Author: Li Li

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Preprints

COVID-19 outcomes among hospitalized men with or without exposure to alpha-1-adrenergic receptor blocking agents

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Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis

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  • Site-wide: 270
  • In respiratory medicine: 3
• Year to date:
  • Site-wide: 4,454
• Since beginning of last month:
  • Site-wide: 3,439

The feasibility of convalescent plasma therapy in severe COVID-19 patients: a pilot study

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  • Site-wide: 430
  • In infectious diseases: 152
• Year to date:
  • Site-wide: 2,415
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  • Site-wide: 4,646

Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experience

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  • Site-wide: 587
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• Year to date:
  • Site-wide: 1,838
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  • Site-wide: 1,815

Cremation based estimates suggest significant under- and delayed reporting of COVID-19 epidemic data in Wuhan and China

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  • Site-wide: 862
  • In infectious diseases: 261
• Year to date:
  • Site-wide: 2,052
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  • Site-wide: 1,049

Multiplexed confocal and super-resolution fluorescence imaging of cytoskeletal and neuronal synapse proteins

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  • Site-wide: 2,180
  • In bioengineering: 17
• Year to date:
  • Site-wide: 33,843
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  • Site-wide: 37,914

Acute Kidney Injury in Hospitalized Patients with COVID-19

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  • Site-wide: 2,988
  • In nephrology: 3
• Year to date:
  • Site-wide: 9,226
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  • Site-wide: 12,279

Estimate of disease heritability using 7.4 million familial relationships inferred from electronic health records

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  • Site-wide: 3,611
  • In genetics: 145
• Year to date:
  • Site-wide: 56,040
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  • Site-wide: 45,975

Clinical and radiographic features of cardiac injury in patients with 2019 novel coronavirus pneumonia

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  • Site-wide: 3,913
  • In cardiovascular medicine: 7
• Year to date:
  • Site-wide: 24,117
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  • Site-wide: 27,954

Analysis of hospitalized COVID-19 patients in the Mount Sinai Health System using electronic medical records (EMR) reveals important prognostic factors for improved clinical outcomes

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  • Site-wide: 4,542
  • In health informatics: 27
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  • Site-wide: 24,373
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  • Site-wide: 26,525

Taking Account of Asymptomatic Infections in Modeling the Transmission Potential of the COVID-19 Outbreak on the Diamond Princess Cruise Ship

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  • Site-wide: 6,559
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  • Site-wide: 38,712

Visualizing Long-Term Single-Molecule Dynamics in vivo by Stochastic Protein Labeling

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  • Site-wide: 7,623
  • In biophysics: 151
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  • Site-wide: 66,600
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  • Site-wide: 90,266

A Fully Automatic Deep Learning System for COVID-19 Diagnostic and Prognostic Analysis

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  • Site-wide: 9,206
  • In health informatics: 50
• Year to date:
  • Site-wide: 24,179
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  • Site-wide: 16,706

Reliable Multiplex Sequencing with Rare Index Mis-Assignment on DNB-Based NGS Platform

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  • Site-wide: 9,303
  • In genomics: 1,022
• Year to date:
  • Site-wide: 49,035
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  • Site-wide: 53,761

CoV Genome Tracker: tracing genomic footprints of Covid-19 pandemic

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  • Site-wide: 10,846
  • In evolutionary biology: 355
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  • Site-wide: 20,134
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  • Site-wide: 22,410

Blood glucose levels in elderly subjects with type 2 diabetes during COVID-19 outbreak: a retrospective study in a single center

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  • Site-wide: 11,002
  • In endocrinology: 7
• Year to date:
  • Site-wide: 15,925
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  • Site-wide: 12,909

Defining the core essential genome of Pseudomonas aeruginosa

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  • Site-wide: 11,450
  • In microbiology: 650
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  • Site-wide: 43,420

A Harmonized Atlas of Spinal Cord Cell Types and Their Computational Classification

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  • Site-wide: 13,024
  • In neuroscience: 1,513
• Year to date:
  • Site-wide: 2,845
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  • Site-wide: 7,260

Origin and evolution of a pandemic lineage of the kiwifruit pathogen Pseudomonas syringae pv. actinidiae

