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Author: Ian J Deary

Rankings

  • All-time downloads: 91,660 (rank: 1,394 )
  • Categories:
    • bioinformatics: 1,324 (rank: 11,367 (tie) )
    • epidemiology: 5,312 (rank: 2,375 )
    • genetic and genomic medicine: 359 (rank: 5,414 (tie) )
    • genetics: 44,117 (rank: 96 )
    • genomics: 6,067 (rank: 3,551 )
    • geriatric medicine: 362 (rank: 341 (tie) )
    • neurology: 749 (rank: 1,394 (tie) )
    • neuroscience: 32,567 (rank: 130 )
    • psychiatry and clinical psychology: 557 (rank: 1,718 (tie) )
    • radiology and imaging: 246 (rank: 1,458 (tie) )

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Preprints

Comparison of structural MRI brain measures between 1.5T and 3T: data from the Lothian Birth Cohort 1936

radiology and imaging more details view paper

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Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

neuroscience more details view paper
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    • Site-wide: 263
    • In neuroscience: 7
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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

genetics more details view paper
  • Downloaded 5,242 times
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    • Site-wide: 1,922
    • In genetics: 68
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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

genetics more details view paper
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    • Site-wide: 2,349
    • In genetics: 85
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Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

genetics more details view paper
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    • Site-wide: 2,370
    • In genetics: 87
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Genomic analysis of family data reveals additional genetic effects on intelligence and personality

genetics more details view paper
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    • Site-wide: 2,616
    • In genetics: 96
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    • Site-wide: 35,904
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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

genetics more details view paper
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    • Site-wide: 3,782
    • In genetics: 155
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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

genetics more details view paper
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    • Site-wide: 5,250
    • In genetics: 238
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Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study of the general population

epidemiology more details view paper
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    • Site-wide: 5,679
    • In epidemiology: 480
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Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia.

genetics more details view paper
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    • Site-wide: 9,140
    • In genetics: 425
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    • Site-wide: 92,622
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    • Site-wide: 119,540

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
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    • Site-wide: 9,733
    • In genetics: 457
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    • Site-wide: 87,131
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Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

genetics more details view paper
  • Downloaded 1,709 times
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    • Site-wide: 9,757
    • In genetics: 458
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    • Site-wide: 59,278
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Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

genetics more details view paper
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    • Site-wide: 10,522
    • In genetics: 502
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    • Site-wide: 95,481
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Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life

genetics more details view paper
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    • Site-wide: 11,877
    • In genetics: 571
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    • Site-wide: 113,039
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116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

genetics more details view paper
  • Downloaded 1,379 times
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    • Site-wide: 13,380
    • In genetics: 645
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    • Site-wide: 64,996
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Bayesian reassessment of the epigenetic architecture of complex traits

genomics more details view paper
  • Downloaded 1,332 times
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    • Site-wide: 14,109
    • In genomics: 1,484
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    • Site-wide: 112,261
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    • Site-wide: 82,306

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

bioinformatics more details view paper
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    • Site-wide: 14,245
    • In bioinformatics: 1,722
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    • Site-wide: 55,253
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    • Site-wide: 57,462

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

genetics more details view paper
  • Downloaded 1,053 times
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    • Site-wide: 20,024
    • In genetics: 954
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    • Site-wide: 87,130
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    • Site-wide: 70,117

Epigenetic prediction of complex traits and death

genomics more details view paper
  • Downloaded 1,009 times
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    • Site-wide: 21,320
    • In genomics: 2,099
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Reliability and validity of the UK Biobank cognitive tests

epidemiology more details view paper
  • Downloaded 935 times
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    • Site-wide: 23,813
    • In epidemiology: 1,335
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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

genetics more details view paper
  • Downloaded 908 times
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    • Site-wide: 24,872
    • In genetics: 1,187
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    • Site-wide: 19,202
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    • Site-wide: 10,087

Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

genetics more details view paper
  • Downloaded 894 times
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    • Site-wide: 25,382
    • In genetics: 1,217
  • Year to date:
    • Site-wide: 89,031
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    • Site-wide: 124,899

Polygenic architecture of human neuroanatomical diversity

neuroscience more details view paper
  • Downloaded 886 times
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    • Site-wide: 25,707
    • In neuroscience: 3,360
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    • Site-wide: 40,261
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A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

genetics more details view paper
  • Downloaded 867 times
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    • Site-wide: 26,457
    • In genetics: 1,260
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    • Site-wide: 114,770
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    • Site-wide: 83,151

Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

neuroscience more details view paper
  • Downloaded 836 times
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    • Site-wide: 27,827
    • In neuroscience: 3,688
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    • Site-wide: 100,231
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Planar cell polarity pathway and development of the human visual cortex

neuroscience more details view paper
  • Downloaded 778 times
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    • Site-wide: 30,849
    • In neuroscience: 4,158
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    • Site-wide: 62,051
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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

genomics more details view paper
  • Downloaded 753 times
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    • Site-wide: 32,258
    • In genomics: 2,846
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    • Site-wide: 102,780
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    • Site-wide: 120,275

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

genetics more details view paper
  • Downloaded 745 times
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    • Site-wide: 32,744
    • In genetics: 1,567
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    • Site-wide: 117,100
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    • Site-wide: 135,322

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

genetics more details view paper
  • Downloaded 731 times
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    • Site-wide: 33,603
    • In genetics: 1,606
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    • Site-wide: 122,465
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Associations between vascular risk factors and brain MRI indices in UK Biobank

neuroscience more details view paper
  • Downloaded 684 times
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    • Site-wide: 36,801
    • In neuroscience: 5,117
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    • Site-wide: 109,547
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    • Site-wide: 82,613

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

genetics more details view paper
  • Downloaded 682 times
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    • Site-wide: 36,945
    • In genetics: 1,746
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    • Site-wide: 76,989
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    • Site-wide: 93,034

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

genetics more details view paper
  • Downloaded 674 times
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    • Site-wide: 37,543
    • In genetics: 1,773
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    • Site-wide: 106,807
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Generalisability of Results from UK Biobank: Comparison With a Pooling of 18 Cohort Studies

epidemiology more details view paper
  • Downloaded 642 times
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    • Site-wide: 40,007
    • In epidemiology: 1,924
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Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

genomics more details view paper
  • Downloaded 637 times
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    • Site-wide: 40,385
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Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

genomics more details view paper
  • Downloaded 633 times
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    • Site-wide: 40,697
    • In genomics: 3,364
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    • Site-wide: 93,171
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Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

genetics more details view paper
  • Downloaded 613 times
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    • Site-wide: 42,387
    • In genetics: 1,985
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    • Site-wide: 12,088
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    • Site-wide: 17,331

Cognitive ability and physical health: a Mendelian randomization study

genetics more details view paper
  • Downloaded 609 times
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    • Site-wide: 42,714
    • In genetics: 2,002
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    • Site-wide: 122,459
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    • Site-wide: 124,303

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

genomics more details view paper
  • Downloaded 533 times
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    • Site-wide: 50,239
    • In genomics: 3,926
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Meta-analysis of exome array data identifies six novel genetic loci for lung function

genetics more details view paper
  • Downloaded 480 times
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    • Site-wide: 56,863
    • In genetics: 2,623
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    • Site-wide: 117,054
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Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

neuroscience more details view paper
  • Downloaded 467 times
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    • Site-wide: 58,514
    • In neuroscience: 8,670
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    • Site-wide: 130,925
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Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

neuroscience more details view paper
  • Downloaded 446 times
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    • Site-wide: 61,418
    • In neuroscience: 9,174
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A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

genetics more details view paper
  • Downloaded 422 times
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    • Site-wide: 64,997
    • In genetics: 2,984
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    • Site-wide: 112,930
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    • Site-wide: 80,710

Epigenetic prediction of major depressive disorder

psychiatry and clinical psychology more details view paper
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    • Site-wide: 65,877
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Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

neuroscience more details view paper
  • Downloaded 416 times
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    • Site-wide: 65,931
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Cognitive impairments in sporadic cerebral small vessel disease (SVD): a systematic review and meta-analysis of cohorts with stroke, dementia and non-clinical presentations of SVD

neurology more details view paper
  • Downloaded 406 times
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    • Site-wide: 67,573
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    • Site-wide: 77,963
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    • Site-wide: 67,655

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

genomics more details view paper
  • Downloaded 399 times
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    • Site-wide: 68,590
    • In genomics: 4,800
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    • Site-wide: 115,809
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    • Site-wide: 100,457

SNPs associated with HHIP expression have differential effects on lung function in males and females

genetics more details view paper
  • Downloaded 390 times
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    • Site-wide: 70,169
    • In genetics: 3,191
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    • Site-wide: 51,016

