Author: Lin Wang

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Preprints

Rapid development of an inactivated vaccine for SARS-CoV-2

• Downloaded 85,006 times
• Download rankings, all-time:
  • Site-wide: 52
  • In microbiology: 6
• Year to date:
  • Site-wide: 404
• Since beginning of last month:
  • Site-wide: 404

Neutrophil-to-Lymphocyte Ratio Predicts Severe Illness Patients with 2019 Novel Coronavirus in the Early Stage

• Downloaded 27,529 times
• Download rankings, all-time:
  • Site-wide: 214
  • In infectious diseases: 86
• Year to date:
  • Site-wide: 808
• Since beginning of last month:
  • Site-wide: 808

Structure of Mpro from COVID-19 virus and discovery of its inhibitors

• Downloaded 23,128 times
• Download rankings, all-time:
  • Site-wide: 274
  • In biochemistry: 1
• Year to date:
  • Site-wide: 1,125
• Since beginning of last month:
  • Site-wide: 1,125

The serial interval of COVID-19 from publicly reported confirmed cases

• Downloaded 17,187 times
• Download rankings, all-time:
  • Site-wide: 377
  • In epidemiology: 62
• Year to date:
  • Site-wide: 1,978
• Since beginning of last month:
  • Site-wide: 1,978

Age-specific mortality and immunity patterns of SARS-CoV-2 infection in 45 countries

• Downloaded 8,230 times
• Download rankings, all-time:
  • Site-wide: 959
  • In epidemiology: 121
• Year to date:
  • Site-wide: 2,808
• Since beginning of last month:
  • Site-wide: 2,808

Risk of 2019 novel coronavirus importations throughout China prior to the Wuhan quarantine

• Downloaded 6,822 times
• Download rankings, all-time:
  • Site-wide: 1,209
  • In epidemiology: 151
• Year to date:
  • Site-wide: 8,775
• Since beginning of last month:
  • Site-wide: 8,775

A simple laboratory parameter facilitates early identification of COVID-19 patients

• Downloaded 3,855 times
• Download rankings, all-time:
  • Site-wide: 2,675
  • In infectious diseases: 528
• Year to date:
  • Site-wide: 29,211
• Since beginning of last month:
  • Site-wide: 29,211

CoolMPS™: Advanced massively parallel sequencing using antibodies specific to each natural nucleobase

• Downloaded 3,754 times
• Download rankings, all-time:
  • Site-wide: 2,777
  • In genomics: 330
• Year to date:
  • Site-wide: 4,109
• Since beginning of last month:
  • Site-wide: 4,109

Spatial epidemiology of networked metapopulation: An overview

• Downloaded 2,580 times
• Download rankings, all-time:
  • Site-wide: 4,772
  • In biophysics: 84
• Year to date:
  • Site-wide: 35,973
• Since beginning of last month:
  • Site-wide: 35,973

Close contacts and household transmission of SARS-CoV-2 in China: a content analysis based on local Heath Commissions' public disclosures.

• Downloaded 2,397 times
• Download rankings, all-time:
  • Site-wide: 5,339
  • In epidemiology: 454
• Year to date:
  • Site-wide: 19,235
• Since beginning of last month:
  • Site-wide: 19,235

A comparison study of SARS-CoV-2 IgG antibody between male and female COVID-19 patients: a possible reason underlying different outcome between gender.

• Downloaded 2,301 times
• Download rankings, all-time:
  • Site-wide: 5,670
  • In infectious diseases: 840
• Year to date:
  • Site-wide: 41,104
• Since beginning of last month:
  • Site-wide: 41,104

Advanced Whole Genome Sequencing Using an Entirely PCR-free Massively Parallel Sequencing Workflow

• Downloaded 1,864 times
• Download rankings, all-time:
  • Site-wide: 7,696
  • In genomics: 857
• Year to date:
  • Site-wide: 6,098
• Since beginning of last month:
  • Site-wide: 6,098

Reliable Multiplex Sequencing with Rare Index Mis-Assignment on DNB-Based NGS Platform

• Downloaded 1,709 times
• Download rankings, all-time:
  • Site-wide: 8,793
  • In genomics: 989
• Year to date:
  • Site-wide: 35,542
• Since beginning of last month:
  • Site-wide: 35,542

