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Author: Stephen R. Quake

Rankings

  • All-time downloads: 152,400 (rank: 744 )
  • Categories:
    • biochemistry: 482 (rank: 15,577 (tie) )
    • bioengineering: 3,639 (rank: 604 )
    • bioinformatics: 7,468 (rank: 1,623 )
    • biophysics: 651 (rank: 10,780 (tie) )
    • cancer biology: 3,592 (rank: 1,603 (tie) )
    • cell biology: 30,248 (rank: 21 )
    • developmental biology: 5,972 (rank: 262 )
    • genetics: 2,060 (rank: 9,954 (tie) )
    • genomics: 46,659 (rank: 244 )
    • immunology: 17,111 (rank: 667 )
    • microbiology: 8,124 (rank: 2,229 (tie) )
    • molecular biology: 459 (rank: 18,029 (tie) )
    • neuroscience: 21,805 (rank: 383 )
    • obstetrics and gynecology: 678 (rank: 543 (tie) )
    • systems biology: 3,452 (rank: 1,416 )

Downloads per author, site-wide

Preprints

A molecular cell atlas of the human lung from single cell RNA sequencing

genomics more details view paper
  • Downloaded 20,684 times
  • Download rankings, all-time:
    • Site-wide: 436
    • In genomics: 16
  • Year to date:
    • Site-wide: 1,041
  • Since beginning of last month:
    • Site-wide: 3,132

Single-cell transcriptomic characterization of 20 organs and tissues from individual mice creates a Tabula Muris

cell biology more details view paper
  • Downloaded 13,705 times
  • Download rankings, all-time:
    • Site-wide: 721
    • In cell biology: 4
  • Year to date:
    • Site-wide: 11,532
  • Since beginning of last month:
    • Site-wide: 18,445

A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse

cell biology more details view paper
  • Downloaded 9,560 times
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    • Site-wide: 1,151
    • In cell biology: 12
  • Year to date:
    • Site-wide: 5,749
  • Since beginning of last month:
    • Site-wide: 13,536

c-Jun Overexpressing CAR-T Cells are Exhaustion-Resistant and Mediate Enhanced Antitumor Activity

immunology more details view paper
  • Downloaded 4,369 times
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    • Site-wide: 3,239
    • In immunology: 119
  • Year to date:
    • Site-wide: 17,454
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    • Site-wide: 37,745

Single cell profiling of total RNA using Smart-seq-total

genomics more details view paper
  • Downloaded 4,201 times
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    • Site-wide: 3,403
    • In genomics: 330
  • Year to date:
    • Site-wide: 2,771
  • Since beginning of last month:
    • Site-wide: 5,912

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ pro-inflammatory macrophages

immunology more details view paper
  • Downloaded 4,032 times
  • Download rankings, all-time:
    • Site-wide: 3,608
    • In immunology: 132
  • Year to date:
    • Site-wide: 8,665
  • Since beginning of last month:
    • Site-wide: 21,170

The murine transcriptome reveals global aging nodes with organ-specific phase and amplitude

genomics more details view paper
  • Downloaded 3,644 times
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    • Site-wide: 4,163
    • In genomics: 415
  • Year to date:
    • Site-wide: 20,848
  • Since beginning of last month:
    • Site-wide: 33,517

Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencing

neuroscience more details view paper
  • Downloaded 3,275 times
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    • Site-wide: 4,858
    • In neuroscience: 386
  • Year to date:
    • Site-wide: 66,137
  • Since beginning of last month:
    • Site-wide: 126,680

Classifying Drosophila Olfactory Projection Neuron Subtypes by Single-cell RNA Sequencing

genomics more details view paper
  • Downloaded 2,966 times
  • Download rankings, all-time:
    • Site-wide: 5,601
    • In genomics: 563
  • Year to date:
    • Site-wide: 109,174
  • Since beginning of last month:
    • Site-wide: 128,553

