Author: Ming Hu

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Preprints

Caution on Kidney Dysfunctions of 2019-nCoV Patients

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  • Site-wide: 793
  • In infectious diseases: 262
• Year to date:
  • Site-wide: 2,764
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  • Site-wide: 5,379

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,110
  • In genetics: 26
• Year to date:
  • Site-wide: 45,127
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  • Site-wide: 37,119

The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions

• Downloaded 3,038 times
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  • Site-wide: 5,123
  • In bioinformatics: 491
• Year to date:
  • Site-wide: 60,952
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  • Site-wide: 43,750

Histone H3 Lysine 4 methyltransferases MLL3 and MLL4 Modulate Long-range Chromatin Interactions at Enhancers

• Downloaded 2,616 times
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  • Site-wide: 6,378
  • In genomics: 651
• Year to date:
  • Site-wide: 77,694
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  • Site-wide: 99,958

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

• Downloaded 2,550 times
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  • Site-wide: 6,621
  • In genetics: 274
• Year to date:
  • Site-wide: 11,475
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  • Site-wide: 21,411

HiCPlus: Resolution Enhancement of Hi-C interaction heatmap

• Downloaded 2,209 times
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  • Site-wide: 8,159
  • In bioinformatics: 912
• Year to date:
  • Site-wide: 98,079
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  • Site-wide: 72,221

CTCF Mediates Dosage and Sequence-context-dependent Transcriptional Insulation through Formation of Local Chromatin Domains

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  • Site-wide: 9,338
  • In molecular biology: 231
• Year to date:
  • Site-wide: 9,531
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  • Site-wide: 24,130

3D Epigenomic Characterization Reveals Insights Into Gene Regulation and Lineage Specification During Corticogenesis

• Downloaded 1,952 times
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  • Site-wide: 9,731
  • In genomics: 973
• Year to date:
  • Site-wide: 14,281
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  • Site-wide: 20,854

CTCF Promotes Long-range Enhancer-promoter Interactions and Lineage-specific Gene Expression in Mammalian Cells

• Downloaded 1,829 times
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  • Site-wide: 10,766
  • In genomics: 1,080
• Year to date:
  • Site-wide: 16,164
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  • Site-wide: 28,141

Removing unwanted variation between samples in Hi-C experiments

• Downloaded 1,593 times
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  • Site-wide: 13,146
  • In genomics: 1,321
• Year to date:
  • Site-wide: 16,316
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  • Site-wide: 10,696

Common DNA sequence variation influences 3-dimensional conformation of the human genome

• Downloaded 1,513 times
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  • Site-wide: 14,210
  • In genomics: 1,420
• Year to date:
  • Site-wide: 142,692
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  • Site-wide: 124,303

Robust Hi-C chromatin loop maps in human neurogenesis and brain tissues at high-resolution

• Downloaded 1,495 times
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  • Site-wide: 14,498
  • In genomics: 1,441
• Year to date:
  • Site-wide: 19,596
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  • Site-wide: 22,211

Reliable sensory processing in mouse visual cortex through inhibitory interactions between Somatostatin and Parvalbumin interneurons

• Downloaded 1,443 times
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  • Site-wide: 15,319
  • In neuroscience: 1,730
• Year to date:
  • Site-wide: 44,659
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  • Site-wide: 30,541

MAPS: model-based analysis of long-range chromatin interactions from PLAC-seq and HiChIP experiments

• Downloaded 1,208 times
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  • Site-wide: 20,013
  • In bioinformatics: 2,285
• Year to date:
  • Site-wide: 104,954
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  • Site-wide: 127,809

Parallel Characterization of cis-Regulatory Elements for Multiple Genes Using CRISPRpath

• Downloaded 867 times
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  • Site-wide: 32,524
  • In genomics: 2,784
• Year to date:
  • Site-wide: 5,365
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  • Site-wide: 3,634

SnapHiC: a computational pipeline to map chromatin contacts from single cell Hi-C data

• Downloaded 788 times
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  • Site-wide: 37,254
  • In bioinformatics: 4,005
• Year to date:
  • Site-wide: 11,279
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  • Site-wide: 36,751

HUGIn: Hi-C Unifying Genomic Interrogator

• Downloaded 749 times
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  • Site-wide: 39,997
  • In genetics: 1,762
• Year to date:
  • Site-wide: 154,106
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  • Site-wide: 157,036

In V4, pair-wise synchrony and correlations depend on the structure of the population code

• Downloaded 747 times
• Download rankings, all-time:
  • Site-wide: 40,121
  • In neuroscience: 5,413
• Year to date:
  • Site-wide: 106,068
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  • Site-wide: 146,023

