Author: Yu Zhang

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Preprints

Mitochondrial Genome Analysis and Phylogeny and Divergence Time Evaluation of the Strix aluco

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The respiratory sound features of COVID-19 patients fill gaps between clinical data and screening methods

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Clinical observations of low molecular weight heparin in relieving inflammation in COVID-19 patients: A retrospective cohort study

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  • Site-wide: 1,208
  • In pharmacology and therapeutics: 4
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  • Site-wide: 52,982

Transmission of corona virus disease 2019 during the incubation period may lead to a quarantine loophole

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  • Site-wide: 2,818
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Survival analysis of hospital length of stay of novel coronavirus (COVID-19) pneumonia patients in Sichuan, China

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  • Site-wide: 5,447
  • In health policy: 25
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  • Site-wide: 10,480

Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase: pseudouridimycin

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  • Site-wide: 7,343
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Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

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  • Site-wide: 7,674
  • In genetics: 280
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Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation Fetus

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  • Site-wide: 8,199
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Cross-type Biomedical Named Entity Recognition with Deep Multi-Task Learning

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  • Site-wide: 76,158

The changing mouse embryo transcriptome at whole tissue and single-cell resolution

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  • Site-wide: 126,183

Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model

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Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs

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  • Site-wide: 16,389
  • In developmental biology: 235
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Multi-omics approach identifies novel age-, time- and treatment-related immunopathological signatures in MIS-C and pediatric COVID-19

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  • Site-wide: 33,372
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  • Site-wide: 19,587

First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-rays

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Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance

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The polyploid state plays a tumor suppressive role in the liver

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Dissociable Roles of Pallidal Neuron Subtypes in Regulating Motor Patterns

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Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions

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  • Site-wide: 25,036
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An atlas of infiltrated B-lymphocytes in breast cancer revealed by paired single-cell RNA-sequencing and antigen receptor profiling

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  • Site-wide: 25,806
  • In immunology: 939
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The origin of domestication genes in goats

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S3norm: simultaneous normalization of sequencing depth and signal-to-noise ratio in epigenomic data

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  • Site-wide: 28,654
  • In bioinformatics: 3,114
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  • Site-wide: 24,186

Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation

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  • Site-wide: 29,048
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Hierarchical Domain Structure Reveals the Divergence of Activity among TADs and Boundaries

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  • Site-wide: 29,896
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An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis

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  • Site-wide: 30,871
  • In genomics: 2,579
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  • Site-wide: 154,283

Gene modules associated with human diseases revealed by network analysis

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  • Site-wide: 32,415
  • In systems biology: 590
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  • Site-wide: 46,080
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  • Site-wide: 117,323

Neurobehavioural Correlates of Obesity are Largely Heritable

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  • Site-wide: 33,878
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  • Site-wide: 91,508

Functional Annotation of Human Cognitive States using Deep Graph Convolution

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  • Site-wide: 34,161
  • In neuroscience: 4,287
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  • Site-wide: 154,774
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  • Site-wide: 128,532

Frequency of mutations in 21 hereditary breast and ovarian cancer susceptibility genes among high-risk Chinese individuals

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  • Site-wide: 34,342
  • In cancer biology: 937
• Year to date:
  • Site-wide: 37,741
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  • Site-wide: 59,987

Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19

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  • Site-wide: 34,460
  • In genetic and genomic medicine: 224
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  • Site-wide: 11,557
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  • Site-wide: 16,668

Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition

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  • Site-wide: 34,832
  • In molecular biology: 925
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  • Site-wide: 197,934
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  • Site-wide: 177,012

QUBIC2: A novel biclustering algorithm for large-scale bulk RNA-sequencing and single-cell RNA-sequencing data analysis

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  • Site-wide: 35,229
  • In bioinformatics: 3,717
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  • Site-wide: 196,047
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  • Site-wide: 155,111

A Novel AuNPs-based Glucose Oxidase Mimic with Enhanced Activity and Selectivity Constructed by Molecular Imprinting and O2-Containing Nanoemulsion Embedding

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  • Site-wide: 35,387
  • In biochemistry: 842
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  • Site-wide: 30,584
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  • Site-wide: 143,111

Anatomical And Functional Organization Of The Human Substantia Nigra And Its Connections

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  • Site-wide: 36,600
  • In neuroscience: 4,819
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  • Site-wide: 174,260

"CapZyme-Seq" comprehensively defines promoter-sequence determinants for RNA 5' capping with NAD+

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  • Site-wide: 38,100
  • In biochemistry: 927
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  • Site-wide: 137,861
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  • Site-wide: 119,129

Diffusion Tensor Tractography of Brainstem Fibers and Its Application in Pain

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  • Site-wide: 38,285
  • In neuroscience: 4,981
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  • Site-wide: 155,417

Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19

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  • Site-wide: 39,637
  • In infectious diseases: 3,402
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  • Site-wide: 13,954

Progressive domain segregation in early embryonic development and underlying correlation to genetic and epigenetic changes

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  • Site-wide: 41,729
  • In developmental biology: 825
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Bayesian Modeling of Epigenetic Variation in Multiple Human Cell Types

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  • Site-wide: 42,208
  • In bioinformatics: 4,337
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Dimensionality reduction by UMAP reinforces sample heterogeneity analysis in bulk transcriptomic data

• Downloaded 951 times
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  • Site-wide: 43,156
  • In bioinformatics: 4,475
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  • Site-wide: 50,061

Unraveling reproducible dynamic states of individual brain functional parcellation

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  • Site-wide: 44,404
  • In neuroscience: 5,807
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  • Site-wide: 152,936
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  • Site-wide: 81,870

Treatment with human umbilical cord-derived mesenchymal stem cells for COVID-19 patients with lung damage: a randomised, double-blind, placebo controlled phase 2 trial

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  • Site-wide: 44,682
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Profiling Mouse Brown and White Adipocytes to Identify Metabolically Relevant Small ORFs and Functional Microproteins

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Chromatin Interaction Neural Network (ChINN): A machine learning-based method for predicting chromatin interactions from DNA sequences

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  • Site-wide: 47,740
  • In bioinformatics: 4,822
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  • Site-wide: 167,924

Snapshot: clustering and visualizing epigenetic history during cell differentiation

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  • Site-wide: 50,110
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The adenosine analogue prodrug ATV006 is orally bioavailable and has potent preclinical efficacy against SARS-CoV-2 and its variants

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Uncovering the Genetic Profiles Underlying the Intrinsic Organization of the Human Cerebellum

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LTMG: A novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data

• Downloaded 792 times
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  • Site-wide: 57,063
  • In bioinformatics: 5,603
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  • Site-wide: 90,103

MS2 RNA aptamer enhances prime editing in rice

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  • Site-wide: 58,979
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  • Site-wide: 28,630

Genomic insights into the phylogeny and biomass-degrading enzymes of rumen ciliates

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Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago

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Membrane potential regulates the dynamic localisation of mammalian proteasomes

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  • Site-wide: 179,432

Genome-wide RNA structure changes during human neurogenesis drive gene regulatory networks

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  • In molecular biology: 1,755
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  • Site-wide: 47,930
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  • Site-wide: 88,819

IAV-CNN: a 2D convolutional neural network model to predict antigenic variants of influenza A virus

• Downloaded 761 times
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  • Site-wide: 60,574
  • In bioinformatics: 5,867
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  • Site-wide: 112,732
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  • Site-wide: 76,780

A comprehensive temporal patterning gene network in Drosophila medulla neuroblasts revealed by single-cell RNA sequencing

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  • Site-wide: 62,722
  • In developmental biology: 1,469
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  • Site-wide: 88,157
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  • Site-wide: 86,435

Prime editing efficiently generates W542L and S621I double mutations in two ALS genes in maize

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  • Site-wide: 64,347
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  • Site-wide: 164,003

The Impact of Psychology Interventions on Changing Mental Health Status and Sleep Quality in University Students during the COVID-19 Pandemic

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  • Site-wide: 65,221
  • In public and global health: 1,126
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  • Site-wide: 103,205

Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli

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  • Site-wide: 67,994
  • In biochemistry: 1,804
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  • Site-wide: 166,636

Optical control of CRISPR-Cas editing with cyclically caged guide RNAs

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  • Site-wide: 72,369
  • In biochemistry: 2,050
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  • Site-wide: 15,513
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  • Site-wide: 31,288

Deep learning models of cognitive processes constrained by human brain connectomes

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  • Site-wide: 74,071
  • In neuroscience: 10,545
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  • Site-wide: 41,086
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  • Site-wide: 89,242

Predicting the required pre-surgery blood volume in surgical patients based on machine learning

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  • Site-wide: 76,706
  • In hematology: 89
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  • Site-wide: 110,671
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  • Site-wide: 131,879

Inter-brain coupling reflects disciplinary differences in real-world classroom learning

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  • Site-wide: 80,321
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  • Site-wide: 50,807
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  • Site-wide: 50,309

Characterization of SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta) and B.1.618 on cell entry, host range, and sensitivity to convalescent plasma and ACE2 decoy receptor

• Downloaded 620 times
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  • Site-wide: 80,408
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  • Site-wide: 42,007

BAI-Net: Individualized Anatomical Human Cerebral Cartography using Graph Convolutional Network

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  • Site-wide: 87,366
  • In neuroscience: 12,643
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  • Site-wide: 147,346
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  • Site-wide: 49,963

Single-shot rAAV5-based Vaccine Provides Long-term Protective Immunity against SARS-CoV-2 and Its Variants

