Author: Jie Zhang

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Preprints

SARS-CoV-2 and SARS-CoV Spike-RBD Structure and Receptor Binding Comparison and Potential Implications on Neutralizing Antibody and Vaccine Development

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  • Site-wide: 1,092
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  • Site-wide: 1,791
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  • Site-wide: 5,891

Rapid and quantitative detection of COVID-19 markers in micro-liter sized samples

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  • Site-wide: 5,128
  • In bioengineering: 53
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  • Site-wide: 11,182
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  • Site-wide: 43,059

Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus

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  • Site-wide: 8,468
  • In biochemistry: 147
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  • Site-wide: 12,821
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  • Site-wide: 21,805

Integration of Mouse and Human Single-cell RNA Sequencing Infers Spatial Cell-type Composition in Human Brains

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  • Site-wide: 8,991
  • In bioinformatics: 996
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  • Site-wide: 24,534

Predictive engineering and optimization of tryptophan metabolism in yeast through a combination of mechanistic and machine learning models

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  • Site-wide: 10,621
  • In bioengineering: 167
• Year to date:
  • Site-wide: 36,523
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  • Site-wide: 57,892

Development of a vaccine against the newly emerging COVID-19 virus based on the receptor binding domain displayed on virus-like particles

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  • Site-wide: 10,667
  • In immunology: 364
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  • Site-wide: 32,890

GANai: Standardizing CT Images using Generative Adversarial Network with Alternative Improvement

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  • Site-wide: 13,962
  • In bioinformatics: 1,577
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  • Site-wide: 47,469

Mutation rate estimation for 15 autosomal STR loci in a large population from Mainland China

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  • Site-wide: 14,548
  • In genetics: 648
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  • Site-wide: 126,867

MORONET: Multi-omics Integration via Graph Convolutional Networks for Biomedical Data Classification

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  • Site-wide: 15,473
  • In bioinformatics: 1,757
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  • Site-wide: 4,995
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  • Site-wide: 16,939

Comparison of SARS-CoV-2 spike protein binding to human, pet, farm animals, and putative intermediate hosts ACE2 and ACE2 receptors

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  • Site-wide: 17,490
  • In bioinformatics: 1,989
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  • Site-wide: 20,766
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  • Site-wide: 46,089

Behavioral clusters revealed by end-to-end decoding from microendoscopic imaging

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  • Site-wide: 18,788
  • In neuroscience: 2,235
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  • Site-wide: 3,189
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  • Site-wide: 8,803

Timing polymerase pausing with TV-PRO-seq: dissecting the interplay of pausing duration and location, and gene expression

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  • Site-wide: 21,692
  • In systems biology: 409
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  • Site-wide: 41,527
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  • Site-wide: 15,198

The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from transcription sites

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  • Site-wide: 23,326
  • In cell biology: 799
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  • Site-wide: 94,169
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  • Site-wide: 86,577

Karyotype stability and unbiased fractionation in the paleo-allotetraploid Cucurbita genomes

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  • Site-wide: 28,845
  • In genomics: 2,545
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  • Site-wide: 135,450
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  • Site-wide: 156,447

Association of 25 hydroxyvitamin D concentration with risk of COVID-19: a Mendelian randomization study

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  • Site-wide: 30,061
  • In infectious diseases: 2,490
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  • Site-wide: 53,129
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  • Site-wide: 46,852

A comparative analysis reveals irreproducibility in searches of scientific literature

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  • Site-wide: 35,500
  • In scientific communication and education: 243
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  • Site-wide: 29,060
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  • Site-wide: 43,025

The functional and genetic associations of neuroimaging data: a toolbox

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  • Site-wide: 36,060
  • In neuroscience: 4,769
• Year to date:
  • Site-wide: 123,598
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  • Site-wide: 99,621

Myricetin Attenuates LPS-induced Inflammation in RAW 264.7 Macrophages and Mouse Models

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  • Site-wide: 36,338
  • In cell biology: 1,397
• Year to date:
  • Site-wide: 45,161
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  • Site-wide: 42,773

EGFR Oncogenes Expressed In Glioblastoma Are Activated As Covalent Dimers And Paradoxically Stimulated By Erlotinib

