Author: Chen Chen

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Preprints

Multi-omics profiling establishes the polypharmacology of FDA Approved CDK4/6 inhibitors and the potential for differential clinical activity

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  • Site-wide: 2,424
  • In cancer biology: 35
• Year to date:
  • Site-wide: 7,253
• Since beginning of last month:
  • Site-wide: 6,378

MVP: predicting pathogenicity of missense variants by deep learning

• Downloaded 3,628 times
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  • Site-wide: 2,953
  • In bioinformatics: 293
• Year to date:
  • Site-wide: 15,754
• Since beginning of last month:
  • Site-wide: 13,911

Clinical characteristics of 101 non-surviving hospitalized patients with COVID-19: A single center, retrospective study

• Downloaded 3,467 times
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  • Site-wide: 3,157
  • In infectious diseases: 588
• Year to date:
  • Site-wide: 7,496
• Since beginning of last month:
  • Site-wide: 5,590

Estimating the case fatality ratio of the COVID-19 epidemic in China

• Downloaded 3,132 times
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  • Site-wide: 3,664
  • In infectious diseases: 640
• Year to date:
  • Site-wide: 22,534
• Since beginning of last month:
  • Site-wide: 16,814

MINERVA: A facile strategy for SARS-CoV-2 whole genome deep sequencing of clinical samples

• Downloaded 1,817 times
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  • Site-wide: 8,054
  • In molecular biology: 205
• Year to date:
  • Site-wide: 15,277
• Since beginning of last month:
  • Site-wide: 16,484

High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

• Downloaded 1,327 times
• Download rankings, all-time:
  • Site-wide: 12,913
  • In biochemistry: 253
• Year to date:
  • Site-wide: 36,176
• Since beginning of last month:
  • Site-wide: 29,651

Life history recorded in the vagino-cervical microbiome

• Downloaded 1,145 times
• Download rankings, all-time:
  • Site-wide: 16,135
  • In microbiology: 904
• Year to date:
  • Site-wide: 37,651
• Since beginning of last month:
  • Site-wide: 54,247

Cryo-ET reveals nucleosome reorganization in condensed mitotic chromosomes in vivo

• Downloaded 979 times
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  • Site-wide: 20,324
  • In cell biology: 710
• Year to date:
  • Site-wide: 49,968
• Since beginning of last month:
  • Site-wide: 64,532

Extension of the in vivo haploid induction system from maize to wheat

• Downloaded 972 times
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  • Site-wide: 20,558
  • In plant biology: 338
• Year to date:
  • Site-wide: 94,022
• Since beginning of last month:
  • Site-wide: None

A VTA GABAergic neural circuit mediates visually evoked innate defensive responses

• Downloaded 855 times
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  • Site-wide: 24,718
  • In neuroscience: 3,277
• Year to date:
  • Site-wide: 32,071
• Since beginning of last month:
  • Site-wide: 29,538

An Mtb-Human Protein-Protein Interaction Map Reveals that Bacterial LpqN Antagonizes CBL, a Host Ubiquitin Ligase that Regulates the Balance Between Anti-Viral and Anti-Bacterial Responses

• Downloaded 829 times
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  • Site-wide: 25,794
  • In microbiology: 1,494
• Year to date:
  • Site-wide: 77,331
• Since beginning of last month:
  • Site-wide: 90,137

Budding yeast chromatin is dispersed in a crowded nucleoplasm in vivo

• Downloaded 759 times
• Download rankings, all-time:
  • Site-wide: 29,142
  • In cell biology: 1,110
• Year to date:
  • Site-wide: 56,431
• Since beginning of last month:
  • Site-wide: 59,603

A collection of yeast cellular electron cryotomography data

• Downloaded 749 times
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  • Site-wide: 29,709
  • In cell biology: 1,137
• Year to date:
  • Site-wide: 82,750
• Since beginning of last month:
  • Site-wide: 72,667

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

• Downloaded 699 times
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  • Site-wide: 32,674
  • In immunology: 892
• Year to date:
  • Site-wide: 54,529
• Since beginning of last month:
  • Site-wide: None

Natural Chromatin Is Heterogeneous And Self Associates In Vitro

• Downloaded 613 times
• Download rankings, all-time:
  • Site-wide: 38,867
  • In cell biology: 1,598
• Year to date:
  • Site-wide: 97,012
• Since beginning of last month:
  • Site-wide: 96,125

Abusers indoors and coronavirus outside: an examination of public discourse about COVID-19 and family violence on Twitter using machine learning

