Author: Dorret I Boomsma

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 875
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  • Site-wide: 32,750
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  • Site-wide: 37,308

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

• Downloaded 8,649 times
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  • Site-wide: 972
  • In genetics: 27
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  • Site-wide: 40,268
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  • Site-wide: 35,569

The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,074
  • In genetics: 31
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  • Site-wide: 14,130
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A reference panel of 64,976 haplotypes for genotype imputation

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  • Site-wide: 2,262
  • In genetics: 82
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  • Site-wide: 81,054
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  • Site-wide: 101,752

Greater male than female variability in regional brain structure across the lifespan

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  • Site-wide: 3,176
  • In neuroscience: 244
• Year to date:
  • Site-wide: 17,824
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  • Site-wide: 27,353

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 4,004
  • In genetics: 168
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  • Site-wide: 55,878
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  • Site-wide: 75,377

Integrative approaches for large-scale transcriptome-wide association studies

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  • Site-wide: 4,343
  • In genetics: 191
• Year to date:
  • Site-wide: 39,520
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  • Site-wide: 40,825

Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 5,193
  • In genetics: 237
• Year to date:
  • Site-wide: 23,664
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  • Site-wide: 29,943

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • Site-wide: 5,385
  • In genetics: 246
• Year to date:
  • Site-wide: 91,718
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  • Site-wide: 94,288

Investigating the Genetic Architecture of Non-Cognitive Skills Using GWAS-by-Subtraction

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  • Site-wide: 6,401
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• Year to date:
  • Site-wide: 5,380
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  • Site-wide: 11,867

Large-scale association analyses identify host factors influencing human gut microbiome composition

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  • Site-wide: 6,532
  • In genetics: 312
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  • Site-wide: 2,901
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  • Site-wide: 6,491

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

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  • Site-wide: 6,669
  • In genetics: 322
• Year to date:
  • Site-wide: 22,523
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  • Site-wide: 21,593

Life-span development of functional brain networks as assessed with minimum spanning tree analysis of resting state EEG.

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  • Site-wide: 7,417
  • In neuroscience: 748
• Year to date:
  • Site-wide: 70,896
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  • Site-wide: 62,617

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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  • Site-wide: 8,232
  • In genetics: 379
• Year to date:
  • Site-wide: 68,744
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  • Site-wide: 63,845

Dynamics of Brain Structure and its Genetic Architecture over the Lifespan

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  • Site-wide: 8,854
  • In genetics: 414
• Year to date:
  • Site-wide: 12,606
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  • Site-wide: 15,166

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,717 times
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  • Site-wide: 9,478
  • In genetics: 450
• Year to date:
  • Site-wide: 85,161
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  • Site-wide: 94,471

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 9,507
  • In genetics: 453
• Year to date:
  • Site-wide: 78,666
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  • Site-wide: 85,472

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 12,530
  • In genetics: 615
• Year to date:
  • Site-wide: 79,280
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  • Site-wide: 55,150

Stratified Linkage Disequilibrium Score Regression reveals enrichment of eQTL effects on complex traits is not tissue specific

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  • Site-wide: 14,033
  • In genomics: 1,484
• Year to date:
  • Site-wide: 49,195
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  • Site-wide: 55,081

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 15,338
  • In genomics: 1,582
• Year to date:
  • Site-wide: 91,319
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  • Site-wide: 125,117

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 16,014
  • In genetics: 790
• Year to date:
  • Site-wide: 5,625
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  • Site-wide: 5,004

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

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  • Site-wide: 16,088
  • In genetics: 793
• Year to date:
  • Site-wide: 79,022
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  • Site-wide: 77,876

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 19,141
  • In genetics: 925
• Year to date:
  • Site-wide: 4,007
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  • Site-wide: 4,348

Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

• Downloaded 1,037 times
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  • Site-wide: 20,034
  • In neuroscience: 2,530
• Year to date:
  • Site-wide: 19,082
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  • Site-wide: 25,642

Genetic Association Study of Childhood Aggression across raters, instruments and age

