Author: Kai Wang

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Preprints

Running ahead of evolution - AI based simulation for predicting future high-risk SARS-CoV-2 variants

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Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case report.

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  • Site-wide: 455
  • In infectious diseases: 174
• Year to date:
  • Site-wide: 28,271
• Since beginning of last month:
  • Site-wide: 9,622

Observing the Cell in Its Native State: Imaging Subcellular Dynamics in Multicellular Organisms

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  • Site-wide: 941
  • In cell biology: 8
• Year to date:
  • Site-wide: 92,129
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  • Site-wide: 90,732

The D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity

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  • Site-wide: 1,394
  • In microbiology: 130
• Year to date:
  • Site-wide: 29,502
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  • Site-wide: 39,129

precisionFDA Truth Challenge V2: Calling variants from short- and long-reads in difficult-to-map regions

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  • Site-wide: 4,579
  • In bioinformatics: 396
• Year to date:
  • Site-wide: 11,347
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  • Site-wide: 8,307

Modelling the coronavirus disease (COVID-19) outbreak on the Diamond Princess ship using the public surveillance data from January 20 to February 20, 2020

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  • Site-wide: 5,154
  • In epidemiology: 497
• Year to date:
  • Site-wide: 81,240
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  • Site-wide: 45,916

Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio)

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  • Site-wide: 5,236
  • In neuroscience: 399
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  • Site-wide: 93,610

Racial and ethnic differences in COVID-19 vaccine hesitancy and uptake

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  • Site-wide: 5,815
  • In epidemiology: 549
• Year to date:
  • Site-wide: 21,884
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  • Site-wide: 7,561

Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China

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  • Site-wide: 6,079
  • In infectious diseases: 1,177
• Year to date:
  • Site-wide: 66,389
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  • Site-wide: 30,181

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

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  • Site-wide: 6,845
  • In immunology: 274
• Year to date:
  • Site-wide: 29,383
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  • Site-wide: 53,056

NanoCaller for accurate detection of SNPs and indels in difficult-to-map regions from long-read sequencing by haplotype-aware deep neural networks

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  • Site-wide: 7,415
  • In bioinformatics: 708
• Year to date:
  • Site-wide: 14,767
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  • Site-wide: 46,256

Estimating the serial interval of the novel coronavirus disease (COVID-19): A statistical analysis using the public data in Hong Kong from January 16 to February 15, 2020

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  • Site-wide: 7,591
  • In epidemiology: 653
• Year to date:
  • Site-wide: 185,354
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  • Site-wide: 104,491

N6-Methyladenine DNA Modification in Human Genome

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  • Site-wide: 8,638
  • In genomics: 811
• Year to date:
  • Site-wide: 73,920
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  • Site-wide: 74,672

NextSV: a meta-caller for structural variants from low-coverage long-read sequencing data

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  • Site-wide: 8,701
  • In genomics: 815
• Year to date:
  • Site-wide: 119,450
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  • Site-wide: 173,788

Isolation and characterization of extracellular vesicles from Caenorhabditis elegans for multi-omic analysis.

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  • Site-wide: 8,717
  • In cell biology: 187
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A variant in TAF1 is associated with a new syndrome with severe intellectual disability and characteristic dysmorphic features

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  • Site-wide: 8,932
  • In genetics: 340
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  • Site-wide: 30,597
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  • Site-wide: 51,518

Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies

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  • Site-wide: 9,902
  • In microbiology: 590
• Year to date:
  • Site-wide: 28,604
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  • Site-wide: 115,614

NanoMod: a computational tool to detect DNA modifications using Nanopore long-read sequencing data

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  • Site-wide: 10,388
  • In bioinformatics: 1,107
• Year to date:
  • Site-wide: 97,166
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  • Site-wide: 173,972

Knowledge-graph-based cell-cell communication inference for spatially resolved transcriptomic data with SpaTalk

