Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,915 bioRxiv papers from 266,490 authors.

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Preprints

Polygenic Hyperlipidemias and Coronary Artery Disease Risk

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Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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Phenome-wide association studies (PheWAS) across large "real-world data" population cohorts support drug target validation

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Genetics of 38 blood and urine biomarkers in the UK Biobank

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  • In genetics: 152 out of 3,319
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Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

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Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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Genome-Wide Association Study Reveals First Locus for Anorexia Nervosa and Metabolic Correlations

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Cell specific eQTL analysis without sorting cells

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Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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metaCCA: Summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis

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  • In bioinformatics: 719 out of 5,899
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Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers

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FINEMAP: Efficient variable selection using summary data from genome-wide association studies

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Genome-wide association study identifies 17 new loci influencing concentrations of circulating cytokines and growth factors

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Genomic prediction of coronary heart disease

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Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

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Refining fine-mapping: effect sizes and regional heritability

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  • In genetics: 566 out of 3,319
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Haplotype sharing provides insights into fine-scale population history and disease in Finland

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  • In genetics: 588 out of 3,319
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Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

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Geographic variation and bias in polygenic scores of complex diseases and traits in Finland

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  • In genetics: 699 out of 3,319
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Genetics of human plasma lipidome: Understanding lipid metabolism and its link to diseases beyond traditional lipids

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  • In genetics: 724 out of 3,319
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  • Site-wide: 8,867 out of 57,915

Mergeomics: integration of diverse genomics resources to identify pathogenic perturbations to biological systems

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  • In systems biology: 300 out of 1,638
• Year to date:
  • Site-wide: 49,273 out of 57,915
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  • Site-wide: 50,739 out of 57,915

Towards a molecular systems model of coronary artery disease

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  • In systems biology: 304 out of 1,638
• Year to date:
  • Site-wide: 42,114 out of 57,915
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  • Site-wide: 51,795 out of 57,915

The rate of false polymorphisms introduced when imputing genotypes from global imputation panels

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  • Site-wide: 37,842 out of 57,915

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

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Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

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Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 40,500 out of 57,915

biMM: Efficient estimation of genetic variances and covariances for cohorts with high-dimensional phenotype measurements

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Whole genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

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Common variant burden contributes significantly to the familial aggregation of migraine in 1,589 families

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Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

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  • Site-wide: 18,306 out of 57,915

Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

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MetaPhat: Detecting and decomposing multivariate associations from univariate genome-wide association statistics

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  • In bioinformatics: 4,552 out of 5,899
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Coronary artery disease risk and lipidomic profiles are similar in familial and population-ascertained hyperlipidemias

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