Author: John Blangero

Downloads per author, site-wide

Preprints

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

• Downloaded 9,038 times
• Download rankings, all-time:
  • Site-wide: 1,444
  • In genomics: 92
• Year to date:
  • Site-wide: 12,490
• Since beginning of last month:
  • Site-wide: 18,622

The genetic architecture of the human cerebral cortex

• Downloaded 8,426 times
• Download rankings, all-time:
  • Site-wide: 1,582
  • In genetics: 35
• Year to date:
  • Site-wide: 24,368
• Since beginning of last month:
  • Site-wide: 29,919

Brain charts for the human lifespan

• Downloaded 6,395 times
• Download rankings, all-time:
  • Site-wide: 2,271
  • In neuroscience: 148
• Year to date:
  • Site-wide: 305
• Since beginning of last month:
  • Site-wide: 4,022

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

• Downloaded 3,397 times
• Download rankings, all-time:
  • Site-wide: 5,446
  • In genomics: 498
• Year to date:
  • Site-wide: 30,733
• Since beginning of last month:
  • Site-wide: 45,593

Whole Genome Sequencing in Psychiatric Disorders: the WGSPD Consortium

• Downloaded 1,817 times
• Download rankings, all-time:
  • Site-wide: 13,655
  • In genomics: 1,240
• Year to date:
  • Site-wide: 87,905
• Since beginning of last month:
  • Site-wide: 132,436

Population sequencing data reveal a compendium of mutational processes in human germline

• Downloaded 1,790 times
• Download rankings, all-time:
  • Site-wide: 13,975
  • In genetics: 565
• Year to date:
  • Site-wide: 51,021
• Since beginning of last month:
  • Site-wide: 41,677

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

• Downloaded 1,782 times
• Download rankings, all-time:
  • Site-wide: 14,068
  • In genetics: 546
• Year to date:
  • Site-wide: 99,217
• Since beginning of last month:
  • Site-wide: 74,115

Clonal hematopoiesis is driven by aberrant activation of TCL1A

• Downloaded 1,750 times
• Download rankings, all-time:
  • Site-wide: 14,469
  • In genetics: 913
• Year to date:
  • Site-wide: 1,457
• Since beginning of last month:
  • Site-wide: 2,015

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 1,513 times
• Download rankings, all-time:
  • Site-wide: 18,059
  • In genetics: 781
• Year to date:
  • Site-wide: 28,205
• Since beginning of last month:
  • Site-wide: 24,114

Non-crossover gene conversions show strong GC bias and unexpected clustering in humans

• Downloaded 1,288 times
• Download rankings, all-time:
  • Site-wide: 23,156
  • In genetics: 918
• Year to date:
  • Site-wide: 129,841
• Since beginning of last month:
  • Site-wide: 151,605

A performance assessment of relatedness inference methods using genome-wide data from thousands of relatives

• Downloaded 1,272 times
• Download rankings, all-time:
  • Site-wide: 23,615
  • In genetics: 938
• Year to date:
  • Site-wide: 125,334
• Since beginning of last month:
  • Site-wide: 117,560

Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate

• Downloaded 1,214 times
• Download rankings, all-time:
  • Site-wide: 25,405
  • In genetics: 996
• Year to date:
  • Site-wide: 149,363
• Since beginning of last month:
  • Site-wide: 142,188

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

• Downloaded 1,035 times
• Download rankings, all-time:
  • Site-wide: 32,329
  • In genetic and genomic medicine: 160
• Year to date:
  • Site-wide: 90,702
• Since beginning of last month:
  • Site-wide: 99,300

Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

• Downloaded 969 times
• Download rankings, all-time:
  • Site-wide: 35,669
  • In neuroscience: 4,463
• Year to date:
  • Site-wide: 84,197
• Since beginning of last month:
  • Site-wide: 55,822

Planar cell polarity pathway and development of the human visual cortex

• Downloaded 952 times
• Download rankings, all-time:
  • Site-wide: 36,578
  • In neuroscience: 4,615
• Year to date:
  • Site-wide: 76,980
• Since beginning of last month:
  • Site-wide: 51,753

Inferring identical by descent sharing of sample ancestors promotes high resolution relative detection

• Downloaded 945 times
• Download rankings, all-time:
  • Site-wide: 37,014
  • In genetics: 1,478
• Year to date:
  • Site-wide: 137,438
• Since beginning of last month:
  • Site-wide: 78,971

Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program

• Downloaded 938 times
• Download rankings, all-time:
  • Site-wide: 37,435
  • In hematology: 35
• Year to date:
  • Site-wide: 63,999
• Since beginning of last month:
  • Site-wide: 44,201

Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives

• Downloaded 914 times
• Download rankings, all-time:
  • Site-wide: 38,890
  • In genetics: 1,602
• Year to date:
  • Site-wide: 73,989
• Since beginning of last month:
  • Site-wide: 73,438