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  • Site-wide: 10,773
  • In bioinformatics: 1,153
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  • Site-wide: None
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  • Site-wide: 48,262

Reduced Default Mode Network Functional Connectivity in Patients with Recurrent Major Depressive Disorder

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  • Site-wide: 13,381
  • In neuroscience: 1,359
• Year to date:
  • Site-wide: 60,874
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  • Site-wide: 51,998

Molecular and cellular phenotypic differences distinguish murine syngeneic models from human tumors

• Downloaded 1,871 times
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  • Site-wide: 14,877
  • In cancer biology: 304
• Year to date:
  • Site-wide: 73,318
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  • Site-wide: 90,633

Deconvolution of Transcriptional Networks Identifies TCF4 as a Master Regulator in Schizophrenia

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  • Site-wide: 15,411
  • In neuroscience: 1,622
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  • Site-wide: None
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  • Site-wide: 149,963

VirTect: a computational method for detecting virus species from RNA-Seq and its application in head and neck squamous cell carcinoma

• Downloaded 1,695 times
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  • Site-wide: 17,333
  • In bioinformatics: 1,871
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  • Site-wide: 94,374

Single-molecule optical mapping enables quantitative measurement of D4Z4 repeats in facioscapulohumeral muscular dystrophy (FSHD)

• Downloaded 1,679 times
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  • Site-wide: 17,607
  • In genomics: 1,591
• Year to date:
  • Site-wide: 132,198
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  • Site-wide: 42,872

Detection of Base Analogs Incorporated During DNA Replication by Nanopore Sequencing

• Downloaded 1,675 times
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  • Site-wide: 17,690
  • In genomics: 1,590
• Year to date:
  • Site-wide: 167,219
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  • Site-wide: 51,389

Capturing volumetric dynamics at high speed in the brain by confocal light field microscopy

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  • Site-wide: 19,667
  • In neuroscience: 2,235
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  • Site-wide: None
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  • Site-wide: 120,994

Localization of balanced chromosome translocation breakpoints by long-read sequencing on the Oxford Nanopore platform

• Downloaded 1,560 times
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  • Site-wide: 19,756
  • In genetics: 798
• Year to date:
  • Site-wide: 112,425
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  • Site-wide: 74,456

A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

• Downloaded 1,427 times
• Download rankings, all-time:
  • Site-wide: 22,832
  • In immunology: 857
• Year to date:
  • Site-wide: 122,904
• Since beginning of last month:
  • Site-wide: 24,239

CancerVar: an Artificial Intelligence empowered platform for clinical interpretation of somatic mutations in cancer

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  • Site-wide: 23,102
  • In cancer biology: 555
• Year to date:
  • Site-wide: 23,972
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  • Site-wide: 77,222

LinkedSV for detection of mosaic structural variants from linked-read exome and genome sequencing data

• Downloaded 1,388 times
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  • Site-wide: 23,876
  • In bioinformatics: 2,613
• Year to date:
  • Site-wide: 73,704
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  • Site-wide: 120,139

HadoopCNV: A Dynamic Programming Imputation Algorithm To Detect Copy Number Variants From Sequencing Data

• Downloaded 1,368 times
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  • Site-wide: 24,454
  • In bioinformatics: 2,665
• Year to date:
  • Site-wide: 50,925
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  • Site-wide: 174,177

Reduced neutralization of SARS-CoV-2 B.1.617 variant by inactivated and RBD-subunit vaccine

• Downloaded 1,331 times
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  • Site-wide: 25,554
  • In microbiology: 1,479
• Year to date:
  • Site-wide: 182,957
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  • Site-wide: 109,692

TNER: A Novel Background Error Suppression Method for Mutation Detection in Circulating Tumor DNA

• Downloaded 1,270 times
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  • Site-wide: 27,529
  • In bioinformatics: 2,954
• Year to date:
  • Site-wide: 191,706
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  • Site-wide: 196,354