• Downloaded 803 times
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  • Site-wide: 36,513
  • In cancer biology: 977
• Year to date:
  • Site-wide: 34,172
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  • Site-wide: 35,681

BERMUDA: A novel deep transfer learning method for single-cell RNA sequencing batch correction reveals hidden high-resolution cellular subtypes

• Downloaded 723 times
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  • Site-wide: 42,283
  • In bioinformatics: 4,473
• Year to date:
  • Site-wide: 150,786
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  • Site-wide: 143,913

Dynamic brain network changes in resting-state reflect neuroplasticity: molecular and cognitive evidence

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  • Site-wide: 43,763
  • In neuroscience: 5,993
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  • Site-wide: 62,586
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  • Site-wide: 64,656

A deep learning approach for tissue spatial quantification and genomic correlations of histopathological images

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  • Site-wide: 47,251
  • In bioinformatics: 4,885
• Year to date:
  • Site-wide: 31,011
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  • Site-wide: 34,661

An orthogonal and pH-tunable sensor-selector for muconic acid biosynthesis in yeast

• Downloaded 617 times
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  • Site-wide: 52,200
  • In synthetic biology: 638
• Year to date:
  • Site-wide: 151,940
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  • Site-wide: 153,053

Reporting the life tracks of confirmed cases can effective prevent and control the COVID-19 outbreak in China

• Downloaded 609 times
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  • Site-wide: 53,113
  • In health policy: 133
• Year to date:
  • Site-wide: 82,014
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  • Site-wide: 65,994

Association between Alzheimer's disease and COVID-19: A bidirectional Mendelian randomization

• Downloaded 602 times
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  • Site-wide: 53,802
  • In genetic and genomic medicine: 235
• Year to date:
  • Site-wide: 56,751
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  • Site-wide: 65,888

Renewable Fatty Acid Ester Production in Clostridium

• Downloaded 593 times
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  • Site-wide: 54,802
  • In bioengineering: 1,049
• Year to date:
  • Site-wide: 54,274
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  • Site-wide: 102,127

MECP2 duplication causes aberrant GABA pathways, circuits and behaviors in transgenic monkeys: neural mappings to patients with autism

• Downloaded 567 times
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  • Site-wide: 58,011
  • In neuroscience: 8,281
• Year to date:
  • Site-wide: 157,462
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  • Site-wide: 148,864

Integrated multi-omics analysis to study the effects of simulated weightlessness on rhesus macaques (Macaca mulatta)

• Downloaded 506 times
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  • Site-wide: 66,253
  • In immunology: 2,021
• Year to date:
  • Site-wide: 119,056
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  • Site-wide: 109,391

TSUNAMI: Translational Bioinformatics Tool Suite For Network Analysis And Mining

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  • Site-wide: 76,757
  • In bioinformatics: 7,080
• Year to date:
  • Site-wide: 100,225
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  • Site-wide: 135,081

Silicone oil-induced ocular hypertension in mouse models glaucomatous neurodegeneration and neuroprotection

• Downloaded 428 times
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  • Site-wide: 79,414
  • In neuroscience: 11,714
• Year to date:
  • Site-wide: 130,561
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  • Site-wide: 132,220

LAmbDA: Label Ambiguous Domain Adaption Dataset Integration Reduces Batch Effects and Improves Subtype Detection

• Downloaded 393 times
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  • Site-wide: 86,130
  • In bioinformatics: 7,709
• Year to date:
  • Site-wide: 141,998
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  • Site-wide: 137,699

Diagnostic Evidence GAuge of Single cells (DEGAS): A flexible deep-transfer learning framework for prioritizing cells in relation to disease

• Downloaded 377 times
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  • Site-wide: 89,417
  • In bioinformatics: 7,933
• Year to date:
  • Site-wide: 45,482
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  • Site-wide: 67,394

Decreased green autofluorescence intensity of lung parenchyma is a potential non-invasive diagnostic biomarker for lung cancer

• Downloaded 367 times
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  • Site-wide: 91,753
  • In biophysics: 3,423
• Year to date:
  • Site-wide: 104,067
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  • Site-wide: 131,366

