Author: Anders M Dale

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Preprints

The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,067
  • In genetics: 31
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  • Site-wide: 12,727
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  • Site-wide: 21,709

Genomewide association study identifies 30 loci associated with bipolar disorder

• Downloaded 7,323 times
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  • Site-wide: 1,200
  • In genetics: 38
• Year to date:
  • Site-wide: 17,697
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  • Site-wide: 16,438

Image processing and analysis methods for the Adolescent Brain Cognitive Development Study

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  • Site-wide: 1,708
  • In neuroscience: 87
• Year to date:
  • Site-wide: 2,420
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  • Site-wide: 1,933

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,261 times
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  • Site-wide: 3,665
  • In genetics: 151
• Year to date:
  • Site-wide: 40,057
• Since beginning of last month:
  • Site-wide: 81,565

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

• Downloaded 3,124 times
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  • Site-wide: 3,887
  • In genomics: 440
• Year to date:
  • Site-wide: 26,544
• Since beginning of last month:
  • Site-wide: 40,231

Genetics of brain age suggest an overlap with common brain disorders

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  • Site-wide: 4,619
  • In neuroscience: 422
• Year to date:
  • Site-wide: 31,955
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  • Site-wide: 32,180

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

• Downloaded 2,120 times
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  • Site-wide: 6,838
  • In psychiatry and clinical psychology: 23
• Year to date:
  • Site-wide: 1,326
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  • Site-wide: 698

Estimating inflation in GWAS summary statistics due to variance distortion from cryptic relatedness

• Downloaded 1,931 times
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  • Site-wide: 7,846
  • In genomics: 856
• Year to date:
  • Site-wide: 10,029
• Since beginning of last month:
  • Site-wide: 16,429

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,717 times
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  • Site-wide: 9,378
  • In genetics: 448
• Year to date:
  • Site-wide: 81,632
• Since beginning of last month:
  • Site-wide: 87,031

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

• Downloaded 1,709 times
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  • Site-wide: 9,447
  • In genetics: 453
• Year to date:
  • Site-wide: 19,941
• Since beginning of last month:
  • Site-wide: 18,918

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,458 times
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  • Site-wide: 11,878
  • In genomics: 1,293
• Year to date:
  • Site-wide: 72,803
• Since beginning of last month:
  • Site-wide: 70,698

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,457 times
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  • Site-wide: 11,882
  • In genetics: 579
• Year to date:
  • Site-wide: 25,298
• Since beginning of last month:
  • Site-wide: 16,964

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

• Downloaded 1,257 times
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  • Site-wide: 14,903
  • In genetics: 741
• Year to date:
  • Site-wide: 69,805
• Since beginning of last month:
  • Site-wide: 68,477

Gene-experience correlation during cognitive development: Evidence from the Adolescent Brain Cognitive Development (ABCD) StudySM

• Downloaded 1,219 times
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  • Site-wide: 15,629
  • In neuroscience: 1,903
• Year to date:
  • Site-wide: 31,961
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  • Site-wide: None

Distinct regionalization patterns of cortical morphology are associated with cognitive performance across different domains

• Downloaded 1,142 times
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  • Site-wide: 17,218
  • In neuroscience: 2,135
• Year to date:
  • Site-wide: 60,037
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  • Site-wide: None

Partitioning the genetic architecture of amyotrophic lateral sclerosis

• Downloaded 1,110 times
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  • Site-wide: 17,941
  • In genetics: 880
• Year to date:
  • Site-wide: 44,021
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  • Site-wide: 57,980

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

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  • Site-wide: 18,158
  • In genetics: 894
• Year to date:
  • Site-wide: 50,956
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  • Site-wide: 40,262

Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

• Downloaded 1,037 times
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  • Site-wide: 19,874
  • In neuroscience: 2,510
• Year to date:
  • Site-wide: 17,170
• Since beginning of last month:
  • Site-wide: 21,238

Personalized genetic assessment of age associated Alzheimers disease risk

• Downloaded 976 times
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  • Site-wide: 21,594
  • In genetics: 1,040
• Year to date:
  • Site-wide: 75,409
• Since beginning of last month:
  • Site-wide: 53,167

