Author: Ian J Deary

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Preprints

A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

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DNA methylation proxies for 16 plasma proteins predict the incidence of 7 leading causes of morbidity

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Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

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Genomic analysis of family data reveals additional genetic effects on intelligence and personality

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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study of the general population

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Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia.

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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

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Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life

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116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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Bayesian reassessment of the epigenetic architecture of complex traits

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Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

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Epigenetic prediction of complex traits and death

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Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

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Reliability and validity of the UK Biobank cognitive tests

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A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

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Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

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Polygenic architecture of human neuroanatomical diversity

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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

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Planar cell polarity pathway and development of the human visual cortex

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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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Associations between vascular risk factors and brain MRI indices in UK Biobank

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Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

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Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

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Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

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Cognitive ability and physical health: a Mendelian randomization study

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Generalisability of Results from UK Biobank: Comparison With a Pooling of 18 Cohort Studies

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Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

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Meta-analysis of exome array data identifies six novel genetic loci for lung function

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Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

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Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

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A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

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Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

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Epigenetic prediction of major depressive disorder

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Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

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Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

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Psychotic-like experiences, polygenic risk scores for schizophrenia and structural properties of the salience, default mode and central-executive networks in healthy participants from UK Biobank

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Cognitive impairments in sporadic cerebral small vessel disease (SVD): a systematic review and meta-analysis of cohorts with stroke, dementia and non-clinical presentations of SVD

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An epigenetic predictor of death captures multi-modal measures of brain health

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The influence of X chromosome variants on trait neuroticism.

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SNPs associated with HHIP expression have differential effects on lung function in males and females

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Blood pressure and cognitive function across the eighth decade: a prospective study of the Lothian Birth Cohort of 1936

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Understanding Cognitive Impairment in Mood Disorders: Mediation Analyses in the UK Biobank Cohort

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Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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An epigenome-wide association study of sex-specific chronological ageing

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Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

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Quantitative Measurements of Enlarged Perivascular Spaces in the Brain are Associated with Retinal Microvascular Parameters in Older Community-Dwelling Subjects

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Age and mortality associated DNA methylation patterns on the X-chromosome in male and female samples

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Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

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Childhood coordination and survival up to six decades later: extended follow-up of participants in the National Child Development Study

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DNA methylation outlier burden, health and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936.

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Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

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DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

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Health literacy, cognitive ability and self-reported diabetes in the English Longitudinal Study of Ageing

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Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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An epigenetic proxy of chronic inflammation outperforms serum levels as a biomarker of brain ageing

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Life course air pollution exposure and cognitive decline: modelled historical air pollution data and the Lothian Birth Cohort 1936

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Birth weight is associated with brain tissue volumes seven decades later, but not with age-associated changes to brain structure

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