Predicting Brain Amyloid using Multivariate Morphometry Statistics, Sparse Coding, and Correntropy: Validation in 1,101 Individuals from the ADNI and OASIS Databases

• Downloaded 353 times
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  • Site-wide: 94,745
  • In bioinformatics: 8,277
• Year to date:
  • Site-wide: 42,139
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  • Site-wide: 82,538

Gut Microbiota in male patients with chronic traumatic complete spinal cord injury

• Downloaded 329 times
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  • Site-wide: 100,441
  • In neuroscience: 15,026
• Year to date:
  • Site-wide: 138,555
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  • Site-wide: 151,977

Causal associations between COVID-19 and Atrial Fibrillation: A bidirectional Mendelian randomization study

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  • Site-wide: 101,655
  • In genetic and genomic medicine: 513
• Year to date:
  • Site-wide: 78,993
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  • Site-wide: 105,519

Inhibitor screening of Spike variants reveals the heterogeneity of neutralizing antibodies to COVID-19 infection and vaccination

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  • Site-wide: 109,312
  • In infectious diseases: 4,835
• Year to date:
  • Site-wide: 27,731
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  • Site-wide: 48,566

Determining the role of inflammation in the selection of JAK2 mutant cells in myeloproliferative neoplasms

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  • Site-wide: 109,264
  • In evolutionary biology: 5,448
• Year to date:
  • Site-wide: 133,599
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  • Site-wide: 110,487

Disentangling effects of climate and land use on biodiversity and ecosystem services - a multi-scale experimental design

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  • Site-wide: 110,458
  • In ecology: 3,391
• Year to date:
  • Site-wide: 28,382
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  • Site-wide: 20,389

A quasi-paired cohort strategy reveals the impaired detoxifying function of microbes in the gut of autistic children

• Downloaded 279 times
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  • Site-wide: 112,913
  • In microbiology: 8,054
• Year to date:
  • Site-wide: 142,762
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  • Site-wide: 128,480

Extracellular Degradation into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD+-produced increases in the Adenylate Pool of BV2 Microglia under Basal Conditions

• Downloaded 279 times
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  • Site-wide: 112,718
  • In cell biology: 5,261
• Year to date:
  • Site-wide: 142,631
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  • Site-wide: 138,264

Mitochondrial Electron Transport Chain Inhibition Suppresses LPS-Induced Inflammatory Responses via TREM1/STAT3 Pathway in BV2 Microglia

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  • Site-wide: 117,309
  • In immunology: 3,506
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  • Site-wide: 105,415
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  • Site-wide: 75,853

NAD+ treatment can increase directly the antioxidant capacity of rotenone-treated differentiated PC12 cells

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  • Site-wide: 118,938
  • In cell biology: 5,536
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  • Site-wide: 130,494
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  • Site-wide: 100,703

Migration of gastric cancer is suppressed by rabies virus glycoprotein via regulating α7-nicotinic acetylcholine receptors/ERK-EMT

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  • Site-wide: 121,218
  • In cancer biology: 3,683
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  • Site-wide: 131,832

Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration

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  • Site-wide: 121,506
  • In neuroscience: 18,236
• Year to date:
  • Site-wide: 134,222
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  • Site-wide: 134,225

Characterization of a Novel Model of Overuse-Induced Calcific Achilles Tendinopathy in Mice: Contralateral Tendinopathy Following Unilateral Tenotomy

• Downloaded 242 times
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  • Site-wide: 122,516
  • In animal behavior and cognition: 1,493
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  • Site-wide: 134,689
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  • Site-wide: 98,901

Differential protein metabolism and regeneration in hypertrophic diaphragm and atrophic gastrocnemius muscles in hibernating Daurian ground squirrels

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  • Site-wide: 126,026
  • In physiology: 1,306
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  • Site-wide: 139,345
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  • Site-wide: 103,455

DIFFERENTIAL EXPRESSION OF CB1 CANNABINOID RECEPTOR AND CANNABINOID RECEPTOR INTERACTING PROTEIN 1A IN LABOR

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  • Site-wide: 127,309
  • In obstetrics and gynecology: 145
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  • Site-wide: 55,226
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  • Site-wide: 55,888

SIRT2, ERK and Nrf2 mediate NAD+ treatment-induced increase in the antioxidant capacity of differentiated PC12 cells under basal conditions

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  • Site-wide: 131,852
  • In cell biology: 6,099
• Year to date:
  • Site-wide: 153,584
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  • Site-wide: 141,720

How do three cytosolic glutamine synthetase isozymes of wheat perform N assimilation and translocation?

