Author: Ian J Deary

Downloads per author, site-wide

Preprints

Comparison of structural MRI brain measures between 1.5T and 3T: data from the Lothian Birth Cohort 1936

No download data for this paper yet.

Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

• Downloaded 25,798 times
• Download rankings, all-time:
  • Site-wide: 263
  • In neuroscience: 7
• Year to date:
  • Site-wide: 2,538
• Since beginning of last month:
  • Site-wide: 3,354

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

• Downloaded 5,242 times
• Download rankings, all-time:
  • Site-wide: 1,922
  • In genetics: 68
• Year to date:
  • Site-wide: 19,427
• Since beginning of last month:
  • Site-wide: 15,753

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,550 times
• Download rankings, all-time:
  • Site-wide: 2,349
  • In genetics: 85
• Year to date:
  • Site-wide: 33,457
• Since beginning of last month:
  • Site-wide: 25,504

Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

• Downloaded 4,521 times
• Download rankings, all-time:
  • Site-wide: 2,370
  • In genetics: 87
• Year to date:
  • Site-wide: 25,727
• Since beginning of last month:
  • Site-wide: 21,893

Genomic analysis of family data reveals additional genetic effects on intelligence and personality

• Downloaded 4,211 times
• Download rankings, all-time:
  • Site-wide: 2,616
  • In genetics: 96
• Year to date:
  • Site-wide: 35,904
• Since beginning of last month:
  • Site-wide: 46,770

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,265 times
• Download rankings, all-time:
  • Site-wide: 3,782
  • In genetics: 155
• Year to date:
  • Site-wide: 47,668
• Since beginning of last month:
  • Site-wide: 91,748

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

• Downloaded 2,588 times
• Download rankings, all-time:
  • Site-wide: 5,250
  • In genetics: 238
• Year to date:
  • Site-wide: 65,624
• Since beginning of last month:
  • Site-wide: 51,012

Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study of the general population

• Downloaded 2,464 times
• Download rankings, all-time:
  • Site-wide: 5,679
  • In epidemiology: 480
• Year to date:
  • Site-wide: 13,418
• Since beginning of last month:
  • Site-wide: 10,337

Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia.

• Downloaded 1,784 times
• Download rankings, all-time:
  • Site-wide: 9,140
  • In genetics: 425
• Year to date:
  • Site-wide: 92,622
• Since beginning of last month:
  • Site-wide: 119,540

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,713 times
• Download rankings, all-time:
  • Site-wide: 9,733
  • In genetics: 457
• Year to date:
  • Site-wide: 87,131
• Since beginning of last month:
  • Site-wide: 124,724

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

• Downloaded 1,709 times
• Download rankings, all-time:
  • Site-wide: 9,757
  • In genetics: 458
• Year to date:
  • Site-wide: 59,278
• Since beginning of last month:
  • Site-wide: 57,117

Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

• Downloaded 1,621 times
• Download rankings, all-time:
  • Site-wide: 10,522
  • In genetics: 502
• Year to date:
  • Site-wide: 95,481
• Since beginning of last month:
  • Site-wide: 119,560

Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life

• Downloaded 1,491 times
• Download rankings, all-time:
  • Site-wide: 11,877
  • In genetics: 571
• Year to date:
  • Site-wide: 113,039
• Since beginning of last month:
  • Site-wide: 135,272

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,379 times
• Download rankings, all-time:
  • Site-wide: 13,380
  • In genetics: 645
• Year to date:
  • Site-wide: 64,996
• Since beginning of last month:
  • Site-wide: 35,804

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 1,332 times
• Download rankings, all-time:
  • Site-wide: 14,109
  • In genomics: 1,484
• Year to date:
  • Site-wide: 112,261
• Since beginning of last month:
  • Site-wide: 82,306

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

• Downloaded 1,324 times
• Download rankings, all-time:
  • Site-wide: 14,245
  • In bioinformatics: 1,722
• Year to date:
  • Site-wide: 55,253
• Since beginning of last month:
  • Site-wide: 57,462