Gene expression in patient-derived neural progenitors implicates WNT5A signaling in the etiology of schizophrenia

• Downloaded 1,264 times
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  • Site-wide: 27,722
  • In genetics: 1,108
• Year to date:
  • Site-wide: 70,932
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  • Site-wide: 140,850

Oligomerization of the NLR immune receptor RPP7 triggered by the atypical resistance protein RPW8/HR as a ligand

• Downloaded 1,246 times
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  • Site-wide: 28,341
  • In plant biology: 405
• Year to date:
  • Site-wide: 40,551
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  • Site-wide: 90,975

iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing cancer driver genes in personal genomes

• Downloaded 1,245 times
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  • Site-wide: 28,379
  • In genomics: 2,385
• Year to date:
  • Site-wide: 193,053
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  • Site-wide: 198,653

LIQA: Long-read Isoform Quantification and Analysis

• Downloaded 1,241 times
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  • Site-wide: 28,551
  • In bioinformatics: 3,112
• Year to date:
  • Site-wide: 80,140
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  • Site-wide: 24,483

Assessing the measurement transfer function of single-cell RNA sequencing

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  • Site-wide: 29,098
  • In genomics: 2,442
• Year to date:
  • Site-wide: 168,925
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  • Site-wide: 198,722

Detecting differential alternative splicing events in scRNA-seq with or without UMIs

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  • Site-wide: 30,362
  • In bioinformatics: 3,210
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  • Site-wide: None
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  • Site-wide: 196,663

MetaRNN: Differentiating Rare Pathogenic and Rare Benign Missense SNVs and InDels Using Deep Learning

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  • Site-wide: 30,435
  • In bioinformatics: 3,581
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  • Site-wide: None
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  • Site-wide: 15,804

Single-cell multi-omics reveals elevated plasticity and stem-cell-like blasts relevant to the poor prognosis of KMT2A-rearranged leukemia

• Downloaded 1,150 times
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  • Site-wide: 32,191
  • In cancer biology: 852
• Year to date:
  • Site-wide: 46,720
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  • Site-wide: 95,103

Progression, recovery and fatality in patients with SARS-CoV-2 related pneumonia in Wuhan, China: a single-centered, retrospective, observational study

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  • Site-wide: 33,304
  • In infectious diseases: 3,040
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  • Site-wide: 45,080
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  • Site-wide: 52,364

Heterogeneous immunological recovery trajectories revealed in post-acute COVID-19

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  • Site-wide: 37,205
  • In infectious diseases: 3,221
• Year to date:
  • Site-wide: 57,655
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  • Site-wide: 63,763

UBE2G1 Governs the Destruction of Cereblon Neomorphic Substrates

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  • Site-wide: 41,649
  • In molecular biology: 1,146
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  • Site-wide: 73,031
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  • Site-wide: 92,195

Constitutive activation of leucine-rich repeat receptor kinase signaling pathways by BAK1-interacting receptor-like kinase 3 chimera

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  • Site-wide: 42,157
  • In plant biology: 776
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  • Site-wide: 29,351
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  • Site-wide: 81,982

Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA

• Downloaded 853 times
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  • Site-wide: 50,937
  • In cell biology: 2,060
• Year to date:
  • Site-wide: 147,995
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  • Site-wide: 121,358

A computational method for direct imputation of cell type-specific expression profiles and cellular compositions from bulk-tissue RNA-Seq in brain disorders

• Downloaded 853 times
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  • Site-wide: 50,957
  • In systems biology: 1,005
• Year to date:
  • Site-wide: 121,742
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  • Site-wide: 131,228

Improved symptoms following bumetanide treatment in children aged 3 to 6 years with autism spectrum disorder: a randomized, double-blind, placebo-controlled trial

• Downloaded 842 times
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  • Site-wide: 52,025
  • In pediatrics: 95
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  • Site-wide: 47,846
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  • Site-wide: 94,683