Single cell RNAseq provides a molecular and cellular cartography of changes to the human endometrium through the menstrual cycle

genomics more details view paper
  • Downloaded 2,783 times
  • Download rankings, all-time:
    • Site-wide: 6,136
    • In genomics: 618
  • Year to date:
    • Site-wide: 33,400
  • Since beginning of last month:
    • Site-wide: 100,533

Pancreas patch-seq links physiologic dysfunction in diabetes to single-cell transcriptomic phenotypes

genomics more details view paper
  • Downloaded 2,756 times
  • Download rankings, all-time:
    • Site-wide: 6,209
    • In genomics: 622
  • Year to date:
    • Site-wide: 48,893
  • Since beginning of last month:
    • Site-wide: 136,741

Serotonin Neurons in the Dorsal and Medial Raphe Nuclei: from Single-Cell Transcriptomes to Whole-Brain Projections

neuroscience more details view paper
  • Downloaded 2,625 times
  • Download rankings, all-time:
    • Site-wide: 6,675
    • In neuroscience: 597
  • Year to date:
    • Site-wide: 27,391
  • Since beginning of last month:
    • Site-wide: 132,664

The Tabula Sapiens: a multiple organ single cell transcriptomic atlas of humans

cell biology more details view paper
  • Downloaded 2,514 times
  • Download rankings, all-time:
    • Site-wide: 7,156
    • In cell biology: 147
  • Year to date:
    • Site-wide: 1,481
  • Since beginning of last month:
    • Site-wide: 1,902

Molecular hallmarks of heterochronic parabiosis at single cell resolution

genomics more details view paper
  • Downloaded 2,503 times
  • Download rankings, all-time:
    • Site-wide: 7,190
    • In genomics: 734
  • Year to date:
    • Site-wide: 3,373
  • Since beginning of last month:
    • Site-wide: 8,149

Brain endothelial cells are exquisite sensors of age-related circulatory cues

neuroscience more details view paper
  • Downloaded 2,367 times
  • Download rankings, all-time:
    • Site-wide: 7,805
    • In neuroscience: 732
  • Year to date:
    • Site-wide: 44,045
  • Since beginning of last month:
    • Site-wide: 104,399

Cerebellar nuclei evolved by repeatedly duplicating a conserved cell type set

neuroscience more details view paper
  • Downloaded 2,333 times
  • Download rankings, all-time:
    • Site-wide: 7,972
    • In neuroscience: 749
  • Year to date:
    • Site-wide: 12,796
  • Since beginning of last month:
    • Site-wide: 13,704

Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA

cancer biology more details view paper
  • Downloaded 2,329 times
  • Download rankings, all-time:
    • Site-wide: 7,992
    • In cancer biology: 120
  • Year to date:
    • Site-wide: 35,250
  • Since beginning of last month:
    • Site-wide: 36,349

A mouse tissue atlas of small non-coding RNA

genomics more details view paper
  • Downloaded 2,308 times
  • Download rankings, all-time:
    • Site-wide: 8,100
    • In genomics: 817
  • Year to date:
    • Site-wide: 21,320
  • Since beginning of last month:
    • Site-wide: 26,916

Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks

neuroscience more details view paper
  • Downloaded 2,296 times
  • Download rankings, all-time:
    • Site-wide: 8,165
    • In neuroscience: 771
  • Year to date:
    • Site-wide: 12,376
  • Since beginning of last month:
    • Site-wide: 22,751

Cell-Surface Proteomic Profiling in the Fly Brain Uncovers New Wiring Regulators

neuroscience more details view paper
  • Downloaded 2,287 times
  • Download rankings, all-time:
    • Site-wide: 8,211
    • In neuroscience: 778
  • Year to date:
    • Site-wide: 109,705
  • Since beginning of last month:
    • Site-wide: 130,687