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  • Site-wide: 132,619
  • In plant biology: 3,700
• Year to date:
  • Site-wide: 131,593
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  • Site-wide: 80,386

Simultaneous Determination of Contents of Flavonol Glycosides and Terpene Lactones in Ginkgo Biloba Tablets by Ultra High Performance Liquid Chromatography Tandem Single Quadrupole Mass Spectrometry Detector

• Downloaded 202 times
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  • Site-wide: 132,946
  • In biochemistry: 4,026
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  • Site-wide: 124,420
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  • Site-wide: 103,381

A novel nonsense mutation c.424G>T (p. G142X) in the first exon of XLas leading to osteopetrosis

• Downloaded 190 times
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  • Site-wide: 135,897
  • In genetics: 5,457
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  • Site-wide: 151,710
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  • Site-wide: 114,388

Role of Differential Expression of miRNAs miR-125a, miR-200a and miR-199a in Metastatic Property of Ovarian Cancer Cell lines and Relationship between miR-199a and its Predicted Target Protein GSK3β

• Downloaded 168 times
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  • Site-wide: 141,134
  • In molecular biology: 4,224
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  • Site-wide: 95,228

The production of 4,182 mouse lines identifies experimental and biological variables impacting Cas9-mediated mutant mouse line production

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  • Site-wide: 143,043
  • In genetics: 5,661
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  • Site-wide: 57,722
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  • Site-wide: 5,810

Landscape composition mediates suppression of major pests by natural enemies in conventional cruciferous vegetables

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  • Site-wide: 143,444
  • In ecology: 4,968
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  • Site-wide: 63,785

A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis

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  • Site-wide: 146,986
  • In cell biology: 6,748
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  • Site-wide: 65,484
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  • Site-wide: 72,399

Common and Disorders-Specific Cortical Thickness Alterations in Internalizing, Externalizing and Thought Disorders in the Preadolescents of the ABCD Study

• Downloaded 138 times
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  • Site-wide: 147,613
  • In psychiatry and clinical psychology: 862
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  • Site-wide: 66,888
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  • Site-wide: 7,368

Yap/Taz-Activated Tert-Expressing Acinar Cells Are Required for Pancreatic Regeneration

• Downloaded 132 times
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  • Site-wide: 148,839
  • In cell biology: 6,811
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  • Site-wide: 69,821
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  • Site-wide: 8,036

Nicotinic acetylcholine receptor partial antagonist polyamides from tunicates and their predatory sea slugs

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  • Site-wide: 151,231
  • In neuroscience: 22,501
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  • Site-wide: 58,908

Identification of de novo mutations in the Chinese ASD cohort via whole-exome sequencing unveils brain regions implicated in autism

• Downloaded 105 times
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  • Site-wide: 153,529
  • In neurology: 889
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  • Site-wide: 85,692
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  • Site-wide: 52,233

ICER controls HIV-1 infection and replication in elite controllers

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  • Site-wide: 156,530
  • In immunology: 4,786
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  • Site-wide: 103,443
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  • Site-wide: 46,733

FEDERATED MORPHOMETRY FEATURE SELECTION FOR HIPPOCAMPAL MORPHOMETRY ASSOCIATED BETA-AMYLOID AND TAU PATHOLOGY

• Downloaded 75 times
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  • Site-wide: 157,334
  • In neuroscience: 23,409
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  • Site-wide: 110,325
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  • Site-wide: 52,166

Changes in nitrogen pools in the maize-soil system after urea or straw application to a typical intensive agricultural soil: A 15N tracer study

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  • Site-wide: 157,472
  • In plant biology: 4,430
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  • Site-wide: 149,378
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  • Site-wide: 136,646

Brain Laterality Dynamics Support Human Cognition

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  • Site-wide: 157,588
  • In neuroscience: 23,455
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