Long-read sequencing identified a causal structural variant in an exome-negative case and enabled preimplantation genetic diagnosis

• Downloaded 827 times
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  • Site-wide: 53,338
  • In genetics: 2,077
• Year to date:
  • Site-wide: 192,034
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  • Site-wide: 175,063

Characterizing the Cancer-Associated Microbiome with Small RNA Sequencing Data

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  • Site-wide: 53,990
  • In bioinformatics: 5,456
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  • Site-wide: 20,520
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  • Site-wide: 52,348

Phen2Gene: Rapid Phenotype-Driven Gene Prioritization for Rare Diseases

• Downloaded 811 times
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  • Site-wide: 54,922
  • In bioinformatics: 5,410
• Year to date:
  • Site-wide: 141,492
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  • Site-wide: 187,829

Ligation-anchored PCR unveils immune repertoire of TCR-beta from whole blood

• Downloaded 741 times
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  • Site-wide: 62,848
  • In genomics: 4,350
• Year to date:
  • Site-wide: 132,446
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  • Site-wide: 198,632

PSC-RED, an Albumin-Free Robust Erythroid Differentiation Method to Produce Enucleated Red Blood Cells from Human Pluripotent Stem Cells

• Downloaded 726 times
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  • Site-wide: 64,812
  • In bioengineering: 1,327
• Year to date:
  • Site-wide: 36,207
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  • Site-wide: 151,654

ADAMTS-family protease MIG-17 regulates synaptic allometry by modifying the extracellular matrix and modulating glia morphology during growth

• Downloaded 720 times
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  • Site-wide: 65,580
  • In neuroscience: 9,078
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  • Site-wide: 116,639
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  • Site-wide: 183,373

Deficiency of gluconeogenic enzyme PCK1 promotes non-alcoholic steatohepatitis progression and fibrosis through PI3K/AKT/PDGF axis activation

• Downloaded 707 times
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  • Site-wide: 67,282
  • In molecular biology: 2,045
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  • Site-wide: 7,641
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  • Site-wide: 19,921

Verticillium dahliae effector VDAL protects MYB6 from degradation by interacting with PUB25/26 E3 ligases for enhancing Verticillium wilt resistance in Arabidopsis

• Downloaded 703 times
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  • Site-wide: 67,711
  • In plant biology: 1,566
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  • Site-wide: 145,764
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  • Site-wide: 115,915

1RS.1BL molecular resolution provides novel contributions to wheat improvement

• Downloaded 630 times
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  • Site-wide: 78,534
  • In genomics: 5,258
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  • Site-wide: 48,488
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  • Site-wide: 18,600

Reduced infectivity but increased immune escape of the new SARS-CoV-2 variant of concern Omicron

• Downloaded 624 times
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  • Site-wide: 79,464
  • In microbiology: 5,142
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  • Site-wide: None
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  • Site-wide: 214,040

A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

• Downloaded 619 times
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  • Site-wide: 80,331
  • In immunology: 2,614
• Year to date:
  • Site-wide: 183,831
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  • Site-wide: 127,057

Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection

• Downloaded 617 times
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  • Site-wide: 80,696
  • In infectious diseases: 4,806
• Year to date:
  • Site-wide: 149,161
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  • Site-wide: 102,933

Mechanistic insights on metabolic dysfunction in PTSD: Role of glucocorticoid receptor sensitivity and energy deficit

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  • Site-wide: 81,901
  • In systems biology: 1,680
• Year to date:
  • Site-wide: 96,248
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  • Site-wide: 116,703

A novel phyllosphere resident Protomyces species that interacts with the Arabidopsis immune system

• Downloaded 608 times
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  • Site-wide: 82,179
  • In microbiology: 5,129
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  • Site-wide: None
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  • Site-wide: 181,636

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

• Downloaded 606 times
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  • Site-wide: 82,509
  • In microbiology: 5,111
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  • Site-wide: None
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  • Site-wide: 214,169

Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1

• Downloaded 583 times
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  • Site-wide: 86,824
  • In genetics: 3,337
• Year to date:
  • Site-wide: 170,894
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  • Site-wide: 75,933

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

• Downloaded 571 times
• Download rankings, all-time:
  • Site-wide: 89,165
  • In immunology: 3,003
• Year to date:
  • Site-wide: 16,207
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  • Site-wide: 58,678

Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products in vitro

• Downloaded 563 times
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  • Site-wide: 90,730
  • In microbiology: 5,829
• Year to date:
  • Site-wide: 83,452
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  • Site-wide: 113,182

Age-related increase in matrix stiffness downregulates α-Klotho in chondrocytes and induces cartilage degeneration

• Downloaded 561 times
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  • Site-wide: 91,059
  • In molecular biology: 2,760
• Year to date:
  • Site-wide: 12,200
• Since beginning of last month:
  • Site-wide: 41,049

MicroRNA-transcriptome networks in whole blood and monocytes of women undergoing preterm labor

• Downloaded 541 times
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  • Site-wide: 95,192
  • In systems biology: 1,978
• Year to date:
  • Site-wide: 113,161
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  • Site-wide: 147,321

Independent parental contributions initiate zygote polarization in Arabidopsis thaliana

• Downloaded 538 times
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  • Site-wide: 95,691
  • In plant biology: 2,457
• Year to date:
  • Site-wide: 85,646
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  • Site-wide: 85,871

Temporal regulation of prenatal embryonic development by paternal imprinted loci

• Downloaded 521 times
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  • Site-wide: 99,356
  • In developmental biology: 2,598
• Year to date:
  • Site-wide: 94,366
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  • Site-wide: 43,421

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

• Downloaded 518 times
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  • Site-wide: 100,193
  • In immunology: 3,234
• Year to date:
  • Site-wide: 104,359
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  • Site-wide: 96,956

DNA demethylation is a driver for chick retina regeneration

• Downloaded 516 times
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  • Site-wide: 100,497
  • In developmental biology: 2,608
• Year to date:
  • Site-wide: 140,704
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  • Site-wide: 187,849

Changes of Humoral Immunity Response in SARS-CoV-2 Convalescent Patients over 8 months

• Downloaded 508 times
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  • Site-wide: 102,330
  • In infectious diseases: 5,442
• Year to date:
  • Site-wide: 151,135
• Since beginning of last month:
  • Site-wide: 137,799

High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions

• Downloaded 508 times
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  • Site-wide: 102,364
  • In neuroscience: 14,769
• Year to date:
  • Site-wide: 145,721
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  • Site-wide: 158,277

Genome-wide selection footprints and deleterious variations in young Asian allotetraploid rapeseed

• Downloaded 505 times
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  • Site-wide: 103,153
  • In genomics: 6,140
• Year to date:
  • Site-wide: 171,080
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  • Site-wide: 146,862

Implications of error-prone long-read whole-genome shotgun sequencing on characterizing reference microbiomes

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  • Site-wide: 104,310
  • In genomics: 6,221
• Year to date:
  • Site-wide: 156,662
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  • Site-wide: 161,812

AxonDeep: Automated Optic Nerve Axon Segmentation in Mice with Deep Learning.

