Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 60,222 bioRxiv papers from 267,721 authors.

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Preprints

Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

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  • In neuroscience: 6 out of 10,621
• Year to date:
  • Site-wide: 394 out of 60,222
• Since beginning of last month:
  • Site-wide: 1,509 out of 60,222

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 8,683 times
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  • Site-wide: 136 out of 60,222
  • In genetics: 13 out of 3,432
• Year to date:
  • Site-wide: 2,225 out of 60,222
• Since beginning of last month:
  • Site-wide: 20,675 out of 60,222

The genetic architecture of the human cerebral cortex

• Downloaded 5,921 times
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  • Site-wide: 286 out of 60,222
  • In genetics: 33 out of 3,432
• Year to date:
  • Site-wide: 233 out of 60,222
• Since beginning of last month:
  • Site-wide: 348 out of 60,222

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 477 out of 60,222
  • In genetics: 51 out of 3,432
• Year to date:
  • Site-wide: 6,092 out of 60,222
• Since beginning of last month:
  • Site-wide: 10,348 out of 60,222

Genomic analysis of family data reveals additional genetic effects on intelligence and personality

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  • Site-wide: 692 out of 60,222
  • In genetics: 69 out of 3,432
• Year to date:
  • Site-wide: 10,603 out of 60,222
• Since beginning of last month:
  • Site-wide: 19,276 out of 60,222

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 3,602 times
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  • Site-wide: 742 out of 60,222
  • In genetics: 72 out of 3,432
• Year to date:
  • Site-wide: 401 out of 60,222
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  • Site-wide: 2,375 out of 60,222

Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

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  • Site-wide: 757 out of 60,222
  • In genetics: 74 out of 3,432
• Year to date:
  • Site-wide: 800 out of 60,222
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  • Site-wide: 2,497 out of 60,222

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 2,890 times
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  • Site-wide: 1,121 out of 60,222
  • In genetics: 105 out of 3,432
• Year to date:
  • Site-wide: 13,593 out of 60,222
• Since beginning of last month:
  • Site-wide: 25,929 out of 60,222

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 2,731 times
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  • Site-wide: 1,248 out of 60,222
  • In genetics: 119 out of 3,432
• Year to date:
  • Site-wide: 12,618 out of 60,222
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  • Site-wide: 12,320 out of 60,222

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

• Downloaded 2,261 times
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  • Site-wide: 1,727 out of 60,222
  • In genetics: 165 out of 3,432
• Year to date:
  • Site-wide: 21,565 out of 60,222
• Since beginning of last month:
  • Site-wide: 19,392 out of 60,222

Genetic analysis identifies molecular systems and biological pathways associated with household income

• Downloaded 2,249 times
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  • Site-wide: 1,742 out of 60,222
  • In genetics: 168 out of 3,432
• Year to date:
  • Site-wide: 258 out of 60,222
• Since beginning of last month:
  • Site-wide: 9,368 out of 60,222

Molecular genetic contributions to self-rated health

• Downloaded 1,953 times
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  • Site-wide: 2,243 out of 60,222
  • In genetics: 216 out of 3,432
• Year to date:
  • Site-wide: 34,839 out of 60,222
• Since beginning of last month:
  • Site-wide: 41,536 out of 60,222

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

• Downloaded 1,822 times
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  • Site-wide: 2,520 out of 60,222
  • In genetics: 237 out of 3,432
• Year to date:
  • Site-wide: 16,672 out of 60,222
• Since beginning of last month:
  • Site-wide: 16,555 out of 60,222

GWAS on family history of Alzheimer's disease

• Downloaded 1,730 times
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  • Site-wide: 2,763 out of 60,222
  • In genetics: 248 out of 3,432
• Year to date:
  • Site-wide: 16,991 out of 60,222
• Since beginning of last month:
  • Site-wide: 32,530 out of 60,222

Genetic Prediction of Male Pattern Baldness

• Downloaded 1,567 times
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  • Site-wide: 3,239 out of 60,222
  • In genetics: 290 out of 3,432
• Year to date:
  • Site-wide: 17,980 out of 60,222
• Since beginning of last month:
  • Site-wide: 18,271 out of 60,222

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

• Downloaded 1,487 times
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  • Site-wide: 3,554 out of 60,222
  • In neuroscience: 542 out of 10,621
• Year to date:
  • Site-wide: 33,394 out of 60,222
• Since beginning of last month:
  • Site-wide: 22,626 out of 60,222

Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

• Downloaded 1,450 times
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  • Site-wide: 3,709 out of 60,222
  • In genetics: 332 out of 3,432
• Year to date:
  • Site-wide: 42,658 out of 60,222
• Since beginning of last month:
  • Site-wide: 43,890 out of 60,222