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

• Downloaded 897 times
• Download rankings, all-time:
  • Site-wide: 39,961
  • In genetics: 1,563
• Year to date:
  • Site-wide: 177,203
• Since beginning of last month:
  • Site-wide: 147,307

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 859 times
• Download rankings, all-time:
  • Site-wide: 42,569
  • In genomics: 3,180
• Year to date:
  • Site-wide: 158,880
• Since beginning of last month:
  • Site-wide: 173,715

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

• Downloaded 729 times
• Download rankings, all-time:
  • Site-wide: 54,054
  • In genomics: 3,773
• Year to date:
  • Site-wide: 164,439
• Since beginning of last month:
  • Site-wide: 185,201

Fast and Powerful Genome Wide Association Analysis of Dense Genetic Data with High Dimensional Imaging Phenotypes

• Downloaded 708 times
• Download rankings, all-time:
  • Site-wide: 56,274
  • In genetics: 2,161
• Year to date:
  • Site-wide: 166,238
• Since beginning of last month:
  • Site-wide: 150,615

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 696 times
• Download rankings, all-time:
  • Site-wide: 57,734
  • In genetic and genomic medicine: 299
• Year to date:
  • Site-wide: 60,295
• Since beginning of last month:
  • Site-wide: 61,069

Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential

• Downloaded 695 times
• Download rankings, all-time:
  • Site-wide: 57,859
  • In genetic and genomic medicine: 353
• Year to date:
  • Site-wide: 22,387
• Since beginning of last month:
  • Site-wide: 19,151

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium

• Downloaded 670 times
• Download rankings, all-time:
  • Site-wide: 60,885
  • In genetics: 2,524
• Year to date:
  • Site-wide: 40,330
• Since beginning of last month:
  • Site-wide: 83,810

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

• Downloaded 588 times
• Download rankings, all-time:
  • Site-wide: 72,175
  • In genetics: 3,422
• Year to date:
  • Site-wide: 24,152
• Since beginning of last month:
  • Site-wide: 23,457

A framework for detecting noncoding rare variant associations of large-scale whole-genome sequencing studies

• Downloaded 577 times
• Download rankings, all-time:
  • Site-wide: 73,824
  • In genetics: 3,779
• Year to date:
  • Site-wide: 15,588
• Since beginning of last month:
  • Site-wide: 22,359

Comprehensive genetic analysis of the human lipidome identifies novel loci controlling lipid homeostasis with links to coronary artery disease

• Downloaded 567 times
• Download rankings, all-time:
  • Site-wide: 75,552
  • In genetic and genomic medicine: 590
• Year to date:
  • Site-wide: 12,289
• Since beginning of last month:
  • Site-wide: 16,421

The reliability and heritability of cortical folds and their genetic correlations across hemispheres

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 86,318
  • In genetics: 3,322
• Year to date:
  • Site-wide: 152,470
• Since beginning of last month:
  • Site-wide: 137,011

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

• Downloaded 454 times
• Download rankings, all-time:
  • Site-wide: 97,519
  • In bioinformatics: 8,202
• Year to date:
  • Site-wide: 109,570
• Since beginning of last month:
  • Site-wide: 139,419

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

• Downloaded 443 times
• Download rankings, all-time:
  • Site-wide: 100,152
  • In genetics: 3,726
• Year to date:
  • Site-wide: 188,910
• Since beginning of last month:
  • Site-wide: 176,828

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 100,622
  • In genetic and genomic medicine: 572
• Year to date:
  • Site-wide: 73,414
• Since beginning of last month:
  • Site-wide: 69,832

Whole genome sequencing identifies common and rare structural variants contributing to hematologic traits in the NHLBI TOPMed program

• Downloaded 373 times
• Download rankings, all-time:
  • Site-wide: 117,531
  • In genetic and genomic medicine: 941
• Year to date:
  • Site-wide: 12,784
• Since beginning of last month:
  • Site-wide: 12,334

Transcriptomic profiling of fibropapillomatosis in green sea turtles (Chelonia mydas) from South Texas

• Downloaded 347 times
• Download rankings, all-time:
  • Site-wide: 124,537
  • In cancer biology: 3,503
• Year to date:
  • Site-wide: 172,953
• Since beginning of last month:
  • Site-wide: 153,922

find-tfbs: a tool to identify functional non-coding variants associated with complex human traits using open chromatin maps and phased whole-genome sequences

• Downloaded 297 times
• Download rankings, all-time:
  • Site-wide: 139,255
  • In genomics: 7,147
• Year to date:
  • Site-wide: 135,731
• Since beginning of last month:
  • Site-wide: 123,396

Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population

• Downloaded 144 times
• Download rankings, all-time:
  • Site-wide: 179,237
  • In psychiatry and clinical psychology: 1,192
• Year to date:
  • Site-wide: 30,652
• Since beginning of last month:
  • Site-wide: 49,769