Author: Jie Xu

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Preprints

Optimizing diagnostic strategy for novel coronavirus pneumonia, a multi-center study in Eastern China

• Downloaded 4,379 times
• Download rankings, all-time:
  • Site-wide: 3,777
  • In infectious diseases: 830
• Year to date:
  • Site-wide: 43,827
• Since beginning of last month:
  • Site-wide: 47,627

An Integrative Framework For Detecting Structural Variations In Cancer Genomes

• Downloaded 4,283 times
• Download rankings, all-time:
  • Site-wide: 3,890
  • In genomics: 343
• Year to date:
  • Site-wide: 142,717
• Since beginning of last month:
  • Site-wide: 141,975

A descriptive study of the impact of diseases control and prevention on the epidemics dynamics and clinical features of SARS-CoV-2 outbreak in Shanghai, lessons learned for metropolis epidemics prevention

• Downloaded 3,377 times
• Download rankings, all-time:
  • Site-wide: 5,481
  • In infectious diseases: 1,062
• Year to date:
  • Site-wide: 27,995
• Since beginning of last month:
  • Site-wide: 24,500

Trends and prediction in daily incidence of novel coronavirus infection in China, Hubei Province and Wuhan City: an application of Farr law

• Downloaded 3,360 times
• Download rankings, all-time:
  • Site-wide: 5,531
  • In epidemiology: 507
• Year to date:
  • Site-wide: 53,566
• Since beginning of last month:
  • Site-wide: 78,291

Heart injury signs are associated with higher and earlier mortality in coronavirus disease 2019 (COVID-19)

• Downloaded 3,246 times
• Download rankings, all-time:
  • Site-wide: 5,813
  • In respiratory medicine: 22
• Year to date:
  • Site-wide: 71,430
• Since beginning of last month:
  • Site-wide: 70,960

The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions

• Downloaded 3,111 times
• Download rankings, all-time:
  • Site-wide: 6,175
  • In bioinformatics: 528
• Year to date:
  • Site-wide: 78,115
• Since beginning of last month:
  • Site-wide: 92,697

Prevalence and clinical features of 2019 novel coronavirus disease (COVID-19) in the Fever Clinic of a teaching hospital in Beijing: a single-center, retrospective study

• Downloaded 3,042 times
• Download rankings, all-time:
  • Site-wide: 6,392
  • In respiratory medicine: 26
• Year to date:
  • Site-wide: 67,413
• Since beginning of last month:
  • Site-wide: 84,589

Associations of stay-at-home order and face-masking recommendation with trends in daily new cases and deaths of laboratory-confirmed COVID-19 in the United States

• Downloaded 1,875 times
• Download rankings, all-time:
  • Site-wide: 13,045
  • In epidemiology: 938
• Year to date:
  • Site-wide: 79,576
• Since beginning of last month:
  • Site-wide: 73,787

An Integrated Framework for Genome Analysis Reveals Numerous Previously Unrecognizable Structural Variants in Leukemia Patients' Samples

• Downloaded 1,806 times
• Download rankings, all-time:
  • Site-wide: 13,742
  • In genomics: 1,268
• Year to date:
  • Site-wide: 53,015
• Since beginning of last month:
  • Site-wide: 40,496

An integrative ENCODE resource for cancer genomics

• Downloaded 1,421 times
• Download rankings, all-time:
  • Site-wide: 19,840
  • In genomics: 1,717
• Year to date:
  • Site-wide: 135,299
• Since beginning of last month:
  • Site-wide: 187,458

Trends and prediction in daily incidence and deaths of COVID-19 in the United States: a search-interest based model

• Downloaded 1,342 times
• Download rankings, all-time:
  • Site-wide: 21,670
  • In epidemiology: 1,451
• Year to date:
  • Site-wide: 25,999
• Since beginning of last month:
  • Site-wide: 5,820

Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence

• Downloaded 1,322 times
• Download rankings, all-time:
  • Site-wide: 22,218
  • In microbiology: 1,202
• Year to date:
  • Site-wide: 165,217
• Since beginning of last month:
  • Site-wide: 169,721

Federated Learning of Electronic Health Records Improves Mortality Prediction in Patients Hospitalized with COVID-19

• Downloaded 1,244 times
• Download rankings, all-time:
  • Site-wide: 24,408
  • In health informatics: 119
• Year to date:
  • Site-wide: 22,270
• Since beginning of last month:
  • Site-wide: 22,046

Cryo-EM structure of the receptor-activated TRPC5 ion channel at 2.9 angstrom resolution

• Downloaded 1,214 times
• Download rankings, all-time:
  • Site-wide: 25,381
  • In biophysics: 622
• Year to date:
  • Site-wide: 129,726
• Since beginning of last month:
  • Site-wide: 114,735

Non-coding germline GATA3 variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia

• Downloaded 1,208 times
• Download rankings, all-time:
  • Site-wide: 25,562
  • In cancer biology: 593
• Year to date:
  • Site-wide: 58,822
• Since beginning of last month:
  • Site-wide: 63,419

