Author: Chen Chen

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Preprints

Multi-omics profiling establishes the polypharmacology of FDA Approved CDK4/6 inhibitors and the potential for differential clinical activity

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  • Site-wide: 3,151
  • In cancer biology: 38
• Year to date:
  • Site-wide: 6,779
• Since beginning of last month:
  • Site-wide: 28,373

MVP: predicting pathogenicity of missense variants by deep learning

• Downloaded 3,961 times
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  • Site-wide: 3,887
  • In bioinformatics: 337
• Year to date:
  • Site-wide: 46,380
• Since beginning of last month:
  • Site-wide: 31,605

Clinical characteristics of 101 non-surviving hospitalized patients with COVID-19: A single center, retrospective study

• Downloaded 3,954 times
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  • Site-wide: 3,895
  • In infectious diseases: 856
• Year to date:
  • Site-wide: 12,897
• Since beginning of last month:
  • Site-wide: 25,963

Estimating the case fatality ratio of the COVID-19 epidemic in China

• Downloaded 3,484 times
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  • Site-wide: 4,670
  • In infectious diseases: 968
• Year to date:
  • Site-wide: 18,967
• Since beginning of last month:
  • Site-wide: 33,208

MINERVA: A facile strategy for SARS-CoV-2 whole genome deep sequencing of clinical samples

• Downloaded 2,022 times
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  • Site-wide: 10,280
  • In molecular biology: 258
• Year to date:
  • Site-wide: 49,799
• Since beginning of last month:
  • Site-wide: 50,193

Global Prevalence of Post-Acute Sequelae of COVID-19 (PASC) or Long COVID: A Meta-Analysis and Systematic Review

• Downloaded 1,764 times
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  • Site-wide: 12,570
  • In epidemiology: 952
• Year to date:
  • Site-wide: 1,009
• Since beginning of last month:
  • Site-wide: 1,389

High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

• Downloaded 1,489 times
• Download rankings, all-time:
  • Site-wide: 16,286
  • In biochemistry: 334
• Year to date:
  • Site-wide: 24,918
• Since beginning of last month:
  • Site-wide: 41,132

Life history recorded in the vagino-cervical microbiome

• Downloaded 1,302 times
• Download rankings, all-time:
  • Site-wide: 19,926
  • In microbiology: 1,156
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 81,837

Extension of the in vivo haploid induction system from maize to wheat

• Downloaded 1,123 times
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  • Site-wide: 24,981
  • In plant biology: 374
• Year to date:
  • Site-wide: 135,544
• Since beginning of last month:
  • Site-wide: 20,886

Cryo-ET reveals nucleosome reorganization in condensed mitotic chromosomes in vivo

• Downloaded 1,051 times
• Download rankings, all-time:
  • Site-wide: 27,632
  • In cell biology: 1,003
• Year to date:
  • Site-wide: 136,717
• Since beginning of last month:
  • Site-wide: 155,458

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

• Downloaded 937 times
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  • Site-wide: 32,716
  • In immunology: 1,094
• Year to date:
  • Site-wide: 38,314
• Since beginning of last month:
  • Site-wide: 44,744

A VTA GABAergic neural circuit mediates visually evoked innate defensive responses

• Downloaded 933 times
• Download rankings, all-time:
  • Site-wide: 32,932
  • In neuroscience: 4,255
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 148,286

An Mtb-Human Protein-Protein Interaction Map Reveals that Bacterial LpqN Antagonizes CBL, a Host Ubiquitin Ligase that Regulates the Balance Between Anti-Viral and Anti-Bacterial Responses

• Downloaded 918 times
• Download rankings, all-time:
  • Site-wide: 33,719
  • In microbiology: 1,981
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 159,905

Budding yeast chromatin is dispersed in a crowded nucleoplasm in vivo

• Downloaded 852 times
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  • Site-wide: 37,545
  • In cell biology: 1,443
• Year to date:
  • Site-wide: 136,304
• Since beginning of last month:
  • Site-wide: 102,185

Abusers indoors and coronavirus outside: an examination of public discourse about COVID-19 and family violence on Twitter using machine learning

• Downloaded 838 times
• Download rankings, all-time:
  • Site-wide: 38,497
  • In public and global health: 705
• Year to date:
  • Site-wide: 68,427
• Since beginning of last month:
  • Site-wide: 34,029

Accelerated Protein Biomarker Discovery from FFPE tissue samples using Single-shot, Short Gradient Microflow SWATH MS

