Author: Anders M. Dale

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Preprints

The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,217
  • In genetics: 32
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  • Site-wide: 18,332
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  • Site-wide: 33,157

Genomewide association study identifies 30 loci associated with bipolar disorder

• Downloaded 7,423 times
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  • Site-wide: 1,367
  • In genetics: 40
• Year to date:
  • Site-wide: 23,523
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  • Site-wide: 27,595

Image processing and analysis methods for the Adolescent Brain Cognitive Development Study

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  • Site-wide: 1,776
  • In neuroscience: 89
• Year to date:
  • Site-wide: 2,724
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  • Site-wide: 3,192

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,326 times
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  • Site-wide: 4,128
  • In genetics: 155
• Year to date:
  • Site-wide: 47,331
• Since beginning of last month:
  • Site-wide: 65,989

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

• Downloaded 3,204 times
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  • Site-wide: 4,367
  • In genomics: 456
• Year to date:
  • Site-wide: 33,674
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  • Site-wide: 56,385

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

• Downloaded 2,850 times
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  • Site-wide: 5,135
  • In psychiatry and clinical psychology: 20
• Year to date:
  • Site-wide: 1,564
• Since beginning of last month:
  • Site-wide: 7,237

Genetics of brain age suggest an overlap with common brain disorders

• Downloaded 2,843 times
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  • Site-wide: 5,156
  • In neuroscience: 450
• Year to date:
  • Site-wide: 38,146
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  • Site-wide: 45,171

Estimating inflation in GWAS summary statistics due to variance distortion from cryptic relatedness

• Downloaded 2,112 times
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  • Site-wide: 7,965
  • In genomics: 840
• Year to date:
  • Site-wide: 11,652
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  • Site-wide: 13,618

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

• Downloaded 1,846 times
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  • Site-wide: 9,733
  • In genetics: 430
• Year to date:
  • Site-wide: 20,530
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  • Site-wide: 19,109

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,768 times
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  • Site-wide: 10,384
  • In genetics: 465
• Year to date:
  • Site-wide: 74,808
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  • Site-wide: 25,796

Gene-experience correlation during cognitive development: Evidence from the Adolescent Brain Cognitive Development (ABCD) StudySM

• Downloaded 1,539 times
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  • Site-wide: 12,661
  • In neuroscience: 1,376
• Year to date:
  • Site-wide: 11,175
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  • Site-wide: 6,819

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,509 times
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  • Site-wide: 13,041
  • In genetics: 597
• Year to date:
  • Site-wide: 39,865
• Since beginning of last month:
  • Site-wide: 99,682

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,476 times
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  • Site-wide: 13,503
  • In genomics: 1,391
• Year to date:
  • Site-wide: 102,054
• Since beginning of last month:
  • Site-wide: 110,663

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

• Downloaded 1,279 times
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  • Site-wide: 16,816
  • In genetics: 791
• Year to date:
  • Site-wide: 96,527
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  • Site-wide: 122,647

Distinct regionalization patterns of cortical morphology are associated with cognitive performance across different domains

• Downloaded 1,271 times
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  • Site-wide: 16,978
  • In neuroscience: 2,026
• Year to date:
  • Site-wide: 35,018
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  • Site-wide: 22,629

Partitioning the genetic architecture of amyotrophic lateral sclerosis

• Downloaded 1,155 times
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  • Site-wide: 19,552
  • In genetics: 907
• Year to date:
  • Site-wide: 59,464
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  • Site-wide: 75,141

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

• Downloaded 1,129 times
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  • Site-wide: 20,190
  • In genetics: 937
• Year to date:
  • Site-wide: 74,840
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  • Site-wide: 121,711

Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

• Downloaded 1,113 times
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  • Site-wide: 20,621
  • In neuroscience: 2,550
• Year to date:
  • Site-wide: 26,589
• Since beginning of last month:
  • Site-wide: 47,876

Personalized genetic assessment of age associated Alzheimers disease risk

• Downloaded 998 times
• Download rankings, all-time:
  • Site-wide: 24,210
  • In genetics: 1,120
• Year to date:
  • Site-wide: 100,187
• Since beginning of last month:
  • Site-wide: 65,451

A genetic risk score to guide age-specific, personalized prostate cancer screening

• Downloaded 964 times
• Download rankings, all-time:
  • Site-wide: 25,499
  • In genetics: 1,179
• Year to date:
  • Site-wide: 133,597
• Since beginning of last month:
  • Site-wide: 120,816

Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD): findings from the ENIGMA-ADHD, -ASD, and -OCD working groups

• Downloaded 918 times
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  • Site-wide: 27,311
  • In neuroscience: 3,510
• Year to date:
  • Site-wide: 52,241
• Since beginning of last month:
  • Site-wide: 20,436

Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers

• Downloaded 868 times
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  • Site-wide: 29,549
  • In neuroscience: 3,844
• Year to date:
  • Site-wide: 125,118
• Since beginning of last month:
  • Site-wide: 138,217

Planar cell polarity pathway and development of the human visual cortex

• Downloaded 807 times
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  • Site-wide: 32,717
  • In neuroscience: 4,336
• Year to date:
  • Site-wide: 73,975
• Since beginning of last month:
  • Site-wide: 147,085

Lipid associated polygenic enrichment in Alzheimer's disease

• Downloaded 794 times
• Download rankings, all-time:
  • Site-wide: 33,438
  • In genetics: 1,542
• Year to date:
  • Site-wide: 75,136
• Since beginning of last month:
  • Site-wide: 97,487

Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

• Downloaded 764 times
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  • Site-wide: 35,259
  • In neuroscience: 4,757
• Year to date:
  • Site-wide: 50,856
• Since beginning of last month:
  • Site-wide: 104,501

Making the MOSTest of imaging genetics

• Downloaded 722 times
• Download rankings, all-time:
  • Site-wide: 38,158
  • In neuroscience: 5,202
• Year to date:
  • Site-wide: 84,799
• Since beginning of last month:
  • Site-wide: 115,963

Polygenic hazard scores in preclinical Alzheimer's disease

• Downloaded 633 times
• Download rankings, all-time:
  • Site-wide: 45,330
  • In genetics: 2,044
• Year to date:
  • Site-wide: 139,767
• Since beginning of last month:
  • Site-wide: 122,945

Immune-related genetic enrichment in frontotemporal dementia

• Downloaded 629 times
• Download rankings, all-time:
  • Site-wide: 45,724
  • In genetics: 2,060
• Year to date:
  • Site-wide: 111,722
• Since beginning of last month:
  • Site-wide: 84,522

Biophysical modeling of the neural origin of EEG and MEG signals

• Downloaded 606 times
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  • Site-wide: 47,939
  • In neuroscience: 6,812
• Year to date:
  • Site-wide: 30,384
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  • Site-wide: 47,486

Pupillary dilation responses as a midlife indicator of risk for Alzheimer's Disease: Association with Alzheimer's disease polygenic risk

• Downloaded 604 times
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  • Site-wide: 48,084
  • In genetics: 2,152
• Year to date:
  • Site-wide: 88,769
• Since beginning of last month:
  • Site-wide: 120,796

Sex-dependent polygenic effects on the clinical progressions of Alzheimer's disease

• Downloaded 598 times
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  • Site-wide: 48,681
  • In genetics: 2,177
• Year to date:
  • Site-wide: 104,331
• Since beginning of last month:
  • Site-wide: 100,818

Four-Sphere Head Model For EEG Signals Revisited

• Downloaded 585 times
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  • Site-wide: 50,067
  • In neuroscience: 7,154
• Year to date:
  • Site-wide: 81,234
• Since beginning of last month:
  • Site-wide: 138,055

Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment

• Downloaded 535 times
• Download rankings, all-time:
  • Site-wide: 55,876
  • In genomics: 4,199
• Year to date:
  • Site-wide: 106,393
• Since beginning of last month:
  • Site-wide: 96,635

Multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.

• Downloaded 526 times
• Download rankings, all-time:
  • Site-wide: 56,961
  • In genetics: 2,530
• Year to date:
  • Site-wide: 24,059
• Since beginning of last month:
  • Site-wide: 24,700

Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition

• Downloaded 495 times
• Download rankings, all-time:
  • Site-wide: 61,076
  • In genetics: 2,726
• Year to date:
  • Site-wide: 91,091
• Since beginning of last month:
  • Site-wide: 111,800

All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors

• Downloaded 484 times
• Download rankings, all-time:
  • Site-wide: 62,549
  • In neuroscience: 9,157
• Year to date:
  • Site-wide: 8,488
• Since beginning of last month:
  • Site-wide: 134,476

Brain structure mediates the association between height and cognitive ability

• Downloaded 484 times
• Download rankings, all-time:
  • Site-wide: 62,637
  • In neuroscience: 9,164
• Year to date:
  • Site-wide: 131,067
• Since beginning of last month:
  • Site-wide: 127,882

