Author: Marcella Rietschel

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,383
  • In genetics: 35
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Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,551
  • In genetics: 41
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  • Site-wide: 29,989
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DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

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  • Site-wide: 3,215
  • In systems biology: 45
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  • Site-wide: 122,857

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 5,187
  • In psychiatry and clinical psychology: 20
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  • Site-wide: 2,182
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  • Site-wide: 8,738

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

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  • Site-wide: 8,505
  • In genetics: 355
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Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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  • Site-wide: 10,207
  • In genetics: 418
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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 10,781
  • In genetics: 458
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Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • In genetics: 493
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  • Site-wide: 4,342
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  • Site-wide: 4,198

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

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  • Site-wide: 12,437
  • In neurology: 29
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  • Site-wide: 2,418
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Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • Site-wide: 12,524
  • In genetics: 539
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  • Site-wide: 26,389
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  • Site-wide: 64,486

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 15,297
  • In genomics: 1,494
• Year to date:
  • Site-wide: 129,636
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  • Site-wide: 140,731

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

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  • Site-wide: 18,543
  • In genetics: 829
• Year to date:
  • Site-wide: 152,800
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  • Site-wide: 149,324

Genomic architecture of human neuroanatomical diversity

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  • Site-wide: 21,968
  • In neuroscience: 2,683
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  • Site-wide: 154,022
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  • Site-wide: 160,533

Cross-validation of technologies for genotyping CYP2D6 and CYP2C19

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  • Site-wide: 22,670
  • In genetics: 995
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Pharmacogenetics of antidepressant response: a polygenic approach

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  • Site-wide: 31,296
  • In genetics: 1,373
• Year to date:
  • Site-wide: 138,223
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  • Site-wide: 152,921

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 32,108
  • In genetics: 1,410
• Year to date:
  • Site-wide: 106,620
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  • Site-wide: 96,448

Polygenic scores for major depressive disorder and depressive symptoms predict response to lithium in patients with bipolar disorder

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  • Site-wide: 33,721
  • In genomics: 2,833
• Year to date:
  • Site-wide: 91,974
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  • Site-wide: 78,810

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 34,369
  • In neuroscience: 4,490
• Year to date:
  • Site-wide: 78,561
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  • Site-wide: 93,084

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • Site-wide: 35,282
  • In genetics: 1,547
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  • Site-wide: 32,051
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Generative network models identify biological mechanisms of altered structural brain connectivity in schizophrenia

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  • Site-wide: 38,580
  • In neuroscience: 5,153
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Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • Site-wide: 40,656
  • In genetics: 1,756
• Year to date:
  • Site-wide: 113,023
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Assessing 42 inflammatory markers in 321 control subjects and 887 major depressive disorder cases: BMI and other confounders and overall predictive ability for current depression

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  • Site-wide: 44,296
  • In neuroscience: 6,074
• Year to date:
  • Site-wide: 75,547
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  • Site-wide: 103,074

Higher genetic risk for schizophrenia is associated with living in urban and populated areas

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  • Site-wide: 47,844
  • In genetics: 2,053
• Year to date:
  • Site-wide: 143,188
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  • Site-wide: 153,611

Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium

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  • Site-wide: 50,888
  • In genomics: 3,845
• Year to date:
  • Site-wide: 81,492
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  • Site-wide: 64,660

New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation

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  • Site-wide: 52,167
  • In genomics: 3,919
• Year to date:
  • Site-wide: 132,862
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  • Site-wide: 128,113

High genetic loading for schizophrenia predicts poor response to lithium in patients with bipolar disorder: A polygenic score and cross-trait genetic analysis

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  • Site-wide: 54,414
  • In genetics: 2,313
• Year to date:
  • Site-wide: 129,979
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  • Site-wide: 91,645

Genotype-phenotype association mining in bipolar disorder: market research meets complex genetics

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  • Site-wide: 59,984
  • In genomics: 4,346
• Year to date:
  • Site-wide: 111,496
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  • Site-wide: 82,842

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies

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  • Site-wide: 60,174
  • In genetics: 2,562
• Year to date:
  • Site-wide: 131,373
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  • Site-wide: 157,147

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

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  • Site-wide: 69,493
  • In genetics: 2,945
• Year to date:
  • Site-wide: 159,568
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  • Site-wide: 160,659

Longitudinal transcriptome-wide gene expression analysis of sleep deprivation treatment shows involvement of circadian genes and immune pathways

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  • Site-wide: 78,658
  • In epidemiology: 3,455
• Year to date:
  • Site-wide: 152,585
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Response to Therapeutic Sleep Deprivation: A Naturalistic Study of Clinical and Genetic Factors and Post-Treatment Depressive Symptom Trajectory

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  • Site-wide: 99,235
  • In epidemiology: 4,238
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  • Site-wide: 156,604

Characterization of Age and Polarity at Onset in Bipolar Disorder

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  • Site-wide: 105,550
  • In psychiatry and clinical psychology: 467
• Year to date:
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Exemplar Scoring Identifies Genetically Separable Phenotypes of Lithium Responsive Bipolar Disorder

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  • Site-wide: 106,622
  • In psychiatry and clinical psychology: 478
• Year to date:
  • Site-wide: 98,536
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  • Site-wide: 114,706

Identification of transdiagnostic psychiatric disorder subtypes using unsupervised learning

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  • Site-wide: 112,681
  • In psychiatry and clinical psychology: 524
• Year to date:
  • Site-wide: 32,126
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  • Site-wide: 54,347

Genetic Contributions to Alcohol Use Disorder Treatment Outcomes: A Genome-wide Pharmacogenomics Study

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  • Site-wide: 119,432
  • In genetic and genomic medicine: 674
• Year to date:
  • Site-wide: 36,069
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  • Site-wide: 82,080

"The Heidelberg Five" Personality Dimensions: Genome-wide Associations, Polygenic Risk for Neuroticism, and Psychopathology 20 Years after Assessment

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  • Site-wide: 127,249
  • In genomics: 6,962
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  • Site-wide: 132,733

Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression

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  • Site-wide: 127,699
  • In psychiatry and clinical psychology: 638
• Year to date:
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  • Site-wide: 69,705

Epigenome-wide Association Study of Alcohol Use Disorder in Five Brain Regions

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  • Site-wide: 134,005
  • In addiction medicine: 78
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Interplay between the Genetics of Personality Traits, severe Psychiatric Disorders, and COVID-19 Host Genetics in the Susceptibility to SARS-CoV-2 Infection

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  • Site-wide: 146,542
  • In genetic and genomic medicine: 889
• Year to date:
  • Site-wide: 64,917
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  • Site-wide: 129,591

Multi-Omics Signatures of Alcohol Use Disorder in the Dorsal and Ventral Striatum

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  • Site-wide: 149,455
  • In addiction medicine: 85
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Connection Failure: Differences in White Matter Microstructure are associated with 5-HTTLPR but not with Risk-Seeking for Losses

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  • Site-wide: 157,310
  • In neuroscience: 23,398
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