Author: Li Li

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Preprints

Characterizing metabolism from bulk and single-cell RNA-seq data using METAFlux

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Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis

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  • Site-wide: 400
  • In respiratory medicine: 4
• Year to date:
  • Site-wide: 5,155
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  • Site-wide: 3,884

The feasibility of convalescent plasma therapy in severe COVID-19 patients: a pilot study

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  • Site-wide: 670
  • In infectious diseases: 240
• Year to date:
  • Site-wide: 8,326
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  • Site-wide: 12,018

Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experience

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  • Site-wide: 818
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  • Site-wide: 11,274

Cremation based estimates suggest significant under- and delayed reporting of COVID-19 epidemic data in Wuhan and China

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  • Site-wide: 1,216
  • In infectious diseases: 383
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  • Site-wide: 42,855

Multiplexed confocal and super-resolution fluorescence imaging of cytoskeletal and neuronal synapse proteins

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  • Site-wide: 3,248
  • In bioengineering: 27
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Acute Kidney Injury in Hospitalized Patients with COVID-19

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  • Site-wide: 3,676
  • In nephrology: 3
• Year to date:
  • Site-wide: 18,254
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  • Site-wide: 42,885

Estimate of disease heritability using 7.4 million familial relationships inferred from electronic health records

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  • Site-wide: 5,161
  • In genetics: 167
• Year to date:
  • Site-wide: 74,911
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  • Site-wide: 112,326

Clinical and radiographic features of cardiac injury in patients with 2019 novel coronavirus pneumonia

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  • Site-wide: 5,418
  • In cardiovascular medicine: 9
• Year to date:
  • Site-wide: 66,065
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  • Site-wide: 95,940

Analysis of hospitalized COVID-19 patients in the Mount Sinai Health System using electronic medical records (EMR) reveals important prognostic factors for improved clinical outcomes

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  • Site-wide: 6,021
  • In health informatics: 32
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  • Site-wide: 31,869

Taking Account of Asymptomatic Infections in Modeling the Transmission Potential of the COVID-19 Outbreak on the Diamond Princess Cruise Ship

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  • Site-wide: 9,326
  • In epidemiology: 727
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  • Site-wide: 136,517

A Harmonized Atlas of Spinal Cord Cell Types and Their Computational Classification

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  • Site-wide: 9,532
  • In neuroscience: 888
• Year to date:
  • Site-wide: 49,468
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  • Site-wide: 39,686

Blood glucose levels in elderly subjects with type 2 diabetes during COVID-19 outbreak: a retrospective study in a single center

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  • Site-wide: 10,597
  • In endocrinology: 10
• Year to date:
  • Site-wide: 19,465
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  • Site-wide: 31,812

Visualizing Long-Term Single-Molecule Dynamics in vivo by Stochastic Protein Labeling

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  • Site-wide: 11,157
  • In biophysics: 206
• Year to date:
  • Site-wide: 91,829
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  • Site-wide: 76,304

A Fully Automatic Deep Learning System for COVID-19 Diagnostic and Prognostic Analysis

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  • Site-wide: 12,087
  • In health informatics: 57
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  • Site-wide: 127,359

The Human Motoneuron Expression Signature is Defined by ALS-Related Genes

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  • Site-wide: 12,091
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  • Site-wide: 660
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  • Site-wide: 1,286

Reliable Multiplex Sequencing with Rare Index Mis-Assignment on DNB-Based NGS Platform

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  • Site-wide: 12,992
  • In genomics: 1,164
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  • Site-wide: 122,320
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  • Site-wide: 91,257

CoV Genome Tracker: tracing genomic footprints of Covid-19 pandemic

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  • Site-wide: 13,576
  • In evolutionary biology: 364
• Year to date:
  • Site-wide: 98,595
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  • Site-wide: 127,185

Defining the core essential genome of Pseudomonas aeruginosa

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  • Site-wide: 16,849
  • In microbiology: 913
• Year to date:
  • Site-wide: 105,110
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  • Site-wide: 160,384

CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor

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  • Site-wide: 23,923
  • In immunology: 843
• Year to date:
  • Site-wide: 46,825
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  • Site-wide: 55,154

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells

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  • Site-wide: 23,919
  • In immunology: 858
• Year to date:
  • Site-wide: 39,022
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  • Site-wide: 35,770

Proliferation impairs cell viability via energy depletion

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  • Site-wide: 26,329
  • In cell biology: 1,111
• Year to date:
  • Site-wide: 15,027
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  • Site-wide: 12,809

