Author: Yu Wang

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Preprints

SABER enables highly multiplexed and amplified detection of DNA and RNA in cells and tissues

• Downloaded 7,243 times
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  • Site-wide: 1,150
  • In genetics: 39
• Year to date:
  • Site-wide: 11,840
• Since beginning of last month:
  • Site-wide: 8,423

Highly multiplexed in situ protein imaging with signal amplification by Immuno-SABER

• Downloaded 5,635 times
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  • Site-wide: 1,604
  • In cell biology: 20
• Year to date:
  • Site-wide: 22,771
• Since beginning of last month:
  • Site-wide: 26,014

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

• Downloaded 3,951 times
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  • Site-wide: 2,613
  • In bioinformatics: 250
• Year to date:
  • Site-wide: 43,818
• Since beginning of last month:
  • Site-wide: 46,067

Modeling the language of life – Deep Learning Protein Sequences

• Downloaded 3,346 times
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  • Site-wide: 3,329
  • In bioinformatics: 347
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  • Site-wide: None
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  • Site-wide: None

ProtTrans: Towards Cracking the Language of Life’s Code Through Self-Supervised Deep Learning and High Performance Computing

• Downloaded 3,238 times
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  • Site-wide: 3,496
  • In bioinformatics: 367
• Year to date:
  • Site-wide: 694
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  • Site-wide: 754

Rapid Sequential In Situ Multiplexing With DNA-Exchange-Imaging

• Downloaded 3,187 times
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  • Site-wide: 3,576
  • In bioengineering: 35
• Year to date:
  • Site-wide: 89,753
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  • Site-wide: None

Multiplexed in situ protein imaging using DNA-barcoded antibodies with extended hybridization chain reactions

• Downloaded 2,621 times
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  • Site-wide: 4,725
  • In cell biology: 90
• Year to date:
  • Site-wide: 6,722
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  • Site-wide: 6,084

High-level correction of the sickle mutation amplified in vivo during erythroid differentiation

• Downloaded 2,285 times
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  • Site-wide: 5,774
  • In genetics: 276
• Year to date:
  • Site-wide: 14,042
• Since beginning of last month:
  • Site-wide: 10,881

Better Strategies for Containing COVID-19 Epidemics --- A Study of 25 Countries via an Extended Varying Coefficient SEIR Model

• Downloaded 1,522 times
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  • Site-wide: 10,528
  • In infectious diseases: 1,188
• Year to date:
  • Site-wide: 25,094
• Since beginning of last month:
  • Site-wide: 14,725

Single-cell transcriptome analyses recapitulate the cellular and developmental responses to abiotic stresses in rice

• Downloaded 1,175 times
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  • Site-wide: 15,522
  • In genomics: 1,636
• Year to date:
  • Site-wide: 4,769
• Since beginning of last month:
  • Site-wide: 6,939

Three dimensional nanoscopy of whole cells and tissues with in situ point spread function retrieval

• Downloaded 1,112 times
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  • Site-wide: 16,914
  • In biophysics: 424
• Year to date:
  • Site-wide: 43,944
• Since beginning of last month:
  • Site-wide: 36,146

The origin of domestication genes in goats

• Downloaded 957 times
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  • Site-wide: 21,031
  • In genomics: 2,114
• Year to date:
  • Site-wide: 81,622
• Since beginning of last month:
  • Site-wide: None

Further genetic diversification in multiple tumors and an evolutionary perspective on therapeutics

• Downloaded 802 times
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  • Site-wide: 27,027
  • In cancer biology: 697
• Year to date:
  • Site-wide: 86,667
• Since beginning of last month:
  • Site-wide: 93,040

Direct microRNA sequencing using Nanopore Induced Phase-Shift Sequencing (NIPSS)

• Downloaded 766 times
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  • Site-wide: 28,797
  • In biophysics: 868
• Year to date:
  • Site-wide: 30,121
• Since beginning of last month:
  • Site-wide: 31,541

Wide sampling of natural diversity identifies novel molecular signatures of C4 photosynthesis

• Downloaded 739 times
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  • Site-wide: 30,265
  • In plant biology: 585
• Year to date:
  • Site-wide: 86,965
• Since beginning of last month:
  • Site-wide: 86,495

Nociceptor-enriched genes required for normal thermal nociception.

