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Author: Rui Chen

Rankings

  • All-time downloads: 41,004 (rank: 6,362 )
  • Categories:
    • bioinformatics: 4,424 (rank: 4,059 )
    • biophysics: 208 (rank: 27,008 (tie) )
    • cancer biology: 745 (rank: 20,745 (tie) )
    • cell biology: 997 (rank: 15,019 (tie) )
    • developmental biology: 2,196 (rank: 2,318 (tie) )
    • ecology: 660 (rank: 10,420 (tie) )
    • epidemiology: 612 (rank: 22,348 (tie) )
    • genetic and genomic medicine: 898 (rank: 7,361 (tie) )
    • genetics: 1,858 (rank: 12,672 (tie) )
    • genomics: 10,178 (rank: 2,505 )
    • immunology: 1,599 (rank: 11,155 (tie) )
    • microbiology: 4,254 (rank: 5,136 (tie) )
    • molecular biology: 316 (rank: 29,510 (tie) )
    • neurology: 1,090 (rank: 2,489 (tie) )
    • neuroscience: 3,205 (rank: 10,462 (tie) )
    • paleontology: 2,438 (rank: 92 (tie) )
    • physiology: 287 (rank: 11,340 (tie) )
    • plant biology: 603 (rank: 12,493 (tie) )
    • systems biology: 2,024 (rank: 2,988 )

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Preprints

Integrative single cell multiomics analysis of human retina indicates a role for hierarchical transcription factors collaboration in genetic effects on gene regulation

genomics more details view paper

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A multi-omics atlas of the human retina at single-cell resolution

genomics more details view paper

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Consequences of PCA graphs, SNP codings, and PCA variants for elucidating population structure

genomics more details view paper
  • Downloaded 8,375 times
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    • Site-wide: 1,694
    • In genomics: 123
  • Year to date:
    • Site-wide: 5,917
  • Since beginning of last month:
    • Site-wide: 3,129

Unbiased integration of single cell multi-omics data

bioinformatics more details view paper
  • Downloaded 3,129 times
  • Download rankings, all-time:
    • Site-wide: 6,716
    • In bioinformatics: 632
  • Year to date:
    • Site-wide: 13,012
  • Since beginning of last month:
    • Site-wide: 19,700

A Cretaceous bug with exaggerated antennae might be a double-edged sword in evolution

paleontology more details view paper
  • Downloaded 2,496 times
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    • Site-wide: 9,307
    • In paleontology: 9
  • Year to date:
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  • Since beginning of last month:
    • Site-wide: 31,769

Epigenomic Profiling and Single-Nucleus-RNA-Seq Reveal Cis-Regulatory Elements in Human Retina, Macula and RPE and Non-Coding Genetic Variation.

neuroscience more details view paper
  • Downloaded 2,067 times
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    • Site-wide: 12,397
    • In neuroscience: 1,221
  • Year to date:
    • Site-wide: 126,256
  • Since beginning of last month:
    • Site-wide: 64,203

Hypoxia induces a transcriptional early primitive streak signature in pluripotent cells enhancing spontaneous elongation and lineage representation in gastruloids

developmental biology more details view paper
  • Downloaded 2,011 times
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    • Site-wide: 12,905
    • In developmental biology: 186
  • Year to date:
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    • Site-wide: 20,747

An optimized 16S rRNA sequencing protocol for vaginal microbiome to avoid biased abundance estimation

microbiology more details view paper
  • Downloaded 1,985 times
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    • Site-wide: 13,163
    • In microbiology: 791
  • Year to date:
    • Site-wide: 15,370
  • Since beginning of last month:
    • Site-wide: 15,882

Single-nuclei RNA-seq on human retinal tissue provides improved transcriptome profiling.

genomics more details view paper
  • Downloaded 1,759 times
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    • Site-wide: 15,841
    • In genomics: 1,417
  • Year to date:
    • Site-wide: 99,821
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    • Site-wide: 52,981

A single-cell RNAseq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding

microbiology more details view paper
  • Downloaded 1,312 times
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    • Site-wide: 25,163
    • In microbiology: 1,406
  • Year to date:
    • Site-wide: 76,166
  • Since beginning of last month:
    • Site-wide: 78,561

