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Author: Li Chen

Rankings

  • All-time downloads: 95,637 (rank: 2,378 )
  • Categories:
    • biochemistry: 619 (rank: 17,128 (tie) )
    • bioinformatics: 10,012 (rank: 1,367 )
    • biophysics: 843 (rank: 11,688 (tie) )
    • cancer biology: 3,270 (rank: 2,946 )
    • cell biology: 697 (rank: 25,410 (tie) )
    • developmental biology: 2,267 (rank: 2,541 )
    • emergency medicine: 3,204 (rank: 73 (tie) )
    • epidemiology: 15,354 (rank: 1,471 )
    • genetic and genomic medicine: 598 (rank: 11,621 (tie) )
    • genetics: 897 (rank: 23,389 (tie) )
    • genomics: 1,765 (rank: 18,902 (tie) )
    • health informatics: 269 (rank: 5,122 (tie) )
    • immunology: 117 (rank: 54,384 (tie) )
    • infectious diseases: 41,882 (rank: 1,850 )
    • intensive care and critical care medicine: 3,483 (rank: 485 )
    • microbiology: 2,783 (rank: 8,525 (tie) )
    • molecular biology: 921 (rank: 11,986 (tie) )
    • nephrology: 243 (rank: 1,514 (tie) )
    • neuroscience: 962 (rank: 42,339 (tie) )
    • obstetrics and gynecology: 272 (rank: 1,983 (tie) )
    • oncology: 515 (rank: 4,051 (tie) )
    • pathology: 1,044 (rank: 2,031 (tie) )
    • physiology: 253 (rank: 13,806 (tie) )
    • systems biology: 2,190 (rank: 2,886 )
    • zoology: 429 (rank: 2,303 (tie) )

Downloads per author, site-wide

Preprints

Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19)

infectious diseases more details view paper
  • Downloaded 23,844 times
  • Download rankings, all-time:
    • Site-wide: 473
    • In infectious diseases: 182
  • Year to date:
    • Site-wide: 11,532
  • Since beginning of last month:
    • Site-wide: 14,941

The feasibility of convalescent plasma therapy in severe COVID-19 patients: a pilot study

infectious diseases more details view paper
  • Downloaded 16,977 times
  • Download rankings, all-time:
    • Site-wide: 694
    • In infectious diseases: 257
  • Year to date:
    • Site-wide: 2,632
  • Since beginning of last month:
    • Site-wide: 6,029

Diagnosis of Acute Respiratory Syndrome Coronavirus 2 Infection by Detection of Nucleocapsid Protein

epidemiology more details view paper
  • Downloaded 13,904 times
  • Download rankings, all-time:
    • Site-wide: 910
    • In epidemiology: 136
  • Year to date:
    • Site-wide: 11,647
  • Since beginning of last month:
    • Site-wide: 20,309

A Novel Triage Tool of Artificial Intelligence Assisted Diagnosis Aid System for Suspected COVID-19 pneumonia In Fever Clinics

emergency medicine more details view paper
  • Downloaded 3,223 times
  • Download rankings, all-time:
    • Site-wide: 6,606
    • In emergency medicine: 9
  • Year to date:
    • Site-wide: 20,251
  • Since beginning of last month:
    • Site-wide: 39,639

Metabolite discovery through global annotation of untargeted metabolomics data

bioinformatics more details view paper
  • Downloaded 2,551 times
  • Download rankings, all-time:
    • Site-wide: 9,278
    • In bioinformatics: 976
  • Year to date:
    • Site-wide: 39,153
  • Since beginning of last month:
    • Site-wide: 18,395

Critical Care for Patients with Severe Covid-2019 in Sichuan Province, China: Provincial Cohort Study

intensive care and critical care medicine more details view paper
  • Downloaded 2,280 times
  • Download rankings, all-time:
    • Site-wide: 11,020
    • In intensive care and critical care medicine: 50
  • Year to date:
    • Site-wide: 17,182
  • Since beginning of last month:
    • Site-wide: 17,173

A two-enzyme adaptive unit within bacterial folate metabolism

systems biology more details view paper
  • Downloaded 1,768 times
  • Download rankings, all-time:
    • Site-wide: 16,249
    • In systems biology: 258
  • Year to date:
    • Site-wide: 146,328
  • Since beginning of last month:
    • Site-wide: 90,528

GMPR: A novel normalization method for microbiome sequencing data

bioinformatics more details view paper
  • Downloaded 1,439 times
  • Download rankings, all-time:
    • Site-wide: 22,528
    • In bioinformatics: 2,496
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 202,379

