Author: Mathew J Garnett

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Preprints

Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screening

• Downloaded 4,546 times
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  • Site-wide: 2,650
  • In cancer biology: 33
• Year to date:
  • Site-wide: 6,463
• Since beginning of last month:
  • Site-wide: 5,373

A cancer pharmacogenomic screen powering crowd-sourced advancement of drug combination prediction

• Downloaded 4,190 times
• Download rankings, all-time:
  • Site-wide: 2,977
  • In bioinformatics: 250
• Year to date:
  • Site-wide: 49,200
• Since beginning of last month:
  • Site-wide: 42,162

Minimal genome-wide human CRISPR-Cas9 library

• Downloaded 2,264 times
• Download rankings, all-time:
  • Site-wide: 7,190
  • In genomics: 762
• Year to date:
  • Site-wide: 17,876
• Since beginning of last month:
  • Site-wide: 22,251

Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

• Downloaded 2,083 times
• Download rankings, all-time:
  • Site-wide: 8,096
  • In systems biology: 137
• Year to date:
  • Site-wide: 42,244
• Since beginning of last month:
  • Site-wide: 96,598

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency datasets

• Downloaded 2,039 times
• Download rankings, all-time:
  • Site-wide: 8,341
  • In cancer biology: 140
• Year to date:
  • Site-wide: 88,876
• Since beginning of last month:
  • Site-wide: 84,902

Integrated cross-study datasets of genetic dependencies in cancer

• Downloaded 2,005 times
• Download rankings, all-time:
  • Site-wide: 8,590
  • In bioinformatics: 989
• Year to date:
  • Site-wide: 2,617
• Since beginning of last month:
  • Site-wide: 9,795

Transcription factor activities enhance markers of drug response in cancer

• Downloaded 2,003 times
• Download rankings, all-time:
  • Site-wide: 8,598
  • In cancer biology: 145
• Year to date:
  • Site-wide: 78,722
• Since beginning of last month:
  • Site-wide: 80,512

CELLector: Genomics Guided Selection of Cancer in vitro Models

• Downloaded 1,981 times
• Download rankings, all-time:
  • Site-wide: 8,761
  • In bioinformatics: 1,018
• Year to date:
  • Site-wide: 85,860
• Since beginning of last month:
  • Site-wide: 144,586

Rapid proteotyping reveals cancer biology and drug response determinants in the NCI-60 cells

• Downloaded 1,800 times
• Download rankings, all-time:
  • Site-wide: 10,091
  • In systems biology: 183
• Year to date:
  • Site-wide: 65,696
• Since beginning of last month:
  • Site-wide: 53,528

Perturbation-response genes reveal signaling footprints in cancer gene expression

• Downloaded 1,596 times
• Download rankings, all-time:
  • Site-wide: 12,041
  • In bioinformatics: 1,398
• Year to date:
  • Site-wide: 64,772
• Since beginning of last month:
  • Site-wide: 48,716

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR/Cas9 screening

• Downloaded 1,149 times
• Download rankings, all-time:
  • Site-wide: 19,643
  • In cancer biology: 456
• Year to date:
  • Site-wide: 105,393
• Since beginning of last month:
  • Site-wide: 143,561

A screen for combination therapies in BRAF/NRAS wild type melanoma identifies nilotinib plus MEK inhibitor as a synergistic combination

• Downloaded 891 times
• Download rankings, all-time:
  • Site-wide: 28,420
  • In cancer biology: 726
• Year to date:
  • Site-wide: 63,802
• Since beginning of last month:
  • Site-wide: 62,028

GDSCTools for Mining Pharmacogenomic Interactions in Cancer

• Downloaded 881 times
• Download rankings, all-time:
  • Site-wide: 28,904
  • In cancer biology: 739
• Year to date:
  • Site-wide: 62,981
• Since beginning of last month:
  • Site-wide: 62,198

Tandem duplications lead to loss of fitness effects in CRISPR-Cas9 data

• Downloaded 843 times
• Download rankings, all-time:
  • Site-wide: 30,697
  • In genomics: 2,720
• Year to date:
  • Site-wide: 104,317
• Since beginning of last month:
  • Site-wide: 106,228

Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting

• Downloaded 747 times
• Download rankings, all-time:
  • Site-wide: 36,327
  • In bioinformatics: 3,966
• Year to date:
  • Site-wide: 140,088
• Since beginning of last month:
  • Site-wide: 106,881

Patient-specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

• Downloaded 717 times
• Download rankings, all-time:
  • Site-wide: 38,452
  • In systems biology: 844
• Year to date:
  • Site-wide: 138,604
• Since beginning of last month:
  • Site-wide: 105,943

Dissecting cancer resistance to therapies with cell-type-specific dynamic logic models

• Downloaded 595 times
• Download rankings, all-time:
  • Site-wide: 48,815
  • In cancer biology: 1,381
• Year to date:
  • Site-wide: 131,452
• Since beginning of last month:
  • Site-wide: 93,239

N-myristoyltransferase inhibition is synthetic lethal in MYC-deregulated cancers

• Downloaded 585 times
• Download rankings, all-time:
  • Site-wide: 49,905
  • In cancer biology: 1,406
• Year to date:
  • Site-wide: 6,346
• Since beginning of last month:
  • Site-wide: 14,251

A statistical framework for assessing pharmacological response and biomarkers using uncertainty estimates

• Downloaded 573 times
• Download rankings, all-time:
  • Site-wide: 51,313
  • In cancer biology: 1,439
• Year to date:
  • Site-wide: 72,271
• Since beginning of last month:
  • Site-wide: 127,062

A landscape of synergistic drug combinations in non-small-cell lung cancer

• Downloaded 564 times
• Download rankings, all-time:
  • Site-wide: 52,261
  • In cancer biology: 1,472
• Year to date:
  • Site-wide: 6,692
• Since beginning of last month:
  • Site-wide: 12,925

CoRe: A robustly benchmarked R package for the identification of core fitness genes in genome-wide pooled CRISPR knock-out screens

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 100,422
  • In bioinformatics: 8,635
• Year to date:
  • Site-wide: 18,070
• Since beginning of last month:
  • Site-wide: 22,513