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

immunology more details view paper
  • Downloaded 1,277 times
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    • Site-wide: 26,294
    • In immunology: 919
  • Year to date:
    • Site-wide: 154,843
  • Since beginning of last month:
    • Site-wide: 148,155

Network-based Translation of GWAS Findings to Pathobiology and Drug Repurposing for Alzheimer's Disease

neurology more details view paper
  • Downloaded 1,128 times
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    • Site-wide: 31,926
    • In neurology: 101
  • Year to date:
    • Site-wide: 67,504
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    • Site-wide: 103,183

Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni

microbiology more details view paper
  • Downloaded 1,098 times
  • Download rankings, all-time:
    • Site-wide: 33,329
    • In microbiology: 1,875
  • Year to date:
    • Site-wide: 110,806
  • Since beginning of last month:
    • Site-wide: 86,527

SMARCA4 regulates spatially restricted metabolic plasticity in 3D multicellular tissue

systems biology more details view paper
  • Downloaded 1,093 times
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    • Site-wide: 33,524
    • In systems biology: 620
  • Year to date:
    • Site-wide: 19,595
  • Since beginning of last month:
    • Site-wide: 56,296

Tissue-specific Gene Expression Prediction Associates Vitiligo with SUOX through an Active Enhancer

genetics more details view paper
  • Downloaded 1,082 times
  • Download rankings, all-time:
    • Site-wide: 34,045
    • In genetics: 1,328
  • Year to date:
    • Site-wide: 107,499
  • Since beginning of last month:
    • Site-wide: 185,299

iGWAS: image-based genome-wide association of self-supervised deep phenotyping of human medical images

genetic and genomic medicine more details view paper
  • Downloaded 851 times
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    • Site-wide: 49,156
    • In genetic and genomic medicine: 383
  • Year to date:
    • Site-wide: 4,469
  • Since beginning of last month:
    • Site-wide: 5,884

ADAMDEC1 maintains a novel growth factor signaling loop in cancer stem cells

cancer biology more details view paper
  • Downloaded 770 times
  • Download rankings, all-time:
    • Site-wide: 57,025
    • In cancer biology: 1,607
  • Year to date:
    • Site-wide: 141,090
  • Since beginning of last month:
    • Site-wide: 100,283

A unique and evolutionarily conserved retinal interneuron relays rod and cone input to the inner plexiform layer

neuroscience more details view paper
  • Downloaded 708 times
  • Download rankings, all-time:
    • Site-wide: 64,378
    • In neuroscience: 8,761
  • Year to date:
    • Site-wide: 140,659
  • Since beginning of last month:
    • Site-wide: 141,705

A computational model of task allocation in social insects: ecology and interactions alone can drive specialisation

ecology more details view paper
  • Downloaded 678 times
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    • Site-wide: 68,520
    • In ecology: 1,511
  • Year to date:
    • Site-wide: 195,200
  • Since beginning of last month:
    • Site-wide: 153,771

A Chemoenzymatic Method for Glycoproteomic N-glycan Type Quantitation

systems biology more details view paper
  • Downloaded 664 times
  • Download rankings, all-time:
    • Site-wide: 70,519
    • In systems biology: 1,408
  • Year to date:
    • Site-wide: 108,097
  • Since beginning of last month:
    • Site-wide: 78,540

A Scalable Algorithm for Structure Identification of Complex Gene Regulatory Network from Temporal Expression Data

bioinformatics more details view paper
  • Downloaded 563 times
  • Download rankings, all-time:
    • Site-wide: 87,197
    • In bioinformatics: 7,481
  • Year to date:
    • Site-wide: 206,890
  • Since beginning of last month:
    • Site-wide: None

A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer

cell biology more details view paper
  • Downloaded 541 times
  • Download rankings, all-time:
    • Site-wide: 91,470
    • In cell biology: 3,995
  • Year to date:
    • Site-wide: 196,686
  • Since beginning of last month:
    • Site-wide: 153,096

Epigenetic adaptation prolongs photoreceptor survival during retinal degeneration

neuroscience more details view paper
  • Downloaded 515 times
  • Download rankings, all-time:
    • Site-wide: 96,892
    • In neuroscience: 14,127
  • Year to date:
    • Site-wide: 123,041
  • Since beginning of last month:
    • Site-wide: 75,537