• Downloaded 736 times
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  • Site-wide: 30,436
  • In neuroscience: 4,186
• Year to date:
  • Site-wide: 60,571
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  • Site-wide: 46,884

Tracing the origin of a new organ by inferring the genetic basis of rumen evolution

• Downloaded 573 times
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  • Site-wide: 42,284
  • In evolutionary biology: 2,273
• Year to date:
  • Site-wide: 31,944
• Since beginning of last month:
  • Site-wide: 59,386

Dual forms of aging-related NADPH diaphorase neurodegeneration in the sacral spinal cord of aged non-human primates

• Downloaded 434 times
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  • Site-wide: 58,260
  • In neuroscience: 8,832
• Year to date:
  • Site-wide: 88,792
• Since beginning of last month:
  • Site-wide: 98,851

The Dimer-dependent Catalytic Activity of RAF Family Kinases Is Revealed Through Characterizing Their Oncogenic Mutants

• Downloaded 431 times
• Download rankings, all-time:
  • Site-wide: 58,665
  • In cancer biology: 1,663
• Year to date:
  • Site-wide: 64,407
• Since beginning of last month:
  • Site-wide: 53,502

Transcription factor SmWRKY1 positively promote the biosynthesis of tanshinones in Salvia miltiorrhiza

• Downloaded 402 times
• Download rankings, all-time:
  • Site-wide: 63,074
  • In bioengineering: 1,146
• Year to date:
  • Site-wide: 68,037
• Since beginning of last month:
  • Site-wide: 39,801

Rapidly reversible mutations generate subclonal genetic diversity and reversible drug resistance

• Downloaded 393 times
• Download rankings, all-time:
  • Site-wide: 64,326
  • In genetics: 3,020
• Year to date:
  • Site-wide: 43,155
• Since beginning of last month:
  • Site-wide: None

Real Time Ultrasound Molecular Imaging of Prostate Cancer with PSMA-targeted Nanobubbles

• Downloaded 386 times
• Download rankings, all-time:
  • Site-wide: 65,459
  • In bioengineering: 1,190
• Year to date:
  • Site-wide: 88,369
• Since beginning of last month:
  • Site-wide: 62,642

Keratin-Based Epidermal Green Autofluorescence is a Common Biomarker of Organ Injury

• Downloaded 386 times
• Download rankings, all-time:
  • Site-wide: 65,495
  • In biophysics: 2,404
• Year to date:
  • Site-wide: 46,729
• Since beginning of last month:
  • Site-wide: 35,979

The medical education level of the administrators of the local health committees in China

• Downloaded 363 times
• Download rankings, all-time:
  • Site-wide: 69,248
  • In medical education: 38
• Year to date:
  • Site-wide: 91,746
• Since beginning of last month:
  • Site-wide: 89,462

HIV protease inhibitor Nelfinavir targets human DDI2 and potentiates proteasome inhibitor-based chemotherapy

• Downloaded 361 times
• Download rankings, all-time:
  • Site-wide: 69,592
  • In cancer biology: 2,026
• Year to date:
  • Site-wide: 70,212
• Since beginning of last month:
  • Site-wide: 60,576

Rare Loss-of-Function Mutations of PTGIR identified in Fibromuscular Dysplasia and Spontaneous Coronary Artery Dissection

• Downloaded 359 times
• Download rankings, all-time:
  • Site-wide: 70,029
  • In genetic and genomic medicine: 210
• Year to date:
  • Site-wide: 49,889
• Since beginning of last month:
  • Site-wide: 37,987

Exogenous putrescine alleviates photoinhibition caused by salt stress through increasing cyclic electron flow in cucumber