The influence of X chromosome variants on trait neuroticism.

genetics more details view paper
  • Downloaded 385 times
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    • Site-wide: 71,012
    • In genetics: 3,217
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    • Site-wide: 106,398
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    • Site-wide: 94,634

Psychotic-like experiences, polygenic risk scores for schizophrenia and structural properties of the salience, default mode and central-executive networks in healthy participants from UK Biobank

neuroscience more details view paper
  • Downloaded 382 times
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    • Site-wide: 71,516
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    • Site-wide: 116,570

An epigenetic predictor of death captures multi-modal measures of brain health

neuroscience more details view paper
  • Downloaded 370 times
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    • Site-wide: 73,628
    • In neuroscience: 11,185
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Blood pressure and cognitive function across the eighth decade: a prospective study of the Lothian Birth Cohort of 1936

geriatric medicine more details view paper
  • Downloaded 362 times
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    • Site-wide: 75,112
    • In geriatric medicine: 43
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Understanding Cognitive Impairment in Mood Disorders: Mediation Analyses in the UK Biobank Cohort

epidemiology more details view paper
  • Downloaded 349 times
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    • Site-wide: 77,539
    • In epidemiology: 3,240
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An epigenetic proxy of chronic inflammation outperforms serum levels as a biomarker of brain ageing

neurology more details view paper
  • Downloaded 343 times
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    • Site-wide: 78,699
    • In neurology: 196
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Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

genetics more details view paper
  • Downloaded 341 times
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    • Site-wide: 79,172
    • In genetics: 3,581
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    • Site-wide: 125,193

An epigenome-wide association study of sex-specific chronological ageing

genomics more details view paper
  • Downloaded 328 times
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    • Site-wide: 81,597
    • In genomics: 5,325
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Pre-pandemic Cognitive Function and COVID-19 Vaccine Hesitancy: Prospective Cohort Study

epidemiology more details view paper
  • Downloaded 302 times
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    • Site-wide: 86,890
    • In epidemiology: 3,587
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    • Site-wide: 8,116
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    • Site-wide: 1,784

Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

neuroscience more details view paper
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    • Site-wide: 90,950
    • In neuroscience: 13,947
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Quantitative Measurements of Enlarged Perivascular Spaces in the Brain are Associated with Retinal Microvascular Parameters in Older Community-Dwelling Subjects

neuroscience more details view paper
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    • Site-wide: 93,233
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Age and mortality associated DNA methylation patterns on the X-chromosome in male and female samples

genetics more details view paper
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DNA methylation outlier burden, health and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936.

genetic and genomic medicine more details view paper
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    • Site-wide: 100,099
    • In genetic and genomic medicine: 420
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Childhood coordination and survival up to six decades later: extended follow-up of participants in the National Child Development Study

epidemiology more details view paper
  • Downloaded 236 times
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    • Site-wide: 101,499
    • In epidemiology: 4,161
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Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

neuroscience more details view paper
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    • Site-wide: 103,973
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Epigenetic scores for the circulating proteome replicate protein-disease predictions as tools for biomarker discovery

genomics more details view paper
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    • In genomics: 6,120
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Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

neuroscience more details view paper
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    • In neuroscience: 16,168
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    • Site-wide: 137,284
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Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

genomics more details view paper
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    • In genomics: 6,143
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DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

neuroscience more details view paper
  • Downloaded 215 times
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    • Site-wide: 106,336
    • In neuroscience: 16,407
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    • Site-wide: 132,213
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Health literacy, cognitive ability and self-reported diabetes in the English Longitudinal Study of Ageing

epidemiology more details view paper
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    • Site-wide: 106,641
    • In epidemiology: 4,404
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    • Site-wide: 103,157

Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort

radiology and imaging more details view paper
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Life course air pollution exposure and cognitive decline: modelled historical air pollution data and the Lothian Birth Cohort 1936

epidemiology more details view paper
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A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

neuroscience more details view paper
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The Influence of Phenotyping Method on Neuroimaging Associations with Depression in UK Biobank

psychiatry and clinical psychology more details view paper
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Birth weight is associated with brain tissue volumes seven decades later, but not with age-associated changes to brain structure

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Cerebral Small Vessel Disease Burden and Longitudinal Cognitive Decline from age 73 to 82: the Lothian Birth Cohort 1936

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