Characterization Of Imprinted Genes In Rice Reveals Post-Fertilization Regulation And Conservation At Some Loci Of Imprinting In Plant Species

plant biology more details view paper
  • Downloaded 509 times
  • Download rankings, all-time:
    • Site-wide: 98,232
    • In plant biology: 2,476
  • Year to date:
    • Site-wide: 195,017
  • Since beginning of last month:
    • Site-wide: 136,856

Stratified Test Accurately Identifies Differentially Expressed Genes Under Batch Effects in Single-Cell Data

bioinformatics more details view paper
  • Downloaded 502 times
  • Download rankings, all-time:
    • Site-wide: 99,740
    • In bioinformatics: 9,019
  • Year to date:
    • Site-wide: 39,717
  • Since beginning of last month:
    • Site-wide: 32,248

Air Pollution and Lipometabolic Disturbance: A Systematic Review and Meta-Analysis

epidemiology more details view paper
  • Downloaded 404 times
  • Download rankings, all-time:
    • Site-wide: 123,984
    • In epidemiology: 5,110
  • Year to date:
    • Site-wide: 118,943
  • Since beginning of last month:
    • Site-wide: 158,677

Retinal organoids derived from rhesus macaque iPSCs undergo accelerated differentiation compared to human stem cells

cell biology more details view paper
  • Downloaded 379 times
  • Download rankings, all-time:
    • Site-wide: 131,085
    • In cell biology: 5,927
  • Year to date:
    • Site-wide: 70,066
  • Since beginning of last month:
    • Site-wide: 164,928

Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control

genetics more details view paper
  • Downloaded 366 times
  • Download rankings, all-time:
    • Site-wide: 135,017
    • In genetics: 6,018
  • Year to date:
    • Site-wide: 18,176
  • Since beginning of last month:
    • Site-wide: 20,229

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

immunology more details view paper
  • Downloaded 354 times
  • Download rankings, all-time:
    • Site-wide: 138,292
    • In immunology: 4,146
  • Year to date:
    • Site-wide: 147,843
  • Since beginning of last month:
    • Site-wide: None

Quantitative Control of Noise in Mammalian Gene Expression by Dynamic Histone Regulations

molecular biology more details view paper
  • Downloaded 332 times
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    • Site-wide: 144,987
    • In molecular biology: 4,134
  • Year to date:
    • Site-wide: 170,648
  • Since beginning of last month:
    • Site-wide: 181,268

GRIPT: A novel case-control analysis method for Mendelian disease gene discovery

genomics more details view paper
  • Downloaded 331 times
  • Download rankings, all-time:
    • Site-wide: 145,230
    • In genomics: 7,455
  • Year to date:
    • Site-wide: 200,384
  • Since beginning of last month:
    • Site-wide: 184,029

Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

genetic and genomic medicine more details view paper
  • Downloaded 331 times
  • Download rankings, all-time:
    • Site-wide: 145,391
    • In genetic and genomic medicine: 1,194
  • Year to date:
    • Site-wide: 21,306
  • Since beginning of last month:
    • Site-wide: 11,801

Advanced Retinal Imaging and Ocular Parameters of the Rhesus Macaque Eye

physiology more details view paper
  • Downloaded 315 times
  • Download rankings, all-time:
    • Site-wide: 149,984
    • In physiology: 1,527
  • Year to date:
    • Site-wide: 116,462
  • Since beginning of last month:
    • Site-wide: 68,420

Integration of multidimensional splicing data and GWAS summary statistics for risk gene discovery

genetics more details view paper
  • Downloaded 310 times
  • Download rankings, all-time:
    • Site-wide: 151,529
    • In genetics: 5,806
  • Year to date:
    • Site-wide: 90,164
  • Since beginning of last month:
    • Site-wide: 181,574

A missense mutation of Ip3r1 in Dp2 mice leads to short-term mydriasis and unfolded protein response in the iris constrictor muscles

genetics more details view paper
  • Downloaded 309 times
  • Download rankings, all-time:
    • Site-wide: 151,948
    • In genetics: 5,602
  • Year to date:
    • Site-wide: 191,746
  • Since beginning of last month:
    • Site-wide: 111,403

