Author: Kai Wang

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Preprints

Deficiency of gluconeogenic enzyme PCK1 promotes non-alcoholic steatohepatitis progression by activation of PI3K/AKT/PDGF axis

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Recombinant adenovirus causes prolonged mobilization of macrophages in the anterior chamber of mice

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Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case report.

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Observing the Cell in Its Native State: Imaging Subcellular Dynamics in Multicellular Organisms

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The D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity

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  • Site-wide: 950
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Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio)

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Modelling the coronavirus disease (COVID-19) outbreak on the Diamond Princess ship using the public surveillance data from January 20 to February 20, 2020

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  • Site-wide: 3,155
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Estimating the serial interval of the novel coronavirus disease (COVID-19): A statistical analysis using the public data in Hong Kong from January 16 to February 15, 2020

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  • Site-wide: 4,432
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NextSV: a meta-caller for structural variants from low-coverage long-read sequencing data

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N6-Methyladenine DNA Modification in Human Genome

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Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China

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  • Site-wide: 5,182
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A variant in TAF1 is associated with a new syndrome with severe intellectual disability and characteristic dysmorphic features

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NanoMod: a computational tool to detect DNA modifications using Nanopore long-read sequencing data

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  • Site-wide: 5,641
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Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

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Isolation and characterization of extracellular vesicles from Caenorhabditis elegans for multi-omic analysis.

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NanoCaller for accurate detection of SNPs and indels in difficult-to-map regions from long-read sequencing by haplotype-aware deep neural networks

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Reduced Default Mode Network Functional Connectivity in Patients with Recurrent Major Depressive Disorder

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  • Site-wide: 9,298
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  • Site-wide: 22,873

Deconvolution of Transcriptional Networks Identifies TCF4 as a Master Regulator in Schizophrenia

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  • Site-wide: 9,382
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Molecular and cellular phenotypic differences distinguish murine syngeneic models from human tumors

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  • Site-wide: 10,103
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Detection of Base Analogs Incorporated During DNA Replication by Nanopore Sequencing

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  • Site-wide: 10,668
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VirTect: a computational method for detecting virus species from RNA-Seq and its application in head and neck squamous cell carcinoma

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Single-molecule optical mapping enables quantitative measurement of D4Z4 repeats in facioscapulohumeral muscular dystrophy (FSHD)

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  • Site-wide: 10,994
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Capturing volumetric dynamics at high speed in the brain by confocal light field microscopy

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  • Site-wide: 59,700

Localization of balanced chromosome translocation breakpoints by long-read sequencing on the Oxford Nanopore platform

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  • Site-wide: 12,587
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LinkedSV for detection of mosaic structural variants from linked-read exome and genome sequencing data

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  • Site-wide: 13,820
  • In bioinformatics: 1,738
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  • Site-wide: 64,266

HadoopCNV: A Dynamic Programming Imputation Algorithm To Detect Copy Number Variants From Sequencing Data

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  • Site-wide: 15,048
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  • Site-wide: 80,939

iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing cancer driver genes in personal genomes

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  • Site-wide: 15,275
  • In genomics: 1,659
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  • Site-wide: 52,519

TNER: A Novel Background Error Suppression Method for Mutation Detection in Circulating Tumor DNA

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  • Site-wide: 16,011
  • In bioinformatics: 1,998
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  • Site-wide: 58,263

Assessing the measurement transfer function of single-cell RNA sequencing

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  • Site-wide: 16,211
  • In genomics: 1,726
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  • Site-wide: 100,190
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  • Site-wide: 100,372

Detecting differential alternative splicing events in scRNA-seq with or without UMIs

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  • Site-wide: 18,350
  • In bioinformatics: 2,272
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  • Site-wide: 44,314

precisionFDA Truth Challenge V2: Calling variants from short- and long-reads in difficult-to-map regions

• Downloaded 997 times
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  • Site-wide: 18,642
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  • Site-wide: 1,314

Oligomerization of the NLR immune receptor RPP7 triggered by the atypical resistance protein RPW8/HR as a ligand

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  • Site-wide: 19,476
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  • Site-wide: 74,170

Constitutive activation of leucine-rich repeat receptor kinase signaling pathways by BAK1-interacting receptor-like kinase 3 chimera

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  • Site-wide: 24,618
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  • Site-wide: 37,141
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  • Site-wide: 36,078

Gene expression in patient-derived neural progenitors implicates WNT5A signaling in the etiology of schizophrenia

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  • Site-wide: 28,414
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  • Site-wide: 39,087

