Author: Li Chen

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Preprints

Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19)

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  • Site-wide: 380
  • In infectious diseases: 143
• Year to date:
  • Site-wide: 6,078
• Since beginning of last month:
  • Site-wide: 11,902

The feasibility of convalescent plasma therapy in severe COVID-19 patients: a pilot study

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  • Site-wide: 564
  • In infectious diseases: 205
• Year to date:
  • Site-wide: 4,310
• Since beginning of last month:
  • Site-wide: 10,504

Diagnosis of Acute Respiratory Syndrome Coronavirus 2 Infection by Detection of Nucleocapsid Protein

• Downloaded 12,815 times
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  • Site-wide: 758
  • In epidemiology: 108
• Year to date:
  • Site-wide: 2,613
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  • Site-wide: 6,967

A Novel Triage Tool of Artificial Intelligence Assisted Diagnosis Aid System for Suspected COVID-19 pneumonia In Fever Clinics

• Downloaded 2,799 times
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  • Site-wide: 5,811
  • In emergency medicine: 9
• Year to date:
  • Site-wide: 7,872
• Since beginning of last month:
  • Site-wide: 10,544

Critical Care for Patients with Severe Covid-2019 in Sichuan Province, China: Provincial Cohort Study

• Downloaded 1,960 times
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  • Site-wide: 9,744
  • In intensive care and critical care medicine: 45
• Year to date:
  • Site-wide: 34,670
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  • Site-wide: 28,936

A two-enzyme adaptive unit within bacterial folate metabolism

• Downloaded 1,649 times
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  • Site-wide: 12,612
  • In systems biology: 215
• Year to date:
  • Site-wide: 95,549
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  • Site-wide: 102,150

Metabolite discovery through global annotation of untargeted metabolomics data

• Downloaded 1,422 times
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  • Site-wide: 15,804
  • In bioinformatics: 1,790
• Year to date:
  • Site-wide: 2,728
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  • Site-wide: 8,973

GMPR: A novel normalization method for microbiome sequencing data

• Downloaded 1,359 times
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  • Site-wide: 16,931
  • In bioinformatics: 1,933
• Year to date:
  • Site-wide: 110,023
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  • Site-wide: 133,580

Gene flow between divergent cereal- and grass-specific lineages of the rice blast fungus Magnaporthe oryzae

• Downloaded 1,303 times
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  • Site-wide: 18,028
  • In microbiology: 1,053
• Year to date:
  • Site-wide: 125,052
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  • Site-wide: 142,974

Sympathetic Nerve Activity Promotes Cardiomyocyte Cell-Cycle Arrest And Binucleation

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  • Site-wide: 21,040
  • In developmental biology: 352
• Year to date:
  • Site-wide: 64,792
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  • Site-wide: 45,783

Destin: toolkit for single-cell analysis of chromatin accessibility

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  • Site-wide: 22,909
  • In bioinformatics: 2,588
• Year to date:
  • Site-wide: 148,661
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  • Site-wide: 144,467

MS-PyCloud: An open-source, cloud computing-based pipeline for LC-MS/MS data analysis

• Downloaded 1,032 times
• Download rankings, all-time:
  • Site-wide: 25,510
  • In bioinformatics: 2,870
• Year to date:
  • Site-wide: 33,859
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  • Site-wide: 43,781

Longitudinal analysis of laboratory findings during the process of recovery for patients with COVID-19

• Downloaded 1,032 times
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  • Site-wide: 25,525
  • In infectious diseases: 2,279
• Year to date:
  • Site-wide: 55,428
• Since beginning of last month:
  • Site-wide: 72,818

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

• Downloaded 996 times
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  • Site-wide: 26,887
  • In cancer biology: 672
• Year to date:
  • Site-wide: 39,369
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  • Site-wide: 89,091

Artificial Intelligence Assisted Early Warning System for Acute Kidney Injury Driven by Multi-Center ICU Database

• Downloaded 983 times
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  • Site-wide: 27,417
  • In intensive care and critical care medicine: 101
• Year to date:
  • Site-wide: 24,727
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  • Site-wide: 47,243

Base editing in Streptomyces with Cas9-deaminase fusions

• Downloaded 950 times
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  • Site-wide: 28,792
  • In microbiology: 1,690
• Year to date:
  • Site-wide: 47,014
• Since beginning of last month:
  • Site-wide: 39,553

Genome-wide circadian rhythm detection methods: systematic evaluations and practical guidelines

• Downloaded 903 times
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  • Site-wide: 30,933
  • In bioinformatics: 3,432
• Year to date:
  • Site-wide: 18,528
• Since beginning of last month:
  • Site-wide: 55,609

Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord

• Downloaded 869 times
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  • Site-wide: 32,691
  • In neuroscience: 4,263
• Year to date:
  • Site-wide: 19,523
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  • Site-wide: 42,229

