Author: Li Chen

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Preprints

Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19)

• Downloaded 23,844 times
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  • Site-wide: 473
  • In infectious diseases: 182
• Year to date:
  • Site-wide: 11,532
• Since beginning of last month:
  • Site-wide: 14,941

The feasibility of convalescent plasma therapy in severe COVID-19 patients: a pilot study

• Downloaded 16,977 times
• Download rankings, all-time:
  • Site-wide: 694
  • In infectious diseases: 257
• Year to date:
  • Site-wide: 2,632
• Since beginning of last month:
  • Site-wide: 6,029

Diagnosis of Acute Respiratory Syndrome Coronavirus 2 Infection by Detection of Nucleocapsid Protein

• Downloaded 13,904 times
• Download rankings, all-time:
  • Site-wide: 910
  • In epidemiology: 136
• Year to date:
  • Site-wide: 11,647
• Since beginning of last month:
  • Site-wide: 20,309

A Novel Triage Tool of Artificial Intelligence Assisted Diagnosis Aid System for Suspected COVID-19 pneumonia In Fever Clinics

• Downloaded 3,223 times
• Download rankings, all-time:
  • Site-wide: 6,606
  • In emergency medicine: 9
• Year to date:
  • Site-wide: 20,251
• Since beginning of last month:
  • Site-wide: 39,639

Metabolite discovery through global annotation of untargeted metabolomics data

• Downloaded 2,551 times
• Download rankings, all-time:
  • Site-wide: 9,278
  • In bioinformatics: 976
• Year to date:
  • Site-wide: 39,153
• Since beginning of last month:
  • Site-wide: 18,395

Critical Care for Patients with Severe Covid-2019 in Sichuan Province, China: Provincial Cohort Study

• Downloaded 2,280 times
• Download rankings, all-time:
  • Site-wide: 11,020
  • In intensive care and critical care medicine: 50
• Year to date:
  • Site-wide: 17,182
• Since beginning of last month:
  • Site-wide: 17,173

A two-enzyme adaptive unit within bacterial folate metabolism

• Downloaded 1,768 times
• Download rankings, all-time:
  • Site-wide: 16,249
  • In systems biology: 258
• Year to date:
  • Site-wide: 146,328
• Since beginning of last month:
  • Site-wide: 90,528

GMPR: A novel normalization method for microbiome sequencing data

• Downloaded 1,439 times
• Download rankings, all-time:
  • Site-wide: 22,528
  • In bioinformatics: 2,496
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 202,379

Gene flow between divergent cereal- and grass-specific lineages of the rice blast fungus Magnaporthe oryzae

• Downloaded 1,390 times
• Download rankings, all-time:
  • Site-wide: 23,812
  • In microbiology: 1,374
• Year to date:
  • Site-wide: 83,023
• Since beginning of last month:
  • Site-wide: 145,580

Sympathetic Nerve Activity Promotes Cardiomyocyte Cell-Cycle Arrest And Binucleation

• Downloaded 1,288 times
• Download rankings, all-time:
  • Site-wide: 26,935
  • In developmental biology: 476
• Year to date:
  • Site-wide: 84,997
• Since beginning of last month:
  • Site-wide: 141,684

Base editing in Streptomyces with Cas9-deaminase fusions

• Downloaded 1,264 times
• Download rankings, all-time:
  • Site-wide: 27,688
  • In microbiology: 1,647
• Year to date:
  • Site-wide: 23,499
• Since beginning of last month:
  • Site-wide: 21,529

Artificial Intelligence Assisted Early Warning System for Acute Kidney Injury Driven by Multi-Center ICU Database

• Downloaded 1,250 times
• Download rankings, all-time:
  • Site-wide: 28,201
  • In intensive care and critical care medicine: 94
• Year to date:
  • Site-wide: 39,707
• Since beginning of last month:
  • Site-wide: 34,179

MS-PyCloud: An open-source, cloud computing-based pipeline for LC-MS/MS data analysis

• Downloaded 1,249 times
• Download rankings, all-time:
  • Site-wide: 28,235
  • In bioinformatics: 3,039
• Year to date:
  • Site-wide: 116,414
• Since beginning of last month:
  • Site-wide: 116,977

Longitudinal analysis of laboratory findings during the process of recovery for patients with COVID-19

• Downloaded 1,171 times
• Download rankings, all-time:
  • Site-wide: 31,261
  • In infectious diseases: 2,916
• Year to date:
  • Site-wide: 94,209
• Since beginning of last month:
  • Site-wide: 124,941

Destin: toolkit for single-cell analysis of chromatin accessibility

• Downloaded 1,146 times
• Download rankings, all-time:
  • Site-wide: 32,340
  • In bioinformatics: 3,418
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 200,468