Understanding Post-Acute Sequelae of SARS-CoV-2 Infection through Data-Driven Analysis with Longitudinal Electronic Health Records: Findings from the RECOVER Initiative

• Downloaded 1,136 times
• Download rankings, all-time:
  • Site-wide: 28,090
  • In health informatics: None
• Year to date:
  • Site-wide: 1,368
• Since beginning of last month:
  • Site-wide: 188

Palmitoylation is critically required for cancer intrinsic PD-1 expression and functions

• Downloaded 1,078 times
• Download rankings, all-time:
  • Site-wide: 30,401
  • In cancer biology: 759
• Year to date:
  • Site-wide: 66,262
• Since beginning of last month:
  • Site-wide: 50,278

Subtype-specific epigenomic landscape and 3D genome structure in bladder cancer

• Downloaded 1,038 times
• Download rankings, all-time:
  • Site-wide: 32,102
  • In genomics: 2,596
• Year to date:
  • Site-wide: 109,855
• Since beginning of last month:
  • Site-wide: 129,192

Metabolomics and proteomics analyses of grain yield reduction in rice under abrupt drought-flood alternation

• Downloaded 844 times
• Download rankings, all-time:
  • Site-wide: 43,682
  • In plant biology: 812
• Year to date:
  • Site-wide: 93,871
• Since beginning of last month:
  • Site-wide: 117,600

Increased green autofluorescence is a marker for non-invasive prediction of H2O2-induced cell death and decreases in the intracellular ATP of HaCaT cells

• Downloaded 769 times
• Download rankings, all-time:
  • Site-wide: 50,040
  • In cell biology: 2,159
• Year to date:
  • Site-wide: 61,268
• Since beginning of last month:
  • Site-wide: 40,726

Reduced graphene oxide membrane as supporting film for high-resolution cryo-EM

• Downloaded 743 times
• Download rankings, all-time:
  • Site-wide: 52,582
  • In biophysics: 1,715
• Year to date:
  • Site-wide: 70,662
• Since beginning of last month:
  • Site-wide: 49,763

Genome-wide co-localization of RNA-DNA interactions and fusion RNA pairs

• Downloaded 726 times
• Download rankings, all-time:
  • Site-wide: 54,334
  • In genomics: 3,757
• Year to date:
  • Site-wide: 166,633
• Since beginning of last month:
  • Site-wide: 176,183

Detecting Large Indels Using Optical Map Data

• Downloaded 563 times
• Download rankings, all-time:
  • Site-wide: 75,882
  • In bioinformatics: 6,681
• Year to date:
  • Site-wide: 139,450
• Since beginning of last month:
  • Site-wide: 169,370

High-Throughput Clinical Trial Emulation with Real World Data and Machine Learning: A Case Study of Drug Repurposing for Alzheimer's Disease

• Downloaded 519 times
• Download rankings, all-time:
  • Site-wide: 83,829
  • In health informatics: 709
• Year to date:
  • Site-wide: 4,657
• Since beginning of last month:
  • Site-wide: 4,327

Development of a federated learning approach to predict acute kidney injury in adult hospitalized patients with COVID-19 in New York City

• Downloaded 511 times
• Download rankings, all-time:
  • Site-wide: 85,419
  • In nephrology: 75
• Year to date:
  • Site-wide: 33,141
• Since beginning of last month:
  • Site-wide: 44,443

Role of PARP1 in oligodendrocyte differentiation during developmental myelination and remyelination after myelin damage

• Downloaded 509 times
• Download rankings, all-time:
  • Site-wide: 85,813
  • In neuroscience: 12,231
• Year to date:
  • Site-wide: 97,513
• Since beginning of last month:
  • Site-wide: 89,564

HIFα regulates developmental myelination independent of autocrine Wnt signaling

• Downloaded 492 times
• Download rankings, all-time:
  • Site-wide: 89,183
  • In neuroscience: 12,599
• Year to date:
  • Site-wide: 103,925
• Since beginning of last month:
  • Site-wide: 87,591

Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity

• Downloaded 491 times
• Download rankings, all-time:
  • Site-wide: 89,360
  • In cancer biology: 2,555
• Year to date:
  • Site-wide: 109,777
• Since beginning of last month:
  • Site-wide: 102,303

Machine learning enabled subgroup analysis with real-world data to inform better clinical trial design

• Downloaded 479 times
• Download rankings, all-time:
  • Site-wide: 91,929
  • In health informatics: 414
• Year to date:
  • Site-wide: 32,990
• Since beginning of last month:
  • Site-wide: 30,003

State heterogeneity of human mobility and COVID-19 epidemics in the European Union

• Downloaded 396 times
• Download rankings, all-time:
  • Site-wide: 111,177
  • In epidemiology: 4,533
• Year to date:
  • Site-wide: 128,747
• Since beginning of last month:
  • Site-wide: 103,626

Diversity and complexity of the large surface protein family in the compacted genomes of various Pneumocystis species

• Downloaded 396 times
• Download rankings, all-time:
  • Site-wide: 111,152
  • In molecular biology: 3,091
• Year to date:
  • Site-wide: 168,181
• Since beginning of last month:
  • Site-wide: 126,936