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 1,053 times
• Download rankings, all-time:
  • Site-wide: 20,024
  • In genetics: 954
• Year to date:
  • Site-wide: 87,130
• Since beginning of last month:
  • Site-wide: 70,117

Epigenetic prediction of complex traits and death

• Downloaded 1,009 times
• Download rankings, all-time:
  • Site-wide: 21,320
  • In genomics: 2,099
• Year to date:
  • Site-wide: 70,397
• Since beginning of last month:
  • Site-wide: 55,616

Reliability and validity of the UK Biobank cognitive tests

• Downloaded 935 times
• Download rankings, all-time:
  • Site-wide: 23,813
  • In epidemiology: 1,335
• Year to date:
  • Site-wide: 51,460
• Since beginning of last month:
  • Site-wide: 41,154

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 908 times
• Download rankings, all-time:
  • Site-wide: 24,872
  • In genetics: 1,187
• Year to date:
  • Site-wide: 19,202
• Since beginning of last month:
  • Site-wide: 10,087

Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

• Downloaded 894 times
• Download rankings, all-time:
  • Site-wide: 25,382
  • In genetics: 1,217
• Year to date:
  • Site-wide: 89,031
• Since beginning of last month:
  • Site-wide: 124,899

Polygenic architecture of human neuroanatomical diversity

• Downloaded 886 times
• Download rankings, all-time:
  • Site-wide: 25,707
  • In neuroscience: 3,360
• Year to date:
  • Site-wide: 40,261
• Since beginning of last month:
  • Site-wide: 39,140

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

• Downloaded 867 times
• Download rankings, all-time:
  • Site-wide: 26,457
  • In genetics: 1,260
• Year to date:
  • Site-wide: 114,770
• Since beginning of last month:
  • Site-wide: 83,151

Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

• Downloaded 836 times
• Download rankings, all-time:
  • Site-wide: 27,827
  • In neuroscience: 3,688
• Year to date:
  • Site-wide: 100,231
• Since beginning of last month:
  • Site-wide: 69,303

Planar cell polarity pathway and development of the human visual cortex

• Downloaded 778 times
• Download rankings, all-time:
  • Site-wide: 30,849
  • In neuroscience: 4,158
• Year to date:
  • Site-wide: 62,051
• Since beginning of last month:
  • Site-wide: 63,373

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 753 times
• Download rankings, all-time:
  • Site-wide: 32,258
  • In genomics: 2,846
• Year to date:
  • Site-wide: 102,780
• Since beginning of last month:
  • Site-wide: 120,275

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 745 times
• Download rankings, all-time:
  • Site-wide: 32,744
  • In genetics: 1,567
• Year to date:
  • Site-wide: 117,100
• Since beginning of last month:
  • Site-wide: 135,322

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

• Downloaded 731 times
• Download rankings, all-time:
  • Site-wide: 33,603
  • In genetics: 1,606
• Year to date:
  • Site-wide: 122,465
• Since beginning of last month:
  • Site-wide: 80,729

Associations between vascular risk factors and brain MRI indices in UK Biobank

• Downloaded 684 times
• Download rankings, all-time:
  • Site-wide: 36,801
  • In neuroscience: 5,117
• Year to date:
  • Site-wide: 109,547
• Since beginning of last month:
  • Site-wide: 82,613

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

• Downloaded 682 times
• Download rankings, all-time:
  • Site-wide: 36,945
  • In genetics: 1,746
• Year to date:
  • Site-wide: 76,989
• Since beginning of last month:
  • Site-wide: 93,034

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 674 times
• Download rankings, all-time:
  • Site-wide: 37,543
  • In genetics: 1,773
• Year to date:
  • Site-wide: 106,807
• Since beginning of last month:
  • Site-wide: 108,105

Generalisability of Results from UK Biobank: Comparison With a Pooling of 18 Cohort Studies