Genome-wide circadian rhythm detection methods: systematic evaluations and practical guidelines

• Downloaded 1,090 times
• Download rankings, all-time:
  • Site-wide: 34,880
  • In bioinformatics: 3,701
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 81,153

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

• Downloaded 1,054 times
• Download rankings, all-time:
  • Site-wide: 36,745
  • In cancer biology: 995
• Year to date:
  • Site-wide: 116,760
• Since beginning of last month:
  • Site-wide: 164,396

Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord

• Downloaded 967 times
• Download rankings, all-time:
  • Site-wide: 42,006
  • In neuroscience: 5,467
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 129,126

The Metabolites NADP+ and NADPH are the Targets of the Circadian Protein Nocturnin (Curled)

• Downloaded 843 times
• Download rankings, all-time:
  • Site-wide: 51,892
  • In biophysics: 1,658
• Year to date:
  • Site-wide: 186,860
• Since beginning of last month:
  • Site-wide: 200,041

Correlation of ELISA based with random access serologic immunoassays for identifying adaptive immune response to SARS-CoV-2

• Downloaded 831 times
• Download rankings, all-time:
  • Site-wide: 53,013
  • In pathology: 240
• Year to date:
  • Site-wide: 133,389
• Since beginning of last month:
  • Site-wide: 102,202

BAMM-SC: A Bayesian mixture model for clustering droplet-based single cell transcriptomic data from population studies

• Downloaded 818 times
• Download rankings, all-time:
  • Site-wide: 54,253
  • In bioinformatics: 5,613
• Year to date:
  • Site-wide: 5,899
• Since beginning of last month:
  • Site-wide: 75,627

Multiplex Fragment Analysis Identifies SARS-CoV-2 Variants

• Downloaded 775 times
• Download rankings, all-time:
  • Site-wide: 58,768
  • In epidemiology: 2,833
• Year to date:
  • Site-wide: 108,626
• Since beginning of last month:
  • Site-wide: 31,311

Genomic analyses reveal the origin of domestic ducks and identify different genetic underpinnings of wild ducks

• Downloaded 748 times
• Download rankings, all-time:
  • Site-wide: 61,984
  • In genomics: 4,378
• Year to date:
  • Site-wide: 36,923
• Since beginning of last month:
  • Site-wide: 127,165

Tbx1 interacts genetically with Vegfr3 to regulate cardiac lymphangiogenesis in mice

• Downloaded 660 times
• Download rankings, all-time:
  • Site-wide: 73,908
  • In developmental biology: 1,819
• Year to date:
  • Site-wide: 45,527
• Since beginning of last month:
  • Site-wide: 145,142

Addressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via PROTAC-Mediated Degradation

• Downloaded 630 times
• Download rankings, all-time:
  • Site-wide: 78,527
  • In biochemistry: 2,153
• Year to date:
  • Site-wide: 52,296
• Since beginning of last month:
  • Site-wide: 31,016

DeepPHiC: Predicting promoter-centered chromatin interactions using a novel deep learning approach

• Downloaded 600 times
• Download rankings, all-time:
  • Site-wide: 83,504
  • In bioinformatics: 7,756
• Year to date:
  • Site-wide: 54,322
• Since beginning of last month:
  • Site-wide: 18,921

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

• Downloaded 597 times
• Download rankings, all-time:
  • Site-wide: 84,152
  • In genomics: 5,389
• Year to date:
  • Site-wide: 162,943
• Since beginning of last month:
  • Site-wide: 142,584

MiR-505-3p, a New Repressor of Puberty Onset in Female Mice

• Downloaded 591 times
• Download rankings, all-time:
  • Site-wide: 85,237
  • In genetics: 3,277
• Year to date:
  • Site-wide: 82,504
• Since beginning of last month:
  • Site-wide: 198,478

Interaction between DNA damage response, translation and apoptosome determines cancer susceptibility to TOP2 poisons

• Downloaded 584 times
• Download rankings, all-time:
  • Site-wide: 86,575
  • In cancer biology: 2,552
• Year to date:
  • Site-wide: 82,772
• Since beginning of last month:
  • Site-wide: 181,860

A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression

• Downloaded 572 times
• Download rankings, all-time:
  • Site-wide: 88,858
  • In cancer biology: 2,665
• Year to date:
  • Site-wide: 98,265
• Since beginning of last month:
  • Site-wide: 43,852

Toxicities of PD-1/PD-L1 Inhibitors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

• Downloaded 521 times
• Download rankings, all-time:
  • Site-wide: 99,321
  • In oncology: 237
• Year to date:
  • Site-wide: 124,869
• Since beginning of last month:
  • Site-wide: 100,785