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,428 times
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  • Site-wide: 3,800 out of 60,222
  • In genetics: 337 out of 3,432
• Year to date:
  • Site-wide: 14,761 out of 60,222
• Since beginning of last month:
  • Site-wide: 13,460 out of 60,222

Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life

• Downloaded 1,320 times
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  • Site-wide: 4,316 out of 60,222
  • In genetics: 361 out of 3,432
• Year to date:
  • Site-wide: 39,949 out of 60,222
• Since beginning of last month:
  • Site-wide: 28,944 out of 60,222

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

• Downloaded 1,300 times
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  • Site-wide: 4,446 out of 60,222
  • In genetics: 373 out of 3,432
• Year to date:
  • Site-wide: 6,571 out of 60,222
• Since beginning of last month:
  • Site-wide: 15,686 out of 60,222

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

• Downloaded 1,270 times
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  • Site-wide: 4,588 out of 60,222
  • In neuroscience: 704 out of 10,621
• Year to date:
  • Site-wide: 42,578 out of 60,222
• Since beginning of last month:
  • Site-wide: 38,955 out of 60,222

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,216 times
• Download rankings, all-time:
  • Site-wide: 4,919 out of 60,222
  • In genomics: 861 out of 4,168
• Year to date:
  • Site-wide: 3,896 out of 60,222
• Since beginning of last month:
  • Site-wide: 10,013 out of 60,222

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,098 times
• Download rankings, all-time:
  • Site-wide: 5,859 out of 60,222
  • In genetics: 472 out of 3,432
• Year to date:
  • Site-wide: 27,547 out of 60,222
• Since beginning of last month:
  • Site-wide: 51,026 out of 60,222

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

• Downloaded 965 times
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  • Site-wide: 7,201 out of 60,222
  • In bioinformatics: 1,315 out of 6,078
• Year to date:
  • Site-wide: 6,677 out of 60,222
• Since beginning of last month:
  • Site-wide: 11,715 out of 60,222

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 926 times
• Download rankings, all-time:
  • Site-wide: 7,690 out of 60,222
  • In bioinformatics: 1,377 out of 6,078
• Year to date:
  • Site-wide: 3,525 out of 60,222
• Since beginning of last month:
  • Site-wide: 25,217 out of 60,222

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

• Downloaded 920 times
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  • Site-wide: 7,787 out of 60,222
  • In neuroscience: 1,196 out of 10,621
• Year to date:
  • Site-wide: 45,333 out of 60,222
• Since beginning of last month:
  • Site-wide: 45,053 out of 60,222

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 861 times
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  • Site-wide: 8,630 out of 60,222
  • In genomics: 1,320 out of 4,168
• Year to date:
  • Site-wide: 30,031 out of 60,222
• Since beginning of last month:
  • Site-wide: 27,290 out of 60,222

Epigenetic prediction of complex traits and death

• Downloaded 848 times
• Download rankings, all-time:
  • Site-wide: 8,847 out of 60,222
  • In genomics: 1,352 out of 4,168
• Year to date:
  • Site-wide: 36,806 out of 60,222
• Since beginning of last month:
  • Site-wide: 41,137 out of 60,222

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 845 times
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  • Site-wide: 8,896 out of 60,222
  • In genetics: 663 out of 3,432
• Year to date:
  • Site-wide: 3,356 out of 60,222
• Since beginning of last month:
  • Site-wide: 8,500 out of 60,222

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 826 times
• Download rankings, all-time:
  • Site-wide: 9,215 out of 60,222
  • In genetics: 685 out of 3,432
• Year to date:
  • Site-wide: 34,646 out of 60,222
• Since beginning of last month:
  • Site-wide: 50,054 out of 60,222

The Stratification Of Major Depressive Disorder Into Genetic Subgroups

• Downloaded 803 times
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  • Site-wide: 9,607 out of 60,222
  • In genetics: 713 out of 3,432
• Year to date:
  • Site-wide: 25,561 out of 60,222
• Since beginning of last month:
  • Site-wide: 37,648 out of 60,222

Genetic “General Intelligence,” Objectively Determined and Measured

• Downloaded 774 times
• Download rankings, all-time:
  • Site-wide: 10,157 out of 60,222
  • In genetics: 738 out of 3,432
• Year to date:
  • Site-wide: 2,025 out of 60,222
• Since beginning of last month:
  • Site-wide: 96 out of 60,222

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 773 times
• Download rankings, all-time:
  • Site-wide: 10,170 out of 60,222
  • In genetics: 741 out of 3,432
• Year to date:
  • Site-wide: 9,626 out of 60,222
• Since beginning of last month:
  • Site-wide: 15,695 out of 60,222