• Downloaded 642 times
• Download rankings, all-time:
  • Site-wide: 40,007
  • In epidemiology: 1,924
• Year to date:
  • Site-wide: 39,276
• Since beginning of last month:
  • Site-wide: 47,866

Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

• Downloaded 637 times
• Download rankings, all-time:
  • Site-wide: 40,385
  • In genomics: 3,343
• Year to date:
  • Site-wide: 135,337
• Since beginning of last month:
  • Site-wide: 136,084

Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

• Downloaded 633 times
• Download rankings, all-time:
  • Site-wide: 40,697
  • In genomics: 3,364
• Year to date:
  • Site-wide: 93,171
• Since beginning of last month:
  • Site-wide: 134,899

Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

• Downloaded 613 times
• Download rankings, all-time:
  • Site-wide: 42,387
  • In genetics: 1,985
• Year to date:
  • Site-wide: 12,088
• Since beginning of last month:
  • Site-wide: 17,331

Cognitive ability and physical health: a Mendelian randomization study

• Downloaded 609 times
• Download rankings, all-time:
  • Site-wide: 42,714
  • In genetics: 2,002
• Year to date:
  • Site-wide: 122,459
• Since beginning of last month:
  • Site-wide: 124,303

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

• Downloaded 533 times
• Download rankings, all-time:
  • Site-wide: 50,239
  • In genomics: 3,926
• Year to date:
  • Site-wide: 57,109
• Since beginning of last month:
  • Site-wide: 30,534

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 480 times
• Download rankings, all-time:
  • Site-wide: 56,863
  • In genetics: 2,623
• Year to date:
  • Site-wide: 117,054
• Since beginning of last month:
  • Site-wide: 94,032

Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

• Downloaded 467 times
• Download rankings, all-time:
  • Site-wide: 58,514
  • In neuroscience: 8,670
• Year to date:
  • Site-wide: 130,925
• Since beginning of last month:
  • Site-wide: 118,165

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

• Downloaded 446 times
• Download rankings, all-time:
  • Site-wide: 61,418
  • In neuroscience: 9,174
• Year to date:
  • Site-wide: 93,571
• Since beginning of last month:
  • Site-wide: 83,493

A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

• Downloaded 422 times
• Download rankings, all-time:
  • Site-wide: 64,997
  • In genetics: 2,984
• Year to date:
  • Site-wide: 112,930
• Since beginning of last month:
  • Site-wide: 80,710

Epigenetic prediction of major depressive disorder

• Downloaded 416 times
• Download rankings, all-time:
  • Site-wide: 65,877
  • In psychiatry and clinical psychology: 213
• Year to date:
  • Site-wide: 115,634
• Since beginning of last month:
  • Site-wide: 87,627

Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

• Downloaded 416 times
• Download rankings, all-time:
  • Site-wide: 65,931
  • In neuroscience: 9,925
• Year to date:
  • Site-wide: 134,165
• Since beginning of last month:
  • Site-wide: None

Cognitive impairments in sporadic cerebral small vessel disease (SVD): a systematic review and meta-analysis of cohorts with stroke, dementia and non-clinical presentations of SVD

• Downloaded 406 times
• Download rankings, all-time:
  • Site-wide: 67,573
  • In neurology: 142
• Year to date:
  • Site-wide: 77,963
• Since beginning of last month:
  • Site-wide: 67,655

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

• Downloaded 399 times
• Download rankings, all-time:
  • Site-wide: 68,590
  • In genomics: 4,800
• Year to date:
  • Site-wide: 115,809
• Since beginning of last month:
  • Site-wide: 100,457

SNPs associated with HHIP expression have differential effects on lung function in males and females

• Downloaded 390 times
• Download rankings, all-time:
  • Site-wide: 70,169
  • In genetics: 3,191
• Year to date:
  • Site-wide: 106,543
• Since beginning of last month:
  • Site-wide: 51,016

The influence of X chromosome variants on trait neuroticism.