The ITPRIPL1- CD3ϵ axis: a novel immune checkpoint controlling T cells activation

• Downloaded 359 times
• Download rankings, all-time:
  • Site-wide: 121,225
  • In immunology: None
• Year to date:
  • Site-wide: 8,173
• Since beginning of last month:
  • Site-wide: 5,200

Genomic insights into the host specific adaptation of the Pneumocystis genus and emergence of the human pathogen Pneumocystis jirovecii

• Downloaded 355 times
• Download rankings, all-time:
  • Site-wide: 122,134
  • In evolutionary biology: 5,659
• Year to date:
  • Site-wide: 128,748
• Since beginning of last month:
  • Site-wide: 102,656

Machine Learning for Identifying Data-Driven Subphenotypes of Incident Post-Acute SARS-CoV-2 Infection Conditions with Large Scale Electronic Health Records: Findings from the RECOVER Initiative

• Downloaded 321 times
• Download rankings, all-time:
  • Site-wide: 131,906
  • In public and global health: None
• Year to date:
  • Site-wide: 9,666
• Since beginning of last month:
  • Site-wide: 1,202

Class II LBD genes ZmLBD5 and ZmLBD33 regulate gibberellin and abscisic acid biosynthesis

• Downloaded 302 times
• Download rankings, all-time:
  • Site-wide: 137,588
  • In plant biology: 3,634
• Year to date:
  • Site-wide: 119,025
• Since beginning of last month:
  • Site-wide: 97,096

dynaPhenoM: Dynamic Phenotype Modeling from Longitudinal Patient Records Using Machine Learning

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 145,941
  • In health informatics: 746
• Year to date:
  • Site-wide: 27,264
• Since beginning of last month:
  • Site-wide: 58,665

Dual functions of ZmGI1 in the photoperiodic flowering pathway and salt stress responses in maize

• Downloaded 249 times
• Download rankings, all-time:
  • Site-wide: 153,176
  • In developmental biology: 4,005
• Year to date:
  • Site-wide: 83,710
• Since beginning of last month:
  • Site-wide: 59,098

Lateral mechanical impedance rather than frontal, promotes cortical expansion of roots

• Downloaded 235 times
• Download rankings, all-time:
  • Site-wide: 157,167
  • In plant biology: 4,031
• Year to date:
  • Site-wide: 189,416
• Since beginning of last month:
  • Site-wide: 185,889

Algorithmic Fairness in Computational Medicine

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 158,466
  • In health informatics: 786
• Year to date:
  • Site-wide: 15,816
• Since beginning of last month:
  • Site-wide: None

Proteasome maturation factor UMP1 confers broad-spectrum disease resistance by modulating H2O2 accumulation in rice

• Downloaded 225 times
• Download rankings, all-time:
  • Site-wide: 160,053
  • In plant biology: 4,259
• Year to date:
  • Site-wide: 115,124
• Since beginning of last month:
  • Site-wide: 155,491

Nasal BCG Exposure Accelerates Dural Lymphatics Development via Macrophages' Role in Newborn Mice

• Downloaded 213 times
• Download rankings, all-time:
  • Site-wide: 163,222
  • In neuroscience: 23,016
• Year to date:
  • Site-wide: 136,134
• Since beginning of last month:
  • Site-wide: 123,490

USH2A gene mutations in rabbits lead to progressive retinal degeneration and hearing loss

• Downloaded 182 times
• Download rankings, all-time:
  • Site-wide: 171,159
  • In developmental biology: 4,384
• Year to date:
  • Site-wide: 22,176
• Since beginning of last month:
  • Site-wide: 43,760

Comparative genomic and pan-genomic characteristion of Staphylococcus epidermidis from different sources unveils the molecular basis and potential biomarkers of pathogenic strains

• Downloaded 168 times
• Download rankings, all-time:
  • Site-wide: 174,211
  • In microbiology: 12,887
• Year to date:
  • Site-wide: 92,726
• Since beginning of last month:
  • Site-wide: 59,805

Asymmetrical adaptations to increases and decreases in environmental volatility

• Downloaded 158 times
• Download rankings, all-time:
  • Site-wide: 176,542
  • In neuroscience: 24,856
• Year to date:
  • Site-wide: 88,632
• Since beginning of last month:
  • Site-wide: 180,667

Protocol for Development of a Reporting Guideline for Causal and Counterfactual Prediction Models

• Downloaded 143 times
• Download rankings, all-time:
  • Site-wide: 179,351
  • In health informatics: 811
• Year to date:
  • Site-wide: 67,926
• Since beginning of last month:
  • Site-wide: 80,121

A novel mechanism of Euonymine inhibits in-stent restenosis through enhancing contractile phenotype of VSMCs by targeting AKT1 and p38MAPK

• Downloaded 90 times
• Download rankings, all-time:
  • Site-wide: 186,798
  • In pharmacology and toxicology: 1,565
• Year to date:
  • Site-wide: 80,893
• Since beginning of last month:
  • Site-wide: 156,031