Origin and evolution of a pandemic lineage of the kiwifruit pathogen Pseudomonas syringae pv. actinidiae

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  • Site-wide: 29,867
  • In epidemiology: 1,644
• Year to date:
  • Site-wide: 174,268
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  • Site-wide: 185,019

Autophagy determines osimertinib resistance through regulation of stem cell-like properties in EGFR-mutant lung cancer

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  • Site-wide: 33,407
  • In cancer biology: 831
• Year to date:
  • Site-wide: 71,736
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  • Site-wide: 38,945

Potential transmission chains of variant B.1.1.7 and co-mutations of SARS-CoV-2

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  • Site-wide: 33,732
  • In microbiology: 1,851
• Year to date:
  • Site-wide: 95,166
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  • Site-wide: 180,871

Systematic Chromatin Architecture Analysis in Xenopus tropicalis Reveals Conserved Three-Dimensional Folding Principles of Vertebrate Genomes

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  • Site-wide: 33,775
  • In genetics: 1,343
• Year to date:
  • Site-wide: 147,876
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  • Site-wide: 150,076

Guiding ATR and PARP inhibitor combinations with chemogenomic screens

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  • Site-wide: 35,186
  • In cancer biology: 1,156
• Year to date:
  • Site-wide: 4,680
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  • Site-wide: 31,430

The ecological genetics of Pseudomonas syringae from kiwifruit leaves

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  • Site-wide: 35,891
  • In microbiology: 2,077
• Year to date:
  • Site-wide: 81,472
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  • Site-wide: 76,087

Relative genomic impacts of translocation history, hatchery practices, and farm selection in Pacific oyster Crassostrea gigas throughout the Northern Hemisphere

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  • Site-wide: 36,439
  • In genetics: 1,586
• Year to date:
  • Site-wide: 43,372
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  • Site-wide: 18,067

CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor

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  • Site-wide: 37,226
  • In genomics: 3,522
• Year to date:
  • Site-wide: 12,100
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  • Site-wide: 19,180

COVID-19 outcomes among hospitalized men with or without exposure to alpha-1-adrenergic receptor blocking agents

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  • Site-wide: 38,260
  • In infectious diseases: 3,257
• Year to date:
  • Site-wide: 27,866
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  • Site-wide: 11,859

Longitudinal single-cell immune profiling revealed distinct innate immune response in asymptomatic COVID-19 patients

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  • Site-wide: 39,474
  • In immunology: 1,316
• Year to date:
  • Site-wide: 64,836
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  • Site-wide: 49,138

Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis

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  • Site-wide: 39,794
  • In cell biology: 1,450
• Year to date:
  • Site-wide: 114,058
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  • Site-wide: 90,978

Lifestyle adaptations of Rhizobium from rhizosphere to symbiosis

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  • Site-wide: 40,199
  • In microbiology: 2,206
• Year to date:
  • Site-wide: 147,909
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  • Site-wide: 165,487

Global Quantitative Mapping of Enhancers in Rice Genome by STARR-seq

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  • Site-wide: 47,805
  • In genomics: 3,442
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  • Site-wide: 166,452
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  • Site-wide: 114,738

A direct comparison of four high risk human papilloma virus tests versus the cobas test for detecting cervical intraepithelial neoplasia and cervical cancer

• Downloaded 696 times
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  • Site-wide: 57,633
  • In epidemiology: 2,768
• Year to date:
  • Site-wide: 74,872
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  • Site-wide: 57,304

Improving Pre-eclampsia Risk Prediction by Modeling Individualized Pregnancy Trajectories Derived from Routinely Collected Electronic Medical Record Data

• Downloaded 694 times
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  • Site-wide: 57,871
  • In obstetrics and gynecology: 72
• Year to date:
  • Site-wide: 14,285
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  • Site-wide: 16,013

Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers

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  • Site-wide: 61,299
  • In systems biology: 1,201
• Year to date:
  • Site-wide: 160,235
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  • Site-wide: 104,193

Regulation of mesenchymal stem cell function by TGFβ-1 on mast cell extracellular vesicles — role of endosomal retention

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  • Site-wide: 61,941
  • In cell biology: 2,510
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  • Site-wide: 163,418
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  • Site-wide: 116,405

MicroRNA775 Promotes Intrinsic Leaf Size and Reduces Cell Wall Pectin Level via a Target Galactosyltransferase in Arabidopsis

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  • Site-wide: 62,130
  • In plant biology: 1,298
• Year to date:
  • Site-wide: 141,916
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  • Site-wide: 135,152