The Effectiveness of China’s National Forest Protection Program and National-level Nature Reserves, 2000 to 2010

• Downloaded 1,524 times
• Download rankings, all-time:
  • Site-wide: 10,421
  • In ecology: 143
• Year to date:
  • Site-wide: 43,547
• Since beginning of last month:
  • Site-wide: 43,547

Solid immersion microscopy readily and inexpensively enables 12 nm resolution on plunge-frozen cells

• Downloaded 1,372 times
• Download rankings, all-time:
  • Site-wide: 12,182
  • In biophysics: 291
• Year to date:
  • Site-wide: 54,103
• Since beginning of last month:
  • Site-wide: 54,103

CoVID-19 in Singapore: Impact of Contact Tracing and Self-awareness on Healthcare Demand

• Downloaded 1,284 times
• Download rankings, all-time:
  • Site-wide: 13,469
  • In health policy: 36
• Year to date:
  • Site-wide: 10,827
• Since beginning of last month:
  • Site-wide: 10,827

COVID-19 serial interval estimates based on confirmed cases in public reports from 86 Chinese cities

• Downloaded 1,282 times
• Download rankings, all-time:
  • Site-wide: 13,490
  • In infectious diseases: 1,310
• Year to date:
  • Site-wide: 7,882
• Since beginning of last month:
  • Site-wide: 7,882

Quantitative fluxomics of circulating metabolites

• Downloaded 1,279 times
• Download rankings, all-time:
  • Site-wide: 13,544
  • In systems biology: 271
• Year to date:
  • Site-wide: 26,720
• Since beginning of last month:
  • Site-wide: 26,720

3′ Branch Ligation: A Novel Method to Ligate Non-Complementary DNA to Recessed or Internal 3′ OH Ends in DNA or RNA

• Downloaded 1,208 times
• Download rankings, all-time:
  • Site-wide: 14,750
  • In molecular biology: 413
• Year to date:
  • Site-wide: 11,840
• Since beginning of last month:
  • Site-wide: 11,840

The Trans-omics Landscape of COVID-19

• Downloaded 1,176 times
• Download rankings, all-time:
  • Site-wide: 15,367
  • In infectious diseases: 1,403
• Year to date:
  • Site-wide: 18,216
• Since beginning of last month:
  • Site-wide: 18,216

Multi-omics study revealing tissue-dependent putative mechanisms of SARS-CoV-2 drug targets on viral infections and complex diseases

• Downloaded 1,158 times
• Download rankings, all-time:
  • Site-wide: 15,744
  • In genetic and genomic medicine: 49
• Year to date:
  • Site-wide: 23,578
• Since beginning of last month:
  • Site-wide: 23,578

Neural evidence for representationally specific prediction in language processing

• Downloaded 1,048 times
• Download rankings, all-time:
  • Site-wide: 18,276
  • In neuroscience: 2,331
• Year to date:
  • Site-wide: 109,475
• Since beginning of last month:
  • Site-wide: 109,475

Nuclear myosin VI regulates the spatial organization of mammalian transcription initiation.

• Downloaded 991 times
• Download rankings, all-time:
  • Site-wide: 19,830
  • In cell biology: 689
• Year to date:
  • Site-wide: 19,797
• Since beginning of last month:
  • Site-wide: 19,797

Proactive social distancing mitigates COVID-19 outbreaks within a month across 58 mainland China cities

• Downloaded 953 times
• Download rankings, all-time:
  • Site-wide: 20,983
  • In infectious diseases: 1,614
• Year to date:
  • Site-wide: 39,715
• Since beginning of last month:
  • Site-wide: 39,715

A cohort study of 223 patients explores the clinical risk factors for the severity diagnosis of COVID-19

• Downloaded 810 times
• Download rankings, all-time:
  • Site-wide: 26,435
  • In infectious diseases: 1,813
• Year to date:
  • Site-wide: 11,341
• Since beginning of last month:
  • Site-wide: 11,341

International risk of the new variant COVID-19 importations originating in the United Kingdom

• Downloaded 755 times
• Download rankings, all-time:
  • Site-wide: 29,197
  • In epidemiology: 1,492
• Year to date:
  • Site-wide: 665
• Since beginning of last month:
  • Site-wide: 665