Human IgE producing B cells have a unique transcriptional program and generate high affinity, allergen-specific antibodies

immunology more details view paper
  • Downloaded 2,112 times
  • Download rankings, all-time:
    • Site-wide: 9,194
    • In immunology: 327
  • Year to date:
    • Site-wide: 43,019
  • Since beginning of last month:
    • Site-wide: 56,846

Single-cell analysis identifies EpCAM+/CDH6+/TROP-2- cells as human liver progenitors.

cell biology more details view paper
  • Downloaded 2,069 times
  • Download rankings, all-time:
    • Site-wide: 9,484
    • In cell biology: 218
  • Year to date:
    • Site-wide: 62,498
  • Since beginning of last month:
    • Site-wide: 109,918

Nonivasive prenatal diagnosis of single-gene disorders using droplet digital PCR

genetics more details view paper
  • Downloaded 2,060 times
  • Download rankings, all-time:
    • Site-wide: 9,548
    • In genetics: 389
  • Year to date:
    • Site-wide: 68,791
  • Since beginning of last month:
    • Site-wide: 135,137

Self-assembling Manifolds in Single-cell RNA Sequencing Data

bioinformatics more details view paper
  • Downloaded 2,009 times
  • Download rankings, all-time:
    • Site-wide: 9,930
    • In bioinformatics: 1,121
  • Year to date:
    • Site-wide: 91,098
  • Since beginning of last month:
    • Site-wide: 33,526

Mapping single-cell atlases throughout Metazoa unravels cell type evolution

bioinformatics more details view paper
  • Downloaded 2,009 times
  • Download rankings, all-time:
    • Site-wide: 9,933
    • In bioinformatics: 1,120
  • Year to date:
    • Site-wide: 3,675
  • Since beginning of last month:
    • Site-wide: 14,409

Single cell transcriptome analysis of human pancreas reveals transcriptional signatures of aging and somatic mutation patterns.

genomics more details view paper
  • Downloaded 1,967 times
  • Download rankings, all-time:
    • Site-wide: 10,249
    • In genomics: 1,009
  • Year to date:
    • Site-wide: 118,447
  • Since beginning of last month:
    • Site-wide: 132,923

Single-cell RNA-seq reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress

systems biology more details view paper
  • Downloaded 1,926 times
  • Download rankings, all-time:
    • Site-wide: 10,579
    • In systems biology: 173
  • Year to date:
    • Site-wide: 125,467
  • Since beginning of last month:
    • Site-wide: 140,874

Transcriptional program of memory B cell activation, broadly binding anti-influenza antibodies, and bystander activation after vaccination revealed by single-cell transcriptomics

immunology more details view paper
  • Downloaded 1,785 times
  • Download rankings, all-time:
    • Site-wide: 11,869
    • In immunology: 410
  • Year to date:
    • Site-wide: 13,083
  • Since beginning of last month:
    • Site-wide: 19,416

Humans are colonized by many uncharacterized and highly divergent microbes

microbiology more details view paper
  • Downloaded 1,631 times
  • Download rankings, all-time:
    • Site-wide: 13,536
    • In microbiology: 782
  • Year to date:
    • Site-wide: 148,738
  • Since beginning of last month:
    • Site-wide: 141,274

Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples

microbiology more details view paper
  • Downloaded 1,583 times
  • Download rankings, all-time:
    • Site-wide: 14,162
    • In microbiology: 820
  • Year to date:
    • Site-wide: 118,105
  • Since beginning of last month:
    • Site-wide: 47,586

Persistent transcriptional programs are associated with remote memory in diverse cells of the medial prefrontal cortex

neuroscience more details view paper
  • Downloaded 1,575 times
  • Download rankings, all-time:
    • Site-wide: 14,282
    • In neuroscience: 1,551
  • Year to date:
    • Site-wide: 37,061
  • Since beginning of last month:
    • Site-wide: 83,355

Discrete and Continuous Cell Identities of the Adult Murine Striatum

neuroscience more details view paper
  • Downloaded 1,546 times
  • Download rankings, all-time:
    • Site-wide: 14,720
    • In neuroscience: 1,619
  • Year to date:
    • Site-wide: 46,171
  • Since beginning of last month:
    • Site-wide: 63,517