Polygenic hazard score predicts aggressive and fatal prostate cancer in multi-ethnic populations

• Downloaded 474 times
• Download rankings, all-time:
  • Site-wide: 64,048
  • In genetic and genomic medicine: 255
• Year to date:
  • Site-wide: 60,099
• Since beginning of last month:
  • Site-wide: 54,495

The genetic architecture of human cortical folding

• Downloaded 455 times
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  • Site-wide: 66,993
  • In genomics: 4,731
• Year to date:
  • Site-wide: 9,292
• Since beginning of last month:
  • Site-wide: 8,027

Williams Syndrome-Specific Neuroarchitectural Profile and Its Associations with Cognitive Features

• Downloaded 445 times
• Download rankings, all-time:
  • Site-wide: 68,512
  • In neuroscience: 10,147
• Year to date:
  • Site-wide: 145,596
• Since beginning of last month:
  • Site-wide: 120,531

The Bayesian polyvertex score (PVS-B): a whole-brain phenotypic prediction framework for neuroimaging studies

• Downloaded 442 times
• Download rankings, all-time:
  • Site-wide: 68,913
  • In neuroscience: 10,212
• Year to date:
  • Site-wide: 58,548
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  • Site-wide: 54,184

Improved characterization of diffusion in normal and cancerous prostate tissue through optimization of the restriction spectrum imaging signal model

• Downloaded 439 times
• Download rankings, all-time:
  • Site-wide: 69,443
  • In radiology and imaging: 107
• Year to date:
  • Site-wide: 55,367
• Since beginning of last month:
  • Site-wide: 37,541

Atypical genomic cortical patterning in autism with poor early language outcome

• Downloaded 436 times
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  • Site-wide: 69,921
  • In neuroscience: 10,383
• Year to date:
  • Site-wide: 24,309
• Since beginning of last month:
  • Site-wide: 28,733

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

• Downloaded 432 times
• Download rankings, all-time:
  • Site-wide: 70,603
  • In genetics: 3,138
• Year to date:
  • Site-wide: 148,197
• Since beginning of last month:
  • Site-wide: 144,658

Improved prediction of schizophrenia by leveraging genetic overlap with brain morphology

• Downloaded 423 times
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  • Site-wide: 72,222
  • In psychiatry and clinical psychology: 250
• Year to date:
  • Site-wide: 37,661
• Since beginning of last month:
  • Site-wide: 47,241

Annotation-Informed Causal Mixture Modeling (AI-MiXeR) reveals phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories

• Downloaded 403 times
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  • Site-wide: 75,609
  • In genetics: 3,320
• Year to date:
  • Site-wide: 112,766
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  • Site-wide: 102,212

A genetic hazard score to personalize prostate cancer screening, applied to population data

• Downloaded 385 times
• Download rankings, all-time:
  • Site-wide: 78,997
  • In genetics: 3,466
• Year to date:
  • Site-wide: 142,382
• Since beginning of last month:
  • Site-wide: 138,082

Correction of Artifacts Induced by B0 Inhomogeneities in Breast MRI using Reduced Field-of-View Echo-Planar Imaging and Enhanced Reverse Polarity Gradient Method

• Downloaded 381 times
• Download rankings, all-time:
  • Site-wide: 79,729
  • In radiology and imaging: 132
• Year to date:
  • Site-wide: 40,550
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  • Site-wide: 16,090

CXCR4 involvement in neurodegenerative diseases

• Downloaded 378 times
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  • Site-wide: 80,164
  • In genetics: 3,526
• Year to date:
  • Site-wide: 141,107
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  • Site-wide: 139,396

Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area

• Downloaded 368 times
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  • Site-wide: 82,017
  • In neuroscience: 12,318
• Year to date:
  • Site-wide: 128,229
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  • Site-wide: 117,447

Continuity and discontinuity in human cortical development and change from embryonic stages to old age

• Downloaded 337 times
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  • Site-wide: 88,476
  • In neuroscience: 13,324
• Year to date:
  • Site-wide: 113,496
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  • Site-wide: 128,368

Voxel-level Classification of Prostate Cancer Using a Four-Compartment Restriction Spectrum Imaging Model

• Downloaded 324 times
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  • Site-wide: 91,329
  • In oncology: 165
• Year to date:
  • Site-wide: 54,187
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  • Site-wide: 68,567

Correcting B0 inhomogeneity-induced distortions in whole-body diffusion MRI of bone