• Downloaded 916 times
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  • Site-wide: 23,973
  • In genomics: 2,306
• Year to date:
  • Site-wide: 15,864
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  • Site-wide: 10,042

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

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  • Site-wide: 27,759
  • In genomics: 2,564
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  • Site-wide: 64,790
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  • Site-wide: 62,425

Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness

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  • Site-wide: 28,919
  • In genetics: 1,396
• Year to date:
  • Site-wide: 116,715
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  • Site-wide: 103,715

Within-sibship GWAS improve estimates of direct genetic effects

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  • Site-wide: 28,953
  • In genetics: 1,398
• Year to date:
  • Site-wide: 1,612
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  • Site-wide: 525

Parental influences on offspring education: indirect genetic effects of non-cognitive skills

• Downloaded 792 times
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  • Site-wide: 29,413
  • In genetics: 1,426
• Year to date:
  • Site-wide: 7,807
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  • Site-wide: 12,178

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 30,692
  • In neuroscience: 4,160
• Year to date:
  • Site-wide: 62,388
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  • Site-wide: 79,430

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 31,634
  • In genomics: 2,819
• Year to date:
  • Site-wide: 94,590
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  • Site-wide: 108,191

Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

• Downloaded 733 times
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  • Site-wide: 32,846
  • In neuroscience: 4,495
• Year to date:
  • Site-wide: 31,098
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  • Site-wide: 56,264

Genome-wide association study of plasma triglycerides, phospholipids and relation to cardio-metabolic risk factors

• Downloaded 722 times
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  • Site-wide: 33,452
  • In epidemiology: 1,671
• Year to date:
  • Site-wide: 49,562
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  • Site-wide: 48,273

Genome-wide identification of directed gene networks using large-scale population genomics data

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  • Site-wide: 33,801
  • In genomics: 2,961
• Year to date:
  • Site-wide: 120,279
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  • Site-wide: 129,889

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

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  • Site-wide: 35,606
  • In genetic and genomic medicine: 112
• Year to date:
  • Site-wide: 10,387
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  • Site-wide: 12,296

Extending Causality Tests With Genetic Instruments: An Integration Of Mendelian Randomization And The Classical Twin Design

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  • Site-wide: 35,662
  • In genetics: 1,701
• Year to date:
  • Site-wide: 91,970
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  • Site-wide: 101,708

The genomic architecture of blood metabolites based on a decade of genome-wide analyses

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  • Site-wide: 36,211
  • In genetics: 1,725
• Year to date:
  • Site-wide: 106,677
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  • Site-wide: 104,721

Incorporating polygenic scores in the twin model to estimate genotype-environment covariance: exploration of statistical power

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  • Site-wide: 37,352
  • In genetics: 1,779
• Year to date:
  • Site-wide: 48,054
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  • Site-wide: 89,659

Predicting biological age based on the BBMRI-NL 1H-NMR metabolomics repository

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  • Site-wide: 37,372
  • In epidemiology: 1,817
• Year to date:
  • Site-wide: 44,878
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  • Site-wide: 45,658

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 587 times
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  • Site-wide: 43,827
  • In sexual and reproductive health: 19
• Year to date:
  • Site-wide: 2,523
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  • Site-wide: 8,602

Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity

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  • Site-wide: 44,569
  • In genetics: 2,086
• Year to date:
  • Site-wide: 123,098
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  • Site-wide: 124,944

Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium

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  • Site-wide: 45,526
  • In genomics: 3,636
• Year to date:
  • Site-wide: 55,106
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  • Site-wide: 52,632

Genetic overlap between schizophrenia and developmental psychopathology: a longitudinal approach applied to common childhood disorders between age 7 and 15 years

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  • Site-wide: 49,220
  • In genetics: 2,297
• Year to date:
  • Site-wide: 125,680
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  • Site-wide: 101,749

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

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  • Site-wide: 49,711
  • In genomics: 3,898
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  • Site-wide: 80,113
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  • Site-wide: 70,276