Cell Types of Origin in the Cell Free Transcriptome in Human Health and Disease

systems biology more details view paper
  • Downloaded 1,526 times
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    • Site-wide: 15,053
    • In systems biology: 256
  • Year to date:
    • Site-wide: 2,927
  • Since beginning of last month:
    • Site-wide: 1,223

Single-cell transcriptional dynamics of flavivirus infection

microbiology more details view paper
  • Downloaded 1,525 times
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    • Site-wide: 15,071
    • In microbiology: 871
  • Year to date:
    • Site-wide: 82,274
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    • Site-wide: 36,075

Coordinating Receptor Expression and Wiring Specificity in Olfactory Receptor Neurons

neuroscience more details view paper
  • Downloaded 1,446 times
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    • Site-wide: 16,370
    • In neuroscience: 1,874
  • Year to date:
    • Site-wide: 74,266
  • Since beginning of last month:
    • Site-wide: 76,642

Coronary blood vessels from distinct origins converge to equivalent states during mouse and human development

developmental biology more details view paper
  • Downloaded 1,271 times
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    • Site-wide: 19,896
    • In developmental biology: 323
  • Year to date:
    • Site-wide: 3,784
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    • Site-wide: 1,947

Single-Cell RNAseq analysis of infiltrating neoplastic cells at the migrating front of human glioblastoma

cancer biology more details view paper
  • Downloaded 1,263 times
  • Download rankings, all-time:
    • Site-wide: 20,112
    • In cancer biology: 467
  • Year to date:
    • Site-wide: 93,162
  • Since beginning of last month:
    • Site-wide: 84,941

Molecular and genetic regulation of pig pancreatic islet cell development

developmental biology more details view paper
  • Downloaded 1,227 times
  • Download rankings, all-time:
    • Site-wide: 21,005
    • In developmental biology: 350
  • Year to date:
    • Site-wide: 46,494
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    • Site-wide: 66,330

Latrophilin-2 repels Teneurin-3+ hippocampal axons during target selection

neuroscience more details view paper
  • Downloaded 1,175 times
  • Download rankings, all-time:
    • Site-wide: 22,401
    • In neuroscience: 2,752
  • Year to date:
    • Site-wide: 11,952
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    • Site-wide: 18,295

PhaMers identifies novel bacteriophage sequences from thermophilic hot springs

bioinformatics more details view paper
  • Downloaded 1,154 times
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    • Site-wide: 23,023
    • In bioinformatics: 2,586
  • Year to date:
    • Site-wide: 92,808
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    • Site-wide: 76,416

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

genomics more details view paper
  • Downloaded 1,125 times
  • Download rankings, all-time:
    • Site-wide: 23,961
    • In genomics: 2,197
  • Year to date:
    • Site-wide: 140,500
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    • Site-wide: 150,482

Evolutionary Origin of the Mammalian Hematopoietic System Found in a Colonial Chordate

immunology more details view paper
  • Downloaded 1,113 times
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    • Site-wide: 24,381
    • In immunology: 843
  • Year to date:
    • Site-wide: 55,516
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    • Site-wide: 69,635

Signatures of Selection in the Human Antibody Repertoire: Selective Sweeps, Competing Subclones, and Neutral Drift

immunology more details view paper
  • Downloaded 1,111 times
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    • Site-wide: 24,428
    • In immunology: 845
  • Year to date:
    • Site-wide: 156,808
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    • Site-wide: 164,460

Hydrogenotrophic methanogenesis in archaeal phylum Verstraetearchaeota reveals the shared ancestry of all methanogens

microbiology more details view paper
  • Downloaded 1,012 times
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    • Site-wide: 28,108
    • In microbiology: 1,638
  • Year to date:
    • Site-wide: 144,067
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    • Site-wide: 155,406