• Downloaded 385 times
• Download rankings, all-time:
  • Site-wide: 71,012
  • In genetics: 3,217
• Year to date:
  • Site-wide: 106,398
• Since beginning of last month:
  • Site-wide: 94,634

Psychotic-like experiences, polygenic risk scores for schizophrenia and structural properties of the salience, default mode and central-executive networks in healthy participants from UK Biobank

• Downloaded 382 times
• Download rankings, all-time:
  • Site-wide: 71,516
  • In neuroscience: 10,824
• Year to date:
  • Site-wide: 127,484
• Since beginning of last month:
  • Site-wide: 116,570

An epigenetic predictor of death captures multi-modal measures of brain health

• Downloaded 370 times
• Download rankings, all-time:
  • Site-wide: 73,628
  • In neuroscience: 11,185
• Year to date:
  • Site-wide: 133,864
• Since beginning of last month:
  • Site-wide: 122,908

Blood pressure and cognitive function across the eighth decade: a prospective study of the Lothian Birth Cohort of 1936

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 75,112
  • In geriatric medicine: 43
• Year to date:
  • Site-wide: 123,414
• Since beginning of last month:
  • Site-wide: 127,890

Understanding Cognitive Impairment in Mood Disorders: Mediation Analyses in the UK Biobank Cohort

• Downloaded 349 times
• Download rankings, all-time:
  • Site-wide: 77,539
  • In epidemiology: 3,240
• Year to date:
  • Site-wide: 128,662
• Since beginning of last month:
  • Site-wide: 132,926

An epigenetic proxy of chronic inflammation outperforms serum levels as a biomarker of brain ageing

• Downloaded 343 times
• Download rankings, all-time:
  • Site-wide: 78,699
  • In neurology: 196
• Year to date:
  • Site-wide: 21,696
• Since beginning of last month:
  • Site-wide: 33,917

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 79,172
  • In genetics: 3,581
• Year to date:
  • Site-wide: 133,147
• Since beginning of last month:
  • Site-wide: 125,193

An epigenome-wide association study of sex-specific chronological ageing

• Downloaded 328 times
• Download rankings, all-time:
  • Site-wide: 81,597
  • In genomics: 5,325
• Year to date:
  • Site-wide: 135,105
• Since beginning of last month:
  • Site-wide: 89,306

Pre-pandemic Cognitive Function and COVID-19 Vaccine Hesitancy: Prospective Cohort Study

• Downloaded 302 times
• Download rankings, all-time:
  • Site-wide: 86,890
  • In epidemiology: 3,587
• Year to date:
  • Site-wide: 8,116
• Since beginning of last month:
  • Site-wide: 1,784

Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

• Downloaded 284 times
• Download rankings, all-time:
  • Site-wide: 90,950
  • In neuroscience: 13,947
• Year to date:
  • Site-wide: 100,197
• Since beginning of last month:
  • Site-wide: 93,311

Quantitative Measurements of Enlarged Perivascular Spaces in the Brain are Associated with Retinal Microvascular Parameters in Older Community-Dwelling Subjects

• Downloaded 273 times
• Download rankings, all-time:
  • Site-wide: 93,233
  • In neuroscience: 14,339
• Year to date:
  • Site-wide: 85,277
• Since beginning of last month:
  • Site-wide: 58,525

Age and mortality associated DNA methylation patterns on the X-chromosome in male and female samples

• Downloaded 249 times
• Download rankings, all-time:
  • Site-wide: 98,542
  • In genetics: 4,360
• Year to date:
  • Site-wide: 119,575
• Since beginning of last month:
  • Site-wide: 106,053

DNA methylation outlier burden, health and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936.