• Downloaded 497 times
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  • Site-wide: 105,069
  • In bioengineering: 2,131
• Year to date:
  • Site-wide: 77,155
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  • Site-wide: 97,383

Single-cell analysis reveals a pathogenic cellular module associated with early allograft dysfunction after liver transplantation

• Downloaded 413 times
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  • Site-wide: 126,350
  • In genomics: 6,999
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  • Site-wide: 145,496
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  • Site-wide: 21,411

Laminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla

• Downloaded 387 times
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  • Site-wide: 133,883
  • In neuroscience: 19,695
• Year to date:
  • Site-wide: 145,145
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  • Site-wide: 85,671

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

• Downloaded 372 times
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  • Site-wide: 138,269
  • In cancer biology: 4,243
• Year to date:
  • Site-wide: 85,399
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  • Site-wide: 136,959

Gluconeogenic Enzyme PCK1 Deficiency Is Critical for CHK2 O-GlcNAcylation and Hepatocellular Carcinoma Growth upon Glucose Deprivation

• Downloaded 372 times
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  • Site-wide: 138,184
  • In cancer biology: 4,224
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  • Site-wide: 157,309
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Recombinant adenovirus causes prolonged mobilization of macrophages in the anterior chamber of mice

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MNC-RED a Chemically Defined Method to Produce Enucleated Red Blood Cells from Adult Peripheral Blood Mononuclear Cells

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O-GlcNAcylation of SAMHD1 Indicating a Link between Metabolic Reprogramming and Anti-HBV Immunity

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The CDK inhibitor SIAMESE targets both CDKA;1 and CDKB1 complexes to establish endoreplication in trichomes

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Exosome component 1 cleaves single-stranded DNA and sensitizes kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor

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Transcriptional Network Analysis on Brains Reveals a Potential Regulatory Role of PPP1R3F in Autism Spectrum Disorders

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A Taphrina strain infecting the model plant Arabidopsis thaliana.

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Temporal Small RNA Expression Profiling Under Drought Reveals a Potential Regulatory Role of snoRNAs in Drought Responses of Maize

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Distinct Brain Mechanisms for Conflict Adaptation Within and Across Conflict Types

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Multiple Sclerosis Patients have an Altered Gut Mycobiome and Increased Fungal to Bacterial Richness Running Title: RRMS Patients have Gut Fungal Dysbiosis

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Epidemiology, Microbiology and Therapeutic Consequences of Chronic Osteomyelitis in Northern China: A Retrospective Analysis of 255 Patients

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A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment

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Integrative multi-omics identifies high risk Multiple Myeloma segment associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways

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Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

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A novel Arabidopsis phyllosphere resident Protomyces sp. and a re-examination of genus Protomyces based on genome sequence data.

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Biological Correlations and Confounding Variables for Quantification of Retinal Ganglion Cells Based on Optical Coherence Tomography Using Diversity Outbred Mice

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Cell type-specific proteogenomic signal diffusion for integrating multi-omics data predicts novel schizophrenia risk genes

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IndepthPathway: an integrated tool for in-depth pathway enrichment analysis based on bulk and single cell sequencing data

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Engineering a Single Extracellular Vesicle Protein and RNA Assay (siEVPRA) via In Situ Fluorescence Microscopy in a UV Micropatterned Array

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Pancreatic Brsk2 amplifies parasympathetic signals to promote type 2 diabetes

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Tyr is Responsible for the Cctq1a QTL and Links Developmental Environment to Central Corneal Thickness Determination

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Knockout of Bbs10 results in lack of cone electrical function and progressive retinal degeneration of rods and cones

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Expanding the Phenotypic spectrum of Ogden syndrome (NAA10-related neurodevelopmental syndrome) and NAA15-related neurodevelopmental syndrome

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Novel Coronavirus Pandemic Impacts Children and Adolescents' Psychological Well-Being in Heavily Hit Chinese Provinces

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Mouse Organ Specific Proteins and Functions

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Structural and functional insight into the plant unique multimodular triphosphosphate tunnel metalloenzymes of Arabidopsis thaliana

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Fecal microbiota and their association with heat stress in Bos taurus

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Clock and riboswitch control of THIC in tandem are essential for appropriate gauging of TDP levels under light/dark cycles in Arabidopsis

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Data Fusion by Matrix Completion for Exposome Target Interaction Prediction

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Host transcriptome and microbiomeinteractions in Holstein cattle under heatstress condition

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