Bacterial fucosidase enables the production of Bombay red blood cells

• Downloaded 513 times
• Download rankings, all-time:
  • Site-wide: 101,292
  • In molecular biology: 2,986
• Year to date:
  • Site-wide: 80,124
• Since beginning of last month:
  • Site-wide: 120,231

Genetic variation within the human papillomavirus type 16 genome is associated with oropharyngeal cancer prognosis

• Downloaded 488 times
• Download rankings, all-time:
  • Site-wide: 107,016
  • In epidemiology: 4,658
• Year to date:
  • Site-wide: 18,903
• Since beginning of last month:
  • Site-wide: 54,991

CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas

• Downloaded 487 times
• Download rankings, all-time:
  • Site-wide: 107,201
  • In cancer biology: 3,248
• Year to date:
  • Site-wide: 151,206
• Since beginning of last month:
  • Site-wide: 149,086

Transposon-mediated telomere destabilization: a driver of genome evolution in the blast fungus

• Downloaded 438 times
• Download rankings, all-time:
  • Site-wide: 119,539
  • In genomics: 6,772
• Year to date:
  • Site-wide: 162,810
• Since beginning of last month:
  • Site-wide: 211,468

Developmental and Intergenerational Landscape of Human Circulatory Lipidome and its Association with Obesity Risk

• Downloaded 434 times
• Download rankings, all-time:
  • Site-wide: 120,475
  • In systems biology: 2,463
• Year to date:
  • Site-wide: 138,705
• Since beginning of last month:
  • Site-wide: 63,096

Venom Isosolenopsin A Delivers Rapid Knockdown of Fire Ant Competitors

• Downloaded 431 times
• Download rankings, all-time:
  • Site-wide: 121,366
  • In zoology: 426
• Year to date:
  • Site-wide: 161,548
• Since beginning of last month:
  • Site-wide: 179,722

FER-mediated tyrosine phosphorylation and PIK3R2/p85β recruitment on IRS4 promotes the PI3K-AKT signaling pathway and tumorigenesis in ovarian cancer

• Downloaded 424 times
• Download rankings, all-time:
  • Site-wide: 123,252
  • In molecular biology: 3,640
• Year to date:
  • Site-wide: 64,493
• Since beginning of last month:
  • Site-wide: 129,677

DeepPerVar: a multimodal deep learning framework for functional interpretation of genetic variants in personal genome

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 123,332
  • In bioinformatics: 10,509
• Year to date:
  • Site-wide: 12,087
• Since beginning of last month:
  • Site-wide: 23,136

A Short Plus Long-Amplicon Based Sequencing Approach Improves Genomic Coverage and Variant Detection In the SARS-CoV-2 Genome

• Downloaded 413 times
• Download rankings, all-time:
  • Site-wide: 126,277
  • In genetic and genomic medicine: 881
• Year to date:
  • Site-wide: 42,845
• Since beginning of last month:
  • Site-wide: 85,666

Exploiting deep transfer learning for the prediction of functional noncoding variants using genomic sequence

• Downloaded 413 times
• Download rankings, all-time:
  • Site-wide: 126,336
  • In bioinformatics: 11,488
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 19,143

CRISPR-Cas9 Screen Reveals PSMB3 Contributes to Gliomagenesis Through Proteasome-Dependent and Independent Mechanisms

• Downloaded 401 times
• Download rankings, all-time:
  • Site-wide: 129,611
  • In cancer biology: 4,063
• Year to date:
  • Site-wide: 51,921
• Since beginning of last month:
  • Site-wide: 33,699

WEVar: a novel statistical learning framework for predicting noncoding regulatory variants

• Downloaded 371 times
• Download rankings, all-time:
  • Site-wide: 138,421
  • In bioinformatics: 11,108
• Year to date:
  • Site-wide: 92,603
• Since beginning of last month:
  • Site-wide: 101,018

Exploring differentially expressed key genes related to development of follicle by RNA-seq in Peking ducks (Anas Platyrhynchos)

• Downloaded 335 times
• Download rankings, all-time:
  • Site-wide: 149,554
  • In developmental biology: 3,975
• Year to date:
  • Site-wide: 147,845
• Since beginning of last month:
  • Site-wide: 180,084

A missense mutation of Ip3r1 in Dp2 mice leads to short-term mydriasis and unfolded protein response in the iris constrictor muscles

• Downloaded 313 times
• Download rankings, all-time:
  • Site-wide: 155,855
  • In genetics: 5,749
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 179,894

Crif1 Promotes Osteoporosis in Mice after Radiation

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 156,764
  • In cell biology: 7,295
• Year to date:
  • Site-wide: 188,303
• Since beginning of last month:
  • Site-wide: 206,621