TWO-SIGMA: a novel TWO-component SInGle cell Model-based Association method for single-cell RNA-seq data

• Downloaded 712 times
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  • Site-wide: 42,883
  • In genomics: 3,420
• Year to date:
  • Site-wide: 48,142
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  • Site-wide: 56,722

BAMM-SC: A Bayesian mixture model for clustering droplet-based single cell transcriptomic data from population studies

• Downloaded 690 times
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  • Site-wide: 44,662
  • In bioinformatics: 4,684
• Year to date:
  • Site-wide: 107,650
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  • Site-wide: 128,073

Integrative analyses of multi-tissue Hi-C and eQTL data demonstrate close spatial proximity between eQTLs and their target genes

• Downloaded 589 times
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  • Site-wide: 54,926
  • In systems biology: 1,200
• Year to date:
  • Site-wide: 117,812
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  • Site-wide: 100,538

FIREcaller: Detecting Frequently Interacting Regions from Hi-C Data

• Downloaded 568 times
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  • Site-wide: 57,462
  • In bioinformatics: 5,702
• Year to date:
  • Site-wide: 104,731
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  • Site-wide: 127,568

Label-free characterization of visual cortical areas in awake mice via three-photon microscopy reveals correlations between functional maps and structural substrates

• Downloaded 555 times
• Download rankings, all-time:
  • Site-wide: 59,069
  • In neuroscience: 8,452
• Year to date:
  • Site-wide: 105,274
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  • Site-wide: 123,245

Choice can be predicted from populations of bursting neurons in superficial layers of monkey V1

• Downloaded 542 times
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  • Site-wide: 60,666
  • In neuroscience: 8,724
• Year to date:
  • Site-wide: 36,858
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  • Site-wide: 11,531

Transcriptional Network Orchestrating Regional Patterning of Cortical Progenitors

• Downloaded 518 times
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  • Site-wide: 63,981
  • In neuroscience: 9,265
• Year to date:
  • Site-wide: 42,127
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  • Site-wide: 34,251

THUNDER: A reference-free deconvolution method to infer cell type proportions from bulk Hi-C data

• Downloaded 393 times
• Download rankings, all-time:
  • Site-wide: 85,587
  • In bioinformatics: 7,668
• Year to date:
  • Site-wide: 40,724
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  • Site-wide: 8,110

Reading-out task variables as a low-dimensional reconstruction of neural spike trains in single trials

• Downloaded 347 times
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  • Site-wide: 95,395
  • In neuroscience: 14,152
• Year to date:
  • Site-wide: 154,899
• Since beginning of last month:
  • Site-wide: 157,206

TWO-SIGMA-G: A New Competitive Gene Set Testing Framework for scRNA-seq Data Accounting for Inter-Gene and Cell-Cell Correlation

• Downloaded 316 times
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  • Site-wide: 102,697
  • In genomics: 6,171
• Year to date:
  • Site-wide: 24,163
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  • Site-wide: 17,526

HiC-ACT: Improved Detection of Chromatin Interactions from Hi-C Data via Aggregated Cauchy Test

• Downloaded 283 times
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  • Site-wide: 110,879
  • In bioinformatics: 9,252
• Year to date:
  • Site-wide: 68,954
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  • Site-wide: 88,422

MUNIn (Multiple sample UNifying long-range chromatin Interaction detector): a statistical framework for identifying long-range chromatin interactions from multiple samples

• Downloaded 224 times
• Download rankings, all-time:
  • Site-wide: 126,201
  • In genetics: 5,141
• Year to date:
  • Site-wide: 78,813
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  • Site-wide: 64,282

Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types

• Downloaded 216 times
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  • Site-wide: 128,293
  • In genetics: 5,197
• Year to date:
  • Site-wide: 39,783
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  • Site-wide: 56,083

HPRep: Quantifying reproducibility in HiChIP and PLAC-seq datasets

• Downloaded 208 times
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  • Site-wide: 130,374
  • In genomics: 7,039
• Year to date:
  • Site-wide: 62,975
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  • Site-wide: 33,690

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis

• Downloaded 196 times
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  • Site-wide: 133,353
  • In genetics: 5,375
• Year to date:
  • Site-wide: 131,865
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  • Site-wide: 131,964

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a new regulator of insulin secretion

• Downloaded 176 times
• Download rankings, all-time:
  • Site-wide: 138,202
  • In cell biology: 6,392
• Year to date:
  • Site-wide: 115,543
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  • Site-wide: 102,484