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Author: Alex Sigal

Rankings

  • All-time downloads: 190,410 (rank: 651 )
  • Categories:
    • bioinformatics: 638 (rank: 27,261 (tie) )
    • epidemiology: 37,667 (rank: 657 )
    • evolutionary biology: 4,387 (rank: 1,011 (tie) )
    • hiv aids: 2,864 (rank: 17 (tie) )
    • immunology: 1,339 (rank: 11,487 (tie) )
    • infectious diseases: 100,834 (rank: 517 )
    • microbiology: 22,990 (rank: 966 )
    • molecular biology: 599 (rank: 15,000 (tie) )

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Preprints

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

immunology more details view paper

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Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa

epidemiology more details view paper
  • Downloaded 38,015 times
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    • Site-wide: 255
    • In epidemiology: 56
  • Year to date:
    • Site-wide: 743
  • Since beginning of last month:
    • Site-wide: 1,015

SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron

infectious diseases more details view paper
  • Downloaded 25,081 times
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    • Site-wide: 415
    • In infectious diseases: 159
  • Year to date:
    • Site-wide: 82
  • Since beginning of last month:
    • Site-wide: 2,758

The continuous evolution of SARS-CoV-2 in South Africa: a new lineage with rapid accumulation of mutations of concern and global detection

infectious diseases more details view paper
  • Downloaded 18,092 times
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    • Site-wide: 605
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  • Year to date:
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SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

microbiology more details view paper
  • Downloaded 17,673 times
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    • Site-wide: 620
    • In microbiology: 71
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Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

infectious diseases more details view paper
  • Downloaded 14,702 times
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    • Site-wide: 780
    • In infectious diseases: 272
  • Year to date:
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SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection

infectious diseases more details view paper
  • Downloaded 12,822 times
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    • Site-wide: 932
    • In infectious diseases: 352
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  • Since beginning of last month:
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A meta-analysis of Early Results to predict Vaccine efficacy against Omicron

infectious diseases more details view paper
  • Downloaded 10,480 times
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    • Site-wide: 1,206
    • In infectious diseases: 393
  • Year to date:
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Omicron sub-lineages BA.4/BA.5 escape BA.1 infection elicited neutralizing immunity

infectious diseases more details view paper
  • Downloaded 8,756 times
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    • Site-wide: 1,508
    • In infectious diseases: None
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SARS-CoV-2 evolved during advanced HIV disease immunosuppression has Beta-like escape of vaccine and Delta infection elicited immunity

infectious diseases more details view paper
  • Downloaded 6,200 times
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    • Site-wide: 2,368
    • In infectious diseases: 646
  • Year to date:
    • Site-wide: 2,438
  • Since beginning of last month:
    • Site-wide: 7,815

Escape of SARS-CoV-2 501Y.V2 variants from neutralization by convalescent plasma

infectious diseases more details view paper
  • Downloaded 6,136 times
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    • Site-wide: 2,404
    • In infectious diseases: 640
  • Year to date:
    • Site-wide: 13,881
  • Since beginning of last month:
    • Site-wide: 13,111

Omicron infection of vaccinated individuals enhances neutralizing immunity against the Delta variant

infectious diseases more details view paper
  • Downloaded 5,711 times
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    • Site-wide: 2,634
    • In infectious diseases: 754
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  • Since beginning of last month:
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Persistent SARS-CoV-2 infection and intra-host evolution in association with advanced HIV infection

infectious diseases more details view paper
  • Downloaded 5,249 times
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    • Site-wide: 2,973
    • In infectious diseases: 771
  • Year to date:
    • Site-wide: 1,317
  • Since beginning of last month:
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Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

evolutionary biology more details view paper
  • Downloaded 4,667 times
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    • Site-wide: 3,472
    • In evolutionary biology: 67
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    • Site-wide: 212
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SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization

microbiology more details view paper
  • Downloaded 3,192 times
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    • Site-wide: 5,957
    • In microbiology: 373
  • Year to date:
    • Site-wide: 15,721
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    • Site-wide: 60,375

HIV status alters disease severity and immune cell responses in beta variant SARS-CoV-2 infection wave

hiv aids more details view paper
  • Downloaded 2,436 times
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    • Site-wide: 8,832
    • In hiv aids: 4
  • Year to date:
    • Site-wide: 23,128
  • Since beginning of last month:
    • Site-wide: 34,980

Major new lineages of SARS-CoV-2 emerge and spread in South Africa during lockdown.

infectious diseases more details view paper
  • Downloaded 1,415 times
  • Download rankings, all-time:
    • Site-wide: 19,988
    • In infectious diseases: 2,160
  • Year to date:
    • Site-wide: 66,835
  • Since beginning of last month:
    • Site-wide: 41,390