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

• Downloaded 699 times
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  • Site-wide: 11,724 out of 60,222
  • In genetics: 836 out of 3,432
• Year to date:
  • Site-wide: 35,300 out of 60,222
• Since beginning of last month:
  • Site-wide: 34,810 out of 60,222

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

• Downloaded 687 times
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  • Site-wide: 12,056 out of 60,222
  • In genetics: 856 out of 3,432
• Year to date:
  • Site-wide: 35,648 out of 60,222
• Since beginning of last month:
  • Site-wide: 38,194 out of 60,222

Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

• Downloaded 684 times
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  • Site-wide: 12,106 out of 60,222
  • In neuroscience: 1,944 out of 10,621
• Year to date:
  • Site-wide: 46,948 out of 60,222
• Since beginning of last month:
  • Site-wide: 50,826 out of 60,222

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 658 times
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  • Site-wide: 12,812 out of 60,222
  • In genetics: 913 out of 3,432
• Year to date:
  • Site-wide: 28,091 out of 60,222
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  • Site-wide: 43,961 out of 60,222

Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

• Downloaded 646 times
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  • Site-wide: 13,132 out of 60,222
  • In genetics: 930 out of 3,432
• Year to date:
  • Site-wide: 24,793 out of 60,222
• Since beginning of last month:
  • Site-wide: 26,652 out of 60,222

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 614 times
• Download rankings, all-time:
  • Site-wide: 14,027 out of 60,222
  • In genetics: 992 out of 3,432
• Year to date:
  • Site-wide: 41,508 out of 60,222
• Since beginning of last month:
  • Site-wide: 38,953 out of 60,222

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 608 times
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  • Site-wide: 14,230 out of 60,222
  • In genomics: 1,876 out of 4,168
• Year to date:
  • Site-wide: 10,611 out of 60,222
• Since beginning of last month:
  • Site-wide: 12,356 out of 60,222

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

• Downloaded 604 times
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  • Site-wide: 14,355 out of 60,222
  • In genetics: 1,010 out of 3,432
• Year to date:
  • Site-wide: 51,842 out of 60,222
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  • Site-wide: 58,787 out of 60,222

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

• Downloaded 594 times
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  • Site-wide: 14,750 out of 60,222
  • In bioinformatics: 2,345 out of 6,078
• Year to date:
  • Site-wide: 46,231 out of 60,222
• Since beginning of last month:
  • Site-wide: 47,122 out of 60,222

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 581 times
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  • Site-wide: 15,196 out of 60,222
  • In genomics: 1,940 out of 4,168
• Year to date:
  • Site-wide: 39,984 out of 60,222
• Since beginning of last month:
  • Site-wide: 51,777 out of 60,222

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

• Downloaded 558 times
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  • Site-wide: 16,015 out of 60,222
  • In genetics: 1,100 out of 3,432
• Year to date:
  • Site-wide: 3,591 out of 60,222
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  • Site-wide: 5,668 out of 60,222

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

• Downloaded 557 times
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  • Site-wide: 16,045 out of 60,222
  • In genomics: 2,031 out of 4,168
• Year to date:
  • Site-wide: 50,430 out of 60,222
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  • Site-wide: 30,368 out of 60,222

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 542 times
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  • Site-wide: 16,597 out of 60,222
  • In genetics: 1,141 out of 3,432
• Year to date:
  • Site-wide: 40,474 out of 60,222
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  • Site-wide: 48,108 out of 60,222

Factors associated with sharing email information and mental health survey participation in two large population cohorts

• Downloaded 527 times
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  • Site-wide: 17,265 out of 60,222
  • In genetics: 1,186 out of 3,432
• Year to date:
  • Site-wide: 12,246 out of 60,222
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  • Site-wide: 21,390 out of 60,222

Genetic contributions to self-reported tiredness

• Downloaded 514 times
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  • Site-wide: 17,784 out of 60,222
  • In genetics: 1,208 out of 3,432
• Year to date:
  • Site-wide: 53,509 out of 60,222
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  • Site-wide: 54,947 out of 60,222

Cognitive ability and physical health: a Mendelian randomization study

• Downloaded 486 times
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  • Site-wide: 19,064 out of 60,222
  • In genetics: 1,292 out of 3,432
• Year to date:
  • Site-wide: 49,338 out of 60,222
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  • Site-wide: 37,460 out of 60,222

Planar cell polarity pathway and development of the human visual cortex

• Downloaded 484 times
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  • Site-wide: 19,143 out of 60,222
  • In neuroscience: 3,173 out of 10,621
• Year to date:
  • Site-wide: 12,630 out of 60,222
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  • Site-wide: 20,293 out of 60,222