Genetically modified pigs are protected from classical swine fever virus

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  • Site-wide: 64,320
  • In genomics: 4,362
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  • Site-wide: 124,879
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  • Site-wide: 142,369

Learning and Mapping Lyme Disease Patient Trajectories from Electronic Medical Data for Stratification of Disease Risk and Therapeutic Response

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  • Site-wide: 67,041
  • In bioinformatics: 6,078
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  • Site-wide: 129,446

Transcriptomic Profiling of Developing Melanocortin Neurons Reveals a Role for Prdm12 in Energy Balance

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  • Site-wide: 67,955
  • In neuroscience: 9,139
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  • Site-wide: 125,508

Shared heritability and functional enrichment across six solid cancers

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  • Site-wide: 69,864
  • In genomics: 4,568
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  • Site-wide: 174,673

The Mitochondrial Calcium Uniporter of Pulmonary Type 2 Cells Determines Severity of ARDS

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  • Site-wide: 70,194
  • In physiology: 479
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Human Chrysomya bezziana myiasis: A systematic review

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  • Site-wide: 71,846
  • In epidemiology: 3,219
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  • Site-wide: 50,571

Continuous cis-regulatory changes in an advantageous gene are linked with adaptive radiation in cichlid fishes

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  • Site-wide: 74,553
  • In evolutionary biology: 3,833
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  • Site-wide: 28,598

Genome of the estuarine oyster provides insights into climate impact and adaptive plasticity

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  • Site-wide: 75,212
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  • Site-wide: 81,509

Multi-site co-mutations and 5’UTR CpG immunity escape drive the evolution of SARS-CoV-2

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  • Site-wide: 77,278
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The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish

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  • Site-wide: 78,317
  • In developmental biology: 1,831
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  • Site-wide: 184,470

Adequacy of Self-Collected Anterior Nares Swabs for SARS-CoV-2 Testing by Grade School Children

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  • Site-wide: 80,711
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• Year to date:
  • Site-wide: 4,446
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  • Site-wide: 20,938

Amplification-free Library Preparation Improves Quality of Hi-C Analysis

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  • Site-wide: 81,330
  • In genomics: 5,040
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  • Site-wide: 185,206
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  • Site-wide: 183,545

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

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  • Site-wide: 85,843
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• Year to date:
  • Site-wide: 4,789
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  • Site-wide: 589

HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development

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  • Site-wide: 85,713
  • In genetics: 3,334
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  • Site-wide: 144,321

Improving postpartum hemorrhage risk prediction using longitudinal electronic medical records

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  • Site-wide: 88,468
  • In obstetrics and gynecology: 107
• Year to date:
  • Site-wide: 54,101
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  • Site-wide: 13,980

Localized and Whole-Room Effects of Portable Air Filtration Units on Aerosol Particle Deposition and Concentration in a Classroom Environment

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  • Site-wide: 89,413
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Age-dependent characterization of the carotid and cerebral artery morphologies in a transgenic mouse model of sickle cell anemia using ultrasound and microcomputed tomography

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  • Site-wide: 89,520
  • In pathology: 396
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  • Site-wide: 172,960

A comprehensive digital phenotype for postpartum hemorrhage

• Downloaded 474 times
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  • Site-wide: 92,795
  • In obstetrics and gynecology: 110
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  • Site-wide: 61,555
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  • Site-wide: 22,088

Noncanonical WNT activation in human right ventricular heart failure

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  • Site-wide: 93,246
  • In cardiovascular medicine: 195
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  • Site-wide: 132,197
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  • Site-wide: 94,631

Inhibition of HSP90 reversed STAT3 mediated muscle wasting induced by cancer cachexia

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  • Site-wide: 96,764
  • In pathology: 462
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  • Site-wide: 92,334
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  • Site-wide: 81,711

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

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  • Site-wide: 101,458
  • In epidemiology: 4,121
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  • Site-wide: 152,310
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Depression and Anxiety in Healthcare Staffs in A Tertiary University Hospital in Luoyang, Henan Province: A Cross-Sectional Observational Study

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  • Site-wide: 102,535
  • In scientific communication and education: 515
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  • Site-wide: 131,567

Anti-BP180 Autoantibodies Are Present in Stroke and Recognize Human Cutaneous BP180 and BP180-NC16A

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  • Site-wide: 103,890
  • In neuroscience: 14,189
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  • Site-wide: 182,775

Comparative analysis of the Accelerated Aged seed transcriptome profiles of maize CSSLs (I178 and X178)