The Metabolites NADP+ and NADPH are the Targets of the Circadian Protein Nocturnin (Curled)

• Downloaded 774 times
• Download rankings, all-time:
  • Site-wide: 38,496
  • In biophysics: 1,201
• Year to date:
  • Site-wide: 111,734
• Since beginning of last month:
  • Site-wide: 93,555

Correlation of ELISA based with random access serologic immunoassays for identifying adaptive immune response to SARS-CoV-2

• Downloaded 701 times
• Download rankings, all-time:
  • Site-wide: 44,119
  • In pathology: 207
• Year to date:
  • Site-wide: 42,421
• Since beginning of last month:
  • Site-wide: 78,133

BAMM-SC: A Bayesian mixture model for clustering droplet-based single cell transcriptomic data from population studies

• Downloaded 690 times
• Download rankings, all-time:
  • Site-wide: 45,055
  • In bioinformatics: 4,725
• Year to date:
  • Site-wide: 110,549
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  • Site-wide: 140,814

Genomic analyses reveal the origin of domestic ducks and identify different genetic underpinnings of wild ducks

• Downloaded 608 times
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  • Site-wide: 53,208
  • In genomics: 3,999
• Year to date:
  • Site-wide: 49,810
• Since beginning of last month:
  • Site-wide: 34,844

Tbx1 interacts genetically with Vegfr3 to regulate cardiac lymphangiogenesis in mice

• Downloaded 554 times
• Download rankings, all-time:
  • Site-wide: 59,709
  • In developmental biology: 1,426
• Year to date:
  • Site-wide: 125,795
• Since beginning of last month:
  • Site-wide: 108,398

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

• Downloaded 531 times
• Download rankings, all-time:
  • Site-wide: 62,776
  • In genomics: 4,506
• Year to date:
  • Site-wide: 156,880
• Since beginning of last month:
  • Site-wide: 156,943

MiR-505-3p, a New Repressor of Puberty Onset in Female Mice

• Downloaded 514 times
• Download rankings, all-time:
  • Site-wide: 65,233
  • In genetics: 2,823
• Year to date:
  • Site-wide: 135,521
• Since beginning of last month:
  • Site-wide: 134,523

Interaction between DNA damage response, translation and apoptosome determines cancer susceptibility to TOP2 poisons

• Downloaded 480 times
• Download rankings, all-time:
  • Site-wide: 70,385
  • In cancer biology: 2,043
• Year to date:
  • Site-wide: 96,921
• Since beginning of last month:
  • Site-wide: 96,036

CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas

• Downloaded 422 times
• Download rankings, all-time:
  • Site-wide: 80,603
  • In cancer biology: 2,378
• Year to date:
  • Site-wide: 123,702
• Since beginning of last month:
  • Site-wide: 100,389

Bacterial fucosidase enables the production of Bombay red blood cells

• Downloaded 391 times
• Download rankings, all-time:
  • Site-wide: 86,782
  • In molecular biology: 2,556
• Year to date:
  • Site-wide: 114,352
• Since beginning of last month:
  • Site-wide: 144,031

Toxicities of PD-1/PD-L1 Inhibitors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

• Downloaded 363 times
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  • Site-wide: 92,748
  • In oncology: 177
• Year to date:
  • Site-wide: 47,559
• Since beginning of last month:
  • Site-wide: 59,605

Venom Isosolenopsin A Delivers Rapid Knockdown of Fire Ant Competitors

• Downloaded 356 times
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  • Site-wide: 94,325
  • In zoology: 348
• Year to date:
  • Site-wide: 158,635
• Since beginning of last month:
  • Site-wide: 159,591

Transposon-mediated telomere destabilization: a driver of genome evolution in the blast fungus

• Downloaded 350 times
• Download rankings, all-time:
  • Site-wide: 95,589
  • In genomics: 5,910
• Year to date:
  • Site-wide: 129,616
• Since beginning of last month:
  • Site-wide: 88,921

Multiplex Fragment Analysis Identifies SARS-CoV-2 Variants

• Downloaded 345 times
• Download rankings, all-time:
  • Site-wide: 96,829
  • In epidemiology: 4,107
• Year to date:
  • Site-wide: 22,208
• Since beginning of last month:
  • Site-wide: 49,938

WEVar: a novel statistical learning framework for predicting noncoding regulatory variants

• Downloaded 265 times
• Download rankings, all-time:
  • Site-wide: 116,617
  • In bioinformatics: 9,590
• Year to date:
  • Site-wide: 69,927
• Since beginning of last month:
  • Site-wide: 129,671

FER-mediated tyrosine phosphorylation and PIK3R2/p85β recruitment on IRS4 promotes the PI3K-AKT signaling pathway and tumorigenesis in ovarian cancer

