Author: Jing Wang

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Preprints

MIDAS: a deep generative model for mosaic integration and knowledge transfer of single-cell multimodal data

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Lipopolysaccharide integrity primes bacterial sensitivity to a cell wall-degrading intermicrobial toxin

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Evaluation of Potential Adverse Events Following COVID-19 mRNA Vaccination Among Adults Aged 65 Years and Older: A Self-Controlled Study in the U.S.

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Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

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The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes

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Viral Kinetics and Antibody Responses in Patients with COVID-19

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Antibody responses to SARS-CoV-2 in COVID-19 patients: the perspective application of serological tests in clinical practice

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  • Site-wide: 790
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Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

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  • Site-wide: 827
  • In immunology: 40
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BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

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  • Site-wide: 877
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Diagnosis of Acute Respiratory Syndrome Coronavirus 2 Infection by Detection of Nucleocapsid Protein

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Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

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The insert sequence in SARS-CoV-2 enhances spike protein cleavage by TMPRSS

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  • Site-wide: 1,434
  • In microbiology: 133
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A Peptide-based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Corona Virus Disease 2019 (COVID-19)

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  • Site-wide: 3,032
  • In infectious diseases: 765
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Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75

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  • Site-wide: 3,440
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Lewy pathology in Parkinson's disease consists of a crowded organellar, membranous medley

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  • Site-wide: 3,949
  • In neuroscience: 258
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Benefits and Risks of Chloroquine and Hydroxychloroquine in The Treatment of Viral Diseases: A Meta-Analysis of Placebo Randomized Controlled Trials

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Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

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Single-cell Stereo-seq enables cell type-specific spatial transcriptome characterization in Arabidopsis leaves

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Mapping a Pandemic: SARS-CoV-2 Seropositivity in the United States

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Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology

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  • Site-wide: 7,632
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Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

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Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation Fetus

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  • Site-wide: 8,199
  • In genomics: 766
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Potential Factors for Prediction of Disease Severity of COVID-19 Patients

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  • Site-wide: 8,433
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Individual bat viromes reveal the co-infection, spillover and emergence risk of potential zoonotic viruses

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  • Site-wide: 10,395
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How long and effective does a mask protect you from an infected person who emits corona virus-laden particles: by implementing physics-based modeling

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  • Site-wide: 10,834
  • In infectious diseases: 1,658
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  • Site-wide: 125,906
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  • Site-wide: 55,703

Omicron BA.2 specifically evades broad sarbecovirus neutralizing antibodies

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  • Site-wide: 10,942
  • In immunology: 438
• Year to date:
  • Site-wide: 6,608
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  • Site-wide: 8,650

What is required to prevent a second major outbreak of the novel coronavirus SARS-CoV-2 upon lifting the metropolitan-wide quarantine of Wuhan city, China

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  • Site-wide: 12,290
  • In infectious diseases: 1,788
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  • Site-wide: 153,319
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  • Site-wide: 132,079

Convergence within divergence: insights of wheat adaptation from Triticum population sequencing

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  • Site-wide: 13,013
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  • Site-wide: 15,142

Tethering Piezo channels to the actin cytoskeleton for mechanogating via the E-cadherin-β-catenin mechanotransduction complex

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  • Site-wide: 13,567
  • In neuroscience: 1,392
• Year to date:
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  • Site-wide: 128,775

Gene co-expression network connectivity is an important determinant of selective constraint

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  • Site-wide: 13,944
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  • Site-wide: 150,044

Flexible control of speed of cortical dynamics

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  • Site-wide: 14,238
  • In neuroscience: 1,463
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  • Site-wide: 153,600

Comparative Population Genomics of Bread Wheat (Triticum aestivum) Reveals Its Cultivation and Breeding History in China

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  • Site-wide: 15,672
  • In plant biology: 166
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Reinforcement regulates timing variability in thalamus

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  • Site-wide: 19,853
  • In neuroscience: 2,300
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  • Site-wide: 75,034

Distinct molecular processes in placentae involved in two major subtypes of preeclampsia

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  • Site-wide: 21,725
  • In genomics: 1,926
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  • Site-wide: 20,375

Initial data release and announcement of the Fish10K: Fish 10,000 Genomes Project

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  • Site-wide: 22,919
  • In genomics: 1,987
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  • Site-wide: 187,634

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

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  • Site-wide: 23,292
  • In immunology: 1,022
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  • Site-wide: 1,096