Interleukin-33 stimulates stress in the endoplasmic reticulum of the human myometrium via an influx of calcium during initiation of labor

• Downloaded 277 times
• Download rankings, all-time:
  • Site-wide: 166,817
  • In obstetrics and gynecology: 238
• Year to date:
  • Site-wide: 106,173
• Since beginning of last month:
  • Site-wide: 97,703

Understanding community level influences on COVID-19 prevalence in England: New insights from comparison over time and space

• Downloaded 273 times
• Download rankings, all-time:
  • Site-wide: 167,918
  • In health informatics: 794
• Year to date:
  • Site-wide: 141,765
• Since beginning of last month:
  • Site-wide: 107,175

Berberine alleviates adiposity and cardiac dysfunction in offspring exposed to gestational diabetes mellitus

• Downloaded 259 times
• Download rankings, all-time:
  • Site-wide: 172,174
  • In physiology: 1,909
• Year to date:
  • Site-wide: 134,286
• Since beginning of last month:
  • Site-wide: 80,870

Pre-clinical Research of Human Amnion-derived Mesenchymal Stem Cells and its First Clinical Treatment for a Severe Uremic Calciphylaxis Patient

• Downloaded 248 times
• Download rankings, all-time:
  • Site-wide: 175,154
  • In nephrology: 152
• Year to date:
  • Site-wide: 139,465
• Since beginning of last month:
  • Site-wide: 111,239

THEMIS is a priming substrate of non-receptor tyrosine phosphatase PTPN6/SHP1 and plays dual roles during T cell development

• Downloaded 245 times
• Download rankings, all-time:
  • Site-wide: 176,009
  • In cell biology: 8,184
• Year to date:
  • Site-wide: 178,919
• Since beginning of last month:
  • Site-wide: 88,525

Ontogeny of plasma lipid metabolism in pregnancy and early childhood: a longitudinal population study

• Downloaded 238 times
• Download rankings, all-time:
  • Site-wide: 177,758
  • In epidemiology: 7,112
• Year to date:
  • Site-wide: 97,904
• Since beginning of last month:
  • Site-wide: 111,918

Increased ketohexokinase-A governs fructose-induced podocyte hypertrophy by IL-6/STAT3 signaling activation

• Downloaded 221 times
• Download rankings, all-time:
  • Site-wide: 182,324
  • In pathology: 1,072
• Year to date:
  • Site-wide: 171,324
• Since beginning of last month:
  • Site-wide: 95,515

ARF4-mediated Retrograde Trafficking Drives Chemoresistance in Glioblastoma

• Downloaded 216 times
• Download rankings, all-time:
  • Site-wide: 183,674
  • In cancer biology: 5,732
• Year to date:
  • Site-wide: 57,252
• Since beginning of last month:
  • Site-wide: 99,350

Multi-task deep autoencoder to predict Alzheimer's disease progression using temporal DNA methylation data in peripheral blood

• Downloaded 200 times
• Download rankings, all-time:
  • Site-wide: 187,465
  • In genetic and genomic medicine: 1,405
• Year to date:
  • Site-wide: 141,377
• Since beginning of last month:
  • Site-wide: 109,258

New efficient intercellular spread mode of respiratory syncytial virus contributes to neutralization escape and persistence

• Downloaded 176 times
• Download rankings, all-time:
  • Site-wide: 192,906
  • In microbiology: 14,650
• Year to date:
  • Site-wide: 57,295
• Since beginning of last month:
  • Site-wide: 167,716

Differential N-terminal processing of beta and gamma actin in vivo

• Downloaded 149 times
• Download rankings, all-time:
  • Site-wide: 198,463
  • In cell biology: 9,114
• Year to date:
  • Site-wide: 143,471
• Since beginning of last month:
  • Site-wide: 158,041

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

• Downloaded 123 times
• Download rankings, all-time:
  • Site-wide: 203,298
  • In immunology: 6,555
• Year to date:
  • Site-wide: 58,805
• Since beginning of last month:
  • Site-wide: 46,732

Genome-wide identification and gene expression analysis of clade A protein phosphatase 2C family genes in Brassica juncea var. tumida

• Downloaded 118 times
• Download rankings, all-time:
  • Site-wide: 204,122
  • In bioinformatics: 14,890
• Year to date:
  • Site-wide: 174,421
• Since beginning of last month:
  • Site-wide: 113,503

TIVAN-indel: A computational framework for annotating and predicting noncoding regulatory small insertion and deletion

• Downloaded 75 times
• Download rankings, all-time:
  • Site-wide: 212,093
  • In bioinformatics: 15,321
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 195,196