• Downloaded 346 times
• Download rankings, all-time:
  • Site-wide: 72,204
  • In plant biology: 1,934
• Year to date:
  • Site-wide: 96,454
• Since beginning of last month:
  • Site-wide: 86,439

Transcriptome Profiling of different types of human respiratory tract cells infected by SARS-CoV-2 Highlight an unique Role for Inflammatory and Interferon Response

• Downloaded 324 times
• Download rankings, all-time:
  • Site-wide: 76,141
  • In immunology: 2,071
• Year to date:
  • Site-wide: 22,139
• Since beginning of last month:
  • Site-wide: 31,060

Control of clathrin-mediated endocytosis by NIMA family kinases

• Downloaded 324 times
• Download rankings, all-time:
  • Site-wide: 76,135
  • In cell biology: 3,520
• Year to date:
  • Site-wide: 118,688
• Since beginning of last month:
  • Site-wide: 106,745

Visualizing dendritic characteristics of corticotropin-releasing hormone neurons at single-cell resolution in the whole mouse brain

• Downloaded 309 times
• Download rankings, all-time:
  • Site-wide: 79,025
  • In neuroscience: 12,255
• Year to date:
  • Site-wide: 35,192
• Since beginning of last month:
  • Site-wide: 32,891

Noninvasive prenatal test of methylmalonic academia cblC type through targeted sequencing of cell-free DNA in maternal plasma

• Downloaded 308 times
• Download rankings, all-time:
  • Site-wide: 79,254
  • In genetics: 3,675
• Year to date:
  • Site-wide: 107,469
• Since beginning of last month:
  • Site-wide: 78,607

Combining gene network, metabolic, and leaf-level models show means to future-proof soybean photosynthesis under rising CO2.

• Downloaded 308 times
• Download rankings, all-time:
  • Site-wide: 79,253
  • In plant biology: 2,135
• Year to date:
  • Site-wide: 108,486
• Since beginning of last month:
  • Site-wide: None

CRISPAltRations: a validated cloud-based approach for interrogation of double-strand break repair mediated by CRISPR genome editing

• Downloaded 278 times
• Download rankings, all-time:
  • Site-wide: 85,429
  • In bioinformatics: 7,680
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Computational Assessment of the Regulation-Modulating Potential for Noncoding Variants

• Downloaded 270 times
• Download rankings, all-time:
  • Site-wide: 87,067
  • In genomics: 5,534
• Year to date:
  • Site-wide: 91,580
• Since beginning of last month:
  • Site-wide: 64,055

Identification of PIM1 substrates reveals a role for NDRG1 in prostate cancer cellular migration and invasion

• Downloaded 262 times
• Download rankings, all-time:
  • Site-wide: 88,797
  • In cancer biology: 2,680
• Year to date:
  • Site-wide: 92,278
• Since beginning of last month:
  • Site-wide: None

The Clinical Significance and Biological Function of DPEP1 in B-cell Acute Lymphoblastic Leukemia

• Downloaded 217 times
• Download rankings, all-time:
  • Site-wide: 98,686
  • In molecular biology: 2,941
• Year to date:
  • Site-wide: 67,809
• Since beginning of last month:
  • Site-wide: 45,168

Optimization of Alginante- poly-L-lysine Microencapsules Strength by Box-Behnken Model for CHO Culture in Stirred Tank Bioreactor

• Downloaded 201 times
• Download rankings, all-time:
  • Site-wide: 102,189
  • In bioengineering: 1,956
• Year to date:
  • Site-wide: 125,209
• Since beginning of last month:
  • Site-wide: None

Early prediction of high risk gestational diabetes mellitus via machine learning models.