• Downloaded 823 times
• Download rankings, all-time:
  • Site-wide: 39,541
  • In cancer biology: 1,065
• Year to date:
  • Site-wide: 75,083
• Since beginning of last month:
  • Site-wide: 33,439

A collection of yeast cellular electron cryotomography data

• Downloaded 799 times
• Download rankings, all-time:
  • Site-wide: 41,234
  • In cell biology: 1,622
• Year to date:
  • Site-wide: 134,766
• Since beginning of last month:
  • Site-wide: 101,508

Combination of deep neural network with attention mechanism enhances the explainability of protein contact prediction

• Downloaded 781 times
• Download rankings, all-time:
  • Site-wide: 42,634
  • In bioinformatics: 4,442
• Year to date:
  • Site-wide: 116,492
• Since beginning of last month:
  • Site-wide: 90,459

Characterization of glutamatergic VTA neural population responses to aversive and rewarding conditioning in freely-moving mice

• Downloaded 725 times
• Download rankings, all-time:
  • Site-wide: 47,345
  • In neuroscience: 6,502
• Year to date:
  • Site-wide: 44,723
• Since beginning of last month:
  • Site-wide: 69,836

METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs

• Downloaded 706 times
• Download rankings, all-time:
  • Site-wide: 49,104
  • In molecular biology: 1,377
• Year to date:
  • Site-wide: 27,901
• Since beginning of last month:
  • Site-wide: 14,575

Natural Chromatin Is Heterogeneous And Self Associates In Vitro

• Downloaded 687 times
• Download rankings, all-time:
  • Site-wide: 51,061
  • In cell biology: 2,148
• Year to date:
  • Site-wide: 136,462
• Since beginning of last month:
  • Site-wide: 143,277

Pregnancy reprograms the enhancer landscape of mammary epithelial cells and alters the response to cMYC-driven oncogenesis

• Downloaded 676 times
• Download rankings, all-time:
  • Site-wide: 52,148
  • In molecular biology: 1,483
• Year to date:
  • Site-wide: 137,751
• Since beginning of last month:
  • Site-wide: 122,895

The characteristics and death risk factors of 132 COVID-19 pneumonia patients with comorbidities: a retrospective single center analysis in Wuhan, China

• Downloaded 670 times
• Download rankings, all-time:
  • Site-wide: 52,833
  • In public and global health: 876
• Year to date:
  • Site-wide: 67,855
• Since beginning of last month:
  • Site-wide: 57,224

A group of nuclear factor Y transcription factors are likely sub-functionalized in the endosperm development of monocot

• Downloaded 665 times
• Download rankings, all-time:
  • Site-wide: 53,369
  • In plant biology: 1,180
• Year to date:
  • Site-wide: 76,796
• Since beginning of last month:
  • Site-wide: 101,991

Inflammation Level Severity and Death in Patients With COVID-19: A Rapid Systematic Review and Meta-Analysis

• Downloaded 629 times
• Download rankings, all-time:
  • Site-wide: 57,480
  • In cardiovascular medicine: 105
• Year to date:
  • Site-wide: 90,718
• Since beginning of last month:
  • Site-wide: 84,088

The female urinary microbiota in relation to the reproductive tract microbiota

• Downloaded 619 times
• Download rankings, all-time:
  • Site-wide: 58,629
  • In microbiology: 3,624
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 99,770

Contrasting determinants of mutation rates in germline and soma

• Downloaded 604 times
• Download rankings, all-time:
  • Site-wide: 60,564
  • In evolutionary biology: 2,922
• Year to date:
  • Site-wide: 103,435
• Since beginning of last month:
  • Site-wide: 117,304

Genomic selection to optimize doubled haploid-based hybrid breeding in maize

• Downloaded 599 times
• Download rankings, all-time:
  • Site-wide: 61,290
  • In genetics: 2,563
• Year to date:
  • Site-wide: 25,571
• Since beginning of last month:
  • Site-wide: 109,766

A multi-scale model of the yeast chromosome-segregation system

• Downloaded 555 times
• Download rankings, all-time:
  • Site-wide: 67,266
  • In cell biology: 2,963
• Year to date:
  • Site-wide: 136,974
• Since beginning of last month:
  • Site-wide: 143,080

A genotype independent DMP-HI system in dicot crops

• Downloaded 553 times
• Download rankings, all-time:
  • Site-wide: 67,544
  • In plant biology: 1,637
• Year to date:
  • Site-wide: 12,346
• Since beginning of last month:
  • Site-wide: 9,171

