Author: Ian J Deary

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Preprints

Topological relationships between perivascular spaces and progression of white matter hyperintensities: a pilot study in a sample of the Lothian Birth Cohort 1936

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Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

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  • Site-wide: 297
  • In neuroscience: 7
• Year to date:
  • Site-wide: 2,734
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  • Site-wide: 41,205

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 2,194
  • In genetics: 69
• Year to date:
  • Site-wide: 21,399
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  • Site-wide: 47,581

Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

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  • Site-wide: 2,673
  • In genetics: 87
• Year to date:
  • Site-wide: 25,102
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  • Site-wide: 13,441

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,611 times
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  • Site-wide: 2,699
  • In genetics: 88
• Year to date:
  • Site-wide: 43,311
• Since beginning of last month:
  • Site-wide: 113,969

Genomic analysis of family data reveals additional genetic effects on intelligence and personality

• Downloaded 4,269 times
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  • Site-wide: 3,028
  • In genetics: 99
• Year to date:
  • Site-wide: 46,779
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  • Site-wide: 105,660

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,352 times
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  • Site-wide: 4,221
  • In genetics: 155
• Year to date:
  • Site-wide: 44,744
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  • Site-wide: 22,622

Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study of the general population

• Downloaded 2,666 times
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  • Site-wide: 5,832
  • In epidemiology: 518
• Year to date:
  • Site-wide: 12,411
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  • Site-wide: 99,365

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

• Downloaded 2,631 times
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  • Site-wide: 5,944
  • In genetics: 248
• Year to date:
  • Site-wide: 76,921
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  • Site-wide: 71,345

Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia.

• Downloaded 1,794 times
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  • Site-wide: 10,487
  • In genetics: 458
• Year to date:
  • Site-wide: 129,634
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  • Site-wide: None

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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  • Site-wide: 10,537
  • In genetics: 462
• Year to date:
  • Site-wide: 53,057
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  • Site-wide: 22,452

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 10,830
  • In genetics: 478
• Year to date:
  • Site-wide: 90,449
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  • Site-wide: 47,962

Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

• Downloaded 1,655 times
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  • Site-wide: 11,804
  • In genetics: 531
• Year to date:
  • Site-wide: 102,722
• Since beginning of last month:
  • Site-wide: 120,086

Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life

• Downloaded 1,532 times
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  • Site-wide: 13,139
  • In genetics: 595
• Year to date:
  • Site-wide: 102,587
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  • Site-wide: 17,896

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,492 times
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  • Site-wide: 13,718
  • In genetics: 625
• Year to date:
  • Site-wide: 43,274
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  • Site-wide: 19,688

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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  • Site-wide: 15,634
  • In bioinformatics: 1,810
• Year to date:
  • Site-wide: 66,293
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  • Site-wide: 105,008

Bayesian reassessment of the epigenetic architecture of complex traits

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  • Site-wide: 15,972
  • In genomics: 1,580
• Year to date:
  • Site-wide: 128,896
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  • Site-wide: 45,247

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 1,069 times
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  • Site-wide: 22,610
  • In genetics: 1,029
• Year to date:
  • Site-wide: 119,057
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  • Site-wide: None

Epigenetic prediction of complex traits and death

• Downloaded 1,028 times
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  • Site-wide: 23,942
  • In genomics: 2,247
• Year to date:
  • Site-wide: 102,558
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  • Site-wide: None

Reliability and validity of the UK Biobank cognitive tests

• Downloaded 998 times
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  • Site-wide: 25,006
  • In epidemiology: 1,458
• Year to date:
  • Site-wide: 56,110
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  • Site-wide: None

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 993 times
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  • Site-wide: 25,192
  • In genetics: 1,144
• Year to date:
  • Site-wide: 25,875
• Since beginning of last month:
  • Site-wide: 114,557

Polygenic architecture of human neuroanatomical diversity

• Downloaded 940 times
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  • Site-wide: 27,266
  • In neuroscience: 3,475
• Year to date:
  • Site-wide: 51,779
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  • Site-wide: 111,357

Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

• Downloaded 908 times
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  • Site-wide: 28,676
  • In genetics: 1,311
• Year to date:
  • Site-wide: 123,163
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  • Site-wide: 120,281

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

• Downloaded 877 times
• Download rankings, all-time:
  • Site-wide: 30,099
  • In genetics: 1,374
• Year to date:
  • Site-wide: 143,100
• Since beginning of last month:
  • Site-wide: 110,896

Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

• Downloaded 858 times
• Download rankings, all-time:
  • Site-wide: 31,051
  • In neuroscience: 4,027
• Year to date:
  • Site-wide: 119,122
• Since beginning of last month:
  • Site-wide: 106,214

Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

• Downloaded 847 times
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  • Site-wide: 31,582
  • In cell biology: 1,196
• Year to date:
  • Site-wide: 4,360
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  • Site-wide: 1,697

Planar cell polarity pathway and development of the human visual cortex

• Downloaded 814 times
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  • Site-wide: 33,353
  • In neuroscience: 4,374
• Year to date:
  • Site-wide: 79,156
• Since beginning of last month:
  • Site-wide: 114,914

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 786 times
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  • Site-wide: 35,091
  • In genomics: 2,963
• Year to date:
  • Site-wide: 106,725
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  • Site-wide: 51,707

Pre-pandemic Cognitive Function and COVID-19 Vaccine Hesitancy: Prospective Cohort Study

• Downloaded 764 times
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  • Site-wide: 36,567
  • In epidemiology: 1,868
• Year to date:
  • Site-wide: 5,040
• Since beginning of last month:
  • Site-wide: 6,844

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 763 times
• Download rankings, all-time:
  • Site-wide: 36,600
  • In genetics: 1,650
• Year to date:
  • Site-wide: 133,558
• Since beginning of last month:
  • Site-wide: 78,247

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

• Downloaded 740 times
• Download rankings, all-time:
  • Site-wide: 38,195
  • In genetics: 1,717
• Year to date:
  • Site-wide: 147,718
• Since beginning of last month:
  • Site-wide: 120,202

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

• Downloaded 711 times
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  • Site-wide: 40,296
  • In genetics: 1,809
• Year to date:
  • Site-wide: 95,972
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  • Site-wide: None

Associations between vascular risk factors and brain MRI indices in UK Biobank

• Downloaded 708 times
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  • Site-wide: 40,501
  • In neuroscience: 5,539
• Year to date:
  • Site-wide: 121,920
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  • Site-wide: None

Generalisability of Results from UK Biobank: Comparison With a Pooling of 18 Cohort Studies

• Downloaded 704 times
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  • Site-wide: 40,782
  • In epidemiology: 2,036
• Year to date:
  • Site-wide: 48,267
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  • Site-wide: 87,699

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 701 times
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  • Site-wide: 41,040
  • In genetics: 1,844
• Year to date:
  • Site-wide: 116,987
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  • Site-wide: 36,969

Epigenetic scores for the circulating proteome as tools for disease prediction

• Downloaded 663 times
• Download rankings, all-time:
  • Site-wide: 44,193
  • In genomics: 3,514
• Year to date:
  • Site-wide: 8,313
• Since beginning of last month:
  • Site-wide: 6,546

Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

• Downloaded 661 times
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  • Site-wide: 44,372
  • In genomics: 3,525
• Year to date:
  • Site-wide: 137,766
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  • Site-wide: 80,950

Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

• Downloaded 655 times
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  • Site-wide: 44,918
  • In genomics: 3,568
• Year to date:
  • Site-wide: 115,466
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  • Site-wide: None

Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

• Downloaded 625 times
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  • Site-wide: 47,695
  • In genetics: 2,126
• Year to date:
  • Site-wide: 26,585
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  • Site-wide: None

Cognitive ability and physical health: a Mendelian randomization study

• Downloaded 617 times
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  • Site-wide: 48,450
  • In genetics: 2,159
• Year to date:
  • Site-wide: 148,510
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  • Site-wide: None

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

• Downloaded 602 times
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  • Site-wide: 49,937
  • In genomics: 3,838
• Year to date:
  • Site-wide: 56,613
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  • Site-wide: 66,480

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 483 times
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  • Site-wide: 64,862
  • In genetics: 2,855
• Year to date:
  • Site-wide: 150,511
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  • Site-wide: None

Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

• Downloaded 478 times
• Download rankings, all-time:
  • Site-wide: 65,636
  • In neuroscience: 9,573
• Year to date:
  • Site-wide: 149,507
• Since beginning of last month:
  • Site-wide: 118,277

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

• Downloaded 474 times
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  • Site-wide: 66,182
  • In neuroscience: 9,684
• Year to date:
  • Site-wide: 108,237
• Since beginning of last month:
  • Site-wide: 122,737

Psychotic-like experiences, polygenic risk scores for schizophrenia and structural properties of the salience, default mode and central-executive networks in healthy participants from UK Biobank

• Downloaded 449 times
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  • Site-wide: 70,224
  • In neuroscience: 10,307
• Year to date:
  • Site-wide: 82,857
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  • Site-wide: 9,027

Cognitive impairments in sporadic cerebral small vessel disease (SVD): a systematic review and meta-analysis of cohorts with stroke, dementia and non-clinical presentations of SVD