• Downloaded 613 times
• Download rankings, all-time:
  • Site-wide: 38,815
  • In public and global health: 523
• Year to date:
  • Site-wide: 22,136
• Since beginning of last month:
  • Site-wide: 15,423

Characterization of glutamatergic VTA neural population responses to aversive and rewarding conditioning in freely-moving mice

• Downloaded 604 times
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  • Site-wide: 39,543
  • In neuroscience: 5,678
• Year to date:
  • Site-wide: None
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  • Site-wide: None

A group of nuclear factor Y transcription factors are likely sub-functionalized in the endosperm development of monocot

• Downloaded 604 times
• Download rankings, all-time:
  • Site-wide: 39,511
  • In plant biology: 858
• Year to date:
  • Site-wide: 107,789
• Since beginning of last month:
  • Site-wide: None

Pregnancy reprograms the enhancer landscape of mammary epithelial cells and alters the response to cMYC-driven oncogenesis

• Downloaded 573 times
• Download rankings, all-time:
  • Site-wide: 42,225
  • In molecular biology: 1,214
• Year to date:
  • Site-wide: 100,825
• Since beginning of last month:
  • Site-wide: 74,846

Accelerated Protein Biomarker Discovery from FFPE tissue samples using Single-shot, Short Gradient Microflow SWATH MS

• Downloaded 560 times
• Download rankings, all-time:
  • Site-wide: 43,447
  • In cancer biology: 1,211
• Year to date:
  • Site-wide: 41,277
• Since beginning of last month:
  • Site-wide: 32,339

Contrasting determinants of mutation rates in germline and soma

• Downloaded 549 times
• Download rankings, all-time:
  • Site-wide: 44,653
  • In evolutionary biology: 2,402
• Year to date:
  • Site-wide: 123,018
• Since beginning of last month:
  • Site-wide: None

Combination of deep neural network with attention mechanism enhances the explainability of protein contact prediction

• Downloaded 530 times
• Download rankings, all-time:
  • Site-wide: 46,567
  • In bioinformatics: 4,919
• Year to date:
  • Site-wide: 13,410
• Since beginning of last month:
  • Site-wide: 11,699

A multi-scale model of the yeast chromosome-segregation system

• Downloaded 522 times
• Download rankings, all-time:
  • Site-wide: 47,381
  • In cell biology: 2,053
• Year to date:
  • Site-wide: 118,804
• Since beginning of last month:
  • Site-wide: None

The characteristics and death risk factors of 132 COVID-19 pneumonia patients with comorbidities: a retrospective single center analysis in Wuhan, China

• Downloaded 495 times
• Download rankings, all-time:
  • Site-wide: 50,363
  • In public and global health: 628
• Year to date:
  • Site-wide: 79,064
• Since beginning of last month:
  • Site-wide: 47,903

Inflammation Level Severity and Death in Patients With COVID-19: A Rapid Systematic Review and Meta-Analysis

• Downloaded 471 times
• Download rankings, all-time:
  • Site-wide: 53,257
  • In cardiovascular medicine: 72
• Year to date:
  • Site-wide: 58,235
• Since beginning of last month:
  • Site-wide: 70,051

The female urinary microbiota in relation to the reproductive tract microbiota

• Downloaded 454 times
• Download rankings, all-time:
  • Site-wide: 55,515
  • In microbiology: 3,606
• Year to date:
  • Site-wide: 41,310
• Since beginning of last month:
  • Site-wide: 39,377

Characterization Of Imprinted Genes In Rice Reveals Post-Fertilization Regulation And Conservation At Some Loci Of Imprinting In Plant Species

• Downloaded 444 times
• Download rankings, all-time:
  • Site-wide: 56,792
  • In plant biology: 1,428
• Year to date:
  • Site-wide: 107,781
• Since beginning of last month:
  • Site-wide: 79,441

HiAlc Klebsiella pneumonia, one of potential chief culprits of non-alcoholic fatty liver disease: through generation of endogenous ethanol

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 57,251
  • In microbiology: 3,730
• Year to date:
  • Site-wide: 50,183
• Since beginning of last month:
  • Site-wide: 26,847

Tuning movement for sensing in an uncertain world

• Downloaded 424 times
• Download rankings, all-time:
  • Site-wide: 59,523
  • In bioinformatics: 5,935
• Year to date:
  • Site-wide: 42,904
• Since beginning of last month:
  • Site-wide: 61,975