Tuning movement for sensing in an uncertain world

• Downloaded 545 times
• Download rankings, all-time:
  • Site-wide: 68,787
  • In bioinformatics: 6,507
• Year to date:
  • Site-wide: 74,228
• Since beginning of last month:
  • Site-wide: 87,643

Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike protein and the human ACE2 receptor

• Downloaded 543 times
• Download rankings, all-time:
  • Site-wide: 68,979
  • In biophysics: 2,427
• Year to date:
  • Site-wide: 55,765
• Since beginning of last month:
  • Site-wide: 25,353

HiAlc Klebsiella pneumonia, one of potential chief culprits of non-alcoholic fatty liver disease: through generation of endogenous ethanol

• Downloaded 530 times
• Download rankings, all-time:
  • Site-wide: 71,065
  • In microbiology: 4,553
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 147,127

Functional divergence of two duplicated Fertilization Independent Endosperm genes in rice with respect to seed development

• Downloaded 481 times
• Download rankings, all-time:
  • Site-wide: 79,328
  • In plant biology: 2,017
• Year to date:
  • Site-wide: 142,725
• Since beginning of last month:
  • Site-wide: 81,056

Characterization Of Imprinted Genes In Rice Reveals Post-Fertilization Regulation And Conservation At Some Loci Of Imprinting In Plant Species

• Downloaded 473 times
• Download rankings, all-time:
  • Site-wide: 80,805
  • In plant biology: 2,052
• Year to date:
  • Site-wide: 104,079
• Since beginning of last month:
  • Site-wide: 102,005

Genetic effect of type 2 Diabetes to the progression of Neurological Diseases

• Downloaded 455 times
• Download rankings, all-time:
  • Site-wide: 84,260
  • In bioinformatics: 7,567
• Year to date:
  • Site-wide: 80,671
• Since beginning of last month:
  • Site-wide: 41,078

A cross-sectional analysis of demographic and behavioral risk factors of SARS-CoV-2 antibody positivity among a sample of U.S. college students

• Downloaded 433 times
• Download rankings, all-time:
  • Site-wide: 88,834
  • In epidemiology: 3,870
• Year to date:
  • Site-wide: 91,022
• Since beginning of last month:
  • Site-wide: 142,275

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation.

• Downloaded 408 times
• Download rankings, all-time:
  • Site-wide: 94,035
  • In developmental biology: 2,507
• Year to date:
  • Site-wide: 119,049
• Since beginning of last month:
  • Site-wide: 65,817

One viral sequence for each host? - The neglected within-host diversity as the main stage of SARS-CoV-2 evolution

• Downloaded 407 times
• Download rankings, all-time:
  • Site-wide: 94,448
  • In evolutionary biology: 4,671
• Year to date:
  • Site-wide: 70,074
• Since beginning of last month:
  • Site-wide: 39,243

Systems-wide Analysis Revealed Shared and Unique Responses to Moderate and Acute High Temperatures in the Green Alga Chlamydomonas reinhardtii

• Downloaded 398 times
• Download rankings, all-time:
  • Site-wide: 96,435
  • In cell biology: 4,431
• Year to date:
  • Site-wide: 5,784
• Since beginning of last month:
  • Site-wide: 32,462

DNA methylation is indispensable for leukemia inhibitory factor dependent embryonic stem cells reprogramming

• Downloaded 372 times
• Download rankings, all-time:
  • Site-wide: 102,322
  • In cell biology: 4,726
• Year to date:
  • Site-wide: 127,968
• Since beginning of last month:
  • Site-wide: 137,774

RNA Polymerase II Independent Recruitment of SPT6 at Transcription Start Sites in Arabidopsis

• Downloaded 359 times
• Download rankings, all-time:
  • Site-wide: 105,515
  • In molecular biology: 3,126
• Year to date:
  • Site-wide: 148,290
• Since beginning of last month:
  • Site-wide: 162,748

Aging metrics incorporating cognitive and physical function capture mortality risk: results from three prospective cohort studies

• Downloaded 347 times
• Download rankings, all-time:
  • Site-wide: 108,690
  • In geriatric medicine: 86
• Year to date:
  • Site-wide: 42,332
• Since beginning of last month:
  • Site-wide: 53,270

Antimicrobial Efficacy and Safety of a Novel Gas Plasma-Activated Catheter Lock Solution

• Downloaded 338 times
• Download rankings, all-time:
  • Site-wide: 110,848
  • In microbiology: 7,747
• Year to date:
  • Site-wide: 78,823
• Since beginning of last month:
  • Site-wide: 125,726

