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Author: Han Chen

Rankings

  • All-time downloads: 24,538 (rank: 9,260 )
  • Categories:
    • bioinformatics: 2,429 (rank: 7,241 (tie) )
    • cancer biology: 244 (rank: 36,573 (tie) )
    • cell biology: 363 (rank: 32,321 (tie) )
    • epidemiology: 489 (rank: 20,804 (tie) )
    • evolutionary biology: 840 (rank: 10,284 (tie) )
    • genetic and genomic medicine: 1,668 (rank: 2,834 (tie) )
    • genetics: 4,364 (rank: 4,497 )
    • genomics: 2,557 (rank: 10,838 (tie) )
    • immunology: 3,948 (rank: 3,079 (tie) )
    • microbiology: 2,003 (rank: 9,149 (tie) )
    • molecular biology: 1,036 (rank: 7,344 (tie) )
    • neuroscience: 4,030 (rank: 6,352 (tie) )
    • systems biology: 567 (rank: 9,318 (tie) )

Downloads per author, site-wide

Preprints

Robust Single-cell Matching and Multi-modalAnalysis Using Shared and Distinct FeaturesReveals Orchestrated Immune Responses

bioinformatics more details view paper

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Spatiotemporal limits of optogenetic manipulations in cortical circuits

neuroscience more details view paper
  • Downloaded 4,030 times
  • Download rankings, all-time:
    • Site-wide: 3,611
    • In neuroscience: 250
  • Year to date:
    • Site-wide: 25,189
  • Since beginning of last month:
    • Site-wide: 36,119

SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19

immunology more details view paper
  • Downloaded 1,549 times
  • Download rankings, all-time:
    • Site-wide: 14,675
    • In immunology: 508
  • Year to date:
    • Site-wide: 2,860
  • Since beginning of last month:
    • Site-wide: 254

Virus-Dependent Immune Conditioning of Tissue Microenvironments

immunology more details view paper
  • Downloaded 1,448 times
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    • Site-wide: 16,353
    • In immunology: 568
  • Year to date:
    • Site-wide: 3,157
  • Since beginning of last month:
    • Site-wide: 3,257

Single-cell profiling of Ebola virus infection in vivo reveals viral and host transcriptional dynamics

microbiology more details view paper
  • Downloaded 1,290 times
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    • Site-wide: 19,444
    • In microbiology: 1,134
  • Year to date:
    • Site-wide: 57,174
  • Since beginning of last month:
    • Site-wide: 88,385

AnnoTree: visualization and exploration of a functionally annotated microbial tree of life

bioinformatics more details view paper
  • Downloaded 1,228 times
  • Download rankings, all-time:
    • Site-wide: 20,968
    • In bioinformatics: 2,369
  • Year to date:
    • Site-wide: 134,327
  • Since beginning of last month:
    • Site-wide: 146,270

Phytophthora methylomes modulated by expanded 6mA methyltransferases are associated with adaptive genome regions

molecular biology more details view paper
  • Downloaded 1,036 times
  • Download rankings, all-time:
    • Site-wide: 27,160
    • In molecular biology: 726
  • Year to date:
    • Site-wide: 147,042
  • Since beginning of last month:
    • Site-wide: 134,893

Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

immunology more details view paper
  • Downloaded 951 times
  • Download rankings, all-time:
    • Site-wide: 30,772
    • In immunology: 1,024
  • Year to date:
    • Site-wide: 5,872
  • Since beginning of last month:
    • Site-wide: 13,801

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

genetics more details view paper
  • Downloaded 880 times
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    • Site-wide: 34,488
    • In genetics: 1,504
  • Year to date:
    • Site-wide: 147,264
  • Since beginning of last month:
    • Site-wide: 151,074

GEM: Scalable and flexible gene-environment interaction analysis in millions of samples

bioinformatics more details view paper
  • Downloaded 792 times
  • Download rankings, all-time:
    • Site-wide: 40,141
    • In bioinformatics: 4,260
  • Year to date:
    • Site-wide: 24,051
  • Since beginning of last month:
    • Site-wide: 68,621

Multiethnic catalog of structural variants and their translational impact for disease phenotypes across 19,652 genomes

genomics more details view paper
  • Downloaded 753 times
  • Download rankings, all-time:
    • Site-wide: 43,211
    • In genomics: 3,412
  • Year to date:
    • Site-wide: 68,990
  • Since beginning of last month:
    • Site-wide: 76,299

Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages

microbiology more details view paper
  • Downloaded 713 times
  • Download rankings, all-time:
    • Site-wide: 46,683
    • In microbiology: 2,820
  • Year to date:
    • Site-wide: 96,506
  • Since beginning of last month:
    • Site-wide: 89,117

The non-essentiality of essential genes suggests a loss-of-function therapeutic strategy for loss-of-function human diseases

genetics more details view paper
  • Downloaded 712 times
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    • Site-wide: 46,758
    • In genetics: 2,010
  • Year to date:
    • Site-wide: 156,621
  • Since beginning of last month:
    • Site-wide: 154,736

Natural selection defines the cellular complexity

evolutionary biology more details view paper
  • Downloaded 583 times
  • Download rankings, all-time:
    • Site-wide: 61,043
    • In evolutionary biology: 2,990
  • Year to date:
    • Site-wide: 150,787
  • Since beginning of last month:
    • Site-wide: 131,512

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

genomics more details view paper
  • Downloaded 569 times
  • Download rankings, all-time:
    • Site-wide: 62,851
    • In genomics: 4,483
  • Year to date:
    • Site-wide: 136,691
  • Since beginning of last month:
    • Site-wide: 84,288

Principles of studying a cell - a non-boastful paper for all molecular biologists

systems biology more details view paper
  • Downloaded 567 times
  • Download rankings, all-time:
    • Site-wide: 63,146
    • In systems biology: 1,391
  • Year to date:
    • Site-wide: 137,234
  • Since beginning of last month:
    • Site-wide: 129,243

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

genetics more details view paper
  • Downloaded 536 times
  • Download rankings, all-time:
    • Site-wide: 67,530
    • In genetics: 2,876
  • Year to date:
    • Site-wide: 93,222
  • Since beginning of last month:
    • Site-wide: 94,670

Polygenic Risk Prediction using Gradient Boosted Trees Captures Non-Linear Genetic Effects and Allele Interactions in Complex Phenotypes

genetic and genomic medicine more details view paper
  • Downloaded 536 times
  • Download rankings, all-time:
    • Site-wide: 67,697
    • In genetic and genomic medicine: 325
  • Year to date:
    • Site-wide: 14,438
  • Since beginning of last month:
    • Site-wide: 11,014

The regulator-executor-phenotype architecture shaped by natural selection

genetics more details view paper
  • Downloaded 501 times
  • Download rankings, all-time:
    • Site-wide: 73,175
    • In genetics: 3,101
  • Year to date:
    • Site-wide: 140,822
  • Since beginning of last month:
    • Site-wide: 123,837

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

genomics more details view paper
  • Downloaded 463 times
  • Download rankings, all-time:
    • Site-wide: 79,795
    • In genomics: 5,232
  • Year to date:
    • Site-wide: 39,125
  • Since beginning of last month:
    • Site-wide: 18,268

Efficient gene-environment interaction tests for large biobank-scale sequencing studies

genetics more details view paper
  • Downloaded 449 times
  • Download rankings, all-time:
    • Site-wide: 82,513
    • In genetics: 3,466
  • Year to date:
    • Site-wide: 57,857
  • Since beginning of last month:
    • Site-wide: 22,889

A unified method for rare variant analysis of gene-environment interactions

genetics more details view paper
  • Downloaded 432 times
  • Download rankings, all-time:
    • Site-wide: 85,938
    • In genetics: 3,591
  • Year to date:
    • Site-wide: 101,405
  • Since beginning of last month:
    • Site-wide: 57,073

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

bioinformatics more details view paper
  • Downloaded 409 times
  • Download rankings, all-time:
    • Site-wide: 90,594
    • In bioinformatics: 7,995
  • Year to date:
    • Site-wide: 90,506
  • Since beginning of last month:
    • Site-wide: 149,140

Estimation of Mediation Effect for High-dimensional Omics Mediators with Application to the Framingham Heart Study

genomics more details view paper
  • Downloaded 408 times
  • Download rankings, all-time:
    • Site-wide: 90,705
    • In genomics: 5,713
  • Year to date:
    • Site-wide: 97,480
  • Since beginning of last month:
    • Site-wide: 96,689

Genome-wide gene-diet interaction analysis in the UK Biobank identifies novel effects on Hemoglobin A1c

genetic and genomic medicine more details view paper
  • Downloaded 403 times
  • Download rankings, all-time:
    • Site-wide: 91,764
    • In genetic and genomic medicine: 476
  • Year to date:
    • Site-wide: 33,572
  • Since beginning of last month:
    • Site-wide: 27,143

Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole Genome Sequencing Studies

genetics more details view paper
  • Downloaded 402 times
  • Download rankings, all-time:
    • Site-wide: 92,143
    • In genetics: 3,826
  • Year to date:
    • Site-wide: 161,321
  • Since beginning of last month:
    • Site-wide: 154,172

Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American specific associations

genomics more details view paper
  • Downloaded 364 times
  • Download rankings, all-time:
    • Site-wide: 100,737
    • In genomics: 6,062
  • Year to date:
    • Site-wide: 152,082
  • Since beginning of last month:
    • Site-wide: 151,551

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

epidemiology more details view paper
  • Downloaded 344 times
  • Download rankings, all-time:
    • Site-wide: 105,481
    • In epidemiology: 4,473
  • Year to date:
    • Site-wide: 139,227
  • Since beginning of last month:
    • Site-wide: 148,801

A framework for detecting noncoding rare variant associations of large-scale whole-genome sequencing studies

genetics more details view paper
  • Downloaded 291 times
  • Download rankings, all-time:
    • Site-wide: 119,151
    • In genetics: 4,833
  • Year to date:
    • Site-wide: 36,060
  • Since beginning of last month:
    • Site-wide: 3,129

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

genetic and genomic medicine more details view paper
  • Downloaded 290 times
  • Download rankings, all-time:
    • Site-wide: 119,458
    • In genetic and genomic medicine: 675
  • Year to date:
    • Site-wide: 36,175
  • Since beginning of last month:
    • Site-wide: 82,740

Multi-locus characterization and phylogenetic inference of Leishmania spp. in snakes from Northwest China

evolutionary biology more details view paper
  • Downloaded 257 times
  • Download rankings, all-time:
    • Site-wide: 128,026
    • In evolutionary biology: 6,215
  • Year to date:
    • Site-wide: 127,002
  • Since beginning of last month:
    • Site-wide: 60,093

Efficiency of a Randomized Confirmatory Basket Trial Design Constrained to Control the False Positive Rate by Indication

cancer biology more details view paper
  • Downloaded 244 times
  • Download rankings, all-time:
    • Site-wide: 131,615
    • In cancer biology: 4,027
  • Year to date:
    • Site-wide: 88,467
  • Since beginning of last month:
    • Site-wide: 79,482

Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers

genetic and genomic medicine more details view paper
  • Downloaded 242 times
  • Download rankings, all-time:
    • Site-wide: 132,210
    • In genetic and genomic medicine: 771
  • Year to date:
    • Site-wide: 46,037
  • Since beginning of last month:
    • Site-wide: 4,223

Extracellular vesicles from retinal pigment epithelial cells expressing R345W-Fibulin-3 induce epithelial-mesenchymal transition in recipient cells

cell biology more details view paper
  • Downloaded 209 times
  • Download rankings, all-time:
    • Site-wide: 140,396
    • In cell biology: 6,482
  • Year to date:
    • Site-wide: 104,080
  • Since beginning of last month:
    • Site-wide: 107,483

Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex

genetic and genomic medicine more details view paper
  • Downloaded 197 times
  • Download rankings, all-time:
    • Site-wide: 143,339
    • In genetic and genomic medicine: 859
  • Year to date:
    • Site-wide: 59,552
  • Since beginning of last month:
    • Site-wide: 27,150

Exploiting Family History in Aggregation Unit-based Genetic Association Tests

genetics more details view paper
  • Downloaded 161 times
  • Download rankings, all-time:
    • Site-wide: 151,269
    • In genetics: 5,880
  • Year to date:
    • Site-wide: 74,894
  • Since beginning of last month:
    • Site-wide: 91,391

Lentiviral vector optimization enhances the expression and cytotoxicity of chimeric antigen receptors

cell biology more details view paper
  • Downloaded 154 times
  • Download rankings, all-time:
    • Site-wide: 152,613
    • In cell biology: 6,976
  • Year to date:
    • Site-wide: 78,602
  • Since beginning of last month:
    • Site-wide: 124,965

FiMAP: A Fast Identity-by-Descent Mapping Test for Biobank-scale Cohorts

epidemiology more details view paper
  • Downloaded 145 times
  • Download rankings, all-time:
    • Site-wide: 154,138
    • In epidemiology: 6,374
  • Year to date:
    • Site-wide: 83,523
  • Since beginning of last month:
    • Site-wide: 106,636

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