Effect of large-scale testing platform in prevention and control of the COVID-19 pandemic: an empirical study with a novel numerical model

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  • Site-wide: 23,849
  • In epidemiology: 1,470
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  • Site-wide: 81,873

CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor

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  • Site-wide: 24,734
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An XA21-Associated Kinase (OsSERK2) regulates immunity mediated by the XA21 and XA3 immune receptors

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  • Site-wide: 24,956
  • In plant biology: 339
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Alien chromatin other than the GST-encoding Fhb7 candidate confers Fusarium head blight resistance in wheat breeding

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  • Site-wide: 25,100
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Predictive Coding Models for Pain Perception

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  • Site-wide: 25,487
  • In neuroscience: 3,047
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  • Site-wide: 99,276

Pervasive Translation in Mycobacterium tuberculosis

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  • Site-wide: 26,212
  • In microbiology: 1,519
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How well do crop modeling groups predict wheat phenology, given calibration data from the target population?

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  • Site-wide: 27,549
  • In plant biology: 391
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Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

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Inhibition of histone acetyltranserase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a novel gain of function

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  • Site-wide: 36,954
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  • Site-wide: 128,361

A Genetically Encoded Fluorescent Sensor Enables Real-time Detection of the Intracellular GTP:GDP Ratio

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Population genomics unravels the Holocene history of Triticum-Aegilops species

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Eleven Routine Clinical Features Predict COVID-19 Severity

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Natural selection and recombination rate variation shape nucleotide polymorphism across the genomes of three related Populus species.

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Phase separation-aided compartmentalization of protein-protein interactions in cells

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Metagenomic and single-cell RNA-seq survey of the H. pylori-infected stomach in asymptomatic individuals

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Deducing the Dose-response Relation for Coronaviruses from COVID-19, SARS and MERS Meta-analysis Results

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PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, andRNA polymerase pause release at select gene targets

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  • Site-wide: 43,056
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  • Site-wide: 8,970

A major locus controls local adaptation and adaptive life history variation in a perennial plant

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  • Site-wide: 45,585
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  • Site-wide: 152,030

Evidence for widespread selection in shaping the genomic landscape during speciation of Populus

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Variation in linked selection and recombination drive genomic divergence during allopatric speciation of European and American aspens

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  • Site-wide: 48,611
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The chaos in calibrating crop models

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  • Site-wide: 48,825
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Single-Cell Transcriptomic Analyses of Tumor Ecosystems and Spatial Architectures in Human Small Cell Lung Cancers

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Multi-model evaluation of phenology prediction for wheat in Australia

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  • Site-wide: 58,014
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Pre-existing antibodies targeting a linear epitope on SARS-CoV-2 S2 cross-reacted with commensal gut bacteria and shaped vaccine induced immunity

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  • Site-wide: 58,264
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  • Site-wide: 25,657

Two faces of perceptual awareness during the attentional blink: Gradual and discrete

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  • Site-wide: 58,499
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Genotyping of structural variation using PacBio high-fidelity sequencing

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  • Site-wide: 62,359
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Release sites are positioned to activate NMDA receptors

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Inhibition of nonsense-mediated decay rescues functional p53β/γ isoforms in MDM2-amplified cancers

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  • Site-wide: 65,459
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Extensive High-Order Complexes within SARS-CoV-2 Proteome Revealed by Compartmentalization-Aided Interaction Screening

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  • Site-wide: 67,017
  • In microbiology: 4,006
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  • Site-wide: 138,873

Single-cell Long Non-coding RNA Landscape of T Cells in Human Cancer Immunity

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  • Site-wide: 67,930
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HER2 Cancer Protrusion Growth Signaling Regulated by Unhindered, Localized Filopodial Dynamics

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  • In cancer biology: 1,996
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Comparison of the COVID-19 infection risks by close contact and aerosol transmission

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RNA degradation analysis reveals ribosome dynamics in complex microbiome samples

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Protection Level and Reusability of a Modified Full-Face Snorkel Mask as Alternative Personal Protective Equipment for Healthcare Workers During the COVID-19 Pandemic

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  • Site-wide: 70,508
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  • Site-wide: 70,853

Haploinsufficiency of Parkinsonism Gene SYNJ1 Contributes to Dopamine neuron Vulnerability in Aged Mice

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Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis

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Single-cell transcriptomics reveals diverse and complex gene expression alterations in human trisomy 18

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Epidemiological and Clinical Characteristics of COVID-19 Patients with Cancers: A Systematic Review and Meta-Analysis of Global Data

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Large ribosomal subunit, eIF5B, Met-tRNAiMet and mRNA cooperate to complete accurate initiation.