Intergenerational transmission of education and ADHD: Effects of parental genotypes

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  • Site-wide: 52,386
  • In genomics: 4,053
• Year to date:
  • Site-wide: 118,771
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  • Site-wide: 124,682

Genetic risk for major depressive disorder and loneliness in gender-specific associations with coronary artery disease

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  • Site-wide: 55,510
  • In genetics: 2,567
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  • Site-wide: 97,528
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  • Site-wide: 87,040

EEG-based age-prediction models as stable and heritable indicators of brain maturational level in children and adolescents

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  • Site-wide: 59,625
  • In neuroscience: 8,922
• Year to date:
  • Site-wide: 127,625
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  • Site-wide: 121,617

Genetic variation in the Major Histocompatibility Complex and association with depression

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  • Site-wide: 62,578
  • In genetics: 2,893
• Year to date:
  • Site-wide: 116,623
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  • Site-wide: 95,887

Multivariate GWAS elucidates the genetic architecture of alcohol consumption and misuse, corrects biases, and reveals novel associations with disease

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  • Site-wide: 67,769
  • In genetics: 3,110
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  • Site-wide: 32,988
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  • Site-wide: 29,721

Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

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  • Site-wide: 72,667
  • In genetics: 3,321
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  • Site-wide: 62,729
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  • Site-wide: 73,278

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

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  • Site-wide: 75,383
  • In genomics: 5,094
• Year to date:
  • Site-wide: 127,227
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  • Site-wide: 127,212

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

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  • Site-wide: 79,315
  • In genetic and genomic medicine: 282
• Year to date:
  • Site-wide: 5,761
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  • Site-wide: 15,591

A genome-wide association study of total child psychiatric problems scores

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  • Site-wide: 82,803
  • In psychiatry and clinical psychology: 274
• Year to date:
  • Site-wide: 47,302
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  • Site-wide: 32,324

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

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  • Site-wide: 88,472
  • In bioinformatics: 7,870
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  • Site-wide: 83,088
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  • Site-wide: 81,564

Genetic meta-analysis of obsessive-compulsive disorder and self-report compulsive symptoms.

• Downloaded 255 times
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  • Site-wide: 95,369
  • In genetics: 4,262
• Year to date:
  • Site-wide: 118,409
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  • Site-wide: 83,847

Contribution of genetic and environmental factors to the onset of preclinical Alzheimer's disease - a monozygotic twin study

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  • Site-wide: 96,956
  • In neurology: 279
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  • Site-wide: 56,032

Ketone body 3-hydroxybutyrate: a biomarker of aggression?

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  • Site-wide: 105,739
  • In epidemiology: 4,356
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  • Site-wide: 77,137
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  • Site-wide: 65,222

The power to detect cultural transmission in the Nuclear Twin Family design with and without polygenic risk scores and in the Transmitted-Non-transmitted (alleles) design

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  • Site-wide: 114,580
  • In genetics: 4,944
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  • Site-wide: 128,859
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  • Site-wide: 117,239

Investigating the relationships between unfavorable sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses

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  • Site-wide: 116,262
  • In epidemiology: 4,777
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  • Site-wide: 51,497
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  • Site-wide: 36,993

Multilevel Twin Models: Geographical Region as a Third Level Variable

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  • Site-wide: 117,063
  • In genetics: 5,024
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  • Site-wide: 82,099
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  • Site-wide: 110,533

Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression

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  • Site-wide: 120,904
  • In psychiatry and clinical psychology: 554
• Year to date:
  • Site-wide: 18,881
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  • Site-wide: 11,750

Safe linkage of cohort and population-based register data in a genome-wide association study on health care expenditure

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  • Site-wide: 122,611
  • In genetics: 5,184
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  • Site-wide: 66,804
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  • Site-wide: 46,209

Novel polygenic risk score links depression-related cortical transcriptomic changes to brain morphology and symptom severity

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  • Site-wide: 128,847
  • In genetic and genomic medicine: 633
• Year to date:
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  • Site-wide: 10,280