Author: Gail Davies

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,393
  • In genetics: 27
• Year to date:
  • Site-wide: 20,576
• Since beginning of last month:
  • Site-wide: 21,548

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

• Downloaded 5,827 times
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  • Site-wide: 2,828
  • In genetics: 79
• Year to date:
  • Site-wide: 5,168
• Since beginning of last month:
  • Site-wide: 29,856

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,875 times
• Download rankings, all-time:
  • Site-wide: 3,617
  • In genetics: 100
• Year to date:
  • Site-wide: 114,409
• Since beginning of last month:
  • Site-wide: 206,684

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,545 times
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  • Site-wide: 5,724
  • In genetics: 185
• Year to date:
  • Site-wide: 70,949
• Since beginning of last month:
  • Site-wide: 51,440

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,432 times
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  • Site-wide: 6,004
  • In genetics: 198
• Year to date:
  • Site-wide: 40,539
• Since beginning of last month:
  • Site-wide: 117,184

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,964 times
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  • Site-wide: 7,431
  • In genetics: 268
• Year to date:
  • Site-wide: 60,313
• Since beginning of last month:
  • Site-wide: 80,027

Genetic analysis identifies molecular systems and biological pathways associated with household income

• Downloaded 2,933 times
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  • Site-wide: 7,541
  • In genetics: 273
• Year to date:
  • Site-wide: 35,918
• Since beginning of last month:
  • Site-wide: 42,718

Genetic “General Intelligence,” Objectively Determined and Measured

• Downloaded 2,841 times
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  • Site-wide: 7,876
  • In genetics: 292
• Year to date:
  • Site-wide: 25,969
• Since beginning of last month:
  • Site-wide: 22,131

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

• Downloaded 2,813 times
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  • Site-wide: 7,999
  • In genetics: 298
• Year to date:
  • Site-wide: 36,125
• Since beginning of last month:
  • Site-wide: 60,627

Molecular genetic contributions to self-rated health

• Downloaded 2,424 times
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  • Site-wide: 10,033
  • In genetics: 384
• Year to date:
  • Site-wide: 29,939
• Since beginning of last month:
  • Site-wide: 151,418

Genetic Prediction of Male Pattern Baldness

• Downloaded 2,263 times
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  • Site-wide: 11,145
  • In genetics: 430
• Year to date:
  • Site-wide: 8,892
• Since beginning of last month:
  • Site-wide: 6,866

GWAS on family history of Alzheimer's disease

• Downloaded 2,137 times
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  • Site-wide: 12,158
  • In genetics: 447
• Year to date:
  • Site-wide: 167,488
• Since beginning of last month:
  • Site-wide: 175,121

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

• Downloaded 2,137 times
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  • Site-wide: 12,160
  • In genetics: 449
• Year to date:
  • Site-wide: 132,649
• Since beginning of last month:
  • Site-wide: 151,668

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

• Downloaded 2,043 times
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  • Site-wide: 12,997
  • In genetics: 488
• Year to date:
  • Site-wide: 168,857
• Since beginning of last month:
  • Site-wide: 60,045

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,867 times
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  • Site-wide: 14,935
  • In genetics: 591
• Year to date:
  • Site-wide: 62,621
• Since beginning of last month:
  • Site-wide: 198,158

Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

• Downloaded 1,845 times
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  • Site-wide: 15,217
  • In genetics: 601
• Year to date:
  • Site-wide: 117,975
• Since beginning of last month:
  • Site-wide: 75,694

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,805 times
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  • Site-wide: 15,742
  • In genetics: 635
• Year to date:
  • Site-wide: 118,717
• Since beginning of last month:
  • Site-wide: 32,783

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

• Downloaded 1,765 times
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  • Site-wide: 16,303
  • In neuroscience: 1,744
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 176,351

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 1,709 times
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  • Site-wide: 17,097
  • In genetics: 692
• Year to date:
  • Site-wide: 65,435
• Since beginning of last month:
  • Site-wide: 78,230

Genome wide analysis of gene dosage in 24,092 individuals shows that 10,000 genes modulate cognitive ability