• Downloaded 579 times
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  • Site-wide: 87,660
  • In immunology: 2,858
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  • Site-wide: 65,725
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  • Site-wide: 107,274

Structural basis for transcription initiation by bacterial ECF σ factors

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  • Site-wide: 88,345
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IFITM3 restricts human metapneumovirus infection

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  • Site-wide: 88,703
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  • Site-wide: 199,295

Complete depletion of Arabidopsis linker histones impairs the correlations among chromatin compartmentalization, DNA methylation and gene expression

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  • Site-wide: 89,719
  • In plant biology: 2,307
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  • Site-wide: 36,648

Circadian control of intrinsic heart rate via a sinus node clock and the pacemaker channel

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  • Site-wide: 89,886
  • In physiology: 646
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Biogenesis of a young, 22-nt microRNA in Phaseoleae species by precursor-programmed uridylation

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  • Site-wide: 90,700
  • In plant biology: 2,260
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  • Site-wide: 204,353

Transferability of Brain decoding using Graph Convolutional Networks

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  • Site-wide: 91,375
  • In neuroscience: 13,186
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  • Site-wide: 54,510
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  • Site-wide: 129,437

The Incubation Period of Severe Acute Respiratory Syndrome Coronavirus 2:A Systematic Review

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  • Site-wide: 91,586
  • In epidemiology: 3,991
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  • Site-wide: 131,128
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  • Site-wide: 100,308

Decoding transcriptional regulation via a human gene expression predictor

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  • Site-wide: 91,962
  • In systems biology: 1,906
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  • Site-wide: 54,546
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  • Site-wide: 193,329

Accurate and Reproducible Functional Maps in 127 Human Cell Types via 2D Genome Segmentation

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  • Site-wide: 94,111
  • In genomics: 5,788
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  • Site-wide: 177,838

Diversity and biogeography of Woesearchaeota: A comprehensive analysis of multi-environment data

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  • Site-wide: 94,096
  • In ecology: 2,439
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  • Site-wide: 34,797

Structural and mechanistic basis of reiterative transcription initiation

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  • Site-wide: 94,329
  • In molecular biology: 2,737
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  • Site-wide: 67,998

FPfilter: A false-positive-specific filter for whole-genome sequencing variant calling from GATK

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  • Site-wide: 95,678
  • In bioinformatics: 8,474
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  • Site-wide: 44,715
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  • Site-wide: 78,175

Clinical characteristics of Covid-19 patients with re-positive test results: an observational study

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  • Site-wide: 95,893
  • In public and global health: 1,471
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  • Site-wide: 121,884

Accurate Name Entity Recognition for Biomedical Literatures: A Combined High-quality Manual Annotation and Deep-learning Natural Language Processing Study

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  • Site-wide: 96,793
  • In bioinformatics: 8,675
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Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p

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  • Site-wide: 97,167
  • In microbiology: 6,266
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  • Site-wide: 129,543

Cancer SIGVAR: A semi-automated interpretation tool for germline variants of hereditary cancer-related genes

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  • Site-wide: 99,082
  • In genetics: 3,807
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  • Site-wide: 76,216
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  • Site-wide: 99,308

Kidney injury molecule-1 is a potential receptor for SARS-CoV-2

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  • Site-wide: 99,780
  • In cell biology: 4,627
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Netrins and receptors control Drosophila optic lobe organization and transmedullary neuron axon targeting

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The PRMT7-dependent methylation of shank2 modulates invasion-proliferation switching during breast cancer metastasis

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  • In cancer biology: 3,075
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  • Site-wide: 196,470

ImmunoTyper-SR: A Novel Computational Approach for Genotyping Immunoglobulin Heavy Chain Variable Genes using Short Read Data

• Downloaded 498 times
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  • Site-wide: 105,071
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Artificial intelligence assisted standard white light endoscopy accurately characters early colorectal cancer: a multicenter diagnostic study

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  • Site-wide: 106,781
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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with critical COVID-19

• Downloaded 482 times
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A non-coding A-to-T Kozak site change related to the transmissibility of Alpha, Delta and Omicron VOCs

• Downloaded 475 times
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Synergistic application of continuous granulation and selective laser sintering 3D printing for the development of pharmaceutical dosage forms with enhanced dissolution rates and physical properties

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  • Site-wide: 110,356

Disrupting myeloid-specific LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation

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  • Site-wide: 111,914
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Progressive domain segregation in early embryonic development and underlying correlation to genetic and epigenetic changes

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Müllerian-inhibiting substance (MIS) is both necessary and sufficient for testicular differentiation in Chinese soft-shelled turtle Pelodiscus sinensis

• Downloaded 454 times
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Structural basis for intrinsic transcription termination

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  • Site-wide: 12,969

Shade-induced transcription of PIF-Direct-Target Genes precedes H3K4-trimethylation chromatin modification rises