Genomic selection to optimize doubled haploid-based hybrid breeding in maize

• Downloaded 379 times
• Download rankings, all-time:
  • Site-wide: 66,480
  • In genetics: 3,121
• Year to date:
  • Site-wide: 32,587
• Since beginning of last month:
  • Site-wide: 34,752

Functional divergence of two duplicated Fertilization Independent Endosperm genes in rice with respect to seed development

• Downloaded 366 times
• Download rankings, all-time:
  • Site-wide: 68,683
  • In plant biology: 1,822
• Year to date:
  • Site-wide: 76,226
• Since beginning of last month:
  • Site-wide: 66,675

Genetic effect of type 2 Diabetes to the progression of Neurological Diseases

• Downloaded 296 times
• Download rankings, all-time:
  • Site-wide: 81,443
  • In bioinformatics: 7,434
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

RNA Polymerase II Independent Recruitment of SPT6 at Transcription Start Sites in Arabidopsis

• Downloaded 291 times
• Download rankings, all-time:
  • Site-wide: 82,576
  • In molecular biology: 2,450
• Year to date:
  • Site-wide: 72,291
• Since beginning of last month:
  • Site-wide: 65,668

DNA methylation is indispensable for leukemia inhibitory factor dependent embryonic stem cells reprogramming

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 83,436
  • In cell biology: 3,891
• Year to date:
  • Site-wide: 48,439
• Since beginning of last month:
  • Site-wide: 70,621

Antimicrobial Efficacy and Safety of a Novel Gas Plasma-Activated Catheter Lock Solution

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 84,391
  • In microbiology: 5,974
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Glutamatergic and GABAergic neuronal populations in the dorsolateral Periacqueductual Gray have different functional roles in fear conditioning

• Downloaded 243 times
• Download rankings, all-time:
  • Site-wide: 92,644
  • In neuroscience: 14,520
• Year to date:
  • Site-wide: 118,568
• Since beginning of last month:
  • Site-wide: 105,283

A cross-sectional analysis of demographic and behavioral risk factors of SARS-CoV-2 antibody positivity among a sample of U.S. college students

• Downloaded 235 times
• Download rankings, all-time:
  • Site-wide: 94,549
  • In epidemiology: 3,826
• Year to date:
  • Site-wide: 3,809
• Since beginning of last month:
  • Site-wide: 2,646

RNF219 interacts with CCR4-NOT in regulating stem cell differentiation

• Downloaded 206 times
• Download rankings, all-time:
  • Site-wide: 100,789
  • In molecular biology: 3,012
• Year to date:
  • Site-wide: 45,929
• Since beginning of last month:
  • Site-wide: None

Dynamic Changes of G-CSF etc. Nine Cytokines in Mouse Bloodstream Infection Models of Staphylococcus aureus and Klebsiella pneumoniae and their Clinical Performances

• Downloaded 165 times
• Download rankings, all-time:
  • Site-wide: 109,405
  • In microbiology: 8,228
• Year to date:
  • Site-wide: 117,325
• Since beginning of last month:
  • Site-wide: 104,764

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation.

• Downloaded 163 times
• Download rankings, all-time:
  • Site-wide: 109,768
  • In developmental biology: 2,969
• Year to date:
  • Site-wide: 46,149
• Since beginning of last month:
  • Site-wide: 36,026

Personalized vagino-cervical microbiome dynamics after oral probiotics

• Downloaded 160 times
• Download rankings, all-time:
  • Site-wide: 110,317
  • In microbiology: 8,313
• Year to date:
  • Site-wide: 69,091
• Since beginning of last month:
  • Site-wide: 100,258

Strong reduction of distal colorectal cancer incidence and mortality but no reduction of proximal colon cancer after screening colonoscopy: prospective cohort study

• Downloaded 130 times
• Download rankings, all-time:
  • Site-wide: 115,979
  • In epidemiology: 4,708
• Year to date:
  • Site-wide: 90,685
• Since beginning of last month:
  • Site-wide: 46,480

Generating Ensembles of Gene Regulatory Networks to Assess Robustness of Disease Modules

• Downloaded 117 times
• Download rankings, all-time:
  • Site-wide: 118,429
  • In bioinformatics: 9,656
• Year to date:
  • Site-wide: 46,079
• Since beginning of last month:
  • Site-wide: 36,465

Identification of a new orthonairovirus associated with human febrile illness in China

• Downloaded 114 times
• Download rankings, all-time:
  • Site-wide: 118,993
  • In microbiology: 9,109
• Year to date:
  • Site-wide: None
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  • Site-wide: None