• Downloaded 200 times
• Download rankings, all-time:
  • Site-wide: 102,413
  • In endocrinology: 75
• Year to date:
  • Site-wide: 69,827
• Since beginning of last month:
  • Site-wide: 73,075

Mesenchymal stem cells with overexpression of Angiotensin-converting enzyme-2 improved the microenvironment and cardiac function in a rat model of myocardial infarction

• Downloaded 195 times
• Download rankings, all-time:
  • Site-wide: 103,468
  • In pharmacology and toxicology: 774
• Year to date:
  • Site-wide: 79,942
• Since beginning of last month:
  • Site-wide: None

Proteomic and Metabolomic Investigation of COVID-19 Patients with Elevated Serum Lactate Dehydrogenase

• Downloaded 193 times
• Download rankings, all-time:
  • Site-wide: 103,949
  • In respiratory medicine: 179
• Year to date:
  • Site-wide: 5,374
• Since beginning of last month:
  • Site-wide: 10,246

Characterization of the gut DNA and RNA viromes in a cohort of Chinese residents and visiting Pakistanis

• Downloaded 168 times
• Download rankings, all-time:
  • Site-wide: 109,104
  • In microbiology: 8,201
• Year to date:
  • Site-wide: 50,047
• Since beginning of last month:
  • Site-wide: 43,954

Molecular and clinicopathological characterization of a prognostic immune gene signature associated with MGMT methylation in glioblastoma

• Downloaded 161 times
• Download rankings, all-time:
  • Site-wide: 110,538
  • In cancer biology: 3,398
• Year to date:
  • Site-wide: 58,780
• Since beginning of last month:
  • Site-wide: 62,001

One-step multiple site-specific base editing by direct embryo injection for precision and pyramid pig breeding

• Downloaded 156 times
• Download rankings, all-time:
  • Site-wide: 111,453
  • In genetics: 4,897
• Year to date:
  • Site-wide: 62,520
• Since beginning of last month:
  • Site-wide: 90,459

Molecular and clinical characterization of 5mC regulators in glioma: results of a multicenter study

• Downloaded 152 times
• Download rankings, all-time:
  • Site-wide: 112,236
  • In cancer biology: 3,469
• Year to date:
  • Site-wide: 92,199
• Since beginning of last month:
  • Site-wide: 90,143

Salicylic acid mediated immune response of Citrus Sinensis to varying frequencies of herbivory and pathogen inoculation

• Downloaded 128 times
• Download rankings, all-time:
  • Site-wide: 116,927
  • In plant biology: 3,250
• Year to date:
  • Site-wide: 92,578
• Since beginning of last month:
  • Site-wide: 87,649

ICOS enhances follicular T helper responses and deteriorates the pathogenic process of liver in mice infected with Schistosoma japonicum

• Downloaded 87 times
• Download rankings, all-time:
  • Site-wide: 124,147
  • In immunology: 3,532
• Year to date:
  • Site-wide: 105,724
• Since beginning of last month:
  • Site-wide: 104,371

Trends and Patterns of Opioid Epidemic: A Large-Scale Retrospective Study of Hospital Visits with Opioid Poisoning in New York State, 2010-2016

• Downloaded 76 times
• Download rankings, all-time:
  • Site-wide: 125,770
  • In public and global health: 1,440
• Year to date:
  • Site-wide: 92,330
• Since beginning of last month:
  • Site-wide: 72,081

Screening, Identification and Growth Promotion Ability of Phosphate Solubilizing Bacteria from Soybean Rhizosphere under Maize-Soybean Intercropping Systems

• Downloaded 70 times
• Download rankings, all-time:
  • Site-wide: 126,565
  • In microbiology: 9,832
• Year to date:
  • Site-wide: 46,915
• Since beginning of last month:
  • Site-wide: 59,762

A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond Blackfan Anemia

• Downloaded 59 times
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  • Site-wide: 127,747
  • In developmental biology: 3,350
• Year to date:
  • Site-wide: 23,534
• Since beginning of last month:
  • Site-wide: 8,578

REVA as a Well-curated Database for Human Expression-modulating Variants

• Downloaded 38 times
• Download rankings, all-time:
  • Site-wide: 129,163
  • In bioinformatics: 10,204
• Year to date:
  • Site-wide: 36,384
• Since beginning of last month:
  • Site-wide: 14,442