Metabolite discovery through global annotation of untargeted metabolomics data

• Downloaded 706 times
• Download rankings, all-time:
  • Site-wide: 31,985
  • In bioinformatics: 3,632
• Year to date:
  • Site-wide: 734
• Since beginning of last month:
  • Site-wide: 734

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

• Downloaded 699 times
• Download rankings, all-time:
  • Site-wide: 32,471
  • In immunology: 885
• Year to date:
  • Site-wide: 49,445
• Since beginning of last month:
  • Site-wide: 49,445

Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies novel methylation loci

• Downloaded 698 times
• Download rankings, all-time:
  • Site-wide: 32,507
  • In genomics: 2,904
• Year to date:
  • Site-wide: 52,370
• Since beginning of last month:
  • Site-wide: 52,370

Measuring protected-area outcomes with leech iDNA: large-scale quantification of vertebrate biodiversity in Ailaoshan reserve

• Downloaded 625 times
• Download rankings, all-time:
  • Site-wide: 37,692
  • In ecology: 903
• Year to date:
  • Site-wide: 30,891
• Since beginning of last month:
  • Site-wide: 30,891

Long-read Individual-molecule Sequencing Reveals CRISPR-induced Genetic Heterogeneity in Human ESCs

• Downloaded 599 times
• Download rankings, all-time:
  • Site-wide: 39,731
  • In molecular biology: 1,136
• Year to date:
  • Site-wide: 76,465
• Since beginning of last month:
  • Site-wide: 76,465

Neural evidence for the prediction of animacy features during language comprehension: Evidence from MEG and EEG Representational Similarity Analysis

• Downloaded 520 times
• Download rankings, all-time:
  • Site-wide: 47,254
  • In neuroscience: 6,939
• Year to date:
  • Site-wide: 71,698
• Since beginning of last month:
  • Site-wide: 71,698

Single-cell Individual Complete mtDNA Sequencing Uncovers Hidden Mitochondrial Heterogeneity in Human and Mouse Oocytes

• Downloaded 511 times
• Download rankings, all-time:
  • Site-wide: 48,194
  • In genomics: 3,848
• Year to date:
  • Site-wide: 2,012
• Since beginning of last month:
  • Site-wide: 2,012

Using eDNA to Detect the Distribution and Density of Invasive Crayfish in the Honghe-Hani Rice Terrace World Heritage Site

• Downloaded 498 times
• Download rankings, all-time:
  • Site-wide: 49,675
  • In ecology: 1,287
• Year to date:
  • Site-wide: 93,528
• Since beginning of last month:
  • Site-wide: 93,528

DNA damage alters nuclear mechanics through chromatin reorganisation.

• Downloaded 479 times
• Download rankings, all-time:
  • Site-wide: 52,046
  • In biophysics: 1,804
• Year to date:
  • Site-wide: 41,082
• Since beginning of last month:
  • Site-wide: 41,082

Factors Associated with Disease Severity and Mortality among Patients with Coronavirus Disease 2019: A Systematic Review and Meta-Analysis

• Downloaded 478 times
• Download rankings, all-time:
  • Site-wide: 52,097
  • In infectious diseases: 2,541
• Year to date:
  • Site-wide: 26,453
• Since beginning of last month:
  • Site-wide: 26,453

Type I Interferon Limits Viral Dissemination-Driven Clinical Heterogeneity in a Native Murine Betacoronavirus Model of COVID-19

• Downloaded 409 times
• Download rankings, all-time:
  • Site-wide: 61,349
  • In immunology: 1,660
• Year to date:
  • Site-wide: 27,541
• Since beginning of last month:
  • Site-wide: 27,541

Alterations in neurovascular coupling following acute traumatic brain injury

• Downloaded 391 times
• Download rankings, all-time:
  • Site-wide: 64,186
  • In neuroscience: 9,780
• Year to date:
  • Site-wide: 109,815
• Since beginning of last month:
  • Site-wide: 109,815

Binding partner regulation of Myosin VI: Loss of tumour-suppressor Dab2 leads to enhanced activity of nuclear myosin

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 66,606
  • In cell biology: 3,027
• Year to date:
  • Site-wide: 97,559
• Since beginning of last month:
  • Site-wide: 97,559

A targeted and tuneable DNA damage tool using CRISPR/Cas9.

