Author: Uwe Völker

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Preprints

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 4,283
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Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

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The Polygenic and Monogenic Basis of Blood Traits and Diseases

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  • Site-wide: 8,127
  • In genetic and genomic medicine: 35
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Cell specific eQTL analysis without sorting cells

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Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

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Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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sPLINK: A Federated, Privacy-Preserving Tool as a Robust Alternative to Meta-Analysis in Genome-Wide Association Studies

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  • Site-wide: 22,257
  • In bioinformatics: 2,564
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Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 22,946
  • In sexual and reproductive health: 15
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Polygenic architecture of human neuroanatomical diversity

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  • In neuroscience: 3,351
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Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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Tissue-specific multiOMICs analysis of atrial fibrillation

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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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  • Site-wide: 93,156
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Genome wide association analysis in dilated cardiomyopathy reveals two new key players in systolic heart failure on chromosome 3p25.1 and 22q11.23

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Discovering patterns of pleiotropy in genome-wide association studies

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  • Site-wide: 47,939
  • In genetics: 2,154
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  • Site-wide: 118,704
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  • Site-wide: 80,943

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

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  • Site-wide: 48,108
  • In genetics: 2,160
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Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

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Common variants in ABCG8 and TRAF3 genes confer risk for gallstone disease and gallbladder cancer in admixed Latinos with Mapuche Native American ancestry

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Metabolic differences between symbiont subpopulations in the deep-sea tubeworm Riftia pachyptila

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Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

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  • Site-wide: 66,470
  • In genetic and genomic medicine: 260
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Genetic factors influencing a neurobiological substrate for psychiatric disorders

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  • Site-wide: 72,069
  • In genetics: 3,195
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  • Site-wide: 107,300

Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels

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  • Site-wide: 75,557
  • In genetics: 3,335
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  • Site-wide: 125,220

Pneumococcal metabolic adaptation and colonization is regulated by the two-component regulatory system 08

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  • Site-wide: 80,821
  • In microbiology: 5,544
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Essentiality of c-di-AMP in Bacillus subtilis: Bypassing mutations converge in potassium and glutamate homeostasis

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  • In microbiology: 6,943
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Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

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  • Site-wide: 98,260
  • In genetics: 4,245
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KCND3 is a novel susceptibility locus for early repolarization

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  • Site-wide: 103,017
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Circulating proteomic patterns in AF related left atrial remodeling indicate involvement of coagulation and complement cascade

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  • Site-wide: 105,144
  • In molecular biology: 3,109
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Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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  • Site-wide: 105,319
  • In genomics: 6,204
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Estimating the effect of lipids on IGF axis and subsequent breast cancer risk

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