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Hybrid incompatibility caused by an epiallele

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Genomic insights into present local adaptation and future climate change vulnerability of a keystone forest tree species in East Asian

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Variation in genome content and predatory phenotypes between Bdellovibrio sp. NC01 isolated from soil and B. bacteriovorus type strain HD100

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Compartmentalization of enhanced biomolecular interactions for high-throughput drug screening in test tubes

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FXa cleaves the SARS-CoV-2 spike protein and blocks cell entry to protect against infection with inferior effects in B.1.1.7 variant

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The impact of National Centralized Drug Procurement policy on the use of policy-related original and generic drugs in public medical institutions in China: A difference-in-difference analysis based on national database

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N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease.

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Genomic insights into longan evolution from a chromosome-level genome assembly and population genomics of longan accessions

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Mechanism of dual pharmacological correction and potentiation of human CFTR

• Downloaded 565 times
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  • Site-wide: 90,558
  • In biophysics: 3,506
• Year to date:
  • Site-wide: 13,281
• Since beginning of last month:
  • Site-wide: 15,321

Controlling pallidal oscillations in real-time in Parkinson's disease using evoked interference deep brain stimulation (eiDBS): proof of concept in the human

• Downloaded 564 times
• Download rankings, all-time:
  • Site-wide: 90,655
  • In neuroscience: 13,023
• Year to date:
  • Site-wide: 120,474
• Since beginning of last month:
  • Site-wide: 136,593

Structural Basis for the Clamping and Ca2+ Activation of SNARE-mediated Fusion by Synaptotagmin

• Downloaded 539 times
• Download rankings, all-time:
  • Site-wide: 95,755
  • In neuroscience: 13,671
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 181,012

VipA N-terminal linker and VipB-VipB interaction modulate the contraction of Type VI secretion system sheath

• Downloaded 526 times
• Download rankings, all-time:
  • Site-wide: 98,599
  • In microbiology: 6,332
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 149,287

Toxicities of PD-1/PD-L1 Inhibitors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

• Downloaded 521 times
• Download rankings, all-time:
  • Site-wide: 99,761
  • In oncology: 237
• Year to date:
  • Site-wide: 130,960
• Since beginning of last month:
  • Site-wide: 97,685

Results of safety monitoring of BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine in U.S. children aged 5-17 years

• Downloaded 516 times
• Download rankings, all-time:
  • Site-wide: 100,912
  • In pediatrics: 210
• Year to date:
  • Site-wide: 3,844
• Since beginning of last month:
  • Site-wide: 19,870

Quantifying Viscous Damping and Stiffness in Parkinsonism Using Data-Driven Model Estimation

• Downloaded 505 times
• Download rankings, all-time:
  • Site-wide: 103,414
  • In bioengineering: 2,057
• Year to date:
  • Site-wide: 146,297
• Since beginning of last month:
  • Site-wide: 171,438

Quantifying respiratory tract deposition of airborne graphene nanoplatelets: The impact of plate-like shape and folded structure

• Downloaded 504 times
• Download rankings, all-time:
  • Site-wide: 103,492
  • In occupational and environmental health: 197
• Year to date:
  • Site-wide: 37,987
• Since beginning of last month:
  • Site-wide: 70,842

Spike Protein Targeting "Nano-Glue" that Captures and Promotes SARS-CoV-2 Elimination

• Downloaded 497 times
• Download rankings, all-time:
  • Site-wide: 105,214
  • In immunology: 3,390
• Year to date:
  • Site-wide: 52,879
• Since beginning of last month:
  • Site-wide: 105,022

Improved subspecies identification in clinical Mycobacterium abscessus complex isolates using whole genome sequence

• Downloaded 495 times
• Download rankings, all-time:
  • Site-wide: 105,721
  • In microbiology: 6,894
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 191,454

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through interaction with Host Cell Factor-1

• Downloaded 488 times
• Download rankings, all-time:
  • Site-wide: 107,441
  • In cancer biology: 3,249
• Year to date:
  • Site-wide: 109,875
• Since beginning of last month:
  • Site-wide: 125,834