Gene flow between divergent cereal- and grass-specific lineages of the rice blast fungus Magnaporthe oryzae

microbiology more details view paper
  • Downloaded 1,390 times
  • Download rankings, all-time:
    • Site-wide: 23,812
    • In microbiology: 1,374
  • Year to date:
    • Site-wide: 83,023
  • Since beginning of last month:
    • Site-wide: 145,580

Sympathetic Nerve Activity Promotes Cardiomyocyte Cell-Cycle Arrest And Binucleation

developmental biology more details view paper
  • Downloaded 1,288 times
  • Download rankings, all-time:
    • Site-wide: 26,935
    • In developmental biology: 476
  • Year to date:
    • Site-wide: 84,997
  • Since beginning of last month:
    • Site-wide: 141,684

Base editing in Streptomyces with Cas9-deaminase fusions

microbiology more details view paper
  • Downloaded 1,264 times
  • Download rankings, all-time:
    • Site-wide: 27,688
    • In microbiology: 1,647
  • Year to date:
    • Site-wide: 23,499
  • Since beginning of last month:
    • Site-wide: 21,529

Artificial Intelligence Assisted Early Warning System for Acute Kidney Injury Driven by Multi-Center ICU Database

intensive care and critical care medicine more details view paper
  • Downloaded 1,250 times
  • Download rankings, all-time:
    • Site-wide: 28,201
    • In intensive care and critical care medicine: 94
  • Year to date:
    • Site-wide: 39,707
  • Since beginning of last month:
    • Site-wide: 34,179

MS-PyCloud: An open-source, cloud computing-based pipeline for LC-MS/MS data analysis

bioinformatics more details view paper
  • Downloaded 1,249 times
  • Download rankings, all-time:
    • Site-wide: 28,235
    • In bioinformatics: 3,039
  • Year to date:
    • Site-wide: 116,414
  • Since beginning of last month:
    • Site-wide: 116,977

Longitudinal analysis of laboratory findings during the process of recovery for patients with COVID-19

infectious diseases more details view paper
  • Downloaded 1,171 times
  • Download rankings, all-time:
    • Site-wide: 31,261
    • In infectious diseases: 2,916
  • Year to date:
    • Site-wide: 94,209
  • Since beginning of last month:
    • Site-wide: 124,941

Destin: toolkit for single-cell analysis of chromatin accessibility

bioinformatics more details view paper
  • Downloaded 1,146 times
  • Download rankings, all-time:
    • Site-wide: 32,340
    • In bioinformatics: 3,418
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 200,468

Genome-wide circadian rhythm detection methods: systematic evaluations and practical guidelines

bioinformatics more details view paper
  • Downloaded 1,090 times
  • Download rankings, all-time:
    • Site-wide: 34,880
    • In bioinformatics: 3,701
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 81,153

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

cancer biology more details view paper
  • Downloaded 1,054 times
  • Download rankings, all-time:
    • Site-wide: 36,745
    • In cancer biology: 995
  • Year to date:
    • Site-wide: 116,760
  • Since beginning of last month:
    • Site-wide: 164,396

Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord

neuroscience more details view paper
  • Downloaded 967 times
  • Download rankings, all-time:
    • Site-wide: 42,006
    • In neuroscience: 5,467
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 129,126

The Metabolites NADP+ and NADPH are the Targets of the Circadian Protein Nocturnin (Curled)

biophysics more details view paper
  • Downloaded 843 times
  • Download rankings, all-time:
    • Site-wide: 51,892
    • In biophysics: 1,658
  • Year to date:
    • Site-wide: 186,860
  • Since beginning of last month:
    • Site-wide: 200,041

Correlation of ELISA based with random access serologic immunoassays for identifying adaptive immune response to SARS-CoV-2

pathology more details view paper
  • Downloaded 831 times
  • Download rankings, all-time:
    • Site-wide: 53,013
    • In pathology: 240
  • Year to date:
    • Site-wide: 133,389
  • Since beginning of last month:
    • Site-wide: 102,202

BAMM-SC: A Bayesian mixture model for clustering droplet-based single cell transcriptomic data from population studies

bioinformatics more details view paper
  • Downloaded 818 times
  • Download rankings, all-time:
    • Site-wide: 54,253
    • In bioinformatics: 5,613
  • Year to date:
    • Site-wide: 5,899
  • Since beginning of last month:
    • Site-wide: 75,627

Multiplex Fragment Analysis Identifies SARS-CoV-2 Variants

epidemiology more details view paper
  • Downloaded 775 times
  • Download rankings, all-time:
    • Site-wide: 58,768
    • In epidemiology: 2,833
  • Year to date:
    • Site-wide: 108,626
  • Since beginning of last month:
    • Site-wide: 31,311