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

• Downloaded 473 times
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  • Site-wide: 19,653 out of 60,222
  • In genetics: 1,338 out of 3,432
• Year to date:
  • Site-wide: 4,678 out of 60,222
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  • Site-wide: 10,880 out of 60,222

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

• Downloaded 455 times
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  • Site-wide: 20,583 out of 60,222
  • In genetics: 1,382 out of 3,432
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  • Site-wide: 58,356 out of 60,222
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  • Site-wide: 58,117 out of 60,222

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

• Downloaded 435 times
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  • Site-wide: 21,690 out of 60,222
  • In genomics: 2,433 out of 4,168
• Year to date:
  • Site-wide: 14,426 out of 60,222
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  • Site-wide: 17,439 out of 60,222

DNA methylation age acceleration and risk factors for Alzheimer's disease

• Downloaded 421 times
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  • Site-wide: 22,504 out of 60,222
  • In genomics: 2,488 out of 4,168
• Year to date:
  • Site-wide: 26,181 out of 60,222
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  • Site-wide: 41,364 out of 60,222

Polygenic architecture of human neuroanatomical diversity

• Downloaded 420 times
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  • Site-wide: 22,522 out of 60,222
  • In neuroscience: 3,768 out of 10,621
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  • Site-wide: 5,711 out of 60,222
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  • Site-wide: 19,258 out of 60,222

Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

• Downloaded 418 times
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  • Site-wide: 22,685 out of 60,222
  • In genomics: 2,500 out of 4,168
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  • Site-wide: 27,349 out of 60,222
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  • Site-wide: 17,760 out of 60,222

Accelerated Epigenetic Ageing in Major Depressive Disorder

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  • Site-wide: 37,998 out of 60,222
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  • Site-wide: 52,213 out of 60,222

Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

• Downloaded 380 times
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  • Site-wide: 25,159 out of 60,222
  • In neuroscience: 4,248 out of 10,621
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  • Site-wide: 48,293 out of 60,222
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  • Site-wide: 48,877 out of 60,222

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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  • Site-wide: 22,425 out of 60,222

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 370 times
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  • In genetics: 1,695 out of 3,432
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  • Site-wide: 55,115 out of 60,222
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  • Site-wide: 51,382 out of 60,222

Polygenic predictors of age-related decline in cognitive ability

• Downloaded 369 times
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  • Site-wide: 34,084 out of 60,222
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  • Site-wide: 42,381 out of 60,222

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

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  • In epidemiology: 380 out of 1,556
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  • Site-wide: 35,836 out of 60,222

Age-related clonal haemopoiesis is associated with increased epigenetic age

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  • Site-wide: 7,341 out of 60,222
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  • Site-wide: 9,852 out of 60,222

Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

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  • Site-wide: 35,753 out of 60,222
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  • Site-wide: 30,715 out of 60,222

Genetic contributions to trail making test performance in UK Biobank

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  • Site-wide: 52,562 out of 60,222
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  • Site-wide: 48,831 out of 60,222

Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

• Downloaded 336 times
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  • Site-wide: 28,403 out of 60,222
  • In neuroscience: 4,808 out of 10,621
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  • Site-wide: 51,864 out of 60,222
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  • Site-wide: 53,558 out of 60,222

A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

• Downloaded 327 times
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  • In genetics: 1,880 out of 3,432
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  • Site-wide: 57,391 out of 60,222
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  • Site-wide: 58,268 out of 60,222

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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  • Site-wide: 9,090 out of 60,222
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  • Site-wide: 36,964 out of 60,222

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

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Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

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Genetic correlations between pain phenotypes and depression and neuroticism

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Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

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Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

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Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

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Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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The influence of X chromosome variants on trait neuroticism.

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The effect of network thresholding and weighting on structural brain networks in the UK Biobank

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An epigenome-wide association study of sex-specific chronological ageing

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Association of Facial Aging with DNA Methylation and Epigenetic Age Predictions

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Epigenetic signatures of starting and stopping smoking

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Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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An epigenetic predictor of death captures multi-modal measures of brain health

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Understanding Cognitive Impairment in Mood Disorders: Mediation Analyses in the UK Biobank Cohort

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Genetic contributions to health literacy

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Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

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Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

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Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

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Birth weight predicts psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

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Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

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Age and mortality associated DNA methylation patterns on the X-chromosome in male and female samples

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Psychotic-like experiences, polygenic risk scores for schizophrenia and structural properties of the salience, default mode and central-executive networks in healthy participants from UK Biobank

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Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

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