Accurate Diagnosis of Colorectal Cancer Based on Histopathology Images Using Artificial Intelligence

• Downloaded 487 times
• Download rankings, all-time:
  • Site-wide: 107,478
  • In pathology: 537
• Year to date:
  • Site-wide: 114,872
• Since beginning of last month:
  • Site-wide: 122,428

Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers

• Downloaded 485 times
• Download rankings, all-time:
  • Site-wide: 108,088
  • In cancer biology: 3,253
• Year to date:
  • Site-wide: 127,240
• Since beginning of last month:
  • Site-wide: 185,504

Omics-Based Interaction Framework - a systems model to reveal molecular drivers of synergy

• Downloaded 469 times
• Download rankings, all-time:
  • Site-wide: 111,879
  • In systems biology: 2,301
• Year to date:
  • Site-wide: 91,277
• Since beginning of last month:
  • Site-wide: 187,884

Integrin β3, a RACK1 interacting protein, is required for porcine reproductive and respiratory syndrome virus infection and NF-κB activation in Marc-145 cells

• Downloaded 462 times
• Download rankings, all-time:
  • Site-wide: 113,627
  • In microbiology: 7,759
• Year to date:
  • Site-wide: 38,092
• Since beginning of last month:
  • Site-wide: 52,835

A Novel Family of Genomics Islands Across Multiple Species of Streptococcus

• Downloaded 459 times
• Download rankings, all-time:
  • Site-wide: 114,247
  • In microbiology: 7,598
• Year to date:
  • Site-wide: 108,401
• Since beginning of last month:
  • Site-wide: 208,496

High-frequency oscillations in the internal globus pallidus: a pathophysiological biomarker in Parkinson's disease?

• Downloaded 458 times
• Download rankings, all-time:
  • Site-wide: 114,667
  • In neuroscience: 16,883
• Year to date:
  • Site-wide: 74,061
• Since beginning of last month:
  • Site-wide: 129,347

Assessment of the aging of the brown adipose tissue by 18F-FDG PET/CT imaging in the progeria mouse model LmnaG609G/G609G

• Downloaded 445 times
• Download rankings, all-time:
  • Site-wide: 117,957
  • In cell biology: 5,435
• Year to date:
  • Site-wide: 195,826
• Since beginning of last month:
  • Site-wide: 150,969

Down-regulated Long Noncoding RNA HOXA11-AS affects trophoblast cell proliferation and migration by regulating RND3 and HOXA7 expression in preeclampsia

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 118,955
  • In molecular biology: 3,474
• Year to date:
  • Site-wide: 98,667
• Since beginning of last month:
  • Site-wide: 204,774

A circadian-like gene network regulates heterochronic miRNA transcription in C. elegans

• Downloaded 438 times
• Download rankings, all-time:
  • Site-wide: 119,882
  • In developmental biology: 3,888
• Year to date:
  • Site-wide: 1,499
• Since beginning of last month:
  • Site-wide: 13,049

Molecular diagnosis of non-syndromic hearing loss patients using a stepwise approach

• Downloaded 432 times
• Download rankings, all-time:
  • Site-wide: 121,176
  • In genetic and genomic medicine: 828
• Year to date:
  • Site-wide: 112,055
• Since beginning of last month:
  • Site-wide: 104,097

Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing

• Downloaded 426 times
• Download rankings, all-time:
  • Site-wide: 122,999
  • In immunology: 3,887
• Year to date:
  • Site-wide: 158,081
• Since beginning of last month:
  • Site-wide: 99,252

Monitoring promoter activity by RNA editing based reporter

• Downloaded 425 times
• Download rankings, all-time:
  • Site-wide: 123,089
  • In molecular biology: 3,643
• Year to date:
  • Site-wide: 87,805
• Since beginning of last month:
  • Site-wide: 96,095

Insights into the susceptibility of rice to a floral disease

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 123,626
  • In plant biology: 3,330
• Year to date:
  • Site-wide: 66,787
• Since beginning of last month:
  • Site-wide: 104,621

Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccine

• Downloaded 420 times
• Download rankings, all-time:
  • Site-wide: 124,725
  • In infectious diseases: 6,269
• Year to date:
  • Site-wide: 70,091
• Since beginning of last month:
  • Site-wide: 23,912

A Mycobacterium tuberculosis effector protein attacks host innate immunity by acting as an unusual ubiquitinating enzyme