Genomic analyses reveal the origin of domestic ducks and identify different genetic underpinnings of wild ducks

genomics more details view paper
  • Downloaded 748 times
  • Download rankings, all-time:
    • Site-wide: 61,984
    • In genomics: 4,378
  • Year to date:
    • Site-wide: 36,923
  • Since beginning of last month:
    • Site-wide: 127,165

Tbx1 interacts genetically with Vegfr3 to regulate cardiac lymphangiogenesis in mice

developmental biology more details view paper
  • Downloaded 660 times
  • Download rankings, all-time:
    • Site-wide: 73,908
    • In developmental biology: 1,819
  • Year to date:
    • Site-wide: 45,527
  • Since beginning of last month:
    • Site-wide: 145,142

Addressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via PROTAC-Mediated Degradation

biochemistry more details view paper
  • Downloaded 630 times
  • Download rankings, all-time:
    • Site-wide: 78,527
    • In biochemistry: 2,153
  • Year to date:
    • Site-wide: 52,296
  • Since beginning of last month:
    • Site-wide: 31,016

DeepPHiC: Predicting promoter-centered chromatin interactions using a novel deep learning approach

bioinformatics more details view paper
  • Downloaded 600 times
  • Download rankings, all-time:
    • Site-wide: 83,504
    • In bioinformatics: 7,756
  • Year to date:
    • Site-wide: 54,322
  • Since beginning of last month:
    • Site-wide: 18,921

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

genomics more details view paper
  • Downloaded 597 times
  • Download rankings, all-time:
    • Site-wide: 84,152
    • In genomics: 5,389
  • Year to date:
    • Site-wide: 162,943
  • Since beginning of last month:
    • Site-wide: 142,584

MiR-505-3p, a New Repressor of Puberty Onset in Female Mice

genetics more details view paper
  • Downloaded 591 times
  • Download rankings, all-time:
    • Site-wide: 85,237
    • In genetics: 3,277
  • Year to date:
    • Site-wide: 82,504
  • Since beginning of last month:
    • Site-wide: 198,478

Interaction between DNA damage response, translation and apoptosome determines cancer susceptibility to TOP2 poisons

cancer biology more details view paper
  • Downloaded 584 times
  • Download rankings, all-time:
    • Site-wide: 86,575
    • In cancer biology: 2,552
  • Year to date:
    • Site-wide: 82,772
  • Since beginning of last month:
    • Site-wide: 181,860

A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression

cancer biology more details view paper
  • Downloaded 572 times
  • Download rankings, all-time:
    • Site-wide: 88,858
    • In cancer biology: 2,665
  • Year to date:
    • Site-wide: 98,265
  • Since beginning of last month:
    • Site-wide: 43,852

Toxicities of PD-1/PD-L1 Inhibitors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

oncology more details view paper
  • Downloaded 521 times
  • Download rankings, all-time:
    • Site-wide: 99,321
    • In oncology: 237
  • Year to date:
    • Site-wide: 124,869
  • Since beginning of last month:
    • Site-wide: 100,785

Bacterial fucosidase enables the production of Bombay red blood cells

molecular biology more details view paper
  • Downloaded 513 times
  • Download rankings, all-time:
    • Site-wide: 101,292
    • In molecular biology: 2,986
  • Year to date:
    • Site-wide: 80,124
  • Since beginning of last month:
    • Site-wide: 120,231

Genetic variation within the human papillomavirus type 16 genome is associated with oropharyngeal cancer prognosis

epidemiology more details view paper
  • Downloaded 488 times
  • Download rankings, all-time:
    • Site-wide: 107,016
    • In epidemiology: 4,658
  • Year to date:
    • Site-wide: 18,903
  • Since beginning of last month:
    • Site-wide: 54,991

CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas

cancer biology more details view paper
  • Downloaded 487 times
  • Download rankings, all-time:
    • Site-wide: 107,201
    • In cancer biology: 3,248
  • Year to date:
    • Site-wide: 151,206
  • Since beginning of last month:
    • Site-wide: 149,086

Transposon-mediated telomere destabilization: a driver of genome evolution in the blast fungus

genomics more details view paper
  • Downloaded 438 times
  • Download rankings, all-time:
    • Site-wide: 119,539
    • In genomics: 6,772
  • Year to date:
    • Site-wide: 162,810
  • Since beginning of last month:
    • Site-wide: 211,468

