: 17,365
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    • Site-wide: 78,156

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection

genomics more details view paper
  • Downloaded 1,005 times
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    • Site-wide: 26,490
    • In genomics: 2,408
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    • Site-wide: 123,616
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Tau-mediated Disruption of the Spliceosome Triggers Cryptic RNA-splicing and Neurodegeneration in Alzheimer's Disease

neuroscience more details view paper
  • Downloaded 812 times
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    • Site-wide: 35,986
    • In neuroscience: 4,744
  • Year to date:
    • Site-wide: 102,228
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    • Site-wide: 115,491

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

bioinformatics more details view paper
  • Downloaded 773 times
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    • Site-wide: 38,579
    • In bioinformatics: 4,132
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    • Site-wide: 121,999
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    • Site-wide: 122,865

Single Cell-type Integrative Network Modeling Identified Novel Microglial-specific Targets for the Phagosome in Alzheimer's disease

systems biology more details view paper
  • Downloaded 754 times
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    • Site-wide: 39,976
    • In systems biology: 856
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    • Site-wide: 26,543
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    • Site-wide: 67,236

Bayesian Genome-wide TWAS method to leverage both cis- and trans- eQTL information through summary statistics

genetics more details view paper
  • Downloaded 753 times
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    • Site-wide: 40,087
    • In genetics: 1,756
  • Year to date:
    • Site-wide: 65,117
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    • Site-wide: 118,687

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality

genetics more details view paper
  • Downloaded 750 times
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    • Site-wide: 40,291
    • In genetics: 1,770
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    • Site-wide: 6,951
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    • Site-wide: 13,444

Large-Scale Deep Multi-Layer Analysis of Alzheimer's Disease Brain Reveals Strong Proteomic Disease-Related Changes Not Observed at the RNA Level

systems biology more details view paper
  • Downloaded 740 times
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    • Site-wide: 41,024
    • In systems biology: 877
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    • Site-wide: 8,626

The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions

immunology more details view paper
  • Downloaded 727 times
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    • Site-wide: 42,026
    • In immunology: 1,342
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    • Site-wide: 105,982
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    • Site-wide: 115,816

TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits

genetics more details view paper
  • Downloaded 714 times
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    • Site-wide: 43,014
    • In genetics: 1,889
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    • Site-wide: 148,053

Genetic data and cognitively-defined late-onset Alzheimer's disease subgroups

genetics more details view paper
  • Downloaded 619 times
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    • Site-wide: 52,034
    • In genetics: 2,246
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Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

genomics more details view paper
  • Downloaded 601 times
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    • Site-wide: 53,999
    • In genomics: 4,037
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    • Site-wide: 125,911
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Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.

neuroscience more details view paper
  • Downloaded 596 times
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    • Site-wide: 54,530
    • In neuroscience: 7,696
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    • Site-wide: 142,369
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Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia

genetics more details view paper
  • Downloaded 560 times
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    • Site-wide: 58,847
    • In genetics: 2,535
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    • Site-wide: 40,668
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Integrated analysis of the aging brain transcriptome and proteome in tauopathy

genomics more details view paper
  • Downloaded 559 times
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    • Site-wide: 58,989
    • In genomics: 4,328
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    • Site-wide: 113,750
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    • Site-wide: 113,278

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

genetic and genomic medicine more details view paper
  • Downloaded 493 times
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    • Site-wide: 68,296
    • In genetic and genomic medicine: 301
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    • Site-wide: 48,519
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    • Site-wide: 84,585

Cascading Epigenomic Analysis for Identifying Disease Genes from the Regulatory Landscape of GWAS Variants

bioinformatics more details view paper
  • Downloaded 385 times
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    • Site-wide: 87,900
    • In bioinformatics: 7,828
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Association between DNA Methylation Levels in Brain Tissue and Late-Life Depression in Community-Based Participants

genetic and genomic medicine more details view paper
  • Downloaded 322 times
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    • Site-wide: 102,241
    • In genetic and genomic medicine: 522
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The Caribbean-Hispanic Alzheimer’s Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms

genomics more details view paper
  • Downloaded 303 times
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    • Site-wide: 106,988
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Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia

genomics more details view paper
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    • Site-wide: 106,837
    • In genomics: 6,311
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A structured evaluation of cryopreservation in generating single cell transcriptomes from cerebrospinal fluid

genetics more details view paper
  • Downloaded 269 times
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    • Site-wide: 115,691
    • In genetics: 4,773
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Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline

genetics more details view paper
  • Downloaded 260 times
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    • Site-wide: 117,847
    • In genetics: 4,852
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Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on alzheimer’s disease risk in humans

neuroscience more details view paper
  • Downloaded 234 times
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    • Site-wide: 124,775
    • In neuroscience: 18,715
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    • Site-wide: 93,538
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Impact of genetic susceptibility to multiple sclerosis on the T cell epigenome: proximal and distal effects

genomics more details view paper
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    • Site-wide: 124,899
    • In genomics: 6,890
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Peripheral Serum Metabolomic Profiles Inform Antecedent Central Cognitive Impairment in Older Adults

neuroscience more details view paper
  • Downloaded 226 times
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    • Site-wide: 126,866
    • In neuroscience: 19,067
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    • Site-wide: 130,823
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Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification

pathology more details view paper
  • Downloaded 220 times
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    • Site-wide: 128,332
    • In pathology: 743
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    • Site-wide: 100,801
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    • Site-wide: 122,079

Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer's disease brain

neurology more details view paper
  • Downloaded 213 times
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    • Site-wide: 130,092
    • In neurology: 578
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Mitochondrial Respiratory Chain Protein Co-Regulation in the Human Brain

cell biology more details view paper
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