• Downloaded 417 times
• Download rankings, all-time:
  • Site-wide: 125,497
  • In microbiology: 8,468
• Year to date:
  • Site-wide: 185,120
• Since beginning of last month:
  • Site-wide: 125,994

The UBAP2L ortholog PQN-59 contributes to stress granule assembly and development in C. elegans

• Downloaded 405 times
• Download rankings, all-time:
  • Site-wide: 128,703
  • In cell biology: 6,008
• Year to date:
  • Site-wide: 117,139
• Since beginning of last month:
  • Site-wide: 135,802

Cargo-free scaffold implant recruits metastatic cancer cells via lung-mimicking myeloid cell S100A8/A9 axis

• Downloaded 400 times
• Download rankings, all-time:
  • Site-wide: 130,138
  • In bioengineering: 2,647
• Year to date:
  • Site-wide: 76,895
• Since beginning of last month:
  • Site-wide: 184,157

Ppard is Essential in Acceleration of Pancreatic Ductal Adenocarcinoma Development by High-Fat Diet in Mutant Kras Mice

• Downloaded 399 times
• Download rankings, all-time:
  • Site-wide: 130,399
  • In cancer biology: 3,969
• Year to date:
  • Site-wide: 132,692
• Since beginning of last month:
  • Site-wide: 48,943

Genomic and TCR Repertoire Intratumor Heterogeneity of Small-cell Lung Cancer and its Impact on Survival

• Downloaded 393 times
• Download rankings, all-time:
  • Site-wide: 132,437
  • In genomics: 7,234
• Year to date:
  • Site-wide: 154,828
• Since beginning of last month:
  • Site-wide: 101,205

Genetic dissection of femoral and tibial microarchitecture

• Downloaded 392 times
• Download rankings, all-time:
  • Site-wide: 132,653
  • In genetics: 4,951
• Year to date:
  • Site-wide: 175,965
• Since beginning of last month:
  • Site-wide: 149,598

ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of liver cells

• Downloaded 390 times
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  • Site-wide: 133,378
  • In microbiology: 9,517
• Year to date:
  • Site-wide: 20,040
• Since beginning of last month:
  • Site-wide: 21,199

First quarter chronicle of COVID-19: an attempt to measure governments response

• Downloaded 389 times
• Download rankings, all-time:
  • Site-wide: 133,561
  • In health policy: 342
• Year to date:
  • Site-wide: 94,739
• Since beginning of last month:
  • Site-wide: 104,063

Tuftsin: a natural molecule against SARS-CoV-2 infection

• Downloaded 352 times
• Download rankings, all-time:
  • Site-wide: 144,490
  • In immunology: 4,572
• Year to date:
  • Site-wide: 50,556
• Since beginning of last month:
  • Site-wide: 194,515

Identification of a missense ARSA mutation in metachromatic leukodystrophy and its potential pathogenic mechanism

• Downloaded 335 times
• Download rankings, all-time:
  • Site-wide: 149,931
  • In genetics: 5,536
• Year to date:
  • Site-wide: 170,890
• Since beginning of last month:
  • Site-wide: 184,953

WUSCHEL-Related Homeobox Genes Cooperate with Cytokinin Signalling to Promote Bulbil Formation in Lilium lancifolium

• Downloaded 331 times
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  • Site-wide: 151,145
  • In developmental biology: 4,144
• Year to date:
  • Site-wide: 17,586
• Since beginning of last month:
  • Site-wide: 46,989

Structure of human cytomegalovirus UL144, an HVEM orthologue, bound to the B and T cell Lymphocyte Attenuator

• Downloaded 324 times
• Download rankings, all-time:
  • Site-wide: 153,078
  • In immunology: 4,778
• Year to date:
  • Site-wide: 168,287
• Since beginning of last month:
  • Site-wide: 208,172

Immunoglobulin-producing AT2-like cells secrete IgA into the extracellular matrix in pulmonary fibrosis

• Downloaded 318 times
• Download rankings, all-time:
  • Site-wide: 154,708
  • In cell biology: 7,390
• Year to date:
  • Site-wide: 22,436
• Since beginning of last month:
  • Site-wide: 49,291

Computational design of highly signaling active membrane receptors through de novo solvent-mediated allosteric networks

• Downloaded 314 times
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  • Site-wide: 155,992
  • In biophysics: 6,093
• Year to date:
  • Site-wide: 87,165
• Since beginning of last month:
  • Site-wide: 70,881