• Downloaded 373 times
• Download rankings, all-time:
  • Site-wide: 67,064
  • In cell biology: 3,056
• Year to date:
  • Site-wide: 1,738
• Since beginning of last month:
  • Site-wide: 1,738

Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect

• Downloaded 358 times
• Download rankings, all-time:
  • Site-wide: 69,632
  • In evolutionary biology: 3,913
• Year to date:
  • Site-wide: 63,562
• Since beginning of last month:
  • Site-wide: 63,562

The biodiversity benefit of native forest over Grain-for-Green plantations

• Downloaded 329 times
• Download rankings, all-time:
  • Site-wide: 74,633
  • In ecology: 2,240
• Year to date:
  • Site-wide: 107,677
• Since beginning of last month:
  • Site-wide: 107,677

A novel deep learning scheme for morphology-based classification of mycobacterial infection in unstained macrophages

• Downloaded 309 times
• Download rankings, all-time:
  • Site-wide: 78,432
  • In bioengineering: 1,467
• Year to date:
  • Site-wide: 85,166
• Since beginning of last month:
  • Site-wide: 85,166

Binding partners regulate unfolding of myosin VI to activate the molecular motor

• Downloaded 281 times
• Download rankings, all-time:
  • Site-wide: 84,182
  • In biophysics: 3,253
• Year to date:
  • Site-wide: 38,315
• Since beginning of last month:
  • Site-wide: 38,315

Genome sequencing combining prenatal ultrasound in the evaluation of fetal CNS structural anomalies

• Downloaded 227 times
• Download rankings, all-time:
  • Site-wide: 95,640
  • In genetic and genomic medicine: 355
• Year to date:
  • Site-wide: 76,274
• Since beginning of last month:
  • Site-wide: 76,274

Tibetan antelope rests like a Puppet

• Downloaded 206 times
• Download rankings, all-time:
  • Site-wide: 100,155
  • In animal behavior and cognition: 1,297
• Year to date:
  • Site-wide: 122,638
• Since beginning of last month:
  • Site-wide: 122,638

Clinical and molecular diagnostic study of 320 Chinese children with epilepsy by Genome Sequencing

• Downloaded 200 times
• Download rankings, all-time:
  • Site-wide: 101,609
  • In genetic and genomic medicine: 389
• Year to date:
  • Site-wide: 51,333
• Since beginning of last month:
  • Site-wide: 51,333

Big data reveals deep associations in physical examination indicators and can help predict overall underlying health status

• Downloaded 188 times
• Download rankings, all-time:
  • Site-wide: 104,102
  • In pathology: 598
• Year to date:
  • Site-wide: 115,162
• Since beginning of last month:
  • Site-wide: 115,162

Post-translational knockdown and post-secretional modification of EsxA unambiguously determine the role of EsxA membrane permeabilizing activity in mycobacterial virulence

• Downloaded 179 times
• Download rankings, all-time:
  • Site-wide: 105,876
  • In microbiology: 7,914
• Year to date:
  • Site-wide: 69,604
• Since beginning of last month:
  • Site-wide: 69,604

Weak predation strength promotes stable coexistence of predators and prey in the same chain and across chains

• Downloaded 163 times
• Download rankings, all-time:
  • Site-wide: 109,041
  • In ecology: 3,857
• Year to date:
  • Site-wide: 89,666
• Since beginning of last month:
  • Site-wide: 89,666

Mycobacterial surface-associated ESX-1 virulence factors play a role in mycobacterial adherence and invasion into lung epithelial cells

• Downloaded 129 times
• Download rankings, all-time:
  • Site-wide: 115,573
  • In biochemistry: 3,479
• Year to date:
  • Site-wide: 75,337
• Since beginning of last month:
  • Site-wide: 75,337

Fate mapping analysis reveals a novel dermal migratory Langerhans-like cell population

• Downloaded 114 times
• Download rankings, all-time:
  • Site-wide: 118,369
  • In immunology: 3,325
• Year to date:
  • Site-wide: 55,826
• Since beginning of last month:
  • Site-wide: 55,826

Immune deposit and vasculopathy in metabolic-active lung tissues of patients with pulmonary tuberculosis

• Downloaded 13 times
• Download rankings, all-time:
  • Site-wide: 127,429
  • In immunology: 3,668
• Year to date:
  • Site-wide: 79,936
• Since beginning of last month:
  • Site-wide: 79,936