A genetic risk score to guide age-specific, personalized prostate cancer screening

• Downloaded 949 times
• Download rankings, all-time:
  • Site-wide: 22,522
  • In genetics: 1,090
• Year to date:
  • Site-wide: 119,796
• Since beginning of last month:
  • Site-wide: 117,904

Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers

• Downloaded 858 times
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  • Site-wide: 26,005
  • In neuroscience: 3,435
• Year to date:
  • Site-wide: 88,877
• Since beginning of last month:
  • Site-wide: 83,629

Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD): findings from the ENIGMA-ADHD, -ASD, and -OCD working groups

• Downloaded 835 times
• Download rankings, all-time:
  • Site-wide: 27,021
  • In neuroscience: 3,593
• Year to date:
  • Site-wide: 69,572
• Since beginning of last month:
  • Site-wide: 87,167

Lipid associated polygenic enrichment in Alzheimer's disease

• Downloaded 769 times
• Download rankings, all-time:
  • Site-wide: 30,374
  • In genetics: 1,474
• Year to date:
  • Site-wide: 48,381
• Since beginning of last month:
  • Site-wide: 57,927

Planar cell polarity pathway and development of the human visual cortex

• Downloaded 769 times
• Download rankings, all-time:
  • Site-wide: 30,362
  • In neuroscience: 4,115
• Year to date:
  • Site-wide: 59,283
• Since beginning of last month:
  • Site-wide: 69,504

Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

• Downloaded 733 times
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  • Site-wide: 32,520
  • In neuroscience: 4,462
• Year to date:
  • Site-wide: 28,331
• Since beginning of last month:
  • Site-wide: 47,498

Making the MOSTest of imaging genetics

• Downloaded 686 times
• Download rankings, all-time:
  • Site-wide: 35,488
  • In neuroscience: 4,937
• Year to date:
  • Site-wide: 76,825
• Since beginning of last month:
  • Site-wide: 80,279

Polygenic hazard scores in preclinical Alzheimer's disease

• Downloaded 621 times
• Download rankings, all-time:
  • Site-wide: 40,444
  • In genetics: 1,926
• Year to date:
  • Site-wide: 122,551
• Since beginning of last month:
  • Site-wide: 117,967

Immune-related genetic enrichment in frontotemporal dementia

• Downloaded 603 times
• Download rankings, all-time:
  • Site-wide: 41,993
  • In genetics: 1,991
• Year to date:
  • Site-wide: 109,009
• Since beginning of last month:
  • Site-wide: 117,969

Sex-dependent polygenic effects on the clinical progressions of Alzheimer's disease

• Downloaded 573 times
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  • Site-wide: 44,661
  • In genetics: 2,098
• Year to date:
  • Site-wide: 88,430
• Since beginning of last month:
  • Site-wide: 58,944

Pupillary dilation responses as a midlife indicator of risk for Alzheimer's Disease: Association with Alzheimer's disease polygenic risk

• Downloaded 571 times
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  • Site-wide: 44,891
  • In genetics: 2,113
• Year to date:
  • Site-wide: 78,397
• Since beginning of last month:
  • Site-wide: 70,107

Four-Sphere Head Model For EEG Signals Revisited

• Downloaded 549 times
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  • Site-wide: 47,165
  • In neuroscience: 6,865
• Year to date:
  • Site-wide: 69,604
• Since beginning of last month:
  • Site-wide: 49,669

Biophysical modeling of the neural origin of EEG and MEG signals

• Downloaded 525 times
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  • Site-wide: 49,613
  • In neuroscience: 7,286
• Year to date:
  • Site-wide: 22,469
• Since beginning of last month:
  • Site-wide: 17,347

Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment

• Downloaded 504 times
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  • Site-wide: 52,168
  • In genomics: 4,043
• Year to date:
  • Site-wide: 111,852
• Since beginning of last month:
  • Site-wide: 125,414

Brain structure mediates the association between height and cognitive ability

• Downloaded 477 times
• Download rankings, all-time:
  • Site-wide: 55,513
  • In neuroscience: 8,258
• Year to date:
  • Site-wide: 91,031
• Since beginning of last month:
  • Site-wide: 107,563

Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition

• Downloaded 466 times
• Download rankings, all-time:
  • Site-wide: 56,887
  • In genetics: 2,656
• Year to date:
  • Site-wide: 74,480
• Since beginning of last month:
  • Site-wide: 43,047

Williams Syndrome-Specific Neuroarchitectural Profile and Its Associations with Cognitive Features

• Downloaded 436 times
• Download rankings, all-time:
  • Site-wide: 61,020
  • In neuroscience: 9,180
• Year to date:
  • Site-wide: 128,969
• Since beginning of last month:
  • Site-wide: 126,757

Polygenic hazard score predicts aggressive and fatal prostate cancer in multi-ethnic populations

• Downloaded 433 times
• Download rankings, all-time:
  • Site-wide: 61,470
  • In genetic and genomic medicine: 197
• Year to date:
  • Site-wide: 42,561
• Since beginning of last month:
  • Site-wide: 46,676

Multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.

• Downloaded 432 times
• Download rankings, all-time:
  • Site-wide: 61,530
  • In genetics: 2,860
• Year to date:
  • Site-wide: 17,427
• Since beginning of last month:
  • Site-wide: 7,293

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

• Downloaded 426 times
• Download rankings, all-time:
  • Site-wide: 62,530
  • In genetics: 2,902
• Year to date:
  • Site-wide: 130,132
• Since beginning of last month:
  • Site-wide: 108,515

The Bayesian polyvertex score (PVS-B): a whole-brain phenotypic prediction framework for neuroimaging studies

• Downloaded 415 times
• Download rankings, all-time:
  • Site-wide: 64,281
  • In neuroscience: 9,707
• Year to date:
  • Site-wide: 33,531
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  • Site-wide: 29,307

All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors

• Downloaded 387 times
• Download rankings, all-time:
  • Site-wide: 68,662
  • In neuroscience: 10,449
• Year to date:
  • Site-wide: 4,076
• Since beginning of last month:
  • Site-wide: 28,571

Annotation-Informed Causal Mixture Modeling (AI-MiXeR) reveals phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories

• Downloaded 384 times
• Download rankings, all-time:
  • Site-wide: 69,074
  • In genetics: 3,174
• Year to date:
  • Site-wide: 90,940
• Since beginning of last month:
  • Site-wide: 98,320

Improved characterization of diffusion in normal and cancerous prostate tissue through optimization of the restriction spectrum imaging signal model

• Downloaded 378 times
• Download rankings, all-time:
  • Site-wide: 70,081
  • In radiology and imaging: 101
• Year to date:
  • Site-wide: 50,594
• Since beginning of last month:
  • Site-wide: 46,765

A genetic hazard score to personalize prostate cancer screening, applied to population data

• Downloaded 375 times
• Download rankings, all-time:
  • Site-wide: 70,688
  • In genetics: 3,232
• Year to date:
  • Site-wide: 122,635
• Since beginning of last month:
  • Site-wide: 130,777

CXCR4 involvement in neurodegenerative diseases

• Downloaded 370 times
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  • Site-wide: 71,547
  • In genetics: 3,264
• Year to date:
  • Site-wide: 114,446
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  • Site-wide: 117,986

The genetic architecture of human cortical folding

• Downloaded 365 times
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  • Site-wide: 72,548
  • In genomics: 4,986
• Year to date:
  • Site-wide: 4,444
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  • Site-wide: 31,582

Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area

• Downloaded 349 times
• Download rankings, all-time:
  • Site-wide: 75,310
  • In neuroscience: 11,486
• Year to date:
  • Site-wide: 118,835
• Since beginning of last month:
  • Site-wide: 100,038

Improved prediction of schizophrenia by leveraging genetic overlap with brain morphology

• Downloaded 349 times
• Download rankings, all-time:
  • Site-wide: 75,323
  • In psychiatry and clinical psychology: 239
• Year to date:
  • Site-wide: 29,922
• Since beginning of last month:
  • Site-wide: 20,601

Continuity and discontinuity in human cortical development and change from embryonic stages to old age

• Downloaded 317 times
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  • Site-wide: 81,442
  • In neuroscience: 12,499
• Year to date:
  • Site-wide: 94,956
• Since beginning of last month:
  • Site-wide: 86,562