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 100,813
  • In radiology and imaging: 179
• Year to date:
  • Site-wide: 30,987
• Since beginning of last month:
  • Site-wide: 54,237

Discrimination of breast cancer from healthy breast tissues using a three-component diffusion-weighted MRI model

• Downloaded 277 times
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  • Site-wide: 101,851
  • In radiology and imaging: 182
• Year to date:
  • Site-wide: 57,440
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  • Site-wide: 35,396

Unique prediction of developmental psychopathology from genetic and familial risk

• Downloaded 276 times
• Download rankings, all-time:
  • Site-wide: 102,155
  • In genetic and genomic medicine: 474
• Year to date:
  • Site-wide: 50,664
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  • Site-wide: None

The effect of sample size on polygenic hazard models for prostate cancer

• Downloaded 253 times
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  • Site-wide: 107,827
  • In genetics: 4,595
• Year to date:
  • Site-wide: 144,062
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  • Site-wide: 110,398

Age dependence of modern clinical risk groups for localized prostate cancer — a population-based study

• Downloaded 242 times
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  • Site-wide: 110,372
  • In epidemiology: 4,595
• Year to date:
  • Site-wide: 113,755
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  • Site-wide: 95,972

MODE for detecting and estimating genetic causal variants

• Downloaded 240 times
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  • Site-wide: 110,716
  • In bioinformatics: 9,264
• Year to date:
  • Site-wide: 131,122
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  • Site-wide: 56,573

Genetic overlap between multivariate measures of human functional brain connectivity and psychiatric disorders

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 113,005
  • In genetic and genomic medicine: 570
• Year to date:
  • Site-wide: 23,872
• Since beginning of last month:
  • Site-wide: 10,673

Multivariate genome-wide association study on tissue-sensitive diffusion metrics identifies key molecular pathways for axonal growth, synaptogenesis, and astrocyte-mediated neuroinflammation

• Downloaded 221 times
• Download rankings, all-time:
  • Site-wide: 115,688
  • In genetics: 4,861
• Year to date:
  • Site-wide: 25,301
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  • Site-wide: 3,728

Characterization of the Diffusion Signal of Breast Tissues using Multi-exponential Models

• Downloaded 199 times
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  • Site-wide: 120,988
  • In radiology and imaging: 251
• Year to date:
  • Site-wide: 96,115
• Since beginning of last month:
  • Site-wide: 41,555

Movement abilities and brain development in preschoolers born very preterm

• Downloaded 197 times
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  • Site-wide: 121,506
  • In neuroscience: 18,451
• Year to date:
  • Site-wide: 131,617
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  • Site-wide: 136,596

Associations between Early Midlife Lifestyle Behaviors, Young Adult Cognitive Reserve and Advanced Predicted Brain Age in Late Midlife

• Downloaded 148 times
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  • Site-wide: 132,910
  • In neuroscience: 20,065
• Year to date:
  • Site-wide: 92,207
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  • Site-wide: 114,013

Spatially Resolved Estimation of Metabolic Oxygen Consumption From Optical Measurements in Cortex

• Downloaded 145 times
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  • Site-wide: 133,499
  • In neuroscience: 20,172
• Year to date:
  • Site-wide: 145,970
• Since beginning of last month:
  • Site-wide: 143,815

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

• Downloaded 137 times
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  • Site-wide: 135,164
  • In genetic and genomic medicine: 739
• Year to date:
  • Site-wide: 44,194
• Since beginning of last month:
  • Site-wide: 49,864

Common genetic and clinical risk factors: Association with fatal prostate cancer in the Cohort of Swedish Men

• Downloaded 131 times
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  • Site-wide: 136,472
  • In genetic and genomic medicine: 746
• Year to date:
  • Site-wide: 93,643
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  • Site-wide: 48,247

Spatially heterogeneous microstructural development within subcortical regions from 9-13 years

• Downloaded 103 times
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  • Site-wide: 141,850
  • In neuroscience: 21,358
• Year to date:
  • Site-wide: 58,960
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  • Site-wide: 48,209

Patient-level detection of grade group >=2 prostate cancer using quantitative diffusion MRI

• Downloaded 96 times
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  • Site-wide: 143,238
  • In oncology: 485
• Year to date:
  • Site-wide: 62,433
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  • Site-wide: 31,626

Microstructural development across white matter from 9-13 years

• Downloaded 82 times
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  • Site-wide: 145,263
  • In neuroscience: 21,844
• Year to date:
  • Site-wide: 71,966
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  • Site-wide: 48,213