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  • Site-wide: 103,888
  • In plant biology: 2,623
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  • Site-wide: 111,707
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  • Site-wide: 105,847

Quantitative proteomics reveals the protective effects of ESD against osteoarthritis via attenuating inflammation and modulating immune response

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  • Site-wide: 104,816
  • In pharmacology and toxicology: 858
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  • Site-wide: 30,545

Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex

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  • Site-wide: 105,819
  • In biochemistry: 2,914
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Resolving a Systematic Error in STARR-seq for Quantitative Enhancer Activity Mapping

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Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis

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  • Site-wide: 107,163
  • In genetics: 4,023
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Live cell biosensors based on the fluorescence lifetime of environment-sensing dyes

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  • Site-wide: 6,875
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Genomic signatures of recent adaptation in a wild bumblebee

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  • Site-wide: 113,845
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  • Site-wide: 69,671

Deep learning identifies pathological abnormalities predictive of graft loss in kidney transplant biopsies

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  • Site-wide: 115,715
  • In pathology: 579
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Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosis

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Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia

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  • Site-wide: 118,362
  • In neuroscience: 17,183
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Identification and genetic validation of drug-comorbidity interactions in type 2 diabetes using data-driven disease trajectory analysis

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  • Site-wide: 119,983
  • In bioinformatics: 9,646
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  • Site-wide: 66,336

Identification and quantification of Lyme pathogen strains by deep sequencing of outer surface protein C (ospC) amplicons

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  • Site-wide: 120,892
  • In microbiology: 7,904
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  • Site-wide: 116,551

Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC

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  • Site-wide: 121,224
  • In bioengineering: None
• Year to date:
  • Site-wide: 8,172
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  • Site-wide: 1,019

A Bidirectional Switch in the Shank3 Phosphorylation State Biases Synapses toward Up or Down Scaling

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  • Site-wide: 121,537
  • In neuroscience: 18,349
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  • Site-wide: 124,715

Crystallographic observation of nonenzymatic RNA primer extension

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  • In biochemistry: 3,381
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  • Site-wide: 141,230

Ab initio Spillover Compensation in CyTOF Data

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Quantitative proteomics and phosphoproteomics of urinary extracellular vesicles define diagnostic and prognostic biosignatures for Parkinson's Disease

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  • Site-wide: 122,895
  • In neurology: 737
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  • Site-wide: 27,012

ESD1 Affects Seed Setting Rate in Rice by Controlling Embryo Sac Development

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  • In plant biology: 3,342
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  • Site-wide: 75,447

The Histone Methyltransferase SETD2 Modulates Oxidative Stress to Attenuate Colonic Inflammation and Tumorigenesis in Mice

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  • In cell biology: 5,718
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  • Site-wide: 120,884

Di-Ras2 Promotes Renal Cell Carcinoma Formation by Activating the MAPK Pathway in the Absence of VHL

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  • Site-wide: 125,141
  • In cancer biology: 3,515
• Year to date:
  • Site-wide: 180,448
• Since beginning of last month:
  • Site-wide: 174,017

Genetic architectures of proximal and distal colorectal cancer are partly distinct

• Downloaded 336 times
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  • Site-wide: 127,538
  • In genetic and genomic medicine: 739
• Year to date:
  • Site-wide: 141,708
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  • Site-wide: 118,114

Structural and Functional Analyses of Hub MicroRNAs in an Integrated Gene Regulatory Network of Arabidopsis

• Downloaded 324 times
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  • Site-wide: 130,995
  • In bioinformatics: 10,054
• Year to date:
  • Site-wide: 158,950
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  • Site-wide: 157,651

A high-fat diet changes astrocytic metabolism to enhance synaptic plasticity and promote exploratory behavior

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  • Site-wide: 131,269
  • In neuroscience: 21,004
• Year to date:
  • Site-wide: 39,485
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  • Site-wide: 46,844

Orchestration of Chlorophyll and Carotenoid Biosynthesis by ORANGE Family Proteins in Plant

• Downloaded 318 times
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  • Site-wide: 132,789
  • In plant biology: 4,637
• Year to date:
  • Site-wide: 9,794
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  • Site-wide: 21,081

Antigenicity and Potential Use of A Novel Brucella Multiepitope Recombinant Protein in the Diagnosis of Brucellosis

• Downloaded 311 times
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  • Site-wide: 134,810
  • In zoology: 504
• Year to date:
  • Site-wide: 137,637
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  • Site-wide: 101,291