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Dysbiotic oral and gut viromes in untreated and treated rheumatoid arthritis patients

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IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration

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Systematic integration of GATA transcription factors and epigenomes via IDEAS paints the regulatory landscape of mouse hematopoietic cells

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RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription

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  • Site-wide: 136,327
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Predicting Collaborative Learning Quality through Physiological Synchrony Recorded by Wearable Biosensors

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Synonymous SNPs of viral genes facilitate virus to escape host antiviral RNAi immunity

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  • Site-wide: 141,206
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Model-based cellular kinetic analysis of SARS-CoV-2 infection: different immune response modes and treatment strategies

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The first crested duck genome reveals clues to genetic compensation and crest cushion formation

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Helicobacter pylori-induced adrenomedullin modulates IFN-γ-producing T-cell responses and contribute to gastritis

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  • Site-wide: 149,075

Direct prediction of regulatory elements from partial data without imputation

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Integrative framework of cross-module deep biomarker for the prognosis of clear cell renal cell carcinoma: A retrospective TCGA project

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Genome Assemblies of the Warthog and Kenyan Domestic Pig Provide Insights into Suidae Evolution and Candidate Genes for African Swine Fever Tolerance

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Chromatin changes in PIF-regulated genes parallel their rapid transcriptional response to light

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A Potential Novel COVID-19 Vaccine With RBD-HR1/HR2 Hexamer Structure

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Inhibition of USP4 attenuates epithelial-mesenchymal transition of renal tubular epithelial cells by TβRI

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Genome-wide H3K9 Acetylation Level Increases with Age-Dependent Senescence of Flag Leaf in Rice (Oryza sativa)

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Deep immune profiling uncovers novel associations with clinical phenotypes of Multisystem Inflammatory Syndrome in Children (MIS-C)

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Cortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity

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Crl activates transcription by stabilizing the active conformation of the master stress factor σS

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The role of swnR gene on the biosynthesis pathway of the swainsonine in Metarhizium anisopliae

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Evaluation of azithromycin or hydroxychloroquine plus azithromycin combination therapy on cardiac conduction and function in guinea pigs

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Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model

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Predicting Axillary Lymph Node Metastasis in Early Breast Cancer Using Deep Learning on Primary Tumor Biopsy Slides

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scFLUX: a web server for metabolic flux and variation prediction using transcriptomics data

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Potential mechanisms of action of celastrol against rheumatoid arthritis: transcriptomic and proteomic analysis

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PP1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission

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Melanoma cells appropriate pericyte:endothelial cell crosstalk during perivascular invasion in the brain

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Representational learning of brain responses in executive function and higher-order cognition using deep graph convolutions

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Ubiquitination occurs in the mitochondrial matrix byeclipsed targeted components of the ubiquitin machinery

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S3V2-IDEAS: a package for normalizing, denoising and integrating epigenomic datasets across different cell types

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Interpretable brain decoding from sensations to cognition to action: graph neural networks reveal the representational hierarchy of human cognition

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A library of promoter-gfp fusion reporters for studying systemic expression pattern of cyclic-di-GMP metabolism-related genes in Pseudomonas aeruginosa

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Human iPSC-derived neuron of 16p11.2 deletion reveals haplotype-specific expression of MAPK3 and its contribution to variable NDD phenotypes

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Stepwise recombination suppression around the mating-type locus in the fungus Schizothecium tetrasporum (Ascomycota, Sordariales)

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Individualized fMRI connectivity defines signatures of antidepressant and placebo responses in major depression

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A SI3-sigma; arch stabilizes cyanobacteria transcription initiation complex

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DNA looping mediates cooperative transcription activation

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Ultrasonic Artificial Intelligence Shows Statistically Equivalent Performance for Thyroid Nodule Diagnosis to Fine Needle Aspiration Cytopathology and BRAFV600E Mutation Analysis Combined

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Comparative analysis about the structure of complete chloroplast genomes in genus Mangifera and accuracy verification about phylogenetic analysis based on gene ycf2 in genus level

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Genomic analysis of population structure, antimicrobial resistance, and virulent factors of methicillin-resistant Macrococcus caseolyticus in global lineages

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Single-cell RNA sequencing reveals the distinctive roles of CD4+ and CD8+ T cells in autoimmune uveitis

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  • Site-wide: 5,125

The Role of Students' Situational Interest in Classroom Learning: An Empirical Study based on both Laboratory and Naturalistic Paradigms

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Swim bladder resonance enhances hearing in crucian carp (Carassius auratus)

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  • Site-wide: 40,129

Acute stress impairs target enhancement but not disrtractor suppression in attention selection: Evidence from the N2pc and Pd

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SETD2 deficiency promotes the transition from PKD to ccRCC by dysregulation of sphingomyelin metabolism

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