Author: Mathew J Garnett

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Preprints

Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screening

• Downloaded 5,634 times
• Download rankings, all-time:
  • Site-wide: 2,691
  • In cancer biology: 32
• Year to date:
  • Site-wide: 3,854
• Since beginning of last month:
  • Site-wide: 4,664

A cancer pharmacogenomic screen powering crowd-sourced advancement of drug combination prediction

• Downloaded 4,360 times
• Download rankings, all-time:
  • Site-wide: 3,796
  • In bioinformatics: 291
• Year to date:
  • Site-wide: 78,422
• Since beginning of last month:
  • Site-wide: 85,750

Pan-cancer proteomic map of 949 human cell lines reveals principles of cancer vulnerabilities

• Downloaded 3,536 times
• Download rankings, all-time:
  • Site-wide: 5,121
  • In systems biology: None
• Year to date:
  • Site-wide: 301
• Since beginning of last month:
  • Site-wide: 1,966

Integrated cross-study datasets of genetic dependencies in cancer

• Downloaded 2,553 times
• Download rankings, all-time:
  • Site-wide: 8,272
  • In bioinformatics: 818
• Year to date:
  • Site-wide: 27,292
• Since beginning of last month:
  • Site-wide: 33,497

Minimal genome-wide human CRISPR-Cas9 library

• Downloaded 2,467 times
• Download rankings, all-time:
  • Site-wide: 8,675
  • In genomics: 813
• Year to date:
  • Site-wide: 66,769
• Since beginning of last month:
  • Site-wide: 46,914

Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

• Downloaded 2,250 times
• Download rankings, all-time:
  • Site-wide: 9,910
  • In systems biology: 144
• Year to date:
  • Site-wide: 78,291
• Since beginning of last month:
  • Site-wide: 54,730

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency datasets

• Downloaded 2,118 times
• Download rankings, all-time:
  • Site-wide: 10,895
  • In cancer biology: 172
• Year to date:
  • Site-wide: 106,872
• Since beginning of last month:
  • Site-wide: 144,888

CELLector: Genomics Guided Selection of Cancer in vitro Models

• Downloaded 2,077 times
• Download rankings, all-time:
  • Site-wide: 11,230
  • In bioinformatics: 1,143
• Year to date:
  • Site-wide: 96,443
• Since beginning of last month:
  • Site-wide: 131,367

Transcription factor activities enhance markers of drug response in cancer

• Downloaded 2,049 times
• Download rankings, all-time:
  • Site-wide: 11,468
  • In cancer biology: 192
• Year to date:
  • Site-wide: 164,943
• Since beginning of last month:
  • Site-wide: 142,672

Rapid proteotyping reveals cancer biology and drug response determinants in the NCI-60 cells

• Downloaded 1,948 times
• Download rankings, all-time:
  • Site-wide: 12,348
  • In systems biology: 195
• Year to date:
  • Site-wide: 70,978
• Since beginning of last month:
  • Site-wide: 44,113

Perturbation-response genes reveal signaling footprints in cancer gene expression

• Downloaded 1,687 times
• Download rankings, all-time:
  • Site-wide: 15,245
  • In bioinformatics: 1,539
• Year to date:
  • Site-wide: 107,454
• Since beginning of last month:
  • Site-wide: 150,320

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR/Cas9 screening

• Downloaded 1,214 times
• Download rankings, all-time:
  • Site-wide: 25,387
  • In cancer biology: 572
• Year to date:
  • Site-wide: 156,545
• Since beginning of last month:
  • Site-wide: 114,015

N-myristoyltransferase inhibition is synthetic lethal in MYC-deregulated cancers

• Downloaded 1,119 times
• Download rankings, all-time:
  • Site-wide: 28,741
  • In cancer biology: 902
• Year to date:
  • Site-wide: 14,271
• Since beginning of last month:
  • Site-wide: 6,693

A screen for combination therapies in BRAF/NRAS wild type melanoma identifies nilotinib plus MEK inhibitor as a synergistic combination

• Downloaded 1,031 times
• Download rankings, all-time:
  • Site-wide: 32,493
  • In cancer biology: 821
• Year to date:
  • Site-wide: 76,893
• Since beginning of last month:
  • Site-wide: 58,799

GDSCTools for Mining Pharmacogenomic Interactions in Cancer

• Downloaded 978 times
• Download rankings, all-time:
  • Site-wide: 35,137
  • In cancer biology: 878
• Year to date:
  • Site-wide: 96,351
• Since beginning of last month:
  • Site-wide: 86,243

A landscape of synergistic drug combinations in non-small-cell lung cancer

• Downloaded 946 times
• Download rankings, all-time:
  • Site-wide: 36,932
  • In cancer biology: 1,118
• Year to date:
  • Site-wide: 19,552
• Since beginning of last month:
  • Site-wide: 29,193

Tandem duplications lead to loss of fitness effects in CRISPR-Cas9 data

• Downloaded 929 times
• Download rankings, all-time:
  • Site-wide: 38,012
  • In genomics: 2,895
• Year to date:
  • Site-wide: 133,683
• Since beginning of last month:
  • Site-wide: 141,105

Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting

• Downloaded 792 times
• Download rankings, all-time:
  • Site-wide: 48,071
  • In bioinformatics: 4,551
• Year to date:
  • Site-wide: 179,463
• Since beginning of last month:
  • Site-wide: 170,998

Base editing screens map mutations affecting IFNγ signalling in cancer

• Downloaded 791 times
• Download rankings, all-time:
  • Site-wide: 48,187
  • In cancer biology: None
• Year to date:
  • Site-wide: 2,485
• Since beginning of last month:
  • Site-wide: 3,320

Patient-specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

• Downloaded 771 times
• Download rankings, all-time:
  • Site-wide: 49,991
  • In systems biology: 954
• Year to date:
  • Site-wide: 169,149
• Since beginning of last month:
  • Site-wide: 184,450

A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens

• Downloaded 745 times
• Download rankings, all-time:
  • Site-wide: 52,426
  • In cancer biology: 1,735
• Year to date:
  • Site-wide: 20,383
• Since beginning of last month:
  • Site-wide: 49,738

CoRe: A robustly benchmarked R package for the identification of core fitness genes in genome-wide pooled CRISPR knock-out screens

• Downloaded 693 times
• Download rankings, all-time:
  • Site-wide: 58,067
  • In bioinformatics: 5,946
• Year to date:
  • Site-wide: 36,513
• Since beginning of last month:
  • Site-wide: 55,495

A statistical framework for assessing pharmacological response and biomarkers using uncertainty estimates

• Downloaded 690 times
• Download rankings, all-time:
  • Site-wide: 58,315
  • In cancer biology: 1,621
• Year to date:
  • Site-wide: 89,369
• Since beginning of last month:
  • Site-wide: 67,743

Dissecting cancer resistance to therapies with cell-type-specific dynamic logic models

• Downloaded 628 times
• Download rankings, all-time:
  • Site-wide: 66,270
  • In cancer biology: 1,751
• Year to date:
  • Site-wide: 182,915
• Since beginning of last month:
  • Site-wide: 174,820