A single-parasite transcriptional atlas of Toxoplasma gondii reveals novel control of antigen expression

bioengineering more details view paper
  • Downloaded 997 times
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    • Site-wide: 28,737
    • In bioengineering: 510
  • Year to date:
    • Site-wide: 104,632
  • Since beginning of last month:
    • Site-wide: 54,531

Single-cell transcriptional atlas of the Chinese horseshoe bat (Rhinolophus sinicus) provides insight into the cellular mechanisms which enable bats to be viral reservoirs

cell biology more details view paper
  • Downloaded 986 times
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    • Site-wide: 29,237
    • In cell biology: 1,089
  • Year to date:
    • Site-wide: 18,229
  • Since beginning of last month:
    • Site-wide: 25,087

Dynamics Of The Human Antibody Repertoire Following B-cell Depletion In Systemic Sclerosis

immunology more details view paper
  • Downloaded 978 times
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    • Site-wide: 29,589
    • In immunology: 998
  • Year to date:
    • Site-wide: 149,995
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    • Site-wide: 157,922

Virus-inclusive single cell RNA sequencing reveals molecular signature predictive of progression to severe dengue infection

immunology more details view paper
  • Downloaded 963 times
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    • Site-wide: 30,231
    • In immunology: 1,012
  • Year to date:
    • Site-wide: 149,959
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    • Site-wide: 151,056

Northstar enables automatic classification of known and novel cell types from tumor samples

bioinformatics more details view paper
  • Downloaded 954 times
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    • Site-wide: 30,626
    • In bioinformatics: 3,377
  • Year to date:
    • Site-wide: 86,718
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    • Site-wide: 135,998

Heterologous reporter expression in the planarian Schmidtea mediterranea through somatic mRNA transfection

bioengineering more details view paper
  • Downloaded 922 times
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    • Site-wide: 32,230
    • In bioengineering: 589
  • Year to date:
    • Site-wide: 6,153
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    • Site-wide: 14,633

Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung revealed at single cell resolution

developmental biology more details view paper
  • Downloaded 903 times
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    • Site-wide: 33,252
    • In developmental biology: 654
  • Year to date:
    • Site-wide: 47,067
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    • Site-wide: 20,519

A Noninvasive Molecular Clock for Fetal Development Predicts Gestational Age and Preterm Delivery

bioengineering more details view paper
  • Downloaded 892 times
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    • Site-wide: 33,872
    • In bioengineering: 629
  • Year to date:
    • Site-wide: 112,824
  • Since beginning of last month:
    • Site-wide: 114,989

An inexpensive semi-automated sample processing pipeline for cell-free RNA

bioengineering more details view paper
  • Downloaded 828 times
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    • Site-wide: 37,688
    • In bioengineering: 711
  • Year to date:
    • Site-wide: 18,245
  • Since beginning of last month:
    • Site-wide: 53,256

RNA splicing programs define tissue compartments and cell types at single cell resolution

bioinformatics more details view paper
  • Downloaded 779 times
  • Download rankings, all-time:
    • Site-wide: 41,156
    • In bioinformatics: 4,325
  • Year to date:
    • Site-wide: 8,019
  • Since beginning of last month:
    • Site-wide: 11,916

Nucleic Acid Cleavage with a Hyperthermophilic Cas9 from an Unculturable Ignavibacterium

genomics more details view paper
  • Downloaded 774 times
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    • Site-wide: 41,544
    • In genomics: 3,305
  • Year to date:
    • Site-wide: 118,089
  • Since beginning of last month:
    • Site-wide: 119,682

The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection

microbiology more details view paper
  • Downloaded 735 times
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    • Site-wide: 44,731
    • In microbiology: 2,676
  • Year to date:
    • Site-wide: 36,534
  • Since beginning of last month:
    • Site-wide: 96,952