• Downloaded 259 times
• Download rankings, all-time:
  • Site-wide: 118,224
  • In molecular biology: 3,529
• Year to date:
  • Site-wide: 64,274
• Since beginning of last month:
  • Site-wide: 79,227

A Short Plus Long-Amplicon Based Sequencing Approach Improves Genomic Coverage and Variant Detection In the SARS-CoV-2 Genome

• Downloaded 246 times
• Download rankings, all-time:
  • Site-wide: 121,464
  • In genetic and genomic medicine: 674
• Year to date:
  • Site-wide: 34,963
• Since beginning of last month:
  • Site-wide: 41,086

A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression

• Downloaded 244 times
• Download rankings, all-time:
  • Site-wide: 121,930
  • In cancer biology: 3,713
• Year to date:
  • Site-wide: 35,327
• Since beginning of last month:
  • Site-wide: 2,917

A missense mutation of Ip3r1 in Dp2 mice leads to short-term mydriasis and unfolded protein response in the iris constrictor muscles

• Downloaded 239 times
• Download rankings, all-time:
  • Site-wide: 123,409
  • In genetics: 5,047
• Year to date:
  • Site-wide: 127,375
• Since beginning of last month:
  • Site-wide: 109,158

Crif1 Promotes Osteoporosis in Mice after Radiation

• Downloaded 238 times
• Download rankings, all-time:
  • Site-wide: 123,789
  • In cell biology: 5,741
• Year to date:
  • Site-wide: 130,517
• Since beginning of last month:
  • Site-wide: 82,285

Exploring differentially expressed key genes related to development of follicle by RNA-seq in Peking ducks (Anas Platyrhynchos)

• Downloaded 232 times
• Download rankings, all-time:
  • Site-wide: 125,372
  • In developmental biology: 3,405
• Year to date:
  • Site-wide: 157,059
• Since beginning of last month:
  • Site-wide: 151,655

Developmental and Intergenerational Landscape of Human Circulatory Lipidome and its Association with Obesity Risk

• Downloaded 232 times
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  • Site-wide: 125,201
  • In systems biology: 2,717
• Year to date:
  • Site-wide: 37,656
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  • Site-wide: 22,508

Addressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via PROTAC-Mediated Degradation

• Downloaded 211 times
• Download rankings, all-time:
  • Site-wide: 130,657
  • In biochemistry: 3,962
• Year to date:
  • Site-wide: 42,236
• Since beginning of last month:
  • Site-wide: 3,747

Berberine alleviates adiposity and cardiac dysfunction in offspring exposed to gestational diabetes mellitus

• Downloaded 145 times
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  • Site-wide: 146,304
  • In physiology: 1,715
• Year to date:
  • Site-wide: 101,138
• Since beginning of last month:
  • Site-wide: 79,201

Increased ketohexokinase-A governs fructose-induced podocyte hypertrophy by IL-6/STAT3 signaling activation

• Downloaded 120 times
• Download rankings, all-time:
  • Site-wide: 151,222
  • In pathology: 928
• Year to date:
  • Site-wide: 87,280
• Since beginning of last month:
  • Site-wide: 114,970

CRISPR-Cas9 Screen Reveals PSMB3 Contributes to Gliomagenesis Through Proteasome-Dependent and Independent Mechanisms

• Downloaded 113 times
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  • Site-wide: 152,255
  • In cancer biology: 4,689
• Year to date:
  • Site-wide: 80,516
• Since beginning of last month:
  • Site-wide: 39,013

Ontogeny of plasma lipid metabolism in pregnancy and early childhood: a longitudinal population study

• Downloaded 98 times
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  • Site-wide: 154,705
  • In epidemiology: 6,378
• Year to date:
  • Site-wide: 90,605
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  • Site-wide: 12,300

ARF4-mediated Retrograde Trafficking Drives Chemoresistance in Glioblastoma

• Downloaded 77 times
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  • Site-wide: 157,241
  • In cancer biology: 4,848
• Year to date:
  • Site-wide: 108,407
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  • Site-wide: 74,200

Pre-clinical Research of Human Amnion-derived Mesenchymal Stem Cells and its First Clinical Treatment for a Severe Uremic Calciphylaxis Patient

• Downloaded 69 times
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  • Site-wide: 158,087
  • In nephrology: 126
• Year to date:
  • Site-wide: 116,962
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  • Site-wide: 20,101

Genome-wide identification and gene expression analysis of clade A protein phosphatase 2C family genes in Brassica juncea var. tumida

• Downloaded 44 times
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  • Site-wide: 159,531
  • In bioinformatics: 11,940
• Year to date:
  • Site-wide: 143,318
• Since beginning of last month:
  • Site-wide: 34,315