• Downloaded 444 times
• Download rankings, all-time:
  • Site-wide: 71,095
  • In neurology: 178
• Year to date:
  • Site-wide: 88,368
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  • Site-wide: 82,724

Epigenetic prediction of major depressive disorder

• Downloaded 443 times
• Download rankings, all-time:
  • Site-wide: 71,110
  • In psychiatry and clinical psychology: 251
• Year to date:
  • Site-wide: 120,063
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  • Site-wide: 82,567

A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

• Downloaded 438 times
• Download rankings, all-time:
  • Site-wide: 71,988
  • In genetics: 3,159
• Year to date:
  • Site-wide: 133,481
• Since beginning of last month:
  • Site-wide: 59,220

Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

• Downloaded 420 times
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  • Site-wide: 75,085
  • In neuroscience: 11,114
• Year to date:
  • Site-wide: 153,652
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  • Site-wide: None

SNPs associated with HHIP expression have differential effects on lung function in males and females

• Downloaded 417 times
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  • Site-wide: 75,562
  • In genetics: 3,298
• Year to date:
  • Site-wide: 116,812
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  • Site-wide: 62,725

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

• Downloaded 411 times
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  • Site-wide: 76,763
  • In genomics: 5,146
• Year to date:
  • Site-wide: 140,143
• Since beginning of last month:
  • Site-wide: 115,222

An epigenetic proxy of chronic inflammation outperforms serum levels as a biomarker of brain ageing

• Downloaded 403 times
• Download rankings, all-time:
  • Site-wide: 78,112
  • In neurology: 214
• Year to date:
  • Site-wide: 32,356
• Since beginning of last month:
  • Site-wide: 74,886

The influence of X chromosome variants on trait neuroticism.

• Downloaded 391 times
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  • Site-wide: 80,478
  • In genetics: 3,491
• Year to date:
  • Site-wide: 144,180
• Since beginning of last month:
  • Site-wide: 115,016

An epigenetic predictor of death captures multi-modal measures of brain health

• Downloaded 390 times
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  • Site-wide: 80,533
  • In neuroscience: 11,988
• Year to date:
  • Site-wide: 141,659
• Since beginning of last month:
  • Site-wide: 63,558

Blood pressure and cognitive function across the eighth decade: a prospective study of the Lothian Birth Cohort of 1936

• Downloaded 383 times
• Download rankings, all-time:
  • Site-wide: 81,908
  • In geriatric medicine: 50
• Year to date:
  • Site-wide: 132,043
• Since beginning of last month:
  • Site-wide: 74,594

Understanding Cognitive Impairment in Mood Disorders: Mediation Analyses in the UK Biobank Cohort

• Downloaded 361 times
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  • Site-wide: 86,386
  • In epidemiology: 3,676
• Year to date:
  • Site-wide: 147,411
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  • Site-wide: 70,174

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

• Downloaded 351 times
• Download rankings, all-time:
  • Site-wide: 88,340
  • In genetics: 3,828
• Year to date:
  • Site-wide: 150,528
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  • Site-wide: None

An epigenome-wide association study of sex-specific chronological ageing

• Downloaded 336 times
• Download rankings, all-time:
  • Site-wide: 91,583
  • In genomics: 5,741
• Year to date:
  • Site-wide: 152,960
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  • Site-wide: None

Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

• Downloaded 298 times
• Download rankings, all-time:
  • Site-wide: 100,359
  • In neuroscience: 15,093
• Year to date:
  • Site-wide: 129,691
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  • Site-wide: 119,718

Childhood coordination and survival up to six decades later: extended follow-up of participants in the National Child Development Study

• Downloaded 290 times
• Download rankings, all-time:
  • Site-wide: 102,016
  • In epidemiology: 4,306
• Year to date:
  • Site-wide: 89,831
• Since beginning of last month:
  • Site-wide: 25,499

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 289 times
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  • Site-wide: 102,387
  • In genomics: 6,141
• Year to date:
  • Site-wide: 69,501
• Since beginning of last month:
  • Site-wide: 89,004

Quantitative Measurements of Enlarged Perivascular Spaces in the Brain are Associated with Retinal Microvascular Parameters in Older Community-Dwelling Subjects

• Downloaded 284 times
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  • Site-wide: 103,499
  • In neuroscience: 15,633
• Year to date:
  • Site-wide: 123,933
• Since beginning of last month:
  • Site-wide: 109,446

Age and mortality associated DNA methylation patterns on the X-chromosome in male and female samples

• Downloaded 276 times
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  • Site-wide: 105,448
  • In genetics: 4,480
• Year to date:
  • Site-wide: 122,912
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  • Site-wide: 45,186

DNA methylation outlier burden, health and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936.