UBE2G1 Governs the Destruction of Cereblon Neomorphic Substrates

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  • Site-wide: 28,854
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Long-read sequencing identified a causal structural variant in an exome-negative case and enabled preimplantation genetic diagnosis

• Downloaded 709 times
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  • Site-wide: 30,188
  • In genetics: 1,524
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  • Site-wide: 82,970

Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA

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  • Site-wide: 34,035
  • In cell biology: 1,385
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Ligation-anchored PCR unveils immune repertoire of TCR-beta from whole blood

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  • Site-wide: 34,207
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Progression, recovery and fatality in patients with SARS-CoV-2 related pneumonia in Wuhan, China: a single-centered, retrospective, observational study

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  • Site-wide: 36,117
  • In infectious diseases: 2,013
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Phen2Gene: Rapid Phenotype-Driven Gene Prioritization for Rare Diseases

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  • Site-wide: 36,114
  • In bioinformatics: 4,053
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A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

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  • Site-wide: 37,365
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ADAMTS-family protease MIG-17 regulates synaptic allometry by modifying the extracellular matrix and modulating glia morphology during growth

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  • Site-wide: 42,928
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Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1

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Mechanistic insights on metabolic dysfunction in PTSD: Role of glucocorticoid receptor sensitivity and energy deficit

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Genome-wide selection footprints and deleterious variations in young Asian allotetraploid rapeseed

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DNA demethylation is a driver for chick retina regeneration

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PSC-RED, an Albumin-Free Robust Erythroid Differentiation Method to Produce Enucleated Red Blood Cells from Human Pluripotent Stem Cells

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  • Site-wide: 59,139
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A computational method for direct imputation of cell type-specific expression profiles and cellular compositions from bulk-tissue RNA-Seq in brain disorders

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Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection

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A novel phyllosphere resident Protomyces species that interacts with the Arabidopsis immune system

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MicroRNA-transcriptome networks in whole blood and monocytes of women undergoing preterm labor

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A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

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  • In immunology: 1,741
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  • Site-wide: 15,586

Implications of error-prone long-read whole-genome shotgun sequencing on characterizing reference microbiomes

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Characterizing the Cancer-Associated Microbiome with Small RNA Sequencing Data

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Single-cell multi-omics reveals elevated plasticity and stem-cell-like blasts relevant to the poor prognosis of KMT2A-rearranged leukemia

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Changes of Humoral Immunity Response in SARS-CoV-2 Convalescent Patients over 8 months

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Transcriptional Network Analysis on Brains Reveals a Potential Regulatory Role of PPP1R3F in Autism Spectrum Disorders

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MNC-RED a Chemically Defined Method to Produce Enucleated Red Blood Cells from Adult Peripheral Blood Mononuclear Cells

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Improved symptoms following bumetanide treatment in children aged 3 to 6 years with autism spectrum disorder: a randomized, double-blind, placebo-controlled trial

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  • Site-wide: 89,956
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LIQA: Long-read Isoform Quantification and Analysis

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The CDK inhibitor SIAMESE targets both CDKA;1 and CDKB1 complexes to establish endoreplication in trichomes

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Temporal regulation of prenatal embryonic development by paternal imprinted loci

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Temporal Small RNA Expression Profiling Under Drought Reveals a Potential Regulatory Role of snoRNAs in Drought Responses of Maize

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Independent parental contributions initiate zygote polarization in Arabidopsis thaliana

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  • Site-wide: 1,992

1RS.1BL molecular resolution provides novel contributions to wheat improvement

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Epidemiology, Microbiology and Therapeutic Consequences of Chronic Osteomyelitis in Northern China: A Retrospective Analysis of 255 Patients

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O-GlcNAcylation of SAMHD1 Indicating a Link between Metabolic Reprogramming and Anti-HBV Immunity

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Cell type-specific proteogenomic signal diffusion for integrating multi-omics data predicts novel schizophrenia risk genes

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A novel Arabidopsis phyllosphere resident Protomyces sp. and a re-examination of genus Protomyces based on genome sequence data.

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Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products in vitro

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CancerVar: a web server for improved evidence-based clinical interpretation of cancer somatic mutations and copy number abnormalities

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Gluconeogenic Enzyme PCK1 Deficiency Is Critical for CHK2 O-GlcNAcylation and Hepatocellular Carcinoma Growth upon Glucose Deprivation

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A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment

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GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

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  • In cancer biology: 3,832
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Biological Correlations and Confounding Variables for Quantification of Retinal Ganglion Cells Based on Optical Coherence Tomography Using Diversity Outbred Mice

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