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

microbiology more details view paper
  • Downloaded 1,310 times
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    • Site-wide: 22,522
    • In microbiology: 1,428
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    • Site-wide: 8,740
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    • Site-wide: 17,278

Naturally-acquired immunity in Syrian Golden Hamsters provides protection from re-exposure to emerging heterosubtypic SARS-CoV-2 variants B.1.1.7 and B.1.351

microbiology more details view paper
  • Downloaded 830 times
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    • Site-wide: 44,788
    • In microbiology: 2,603
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    • Site-wide: 88,409
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    • Site-wide: 56,548

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

immunology more details view paper
  • Downloaded 799 times
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    • Site-wide: 47,389
    • In immunology: 1,517
  • Year to date:
    • Site-wide: 70,623
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    • Site-wide: 36,505

The importance of time post-vaccination in determining the decrease in vaccine efficacy against SARS-CoV-2 variants of concern

epidemiology more details view paper
  • Downloaded 752 times
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    • Site-wide: 51,679
    • In epidemiology: 2,467
  • Year to date:
    • Site-wide: 77,193
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    • Site-wide: 82,394

HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells

microbiology more details view paper
  • Downloaded 663 times
  • Download rankings, all-time:
    • Site-wide: 61,605
    • In microbiology: 3,640
  • Year to date:
    • Site-wide: 72,364
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    • Site-wide: 155,002

The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes

microbiology more details view paper
  • Downloaded 619 times
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    • Site-wide: 67,340
    • In microbiology: None
  • Year to date:
    • Site-wide: 3,570
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    • Site-wide: 12,901

Viral apoptosis evasion via the MAPK pathway by use of a host long noncoding RNA

molecular biology more details view paper
  • Downloaded 603 times
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    • Site-wide: 69,814
    • In molecular biology: 1,802
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    • Site-wide: 190,491
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    • Site-wide: 189,628

Development of highly potent neutralising nanobodies against multiple SARS-CoV-2 variants including the variant of concern B.1.351

immunology more details view paper
  • Downloaded 599 times
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    • Site-wide: 70,432
    • In immunology: 2,057
  • Year to date:
    • Site-wide: 80,636
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    • Site-wide: 109,946

Immunogenicity of the Ad26.CoV2.S vaccine in people living with HIV

hiv aids more details view paper
  • Downloaded 587 times
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    • Site-wide: 72,183
    • In hiv aids: 43
  • Year to date:
    • Site-wide: 33,154
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Beta infection combined with Pfizer BNT162b2 vaccination leads to broadened neutralizing immunity against Omicron

infectious diseases more details view paper
  • Downloaded 504 times
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    • Site-wide: 86,758
    • In infectious diseases: None
  • Year to date:
    • Site-wide: 4,867
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    • Site-wide: 24,900

HIV cell-to-cell spread slows evolution of drug resistance

evolutionary biology more details view paper
  • Downloaded 481 times
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    • Site-wide: 91,350
    • In evolutionary biology: 4,979
  • Year to date:
    • Site-wide: 32,768
  • Since beginning of last month:
    • Site-wide: 35,000

Aggregated Mycobacterium tuberculosis enhances the inflammatory response

microbiology more details view paper
  • Downloaded 396 times
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    • Site-wide: 111,104
    • In microbiology: 8,160
  • Year to date:
    • Site-wide: 62,730
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The CNS in the face of ART contains T cell origin HIV which can lead to drug resistance

microbiology more details view paper
  • Downloaded 383 times
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    • Site-wide: 114,470
    • In microbiology: 7,283
  • Year to date:
    • Site-wide: 185,337
  • Since beginning of last month:
    • Site-wide: 175,624

Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

bioinformatics more details view paper
  • Downloaded 359 times
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    • Site-wide: 120,968
    • In bioinformatics: 9,395
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Interference with HIV infection of the first cell is essential for viral clearance in a pre-exposure prophylaxis model

bioinformatics more details view paper
  • Downloaded 308 times
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    • Site-wide: 135,576
    • In bioinformatics: 10,275
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    • Site-wide: 164,663

Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology

microbiology more details view paper
  • Downloaded 226 times
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    • Site-wide: 159,894
    • In microbiology: 11,311
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Complementation can maintain a quasispecies of drug sensitive and resistant HIV

evolutionary biology more details view paper
  • Downloaded 200 times
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    • Site-wide: 166,514
    • In evolutionary biology: 7,354
  • Year to date:
    • Site-wide: 158,775
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    • Site-wide: 151,954

Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition

infectious diseases more details view paper
  • Downloaded 164 times
  • Download rankings, all-time:
    • Site-wide: 175,257
    • In infectious diseases: None
  • Year to date:
    • Site-wide: 25,490
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