Author: Marcella Rietschel

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,065
  • In genetics: 31
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  • Site-wide: 12,486
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Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,200
  • In genetics: 38
• Year to date:
  • Site-wide: 17,389
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  • Site-wide: 15,430

DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

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  • Site-wide: 2,465
  • In systems biology: 32
• Year to date:
  • Site-wide: 63,674
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  • Site-wide: 70,417

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 6,820
  • In psychiatry and clinical psychology: 23
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  • Site-wide: 1,301
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  • Site-wide: 666

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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  • Site-wide: 8,120
  • In genetics: 373
• Year to date:
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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 8,803
  • In genetics: 417
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  • Site-wide: 49,152
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Dynamics of Brain Structure and its Genetic Architecture over the Lifespan

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  • Site-wide: 8,841
  • In genetics: 420
• Year to date:
  • Site-wide: 12,155
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Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 9,360
  • In genetics: 448
• Year to date:
  • Site-wide: 81,069
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  • Site-wide: 87,215

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • Site-wide: 11,384
  • In genetics: 548
• Year to date:
  • Site-wide: 16,652
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  • Site-wide: 17,725

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 11,843
  • In genomics: 1,291
• Year to date:
  • Site-wide: 71,844
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  • Site-wide: 69,581

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

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  • Site-wide: 14,218
  • In genetics: 698
• Year to date:
  • Site-wide: 99,367
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  • Site-wide: 108,755

Genomic architecture of human neuroanatomical diversity

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  • Site-wide: 16,847
  • In neuroscience: 2,084
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  • Site-wide: 95,405
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  • Site-wide: 109,155

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 18,914
  • In genetics: 923
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  • Site-wide: 3,494
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  • Site-wide: 3,112

Pharmacogenetics of antidepressant response: a polygenic approach

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  • Site-wide: 24,587
  • In genetics: 1,187
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  • Site-wide: 80,044
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  • Site-wide: 87,125

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 26,615
  • In genetics: 1,292
• Year to date:
  • Site-wide: 74,743
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  • Site-wide: 70,525

Cross-validation of technologies for genotyping CYP2D6 and CYP2C19

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  • Site-wide: 28,035
  • In genetics: 1,366
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  • Site-wide: 19,135
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Polygenic scores for major depressive disorder and depressive symptoms predict response to lithium in patients with bipolar disorder

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  • Site-wide: 29,061
  • In genomics: 2,659
• Year to date:
  • Site-wide: 77,754
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  • Site-wide: 70,618

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 30,304
  • In neuroscience: 4,100
• Year to date:
  • Site-wide: 58,202
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  • Site-wide: 70,481

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • Site-wide: 32,453
  • In genetics: 1,571
• Year to date:
  • Site-wide: 11,592
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  • Site-wide: 7,235

Generative network models identify biological mechanisms of altered structural brain connectivity in schizophrenia

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  • Site-wide: 33,340
  • In neuroscience: 4,599
• Year to date:
  • Site-wide: 71,543
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  • Site-wide: 49,417

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • Site-wide: 33,687
  • In genetics: 1,636
• Year to date:
  • Site-wide: 77,243
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Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

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  • Site-wide: 35,482
  • In neurology: 64
• Year to date:
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  • Site-wide: 475

Higher genetic risk for schizophrenia is associated with living in urban and populated areas

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  • Site-wide: 37,972
  • In genetics: 1,805
• Year to date:
  • Site-wide: 98,367
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  • Site-wide: 87,214

Assessing 42 inflammatory markers in 321 control subjects and 887 major depressive disorder cases: BMI and other confounders and overall predictive ability for current depression

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  • Site-wide: 41,231
  • In neuroscience: 5,879
• Year to date:
  • Site-wide: 73,317
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  • Site-wide: 60,268

New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation

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  • Site-wide: 43,186
  • In genomics: 3,524
• Year to date:
  • Site-wide: 122,642
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  • Site-wide: 109,669

High genetic loading for schizophrenia predicts poor response to lithium in patients with bipolar disorder: A polygenic score and cross-trait genetic analysis

• Downloaded 571 times
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  • Site-wide: 44,789
  • In genetics: 2,111
• Year to date:
  • Site-wide: 107,053
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  • Site-wide: 87,264

Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium

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  • Site-wide: 46,312
  • In genomics: 3,703
• Year to date:
  • Site-wide: 65,899
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  • Site-wide: 102,443

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies

• Downloaded 524 times
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  • Site-wide: 49,723
  • In genetics: 2,324
• Year to date:
  • Site-wide: 107,018
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  • Site-wide: 98,109

Genotype-phenotype association mining in bipolar disorder: market research meets complex genetics

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  • Site-wide: 52,210
  • In genomics: 4,038
• Year to date:
  • Site-wide: 108,690
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  • Site-wide: 109,682

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

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  • Site-wide: 53,777
  • In genetics: 2,500
• Year to date:
  • Site-wide: 129,845
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  • Site-wide: 108,128

Longitudinal transcriptome-wide gene expression analysis of sleep deprivation treatment shows involvement of circadian genes and immune pathways

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  • Site-wide: 61,449
  • In epidemiology: 2,651
• Year to date:
  • Site-wide: 104,516
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  • Site-wide: 89,682

Response to Therapeutic Sleep Deprivation: A Naturalistic Study of Clinical and Genetic Factors and Post-Treatment Depressive Symptom Trajectory

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  • Site-wide: 76,728
  • In epidemiology: 3,193
• Year to date:
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  • Site-wide: 92,029

Exemplar Scoring Identifies Genetically Separable Phenotypes of Lithium Responsive Bipolar Disorder

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  • Site-wide: 94,634
  • In psychiatry and clinical psychology: 345
• Year to date:
  • Site-wide: 63,086
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  • Site-wide: 47,936

"The Heidelberg Five" Personality Dimensions: Genome-wide Associations, Polygenic Risk for Neuroticism, and Psychopathology 20 Years after Assessment

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  • Site-wide: 107,994
  • In genomics: 6,228
• Year to date:
  • Site-wide: 81,423
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  • Site-wide: 101,662

Identification of transdiagnostic psychiatric disorder subtypes using unsupervised learning

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  • Site-wide: 119,983
  • In psychiatry and clinical psychology: 547
• Year to date:
  • Site-wide: 16,948
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  • Site-wide: 22,988

Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression

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  • Site-wide: 120,539
  • In psychiatry and clinical psychology: 551
• Year to date:
  • Site-wide: 17,431
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  • Site-wide: 9,067

Genetic Contributions to Alcohol Use Disorder Treatment Outcomes: A Genome-wide Pharmacogenomics Study

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  • Site-wide: 125,955
  • In genetic and genomic medicine: 613
• Year to date:
  • Site-wide: 23,358
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  • Site-wide: 19,636

Connection Failure: Differences in White Matter Microstructure are associated with 5-HTTLPR but not with Risk-Seeking for Losses

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  • Site-wide: 133,943
  • In neuroscience: 20,454
• Year to date:
  • Site-wide: 84,514
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  • Site-wide: 69,193