DRAMS: A Tool to Detect and Re-Align Mixed-up Samples for Integrative Studies of Multi-omics Data

bioinformatics more details view paper
  • Downloaded 294 times
  • Download rankings, all-time:
    • Site-wide: 156,237
    • In bioinformatics: 11,804
  • Year to date:
    • Site-wide: 197,172
  • Since beginning of last month:
    • Site-wide: 130,564

SOX7 deficiency causes ventricular septal defects through its effects on endocardial-to-mesenchymal transition and the expression of Wnt4 and Bmp2

developmental biology more details view paper
  • Downloaded 257 times
  • Download rankings, all-time:
    • Site-wide: 167,100
    • In developmental biology: 4,350
  • Year to date:
    • Site-wide: 145,209
  • Since beginning of last month:
    • Site-wide: 126,768

Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe

biophysics more details view paper
  • Downloaded 241 times
  • Download rankings, all-time:
    • Site-wide: 171,566
    • In biophysics: 6,579
  • Year to date:
    • Site-wide: 34,651
  • Since beginning of last month:
    • Site-wide: 89,850

Analysis on epidemiological characteristics of 4 species natural-focal diseases in Shandong Province, China in 2009-2017: a descriptive analysis

epidemiology more details view paper
  • Downloaded 240 times
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    • Site-wide: 171,886
    • In epidemiology: 6,774
  • Year to date:
    • Site-wide: 204,897
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    • Site-wide: 202,899

Elevated colonic microbiota-associated paucimannosidic and truncated N-glycans in pediatric ulcerative colitis

systems biology more details view paper
  • Downloaded 203 times
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    • Site-wide: 181,331
    • In systems biology: 3,511
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    • Site-wide: 184,458
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    • Site-wide: 160,981

Characterizing transition cells in developmental processes from scRNA-seq data

bioinformatics more details view paper
  • Downloaded 197 times
  • Download rankings, all-time:
    • Site-wide: 182,642
    • In bioinformatics: 13,492
  • Year to date:
    • Site-wide: 46,094
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    • Site-wide: 175,634

Integrated Immunopeptidomics and Proteomics Study Reveals Imbalanced Innate and Adaptive Immune Responses to SARS-Cov-2 Infection

immunology more details view paper
  • Downloaded 184 times
  • Download rankings, all-time:
    • Site-wide: 185,535
    • In immunology: None
  • Year to date:
    • Site-wide: 50,593
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    • Site-wide: 12,461

Age-Related Changes in the Rhesus Macaque Eye

systems biology more details view paper
  • Downloaded 161 times
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    • Site-wide: 190,552
    • In systems biology: 3,624
  • Year to date:
    • Site-wide: 140,239
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    • Site-wide: 179,944

Single Cell RNA Sequencing of the Adult Drosophila Eye Reveals Distinct Clusters and Novel Marker Genes for All Major Cell Types

genomics more details view paper
  • Downloaded 147 times
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    • Site-wide: 193,136
    • In genomics: None
  • Year to date:
    • Site-wide: 66,339
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    • Site-wide: 3,189

From multi-omics data to the cancer druggable genediscovery: a novel machine learning-based approach

bioinformatics more details view paper
  • Downloaded 144 times
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    • Site-wide: 193,601
    • In bioinformatics: None
  • Year to date:
    • Site-wide: 67,618
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    • Site-wide: 35,663

OsMADS58 stabilizes gene regulatory circuits during rice stamen development

plant biology more details view paper
  • Downloaded 133 times
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    • Site-wide: 195,694
    • In plant biology: 5,318
  • Year to date:
    • Site-wide: 134,989
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    • Site-wide: 145,929

The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless

developmental biology more details view paper
  • Downloaded 132 times
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    • Site-wide: 195,885
    • In developmental biology: 4,925
  • Year to date:
    • Site-wide: 127,545
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    • Site-wide: 125,273

Kin17 drives dissociation of Mira from the centrosome in neuroblasts by regulating splicing of Flfl

cell biology more details view paper
  • Downloaded 127 times
  • Download rankings, all-time:
    • Site-wide: 196,747
    • In cell biology: 8,701
  • Year to date:
    • Site-wide: 132,260
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    • Site-wide: 192,037

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