Developmental and Intergenerational Landscape of Human Circulatory Lipidome and its Association with Obesity Risk

systems biology more details view paper
  • Downloaded 434 times
  • Download rankings, all-time:
    • Site-wide: 120,475
    • In systems biology: 2,463
  • Year to date:
    • Site-wide: 138,705
  • Since beginning of last month:
    • Site-wide: 63,096

Venom Isosolenopsin A Delivers Rapid Knockdown of Fire Ant Competitors

zoology more details view paper
  • Downloaded 431 times
  • Download rankings, all-time:
    • Site-wide: 121,366
    • In zoology: 426
  • Year to date:
    • Site-wide: 161,548
  • Since beginning of last month:
    • Site-wide: 179,722

FER-mediated tyrosine phosphorylation and PIK3R2/p85β recruitment on IRS4 promotes the PI3K-AKT signaling pathway and tumorigenesis in ovarian cancer

molecular biology more details view paper
  • Downloaded 424 times
  • Download rankings, all-time:
    • Site-wide: 123,252
    • In molecular biology: 3,640
  • Year to date:
    • Site-wide: 64,493
  • Since beginning of last month:
    • Site-wide: 129,677

DeepPerVar: a multimodal deep learning framework for functional interpretation of genetic variants in personal genome

bioinformatics more details view paper
  • Downloaded 423 times
  • Download rankings, all-time:
    • Site-wide: 123,332
    • In bioinformatics: 10,509
  • Year to date:
    • Site-wide: 12,087
  • Since beginning of last month:
    • Site-wide: 23,136

A Short Plus Long-Amplicon Based Sequencing Approach Improves Genomic Coverage and Variant Detection In the SARS-CoV-2 Genome

genetic and genomic medicine more details view paper
  • Downloaded 413 times
  • Download rankings, all-time:
    • Site-wide: 126,277
    • In genetic and genomic medicine: 881
  • Year to date:
    • Site-wide: 42,845
  • Since beginning of last month:
    • Site-wide: 85,666

Exploiting deep transfer learning for the prediction of functional noncoding variants using genomic sequence

bioinformatics more details view paper
  • Downloaded 413 times
  • Download rankings, all-time:
    • Site-wide: 126,336
    • In bioinformatics: 11,488
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 19,143

CRISPR-Cas9 Screen Reveals PSMB3 Contributes to Gliomagenesis Through Proteasome-Dependent and Independent Mechanisms

cancer biology more details view paper
  • Downloaded 401 times
  • Download rankings, all-time:
    • Site-wide: 129,611
    • In cancer biology: 4,063
  • Year to date:
    • Site-wide: 51,921
  • Since beginning of last month:
    • Site-wide: 33,699

WEVar: a novel statistical learning framework for predicting noncoding regulatory variants

bioinformatics more details view paper
  • Downloaded 371 times
  • Download rankings, all-time:
    • Site-wide: 138,421
    • In bioinformatics: 11,108
  • Year to date:
    • Site-wide: 92,603
  • Since beginning of last month:
    • Site-wide: 101,018

Exploring differentially expressed key genes related to development of follicle by RNA-seq in Peking ducks (Anas Platyrhynchos)

developmental biology more details view paper
  • Downloaded 335 times
  • Download rankings, all-time:
    • Site-wide: 149,554
    • In developmental biology: 3,975
  • Year to date:
    • Site-wide: 147,845
  • Since beginning of last month:
    • Site-wide: 180,084

A missense mutation of Ip3r1 in Dp2 mice leads to short-term mydriasis and unfolded protein response in the iris constrictor muscles

genetics more details view paper
  • Downloaded 313 times
  • Download rankings, all-time:
    • Site-wide: 155,855
    • In genetics: 5,749
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 179,894

Crif1 Promotes Osteoporosis in Mice after Radiation

cell biology more details view paper
  • Downloaded 310 times
  • Download rankings, all-time:
    • Site-wide: 156,764
    • In cell biology: 7,295
  • Year to date:
    • Site-wide: 188,303
  • Since beginning of last month:
    • Site-wide: 206,621

Interleukin-33 stimulates stress in the endoplasmic reticulum of the human myometrium via an influx of calcium during initiation of labor

obstetrics and gynecology more details view paper
  • Downloaded 277 times
  • Download rankings, all-time:
    • Site-wide: 166,817
    • In obstetrics and gynecology: 238
  • Year to date:
    • Site-wide: 106,173
  • Since beginning of last month:
    • Site-wide: 97,703

