Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 50,150 bioRxiv papers from 233,740 authors.

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Preprints

Age and mortality associated DNA methylation patterns on the X-chromosome in male and female samples

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Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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The genetic architecture of the human cerebral cortex

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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • In genetics: 45 out of 2,951
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Genomic analysis of family data reveals additional genetic effects on intelligence and personality

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 246 out of 50,150
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Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

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Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci

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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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Genetic analysis identifies molecular systems and biological pathways associated with household income

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  • In genetics: 168 out of 2,951
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  • Site-wide: 116 out of 50,150
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  • Site-wide: 120 out of 50,150

Molecular genetic contributions to self-rated health

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Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

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  • In genetics: 216 out of 2,951
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  • Site-wide: 13,685 out of 50,150
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GWAS on family history of Alzheimer's disease

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  • In genetics: 223 out of 2,951
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  • Site-wide: 11,127 out of 50,150
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Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia.

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  • Site-wide: 32,686 out of 50,150

Genetic Prediction of Male Pattern Baldness

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  • Site-wide: 16,411 out of 50,150
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  • Site-wide: 10,248 out of 50,150

A combined analysis of genetically correlated traits identifies 107 loci associated with intelligence

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  • In genetics: 273 out of 2,951
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  • Site-wide: 18,973 out of 50,150
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  • Site-wide: 19,816 out of 50,150

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

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  • In neuroscience: 452 out of 8,750
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  • Site-wide: 29,637 out of 50,150
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  • Site-wide: 27,344 out of 50,150

Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

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  • In genetics: 299 out of 2,951
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  • Site-wide: 36,202 out of 50,150
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  • Site-wide: 31,460 out of 50,150

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 19,754 out of 50,150

Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life

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  • In genetics: 331 out of 2,951
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  • Site-wide: 34,615 out of 50,150
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  • Site-wide: 31,543 out of 50,150

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

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  • In neuroscience: 594 out of 8,750
• Year to date:
  • Site-wide: 32,703 out of 50,150
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  • Site-wide: 33,871 out of 50,150

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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  • In genetics: 358 out of 2,951
• Year to date:
  • Site-wide: 4,889 out of 50,150
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  • Site-wide: 7,264 out of 50,150

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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  • Site-wide: 4,994 out of 50,150
  • In genomics: 873 out of 3,634
• Year to date:
  • Site-wide: 2,827 out of 50,150
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  • Site-wide: 6,922 out of 50,150

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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  • In genetics: 422 out of 2,951
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  • Site-wide: 19,950 out of 50,150
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  • Site-wide: 17,453 out of 50,150

Intelligence and neuroticism in relation to depression and psychological distress: evidence of interaction using data from Generation Scotland: Scottish Family Health Study and UK Biobank

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  • In genomics: 923 out of 3,634
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  • Site-wide: 25,102 out of 50,150

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

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  • Site-wide: 32,326 out of 50,150

OSCA: a tool for omic-data-based complex trait analysis

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  • In bioinformatics: 1,353 out of 5,266
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  • Site-wide: 3,387 out of 50,150

Epigenetic prediction of complex traits and death

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  • Site-wide: 28,254 out of 50,150
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  • Site-wide: 34,926 out of 50,150

Identification of 55,000 Replicated DNA Methylation QTL

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  • Site-wide: 30,106 out of 50,150

An epigenome-wide association study of educational attainment (n = 10,767)

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  • Site-wide: 32,875 out of 50,150
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  • Site-wide: 44,324 out of 50,150

The Stratification Of Major Depressive Disorder Into Genetic Subgroups

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Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

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Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

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GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

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  • Site-wide: 28,269 out of 50,150

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

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  • Site-wide: 24,038 out of 50,150

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

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  • Site-wide: 25,921 out of 50,150

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

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  • Site-wide: 19,611 out of 50,150

Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

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  • Site-wide: 17,501 out of 50,150

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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  • Site-wide: 41,621 out of 50,150

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

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  • Site-wide: 43,027 out of 50,150

Brain imaging correlates of general intelligence in UK Biobank

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  • Site-wide: 226 out of 50,150

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 41,112 out of 50,150

Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

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  • Site-wide: 48,087 out of 50,150

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

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  • Site-wide: 40,660 out of 50,150

Bayesian reassessment of the epigenetic architecture of complex traits

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Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

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  • Site-wide: 44,955 out of 50,150

Genetic contributions to self-reported tiredness

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  • Site-wide: 43,909 out of 50,150

Cognitive ability and physical health: a Mendelian randomization study

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  • Site-wide: 43,039 out of 50,150
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  • Site-wide: 41,044 out of 50,150

Factors associated with sharing email information and mental health survey participation in two large population cohorts

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  • Site-wide: 4,819 out of 50,150

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

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  • Site-wide: 47,371 out of 50,150

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

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DNA methylation age acceleration and risk factors for Alzheimer's disease

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Accelerated Epigenetic Ageing in Major Depressive Disorder

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Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

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Meta-analysis of exome array data identifies six novel genetic loci for lung function

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Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

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A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

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Polygenic predictors of age-related decline in cognitive ability

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An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

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Polygenic architecture of human neuroanatomical diversity

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Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

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Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

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Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

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Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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Age-related clonal haemopoiesis is associated with increased epigenetic age

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Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

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The influence of X chromosome variants on trait neuroticism.

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Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

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Epigenetic signatures of starting and stopping smoking

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Association of Facial Aging with DNA Methylation and Epigenetic Age Predictions

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Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

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SNPs associated with HHIP expression have differential effects on lung function in males and females

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An epigenome-wide association study of sex-specific chronological ageing

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Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

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Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

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