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance anti-HIV activity in vitro

• Downloaded 308 times
• Download rankings, all-time:
  • Site-wide: 157,732
  • In bioengineering: 3,347
• Year to date:
  • Site-wide: 83,738
• Since beginning of last month:
  • Site-wide: 24,148

PQN-59 antagonizes microRNA-mediated repression and functions in stress granule formation during C. elegans development

• Downloaded 308 times
• Download rankings, all-time:
  • Site-wide: 157,821
  • In developmental biology: 4,188
• Year to date:
  • Site-wide: 87,890
• Since beginning of last month:
  • Site-wide: 69,961

Decreased kinesin-1 mitigates NMDA-induced exicitotoxicity and ischemia-evoked neurodegeneration

• Downloaded 303 times
• Download rankings, all-time:
  • Site-wide: 159,302
  • In neuroscience: 23,276
• Year to date:
  • Site-wide: 177,595
• Since beginning of last month:
  • Site-wide: 178,629

Revealing the functions of supra-temporal and insular auditory responsive areas in humans

• Downloaded 303 times
• Download rankings, all-time:
  • Site-wide: 159,374
  • In neuroscience: 23,299
• Year to date:
  • Site-wide: 129,738
• Since beginning of last month:
  • Site-wide: 212,001

Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome

• Downloaded 295 times
• Download rankings, all-time:
  • Site-wide: 161,855
  • In molecular biology: 4,861
• Year to date:
  • Site-wide: 52,406
• Since beginning of last month:
  • Site-wide: 70,850

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

• Downloaded 295 times
• Download rankings, all-time:
  • Site-wide: 161,916
  • In pharmacology and toxicology: 1,251
• Year to date:
  • Site-wide: 199,661
• Since beginning of last month:
  • Site-wide: 138,926

Filtration Performance Degradation of In-Use Masks by Vapors from Alcohol-Based Hand Sanitizers and the Mitigation Solutions

• Downloaded 292 times
• Download rankings, all-time:
  • Site-wide: 162,843
  • In public and global health: 2,351
• Year to date:
  • Site-wide: 153,448
• Since beginning of last month:
  • Site-wide: 140,285

Identification of a multipotent lung progenitor for lung regeneration

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 164,131
  • In cell biology: 7,930
• Year to date:
  • Site-wide: 18,771
• Since beginning of last month:
  • Site-wide: 19,776

A non-human primate model with Alzheimer's disease-like pathology induced by hippocampal overexpression of human tau

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 164,179
  • In neuroscience: 24,789
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 22,496

Moxifloxacin efficacy against Mycobacterium abscessus in vivo using zebrafish model

• Downloaded 281 times
• Download rankings, all-time:
  • Site-wide: 166,121
  • In microbiology: 11,939
• Year to date:
  • Site-wide: 132,948
• Since beginning of last month:
  • Site-wide: 125,436

Dissecting the loci underlying maturation timing in Atlantic salmon using haplotype and multi-SNP based association methods

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 167,844
  • In evolutionary biology: 7,574
• Year to date:
  • Site-wide: 143,405
• Since beginning of last month:
  • Site-wide: 108,228

VGLUT3-p.A211V variant fuses stereocilia bundle and elongates synaptic ribbons in the human deafness DFNA25

• Downloaded 265 times
• Download rankings, all-time:
  • Site-wide: 170,705
  • In neuroscience: 24,964
• Year to date:
  • Site-wide: 126,313
• Since beginning of last month:
  • Site-wide: 129,560

3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 173,545
  • In cancer biology: 5,486
• Year to date:
  • Site-wide: 52,855
• Since beginning of last month:
  • Site-wide: 87,169

Pre-clinical Research of Human Amnion-derived Mesenchymal Stem Cells and its First Clinical Treatment for a Severe Uremic Calciphylaxis Patient

• Downloaded 252 times
• Download rankings, all-time:
  • Site-wide: 174,376
  • In nephrology: 152
• Year to date:
  • Site-wide: 82,430
• Since beginning of last month:
  • Site-wide: 112,716

Increased reliability of visually-evoked activity in area V1 of the MECP2-duplication mouse model of autism

• Downloaded 248 times
• Download rankings, all-time:
  • Site-wide: 175,412
  • In neuroscience: 26,464
• Year to date:
  • Site-wide: 31,802
• Since beginning of last month:
  • Site-wide: 83,986