• Downloaded 242 times
• Download rankings, all-time:
  • Site-wide: 100,099
  • In genetic and genomic medicine: 420
• Year to date:
  • Site-wide: 101,146
• Since beginning of last month:
  • Site-wide: 103,480

Childhood coordination and survival up to six decades later: extended follow-up of participants in the National Child Development Study

• Downloaded 236 times
• Download rankings, all-time:
  • Site-wide: 101,499
  • In epidemiology: 4,161
• Year to date:
  • Site-wide: 115,836
• Since beginning of last month:
  • Site-wide: 101,329

Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

• Downloaded 225 times
• Download rankings, all-time:
  • Site-wide: 103,973
  • In neuroscience: 16,032
• Year to date:
  • Site-wide: 131,154
• Since beginning of last month:
  • Site-wide: 134,727

Epigenetic scores for the circulating proteome replicate protein-disease predictions as tools for biomarker discovery

• Downloaded 223 times
• Download rankings, all-time:
  • Site-wide: 104,387
  • In genomics: 6,120
• Year to date:
  • Site-wide: 31,305
• Since beginning of last month:
  • Site-wide: None

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

• Downloaded 222 times
• Download rankings, all-time:
  • Site-wide: 104,664
  • In neuroscience: 16,168
• Year to date:
  • Site-wide: 137,284
• Since beginning of last month:
  • Site-wide: 133,179

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 220 times
• Download rankings, all-time:
  • Site-wide: 105,109
  • In genomics: 6,143
• Year to date:
  • Site-wide: 88,363
• Since beginning of last month:
  • Site-wide: 59,295

DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

• Downloaded 215 times
• Download rankings, all-time:
  • Site-wide: 106,336
  • In neuroscience: 16,407
• Year to date:
  • Site-wide: 132,213
• Since beginning of last month:
  • Site-wide: 131,592

Health literacy, cognitive ability and self-reported diabetes in the English Longitudinal Study of Ageing

• Downloaded 214 times
• Download rankings, all-time:
  • Site-wide: 106,641
  • In epidemiology: 4,404
• Year to date:
  • Site-wide: 108,484
• Since beginning of last month:
  • Site-wide: 103,157

Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort

• Downloaded 174 times
• Download rankings, all-time:
  • Site-wide: 115,565
  • In radiology and imaging: 227
• Year to date:
  • Site-wide: 17,030
• Since beginning of last month:
  • Site-wide: 24,643

Life course air pollution exposure and cognitive decline: modelled historical air pollution data and the Lothian Birth Cohort 1936

• Downloaded 170 times
• Download rankings, all-time:
  • Site-wide: 116,214
  • In epidemiology: 4,796
• Year to date:
  • Site-wide: 52,488
• Since beginning of last month:
  • Site-wide: 112,039

A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

• Downloaded 164 times
• Download rankings, all-time:
  • Site-wide: 117,583
  • In neuroscience: 18,056
• Year to date:
  • Site-wide: 53,742
• Since beginning of last month:
  • Site-wide: 36,378

The Influence of Phenotyping Method on Neuroimaging Associations with Depression in UK Biobank

• Downloaded 141 times
• Download rankings, all-time:
  • Site-wide: 122,496
  • In psychiatry and clinical psychology: 573
• Year to date:
  • Site-wide: 43,859
• Since beginning of last month:
  • Site-wide: 65,359

Birth weight is associated with brain tissue volumes seven decades later, but not with age-associated changes to brain structure

• Downloaded 121 times
• Download rankings, all-time:
  • Site-wide: 126,510
  • In neuroscience: 19,334
• Year to date:
  • Site-wide: 80,024
• Since beginning of last month:
  • Site-wide: 78,437

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

• Downloaded 117 times
• Download rankings, all-time:
  • Site-wide: 127,300
  • In genetic and genomic medicine: 636
• Year to date:
  • Site-wide: 27,489
• Since beginning of last month:
  • Site-wide: 33,837

Cerebral Small Vessel Disease Burden and Longitudinal Cognitive Decline from age 73 to 82: the Lothian Birth Cohort 1936

• Downloaded 72 times
• Download rankings, all-time:
  • Site-wide: 134,506
  • In radiology and imaging: 287
• Year to date:
  • Site-wide: 44,789
• Since beginning of last month:
  • Site-wide: 9,327