Author: Han Chen

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Preprints

Robust Single-cell Matching and Multi-modalAnalysis Using Shared and Distinct FeaturesReveals Orchestrated Immune Responses

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Spatiotemporal limits of optogenetic manipulations in cortical circuits

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SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19

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Virus-Dependent Immune Conditioning of Tissue Microenvironments

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Single-cell profiling of Ebola virus infection in vivo reveals viral and host transcriptional dynamics

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AnnoTree: visualization and exploration of a functionally annotated microbial tree of life

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Phytophthora methylomes modulated by expanded 6mA methyltransferases are associated with adaptive genome regions

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Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

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Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

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GEM: Scalable and flexible gene-environment interaction analysis in millions of samples

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Multiethnic catalog of structural variants and their translational impact for disease phenotypes across 19,652 genomes

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Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages

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The non-essentiality of essential genes suggests a loss-of-function therapeutic strategy for loss-of-function human diseases

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Natural selection defines the cellular complexity

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Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

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Principles of studying a cell - a non-boastful paper for all molecular biologists

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Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

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Polygenic Risk Prediction using Gradient Boosted Trees Captures Non-Linear Genetic Effects and Allele Interactions in Complex Phenotypes

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The regulator-executor-phenotype architecture shaped by natural selection

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Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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Efficient gene-environment interaction tests for large biobank-scale sequencing studies

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A unified method for rare variant analysis of gene-environment interactions

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Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

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Estimation of Mediation Effect for High-dimensional Omics Mediators with Application to the Framingham Heart Study

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Genome-wide gene-diet interaction analysis in the UK Biobank identifies novel effects on Hemoglobin A1c

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Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole Genome Sequencing Studies

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Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American specific associations

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Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

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A framework for detecting noncoding rare variant associations of large-scale whole-genome sequencing studies

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BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

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Multi-locus characterization and phylogenetic inference of Leishmania spp. in snakes from Northwest China

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Efficiency of a Randomized Confirmatory Basket Trial Design Constrained to Control the False Positive Rate by Indication

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Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers

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Extracellular vesicles from retinal pigment epithelial cells expressing R345W-Fibulin-3 induce epithelial-mesenchymal transition in recipient cells

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Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex

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Exploiting Family History in Aggregation Unit-based Genetic Association Tests

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Lentiviral vector optimization enhances the expression and cytotoxicity of chimeric antigen receptors

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FiMAP: A Fast Identity-by-Descent Mapping Test for Biobank-scale Cohorts

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