• Downloaded 272 times
• Download rankings, all-time:
  • Site-wide: 106,375
  • In genetic and genomic medicine: 521
• Year to date:
  • Site-wide: 108,989
• Since beginning of last month:
  • Site-wide: 74,316

Health literacy, cognitive ability and self-reported diabetes in the English Longitudinal Study of Ageing

• Downloaded 248 times
• Download rankings, all-time:
  • Site-wide: 112,310
  • In epidemiology: 4,712
• Year to date:
  • Site-wide: 107,729
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  • Site-wide: None

Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

• Downloaded 237 times
• Download rankings, all-time:
  • Site-wide: 115,073
  • In neuroscience: 17,417
• Year to date:
  • Site-wide: 147,973
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  • Site-wide: 114,701

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 116,621
  • In neuroscience: 17,649
• Year to date:
  • Site-wide: 153,495
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  • Site-wide: None

DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

• Downloaded 226 times
• Download rankings, all-time:
  • Site-wide: 117,947
  • In neuroscience: 17,805
• Year to date:
  • Site-wide: 149,766
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  • Site-wide: 115,790

Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort

• Downloaded 221 times
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  • Site-wide: 119,265
  • In radiology and imaging: 246
• Year to date:
  • Site-wide: 29,459
• Since beginning of last month:
  • Site-wide: 101,134

A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

• Downloaded 217 times
• Download rankings, all-time:
  • Site-wide: 120,180
  • In neuroscience: 18,172
• Year to date:
  • Site-wide: 62,332
• Since beginning of last month:
  • Site-wide: 30,081

Blood-based epigenome-wide analyses of cognitive abilities

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 124,594
  • In genetic and genomic medicine: 669
• Year to date:
  • Site-wide: 33,358
• Since beginning of last month:
  • Site-wide: 103,682

Life course air pollution exposure and cognitive decline: modelled historical air pollution data and the Lothian Birth Cohort 1936

• Downloaded 195 times
• Download rankings, all-time:
  • Site-wide: 125,600
  • In epidemiology: 5,290
• Year to date:
  • Site-wide: 79,246
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  • Site-wide: 98,138

The Influence of Phenotyping Method on Neuroimaging Associations with Depression in UK Biobank

• Downloaded 187 times
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  • Site-wide: 127,557
  • In psychiatry and clinical psychology: 615
• Year to date:
  • Site-wide: 58,538
• Since beginning of last month:
  • Site-wide: 39,665

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

• Downloaded 175 times
• Download rankings, all-time:
  • Site-wide: 130,428
  • In genetic and genomic medicine: 709
• Year to date:
  • Site-wide: 38,902
• Since beginning of last month:
  • Site-wide: 15,100

Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk

• Downloaded 160 times
• Download rankings, all-time:
  • Site-wide: 133,881
  • In genetic and genomic medicine: 738
• Year to date:
  • Site-wide: 43,121
• Since beginning of last month:
  • Site-wide: 125,110

Comparison of structural MRI brain measures between 1.5T and 3T: data from the Lothian Birth Cohort 1936

• Downloaded 156 times
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  • Site-wide: 134,752
  • In radiology and imaging: 303
• Year to date:
  • Site-wide: 44,376
• Since beginning of last month:
  • Site-wide: 23,989

Local CpG density affects the trajectory of age-associated epigenetic changes

• Downloaded 154 times
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  • Site-wide: 135,265
  • In genetics: 5,461
• Year to date:
  • Site-wide: 44,991
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  • Site-wide: 85,788

Birth weight is associated with brain tissue volumes seven decades later, but not with age-associated changes to brain structure

• Downloaded 136 times
• Download rankings, all-time:
  • Site-wide: 139,217
  • In neuroscience: 20,901
• Year to date:
  • Site-wide: 114,606
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  • Site-wide: 128,511

Cerebral Small Vessel Disease Burden and Longitudinal Cognitive Decline from age 73 to 82: the Lothian Birth Cohort 1936

• Downloaded 134 times
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  • Site-wide: 139,750
  • In radiology and imaging: 319
• Year to date:
  • Site-wide: 52,494
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  • Site-wide: 123,996

DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

• Downloaded 114 times
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  • Site-wide: 143,761
  • In psychiatry and clinical psychology: 832
• Year to date:
  • Site-wide: 61,457
• Since beginning of last month:
  • Site-wide: 11,657

Contribution of white matter hyperintensities to ventricular enlargement in older adults

• Downloaded 108 times
• Download rankings, all-time:
  • Site-wide: 144,910
  • In radiology and imaging: 337
• Year to date:
  • Site-wide: 64,707
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  • Site-wide: 123,746