Understanding community level influences on COVID-19 prevalence in England: New insights from comparison over time and space

health informatics more details view paper
  • Downloaded 273 times
  • Download rankings, all-time:
    • Site-wide: 167,918
    • In health informatics: 794
  • Year to date:
    • Site-wide: 141,765
  • Since beginning of last month:
    • Site-wide: 107,175

Berberine alleviates adiposity and cardiac dysfunction in offspring exposed to gestational diabetes mellitus

physiology more details view paper
  • Downloaded 259 times
  • Download rankings, all-time:
    • Site-wide: 172,174
    • In physiology: 1,909
  • Year to date:
    • Site-wide: 134,286
  • Since beginning of last month:
    • Site-wide: 80,870

Pre-clinical Research of Human Amnion-derived Mesenchymal Stem Cells and its First Clinical Treatment for a Severe Uremic Calciphylaxis Patient

nephrology more details view paper
  • Downloaded 248 times
  • Download rankings, all-time:
    • Site-wide: 175,154
    • In nephrology: 152
  • Year to date:
    • Site-wide: 139,465
  • Since beginning of last month:
    • Site-wide: 111,239

THEMIS is a priming substrate of non-receptor tyrosine phosphatase PTPN6/SHP1 and plays dual roles during T cell development

cell biology more details view paper
  • Downloaded 245 times
  • Download rankings, all-time:
    • Site-wide: 176,009
    • In cell biology: 8,184
  • Year to date:
    • Site-wide: 178,919
  • Since beginning of last month:
    • Site-wide: 88,525

Ontogeny of plasma lipid metabolism in pregnancy and early childhood: a longitudinal population study

epidemiology more details view paper
  • Downloaded 238 times
  • Download rankings, all-time:
    • Site-wide: 177,758
    • In epidemiology: 7,112
  • Year to date:
    • Site-wide: 97,904
  • Since beginning of last month:
    • Site-wide: 111,918

Increased ketohexokinase-A governs fructose-induced podocyte hypertrophy by IL-6/STAT3 signaling activation

pathology more details view paper
  • Downloaded 221 times
  • Download rankings, all-time:
    • Site-wide: 182,324
    • In pathology: 1,072
  • Year to date:
    • Site-wide: 171,324
  • Since beginning of last month:
    • Site-wide: 95,515

ARF4-mediated Retrograde Trafficking Drives Chemoresistance in Glioblastoma

cancer biology more details view paper
  • Downloaded 216 times
  • Download rankings, all-time:
    • Site-wide: 183,674
    • In cancer biology: 5,732
  • Year to date:
    • Site-wide: 57,252
  • Since beginning of last month:
    • Site-wide: 99,350

Multi-task deep autoencoder to predict Alzheimer's disease progression using temporal DNA methylation data in peripheral blood

genetic and genomic medicine more details view paper
  • Downloaded 200 times
  • Download rankings, all-time:
    • Site-wide: 187,465
    • In genetic and genomic medicine: 1,405
  • Year to date:
    • Site-wide: 141,377
  • Since beginning of last month:
    • Site-wide: 109,258

New efficient intercellular spread mode of respiratory syncytial virus contributes to neutralization escape and persistence

microbiology more details view paper
  • Downloaded 176 times
  • Download rankings, all-time:
    • Site-wide: 192,906
    • In microbiology: 14,650
  • Year to date:
    • Site-wide: 57,295
  • Since beginning of last month:
    • Site-wide: 167,716

Differential N-terminal processing of beta and gamma actin in vivo

cell biology more details view paper
  • Downloaded 149 times
  • Download rankings, all-time:
    • Site-wide: 198,463
    • In cell biology: 9,114
  • Year to date:
    • Site-wide: 143,471
  • Since beginning of last month:
    • Site-wide: 158,041

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

immunology more details view paper
  • Downloaded 123 times
  • Download rankings, all-time:
    • Site-wide: 203,298
    • In immunology: 6,555
  • Year to date:
    • Site-wide: 58,805
  • Since beginning of last month:
    • Site-wide: 46,732

Genome-wide identification and gene expression analysis of clade A protein phosphatase 2C family genes in Brassica juncea var. tumida

bioinformatics more details view paper
  • Downloaded 118 times
  • Download rankings, all-time:
    • Site-wide: 204,122
    • In bioinformatics: 14,890
  • Year to date:
    • Site-wide: 174,421
  • Since beginning of last month:
    • Site-wide: 113,503

TIVAN-indel: A computational framework for annotating and predicting noncoding regulatory small insertion and deletion

bioinformatics more details view paper
  • Downloaded 75 times
  • Download rankings, all-time:
    • Site-wide: 212,093
    • In bioinformatics: 15,321
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 195,196

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