Early prediction of preeclampsia in pregnancy with circulating cell-free RNA

obstetrics and gynecology more details view paper
  • Downloaded 678 times
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    • Site-wide: 50,019
    • In obstetrics and gynecology: 49
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    • Site-wide: 9,983
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    • Site-wide: 9,459

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

cell biology more details view paper
  • Downloaded 670 times
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    • Site-wide: 50,830
    • In cell biology: 2,158
  • Year to date:
    • Site-wide: 10,183
  • Since beginning of last month:
    • Site-wide: 9,779

Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo

biophysics more details view paper
  • Downloaded 651 times
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    • Site-wide: 52,810
    • In biophysics: 1,732
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Matrix-corrected mass spectrometry enables sensitive detection of food allergens and reveals widespread soy contamination of processed foods

immunology more details view paper
  • Downloaded 648 times
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    • Site-wide: 53,193
    • In immunology: 1,654
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    • Site-wide: 72,907
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Functional characterization and lineage analysis of broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

microbiology more details view paper
  • Downloaded 643 times
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    • Site-wide: 53,786
    • In microbiology: 3,312
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    • Site-wide: 86,663
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    • Site-wide: 93,356

Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons

neuroscience more details view paper
  • Downloaded 624 times
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    • Site-wide: 55,910
    • In neuroscience: 7,981
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    • Site-wide: 81,561
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    • Site-wide: 97,096

Molecular and Morphological Signatures of Chordate Development: Two Distinct Pathways, One Tunicate

developmental biology more details view paper
  • Downloaded 623 times
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    • Site-wide: 56,111
    • In developmental biology: 1,321
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    • Site-wide: 93,388
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    • Site-wide: 80,559

Single-cell analysis of Schistosoma mansoni reveals a conserved genetic program controlling germline stem cell fate

developmental biology more details view paper
  • Downloaded 567 times
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    • Site-wide: 63,067
    • In developmental biology: 1,525
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    • Site-wide: 74,451
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    • Site-wide: 68,536

Modeling Spatial Correlation of Transcripts With Application to Developing Pancreas

bioinformatics more details view paper
  • Downloaded 563 times
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    • Site-wide: 63,649
    • In bioinformatics: 6,154
  • Year to date:
    • Site-wide: 144,700
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    • Site-wide: 144,350

Viral Taxonomy Derived From Evolutionary Genome Relationships

genomics more details view paper
  • Downloaded 554 times
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    • Site-wide: 64,875
    • In genomics: 4,591
  • Year to date:
    • Site-wide: 145,370
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    • Site-wide: 147,119

A cell atlas of the fly kidney

developmental biology more details view paper
  • Downloaded 495 times
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    • Site-wide: 74,106
    • In developmental biology: 1,884
  • Year to date:
    • Site-wide: 16,327
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    • Site-wide: 17,184

Kinetics and Fidelity of Psychrophilic DNA Polymerases

biochemistry more details view paper
  • Downloaded 482 times
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    • Site-wide: 76,383
    • In biochemistry: 2,103
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    • Site-wide: 44,219
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    • Site-wide: 51,313

Non-invasive characterization of human bone marrow by cell free messenger-RNA reveals response to growth factor stimulation and hematopoietic reconstitution after transplantation

molecular biology more details view paper
  • Downloaded 459 times
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    • Site-wide: 80,550
    • In molecular biology: 2,348
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    • Site-wide: 159,763
  • Since beginning of last month:
    • Site-wide: 159,170

Differential Impacts on Host Transcription by ROP and GRA Effectors from the Intracellular Parasite Toxoplasma gondii

microbiology more details view paper
  • Downloaded 442 times
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    • Site-wide: 83,923
    • In microbiology: 5,599
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    • Site-wide: 130,644
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    • Site-wide: 135,963

Cell-free DNA Reveals Potential Zoonotic Reservoirs in Non-Human Primates

microbiology more details view paper
  • Downloaded 441 times
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    • Site-wide: 84,143
    • In microbiology: 5,612
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Hepatitis C Virus Infects and Perturbs Liver Stem Cells

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