• Downloaded 1,406 times
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  • Site-wide: 23,418
  • In genetics: 943
• Year to date:
  • Site-wide: 28,479
• Since beginning of last month:
  • Site-wide: 101,077

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 1,377 times
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  • Site-wide: 24,172
  • In genetics: 976
• Year to date:
  • Site-wide: 13,863
• Since beginning of last month:
  • Site-wide: 27,043

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 883 times
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  • Site-wide: 48,383
  • In genomics: 3,575
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 91,803

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

• Downloaded 865 times
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  • Site-wide: 49,902
  • In genetics: 1,942
• Year to date:
  • Site-wide: 137,571
• Since beginning of last month:
  • Site-wide: 116,160

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

• Downloaded 856 times
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  • Site-wide: 50,657
  • In genetics: 1,961
• Year to date:
  • Site-wide: 167,805
• Since beginning of last month:
  • Site-wide: 180,775

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 828 times
• Download rankings, all-time:
  • Site-wide: 53,303
  • In genetics: 2,071
• Year to date:
  • Site-wide: 188,454
• Since beginning of last month:
  • Site-wide: 198,273

Genetic contributions to self-reported tiredness

• Downloaded 807 times
• Download rankings, all-time:
  • Site-wide: 55,370
  • In genetics: 2,142
• Year to date:
  • Site-wide: 118,001
• Since beginning of last month:
  • Site-wide: 198,198

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

• Downloaded 804 times
• Download rankings, all-time:
  • Site-wide: 55,687
  • In genetics: 2,148
• Year to date:
  • Site-wide: 132,645
• Since beginning of last month:
  • Site-wide: 208,814

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

• Downloaded 803 times
• Download rankings, all-time:
  • Site-wide: 55,735
  • In genomics: 3,953
• Year to date:
  • Site-wide: 188,886
• Since beginning of last month:
  • Site-wide: 174,783

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

• Downloaded 781 times
• Download rankings, all-time:
  • Site-wide: 58,068
  • In genomics: 4,097
• Year to date:
  • Site-wide: 120,083
• Since beginning of last month:
  • Site-wide: 65,728

Transcriptome-wide and Stratified Genomic Structural Equation Modeling Identify Neurobiological Pathways Underlying General and Specific Cognitive Functions

• Downloaded 732 times
• Download rankings, all-time:
  • Site-wide: 64,000
  • In genetic and genomic medicine: 408
• Year to date:
  • Site-wide: 42,970
• Since beginning of last month:
  • Site-wide: 56,702

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

• Downloaded 674 times
• Download rankings, all-time:
  • Site-wide: 71,773
  • In genetics: 2,750
• Year to date:
  • Site-wide: 132,716
• Since beginning of last month:
  • Site-wide: 175,331

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 582 times
• Download rankings, all-time:
  • Site-wide: 87,021
  • In genetics: 3,313
• Year to date:
  • Site-wide: 189,263
• Since beginning of last month:
  • Site-wide: 175,197

Polygenic predictors of age-related decline in cognitive ability

• Downloaded 566 times
• Download rankings, all-time:
  • Site-wide: 90,037
  • In genomics: 5,603
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 198,402

Genetic contributions to trail making test performance in UK Biobank

• Downloaded 565 times
• Download rankings, all-time:
  • Site-wide: 90,331
  • In genetics: 3,434
• Year to date:
  • Site-wide: 188,630
• Since beginning of last month:
  • Site-wide: 175,257

Genetic contributions to health literacy

• Downloaded 523 times
• Download rankings, all-time:
  • Site-wide: 99,034
  • In epidemiology: 4,325
• Year to date:
  • Site-wide: 62,214
• Since beginning of last month:
  • Site-wide: 75,513

The influence of X chromosome variants on trait neuroticism.

• Downloaded 443 times
• Download rankings, all-time:
  • Site-wide: 118,094
  • In genetics: 4,422
• Year to date:
  • Site-wide: 190,719
• Since beginning of last month:
  • Site-wide: 179,164

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 417 times
• Download rankings, all-time:
  • Site-wide: 125,285
  • In genetics: 4,677
• Year to date:
  • Site-wide: 190,482
• Since beginning of last month:
  • Site-wide: 209,766