Annealing synchronizes the 70S ribosome into a minimum-energy conformation

• Downloaded 308 times
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  • Site-wide: 135,828
  • In biophysics: 4,906
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  • Site-wide: 77,314
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  • Site-wide: 122,833

AMP-Kinase mediates regulation of glomerular volume and podocyte survival

• Downloaded 305 times
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  • Site-wide: 136,730
  • In systems biology: 2,784
• Year to date:
  • Site-wide: 105,842
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  • Site-wide: 110,247

5-HAYED peptide can protect AD brain by scavenging the redundant iron ions and the catalyzed radicals

• Downloaded 297 times
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  • Site-wide: 139,149
  • In neuroscience: 19,688
• Year to date:
  • Site-wide: 159,459
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  • Site-wide: 161,519

Optimal fertigation for high yield and fruit quality of greenhouse strawberry

• Downloaded 296 times
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  • Site-wide: 139,250
  • In plant biology: 3,697
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  • Site-wide: 124,490
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  • Site-wide: 101,360

SETD2 deficiency impairs β-catenin destruction complex to facilitate renal cell carcinoma formation

• Downloaded 287 times
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  • Site-wide: 141,952
  • In cancer biology: 4,061
• Year to date:
  • Site-wide: 137,746
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  • Site-wide: 158,160

Association of in-hospital use of ACE-I/ARB and COVID-19 outcomes in African American population

• Downloaded 269 times
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  • Site-wide: 147,444
  • In infectious diseases: 6,500
• Year to date:
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  • Site-wide: 27,489

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

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  • Site-wide: 147,598
  • In cancer biology: 4,237
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  • Site-wide: 107,472

Extensive Chromatin Structure-Function Association Revealed by Accurate Compartmentalization Characterization

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  • Site-wide: 148,605
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  • Site-wide: 137,682

A novel nonsense mutation c.424G>T (p. G142X) in the first exon of XLas leading to osteopetrosis

• Downloaded 249 times
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  • Site-wide: 153,451
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  • Site-wide: 140,452

Primary pterygium was not associated with corneal endothelial cell decrease in a rural Chinese population

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  • Site-wide: 154,686
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• Year to date:
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Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance

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  • Site-wide: 157,196
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  • Site-wide: 102,468

Structural insight into molecular inhibitory mechanism of InsP6 on African Swine Fever Virus mRNA-decapping enzyme g5Rp

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  • Site-wide: 158,277
  • In biochemistry: 4,949
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  • Site-wide: 99,230

Transcriptome profiling reveals the mechanism of ripening and epidermal senescence in passionfruit (Passiflora edulia Sims)

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  • Site-wide: 158,549
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  • Site-wide: 178,626

Epac1 regulates cellular SUMOylation by promoting the formation of SUMO-activating nuclear condensates

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  • Site-wide: 159,630
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Structural variation, functional differentiation and expression characteristics of the AP2/ERF gene family and its response to cold stress and methyl jasmonate in Panax ginseng C.A. Meyer

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  • Site-wide: 161,892
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  • Site-wide: 149,537

Actin fence therapy with exogenous V12Rac1 protects against Acute Lung Injury

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  • Site-wide: 166,963
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  • Site-wide: 154,350

Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver Russell Syndrome-like mouse models

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  • Site-wide: 176,387
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• Year to date:
  • Site-wide: 26,771
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Hsa-miR-31-5p controls a metabolic switch in psoriatic keratinocytes that identifies therapeutic intervention

• Downloaded 143 times
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  • Site-wide: 179,197
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  • Site-wide: 58,451

The impact of Illinois' comprehensive handheld phone ban on talking on handheld and handsfree cellphones while driving

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  • Site-wide: 179,883
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• Year to date:
  • Site-wide: 31,502
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  • Site-wide: 41,279

Ex vivo and in vivo evidence that cigarette smoke-exposed T regulatory cells impair host immunity against Mycobacterium tuberculosis

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Talking on handsfree and handheld cellphones while driving in association with handheld phone bans.

• Downloaded 108 times
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  • Site-wide: 184,589
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• Year to date:
  • Site-wide: 42,213
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  • Site-wide: 58,320

Salicylic acid and risk of colorectal cancer: a two sample Mendelian randomization study

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  • Site-wide: 184,707
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  • Site-wide: 122,622
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  • Site-wide: 110,018

Development of recombinant monoclonal antibodies targeting conserved VlsE epitopes in Lyme disease pathogens

• Downloaded 39 times
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  • Site-wide: 190,338
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  • Site-wide: 105,425
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  • Site-wide: 33,727