Alterations in neural stem cell quiescence and activation in the 3xTG-AD model of Alzheimers Disease

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 180,151
  • In neuroscience: 26,819
• Year to date:
  • Site-wide: 14,593
• Since beginning of last month:
  • Site-wide: 63,345

Haplotype-resolved assemblies and variant benchmark of a Chinese Quartet

• Downloaded 229 times
• Download rankings, all-time:
  • Site-wide: 180,614
  • In genomics: 8,777
• Year to date:
  • Site-wide: 41,521
• Since beginning of last month:
  • Site-wide: 74,264

CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts

• Downloaded 227 times
• Download rankings, all-time:
  • Site-wide: 181,211
  • In systems biology: 3,585
• Year to date:
  • Site-wide: 66,498
• Since beginning of last month:
  • Site-wide: 71,130

Effect size, sample size and power of forced swim test assays in mice: Guidelines for investigators to optimize reproducibility

• Downloaded 225 times
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  • Site-wide: 181,585
  • In scientific communication and education: 911
• Year to date:
  • Site-wide: 62,841
• Since beginning of last month:
  • Site-wide: 170,136

Mental Workload Classification of Oceanauts from EEG Data Using Multiclass Support Vector Machines

• Downloaded 223 times
• Download rankings, all-time:
  • Site-wide: 182,171
  • In scientific communication and education: 909
• Year to date:
  • Site-wide: 146,758
• Since beginning of last month:
  • Site-wide: 114,563

The synergistic effect of circRNA methylation promotes pulmonary fibrosis

• Downloaded 209 times
• Download rankings, all-time:
  • Site-wide: 185,738
  • In pharmacology and toxicology: 1,574
• Year to date:
  • Site-wide: 32,109
• Since beginning of last month:
  • Site-wide: 106,636

Optogenetic activation of visual thalamus generates artificial visual percepts

• Downloaded 197 times
• Download rankings, all-time:
  • Site-wide: 188,483
  • In neuroscience: None
• Year to date:
  • Site-wide: 126,028
• Since beginning of last month:
  • Site-wide: 814

Shift of the insoluble content of the proteome in aging mouse brain

• Downloaded 190 times
• Download rankings, all-time:
  • Site-wide: 190,149
  • In cell biology: None
• Year to date:
  • Site-wide: 7,767
• Since beginning of last month:
  • Site-wide: 1,116

The immunogenomic landscape of cattle

• Downloaded 187 times
• Download rankings, all-time:
  • Site-wide: 190,821
  • In genomics: 9,064
• Year to date:
  • Site-wide: 97,319
• Since beginning of last month:
  • Site-wide: 62,009

The Clinical Response of Upadacitinib and Risankizumab is Associated with Reduced Inflammatory Bowel Disease Anti-TNFα Inadequate Response Mechanisms

• Downloaded 186 times
• Download rankings, all-time:
  • Site-wide: 191,100
  • In immunology: 6,265
• Year to date:
  • Site-wide: 18,566
• Since beginning of last month:
  • Site-wide: 73,428

Quartet DNA reference materials and datasets for comprehensively evaluating germline variants calling performance

• Downloaded 184 times
• Download rankings, all-time:
  • Site-wide: 191,492
  • In bioinformatics: 14,632
• Year to date:
  • Site-wide: 15,898
• Since beginning of last month:
  • Site-wide: 19,953

Rapid and fully automated blood vasculature analysis in 3D light-sheet image volumes of different organs

• Downloaded 180 times
• Download rankings, all-time:
  • Site-wide: 192,450
  • In bioinformatics: 14,371
• Year to date:
  • Site-wide: 42,033
• Since beginning of last month:
  • Site-wide: 26,894

Genomic signals of local adaptation and hybridization in Asian white birch

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 192,711
  • In evolutionary biology: 8,514
• Year to date:
  • Site-wide: 190,666
• Since beginning of last month:
  • Site-wide: 172,241

Genomic analyses identify biological processes and functions between M1 and M2 macrophages

• Downloaded 176 times
• Download rankings, all-time:
  • Site-wide: 193,116
  • In bioinformatics: 14,267
• Year to date:
  • Site-wide: 150,187
• Since beginning of last month:
  • Site-wide: 157,650

Molecular mechanisms associated with multiple sclerosis progression, severity and phenotype

