Author: Alex Sigal

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Preprints

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

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Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa

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SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron

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The continuous evolution of SARS-CoV-2 in South Africa: a new lineage with rapid accumulation of mutations of concern and global detection

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SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

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Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

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SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection

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A meta-analysis of Early Results to predict Vaccine efficacy against Omicron

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Omicron sub-lineages BA.4/BA.5 escape BA.1 infection elicited neutralizing immunity

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SARS-CoV-2 evolved during advanced HIV disease immunosuppression has Beta-like escape of vaccine and Delta infection elicited immunity

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Escape of SARS-CoV-2 501Y.V2 variants from neutralization by convalescent plasma

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Omicron infection of vaccinated individuals enhances neutralizing immunity against the Delta variant

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Persistent SARS-CoV-2 infection and intra-host evolution in association with advanced HIV infection

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Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

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SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization

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HIV status alters disease severity and immune cell responses in beta variant SARS-CoV-2 infection wave

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Major new lineages of SARS-CoV-2 emerge and spread in South Africa during lockdown.

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A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

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Naturally-acquired immunity in Syrian Golden Hamsters provides protection from re-exposure to emerging heterosubtypic SARS-CoV-2 variants B.1.1.7 and B.1.351

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Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

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The importance of time post-vaccination in determining the decrease in vaccine efficacy against SARS-CoV-2 variants of concern

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HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells

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The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes

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Viral apoptosis evasion via the MAPK pathway by use of a host long noncoding RNA

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Development of highly potent neutralising nanobodies against multiple SARS-CoV-2 variants including the variant of concern B.1.351

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  • In immunology: 2,057
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Immunogenicity of the Ad26.CoV2.S vaccine in people living with HIV

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  • Site-wide: 72,183
  • In hiv aids: 43
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Beta infection combined with Pfizer BNT162b2 vaccination leads to broadened neutralizing immunity against Omicron

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HIV cell-to-cell spread slows evolution of drug resistance

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Aggregated Mycobacterium tuberculosis enhances the inflammatory response

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The CNS in the face of ART contains T cell origin HIV which can lead to drug resistance

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Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

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Interference with HIV infection of the first cell is essential for viral clearance in a pre-exposure prophylaxis model

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Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology

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Complementation can maintain a quasispecies of drug sensitive and resistant HIV

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Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition

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