Correction of Artifacts Induced by B0 Inhomogeneities in Breast MRI using Reduced Field-of-View Echo-Planar Imaging and Enhanced Reverse Polarity Gradient Method

• Downloaded 294 times
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  • Site-wide: 86,095
  • In radiology and imaging: 135
• Year to date:
  • Site-wide: 40,861
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  • Site-wide: 38,702

Voxel-level Classification of Prostate Cancer Using a Four-Compartment Restriction Spectrum Imaging Model

• Downloaded 282 times
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  • Site-wide: 88,729
  • In oncology: 152
• Year to date:
  • Site-wide: 36,249
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  • Site-wide: 28,109

Atypical genomic patterning of the cerebral cortex in autism with poor early language outcome

• Downloaded 254 times
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  • Site-wide: 94,914
  • In neuroscience: 14,722
• Year to date:
  • Site-wide: 53,235
• Since beginning of last month:
  • Site-wide: 41,913

The effect of sample size on polygenic hazard models for prostate cancer

• Downloaded 240 times
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  • Site-wide: 98,015
  • In genetics: 4,376
• Year to date:
  • Site-wide: 132,701
• Since beginning of last month:
  • Site-wide: 131,172

Age dependence of modern clinical risk groups for localized prostate cancer — a population-based study

• Downloaded 222 times
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  • Site-wide: 101,929
  • In epidemiology: 4,182
• Year to date:
  • Site-wide: 94,359
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  • Site-wide: 106,389

Delineating genetic and familial risk for psychopathology in the ABCD study

• Downloaded 222 times
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  • Site-wide: 101,895
  • In genetic and genomic medicine: 419
• Year to date:
  • Site-wide: 38,523
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  • Site-wide: 31,491

MODE for detecting and estimating genetic causal variants

• Downloaded 215 times
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  • Site-wide: 103,389
  • In bioinformatics: 8,797
• Year to date:
  • Site-wide: 133,903
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  • Site-wide: 133,594

Discrimination of breast cancer from healthy breast tissues using a three-component diffusion-weighted MRI model

• Downloaded 214 times
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  • Site-wide: 103,640
  • In radiology and imaging: 185
• Year to date:
  • Site-wide: 57,849
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  • Site-wide: 52,012

Movement abilities and brain development in preschoolers born very preterm

• Downloaded 186 times
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  • Site-wide: 110,004
  • In neuroscience: 17,006
• Year to date:
  • Site-wide: 104,656
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  • Site-wide: 124,420

Characterization of the Diffusion Signal of Breast Tissues using Multi-exponential Models

• Downloaded 165 times
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  • Site-wide: 114,258
  • In radiology and imaging: 228
• Year to date:
  • Site-wide: 97,312
• Since beginning of last month:
  • Site-wide: 66,142

Spatially Resolved Estimation of Metabolic Oxygen Consumption From Optical Measurements in Cortex

• Downloaded 138 times
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  • Site-wide: 119,797
  • In neuroscience: 18,480
• Year to date:
  • Site-wide: 124,928
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  • Site-wide: 122,765

Correcting B0 inhomogeneity-induced distortions in whole-body diffusion MRI of bone

• Downloaded 136 times
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  • Site-wide: 120,324
  • In radiology and imaging: 255
• Year to date:
  • Site-wide: 57,895
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  • Site-wide: None

Associations between Early Midlife Lifestyle Behaviors, Young Adult Cognitive Reserve and Advanced Predicted Brain Age in Late Midlife

• Downloaded 126 times
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  • Site-wide: 122,270
  • In neuroscience: 18,806
• Year to date:
  • Site-wide: 63,830
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  • Site-wide: 54,233

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

• Downloaded 95 times
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  • Site-wide: 127,818
  • In genetic and genomic medicine: 624
• Year to date:
  • Site-wide: 26,658
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  • Site-wide: 51,625

Common genetic and clinical risk factors: Association with fatal prostate cancer in the Cohort of Swedish Men

• Downloaded 91 times
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  • Site-wide: 128,476
  • In genetic and genomic medicine: 628
• Year to date:
  • Site-wide: 105,581
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  • Site-wide: 90,977