• Downloaded 168 times
• Download rankings, all-time:
  • Site-wide: 194,857
  • In neurology: 1,500
• Year to date:
  • Site-wide: 13,165
• Since beginning of last month:
  • Site-wide: 9,097

ScanTecc classifies primary cancers via cell-free extrachromosomal circular DNA in peripheral blood

• Downloaded 156 times
• Download rankings, all-time:
  • Site-wide: 197,370
  • In oncology: 765
• Year to date:
  • Site-wide: 68,890
• Since beginning of last month:
  • Site-wide: 82,901

Classification of electrically-evoked compound action potentials in the parkinsonian subthalamic nucleus region

• Downloaded 150 times
• Download rankings, all-time:
  • Site-wide: 198,621
  • In neuroscience: 28,767
• Year to date:
  • Site-wide: 125,693
• Since beginning of last month:
  • Site-wide: 97,210

Genomic analyses identify biological processes in ZKSCAN3-deficient colorectal cancer cells

• Downloaded 146 times
• Download rankings, all-time:
  • Site-wide: 199,382
  • In bioinformatics: 14,609
• Year to date:
  • Site-wide: 145,128
• Since beginning of last month:
  • Site-wide: 194,662

The Impact of a Dynamic Working Environment on Human Gut Microbiota

• Downloaded 146 times
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  • Site-wide: 199,435
  • In microbiology: 15,163
• Year to date:
  • Site-wide: 65,580
• Since beginning of last month:
  • Site-wide: 170,056

Ratio-based quantitative multiomics profiling using universal reference materials empowers data integration

• Downloaded 140 times
• Download rankings, all-time:
  • Site-wide: 200,383
  • In systems biology: 3,872
• Year to date:
  • Site-wide: 69,323
• Since beginning of last month:
  • Site-wide: 40,133

Quartet RNA reference materials and ratio-based reference datasets for reliable transcriptomic profiling

• Downloaded 136 times
• Download rankings, all-time:
  • Site-wide: 201,280
  • In genetics: 7,057
• Year to date:
  • Site-wide: 29,222
• Since beginning of last month:
  • Site-wide: 62,273

Proteomics Investigation of Diverse Serological Patterns in COVID-19

• Downloaded 119 times
• Download rankings, all-time:
  • Site-wide: 204,316
  • In infectious diseases: 8,421
• Year to date:
  • Site-wide: 159,363
• Since beginning of last month:
  • Site-wide: 73,781

Identification of biological processes and signaling pathways in the stretched nucleus pulposus cells

• Downloaded 101 times
• Download rankings, all-time:
  • Site-wide: 207,527
  • In bioinformatics: 14,945
• Year to date:
  • Site-wide: 147,431
• Since beginning of last month:
  • Site-wide: 165,164

REM Sleep Movements in Parkinson's Disease: Is the Basal Ganglia Engaged?

• Downloaded 99 times
• Download rankings, all-time:
  • Site-wide: 208,073
  • In neuroscience: 30,070
• Year to date:
  • Site-wide: 160,484
• Since beginning of last month:
  • Site-wide: 96,169

A small H2O-soluble ingredient of royal jelly lower cholesterol levels in liver cells by suppressing squalene epoxidase

• Downloaded 72 times
• Download rankings, all-time:
  • Site-wide: 213,025
  • In cell biology: 9,648
• Year to date:
  • Site-wide: 190,882
• Since beginning of last month:
  • Site-wide: 173,670

Oxytocin enhances pleasantness and neural responses to CT-fiber-mediated social touch via increased peripheral concentrations

• Downloaded 71 times
• Download rankings, all-time:
  • Site-wide: 213,137
  • In pharmacology and therapeutics: None
• Year to date:
  • Site-wide: 2,178
• Since beginning of last month:
  • Site-wide: None

Relationship between blood bone metabolic biomarkers and anemia in CKD patients

• Downloaded 67 times
• Download rankings, all-time:
  • Site-wide: 213,915
  • In nephrology: None
• Year to date:
  • Site-wide: 6,696
• Since beginning of last month:
  • Site-wide: 12,968

Neural signatures of second language proficiency in narrative processing.

• Downloaded 51 times
• Download rankings, all-time:
  • Site-wide: 216,101
  • In neuroscience: 30,889
• Year to date:
  • Site-wide: 160,250
• Since beginning of last month:
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Therapeutic effects of human amnion-derived mesenchymal stem cells on hypercoagulability in a uremic calciphylaxis patient

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