Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 55,041 bioRxiv papers from 254,018 authors.

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Preprints

Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

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Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

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An epigenetic predictor of death captures multi-modal measures of brain health

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Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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The genetic architecture of the human cerebral cortex

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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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Genomic analysis of family data reveals additional genetic effects on intelligence and personality

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

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Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci

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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • In genetics: 101 out of 3,183
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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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  • In genetics: 154 out of 3,183
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Genetic analysis identifies molecular systems and biological pathways associated with household income

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  • In genetics: 168 out of 3,183
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  • Site-wide: 170 out of 55,041
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  • Site-wide: 11,106 out of 55,041

Molecular genetic contributions to self-rated health

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Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

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  • In genetics: 220 out of 3,183
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  • Site-wide: 14,479 out of 55,041
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  • Site-wide: 13,136 out of 55,041

GWAS on family history of Alzheimer's disease

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  • In genetics: 231 out of 3,183
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  • Site-wide: 13,005 out of 55,041
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  • Site-wide: 23,952 out of 55,041

Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia.

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  • Site-wide: 43,027 out of 55,041
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  • Site-wide: 41,289 out of 55,041

Genetic Prediction of Male Pattern Baldness

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  • In genetics: 279 out of 3,183
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  • Site-wide: 18,645 out of 55,041
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  • Site-wide: 30,356 out of 55,041

A combined analysis of genetically correlated traits identifies 107 loci associated with intelligence

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  • In genetics: 286 out of 3,183
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  • Site-wide: 21,625 out of 55,041
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  • Site-wide: 25,777 out of 55,041

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

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  • In neuroscience: 484 out of 9,701
• Year to date:
  • Site-wide: 35,978 out of 55,041
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  • Site-wide: 48,265 out of 55,041

Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

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  • In genetics: 305 out of 3,183
• Year to date:
  • Site-wide: 34,873 out of 55,041
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  • Site-wide: 15,240 out of 55,041

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • In genetics: 331 out of 3,183
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  • Site-wide: 15,024 out of 55,041
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  • Site-wide: 10,029 out of 55,041

Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life

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  • In genetics: 342 out of 3,183
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  • Site-wide: 33,472 out of 55,041
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  • Site-wide: 16,456 out of 55,041

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

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  • In neuroscience: 624 out of 9,701
• Year to date:
  • Site-wide: 36,890 out of 55,041
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  • Site-wide: 38,579 out of 55,041

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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  • In genetics: 358 out of 3,183
• Year to date:
  • Site-wide: 5,340 out of 55,041
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  • Site-wide: 6,736 out of 55,041

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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  • Site-wide: 4,913 out of 55,041
  • In genomics: 847 out of 3,902
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  • Site-wide: 3,140 out of 55,041
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  • Site-wide: 7,142 out of 55,041

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,074 times
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  • Site-wide: 5,230 out of 55,041
  • In genetics: 440 out of 3,183
• Year to date:
  • Site-wide: 21,320 out of 55,041
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  • Site-wide: 23,091 out of 55,041

Intelligence and neuroticism in relation to depression and psychological distress: evidence of interaction using data from Generation Scotland: Scottish Family Health Study and UK Biobank

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  • In genomics: 959 out of 3,902
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  • Site-wide: 40,790 out of 55,041

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

• Downloaded 897 times
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  • In neuroscience: 1,060 out of 9,701
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  • Site-wide: 39,306 out of 55,041
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  • Site-wide: 25,630 out of 55,041

OSCA: a tool for omic-data-based complex trait analysis

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  • In bioinformatics: 1,315 out of 5,694
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  • Site-wide: 13,858 out of 55,041

Epigenetic prediction of complex traits and death

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  • In genomics: 1,227 out of 3,902
• Year to date:
  • Site-wide: 30,070 out of 55,041
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  • Site-wide: 24,590 out of 55,041

Identification of 55,000 Replicated DNA Methylation QTL

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  • In genomics: 1,267 out of 3,902
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  • Site-wide: 33,242 out of 55,041

An epigenome-wide association study of educational attainment (n = 10,767)

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  • In genetics: 671 out of 3,183
• Year to date:
  • Site-wide: 38,822 out of 55,041
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  • Site-wide: 51,987 out of 55,041

The Stratification Of Major Depressive Disorder Into Genetic Subgroups

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  • In genetics: 682 out of 3,183
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Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

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  • In genetics: 760 out of 3,183
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Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

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  • In neuroscience: 1,675 out of 9,701
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  • Site-wide: 31,439 out of 55,041

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

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  • Site-wide: 30,660 out of 55,041
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  • Site-wide: 29,987 out of 55,041

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

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  • In genetics: 808 out of 3,183
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  • Site-wide: 39,773 out of 55,041

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

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  • Site-wide: 32,366 out of 55,041

Brain imaging correlates of general intelligence in UK Biobank

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  • Site-wide: 1,697 out of 55,041
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  • Site-wide: 8,766 out of 55,041

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

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  • Site-wide: 33,443 out of 55,041
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  • Site-wide: 33,691 out of 55,041

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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  • Site-wide: 27,852 out of 55,041

Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

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Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

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  • Site-wide: 20,360 out of 55,041

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 24,382 out of 55,041

Bayesian reassessment of the epigenetic architecture of complex traits

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  • Site-wide: 9,636 out of 55,041
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  • Site-wide: 42,277 out of 55,041

Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

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  • Site-wide: 42,114 out of 55,041

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

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  • Site-wide: 50,830 out of 55,041

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

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  • Site-wide: 41,724 out of 55,041

Genetic contributions to self-reported tiredness

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  • Site-wide: 40,941 out of 55,041

Cognitive ability and physical health: a Mendelian randomization study

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  • Site-wide: 42,868 out of 55,041
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  • Site-wide: 28,458 out of 55,041

Factors associated with sharing email information and mental health survey participation in two large population cohorts

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  • Site-wide: 21,525 out of 55,041

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

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  • Site-wide: 44,791 out of 55,041

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

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  • Site-wide: 24,555 out of 55,041

DNA methylation age acceleration and risk factors for Alzheimer's disease

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  • Site-wide: 19,987 out of 55,041

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

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Accelerated Epigenetic Ageing in Major Depressive Disorder

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Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

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Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

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Meta-analysis of exome array data identifies six novel genetic loci for lung function

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Polygenic predictors of age-related decline in cognitive ability

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Polygenic architecture of human neuroanatomical diversity

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An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

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Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

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Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

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Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

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Age-related clonal haemopoiesis is associated with increased epigenetic age

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Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

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Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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The influence of X chromosome variants on trait neuroticism.

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Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

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Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

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Epigenetic signatures of starting and stopping smoking

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Association of Facial Aging with DNA Methylation and Epigenetic Age Predictions

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The effect of network thresholding and weighting on structural brain networks in the UK Biobank

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Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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An epigenome-wide association study of sex-specific chronological ageing

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SNPs associated with HHIP expression have differential effects on lung function in males and females

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Genetic comorbidity between major depression and cardio-metabolic disease, stratified by age at onset of major depression.

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Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

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Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

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Understanding Cognitive Impairment in Mood Disorders: Mediation Analyses in the UK Biobank Cohort

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Birth weight predicts psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

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Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

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Age and mortality associated DNA methylation patterns on the X-chromosome in male and female samples

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