RNF219 interacts with CCR4-NOT in regulating stem cell differentiation

• Downloaded 323 times
• Download rankings, all-time:
  • Site-wide: 114,877
  • In molecular biology: 3,397
• Year to date:
  • Site-wide: 123,440
• Since beginning of last month:
  • Site-wide: 73,610

Identification of a new orthonairovirus associated with human febrile illness in China

• Downloaded 318 times
• Download rankings, all-time:
  • Site-wide: 116,201
  • In microbiology: 8,181
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 128,050

Glutamatergic and GABAergic neuronal populations in the dorsolateral Periacqueductual Gray have different functional roles in fear conditioning

• Downloaded 317 times
• Download rankings, all-time:
  • Site-wide: 116,425
  • In neuroscience: 17,381
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 131,758

Personalized vagino-cervical microbiome dynamics after oral probiotics

• Downloaded 272 times
• Download rankings, all-time:
  • Site-wide: 128,673
  • In microbiology: 9,245
• Year to date:
  • Site-wide: 124,143
• Since beginning of last month:
  • Site-wide: 133,444

Strong reduction of distal colorectal cancer incidence and mortality but no reduction of proximal colon cancer after screening colonoscopy: prospective cohort study

• Downloaded 262 times
• Download rankings, all-time:
  • Site-wide: 131,346
  • In epidemiology: 5,544
• Year to date:
  • Site-wide: 19,904
• Since beginning of last month:
  • Site-wide: 85,787

Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis

• Downloaded 239 times
• Download rankings, all-time:
  • Site-wide: 137,414
  • In developmental biology: 3,710
• Year to date:
  • Site-wide: 24,186
• Since beginning of last month:
  • Site-wide: 24,976

Dynamic Changes of G-CSF etc. Nine Cytokines in Mouse Bloodstream Infection Models of Staphylococcus aureus and Klebsiella pneumoniae and their Clinical Performances

• Downloaded 230 times
• Download rankings, all-time:
  • Site-wide: 139,756
  • In microbiology: 10,223
• Year to date:
  • Site-wide: 137,538
• Since beginning of last month:
  • Site-wide: 151,922

Generating Ensembles of Gene Regulatory Networks to Assess Robustness of Disease Modules

• Downloaded 228 times
• Download rankings, all-time:
  • Site-wide: 140,256
  • In bioinformatics: 10,993
• Year to date:
  • Site-wide: 115,110
• Since beginning of last month:
  • Site-wide: 89,685

High-risk alcohol consumption may increase the risk of SARS-CoV-2 seroconversion: a prospective seroepidemiologic cohort study among American college students

• Downloaded 220 times
• Download rankings, all-time:
  • Site-wide: 142,404
  • In epidemiology: 5,969
• Year to date:
  • Site-wide: 32,768
• Since beginning of last month:
  • Site-wide: 78,765

Pre-diabetes increases tuberculosis disease severity, while high body fat without impaired glucose tolerance is protective

• Downloaded 214 times
• Download rankings, all-time:
  • Site-wide: 143,959
  • In immunology: 4,386
• Year to date:
  • Site-wide: 53,929
• Since beginning of last month:
  • Site-wide: 116,159

Virtual Exam for Parkinson's Disease Enables Frequent and Reliable Measurements of Motor Function

• Downloaded 148 times
• Download rankings, all-time:
  • Site-wide: 158,807
  • In neurology: 941
• Year to date:
  • Site-wide: 1,654
• Since beginning of last month:
  • Site-wide: 11,140

High blood uric acid is associated with reduced risks of mild cognitive impairment among older adults in China: a 9-year prospective cohort study

• Downloaded 126 times
• Download rankings, all-time:
  • Site-wide: 162,829
  • In epidemiology: 6,741
• Year to date:
  • Site-wide: 95,595
• Since beginning of last month:
  • Site-wide: 42,079

Predictive utility of mortality by aging measures at different hierarchical levels and the response to modifiable lifestyle factors:Implications for geroprotective programs

• Downloaded 84 times
• Download rankings, all-time:
  • Site-wide: 168,474
  • In geriatric medicine: 119
• Year to date:
  • Site-wide: 24,678
• Since beginning of last month:
  • Site-wide: 11,058

Does healthy lifestyle attenuate the detrimental effects of urinary polycyclic aromatic hydrocarbons on phenotypic aging? An analysis from NHANES 2001-2010

• Downloaded 74 times
• Download rankings, all-time:
  • Site-wide: 169,399
  • In epidemiology: 6,942
• Year to date:
  • Site-wide: 7,066
• Since beginning of last month:
  • Site-wide: 12,532