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  • Site-wide: 21,045
  • In epidemiology: 1,223
• Year to date:
  • Site-wide: 79,076
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  • Site-wide: 97,029

CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor

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  • Site-wide: 24,282
  • In immunology: 715
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  • Site-wide: 17,304
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  • Site-wide: 23,369

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells

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  • Site-wide: 27,305
  • In immunology: 787
• Year to date:
  • Site-wide: 14,156
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  • Site-wide: 14,608

Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis

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  • Site-wide: 28,521
  • In cell biology: 1,070
• Year to date:
  • Site-wide: 86,820
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  • Site-wide: 85,534

Autophagy determines osimertinib resistance through regulation of stem cell-like properties in EGFR-mutant lung cancer

• Downloaded 797 times
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  • Site-wide: 28,847
  • In cancer biology: 743
• Year to date:
  • Site-wide: 52,952
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  • Site-wide: 49,524

Systematic Chromatin Architecture Analysis in Xenopus tropicalis Reveals Conserved Three-Dimensional Folding Principles of Vertebrate Genomes

• Downloaded 785 times
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  • Site-wide: 29,398
  • In genetics: 1,427
• Year to date:
  • Site-wide: 20,654
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  • Site-wide: 22,674

The ecological genetics of Pseudomonas syringae from kiwifruit leaves

• Downloaded 761 times
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  • Site-wide: 30,752
  • In microbiology: 1,825
• Year to date:
  • Site-wide: 87,911
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  • Site-wide: 69,353

Lifestyle adaptations of Rhizobium from rhizosphere to symbiosis

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  • Site-wide: 31,291
  • In microbiology: 1,857
• Year to date:
  • Site-wide: 18,250
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  • Site-wide: 35,831

Global Quantitative Mapping of Enhancers in Rice Genome by STARR-seq

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  • Site-wide: 34,200
  • In genomics: 2,996
• Year to date:
  • Site-wide: 99,335
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  • Site-wide: 116,184

Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers

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  • Site-wide: 41,866
  • In systems biology: 958
• Year to date:
  • Site-wide: 86,656
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  • Site-wide: 73,368

Regulation of mesenchymal stem cell function by TGFβ-1 on mast cell extracellular vesicles — role of endosomal retention

• Downloaded 582 times
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  • Site-wide: 43,761
  • In cell biology: 1,836
• Year to date:
  • Site-wide: 84,170
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  • Site-wide: 78,761

Longitudinal single-cell immune profiling revealed distinct innate immune response in asymptomatic COVID-19 patients

• Downloaded 579 times
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  • Site-wide: 44,078
  • In immunology: 1,233
• Year to date:
  • Site-wide: 31,824
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  • Site-wide: 35,955

Genetically modified pigs are protected from classical swine fever virus

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  • Site-wide: 45,743
  • In genomics: 3,670
• Year to date:
  • Site-wide: 107,300
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  • Site-wide: 88,624

A direct comparison of four high risk human papilloma virus tests versus the cobas test for detecting cervical intraepithelial neoplasia and cervical cancer

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  • Site-wide: 48,843
  • In epidemiology: 2,206
• Year to date:
  • Site-wide: 64,579
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  • Site-wide: 49,844

Shared heritability and functional enrichment across six solid cancers

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  • Site-wide: 49,035
  • In genomics: 3,871
• Year to date:
  • Site-wide: 117,853
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  • Site-wide: 117,791

Transcriptomic Profiling of Developing Melanocortin Neurons Reveals a Role for Prdm12 in Energy Balance

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  • Site-wide: 53,202
  • In neuroscience: 7,874
• Year to date:
  • Site-wide: 72,585
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  • Site-wide: 93,774

Learning and Mapping Lyme Disease Patient Trajectories from Electronic Medical Data for Stratification of Disease Risk and Therapeutic Response

• Downloaded 491 times
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  • Site-wide: 53,673
  • In bioinformatics: 5,472
• Year to date:
  • Site-wide: 66,573
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  • Site-wide: 49,393

MicroRNA775 Promotes Intrinsic Leaf Size and Reduces Cell Wall Pectin Level via a Target Galactosyltransferase in Arabidopsis

• Downloaded 484 times
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  • Site-wide: 54,507
  • In plant biology: 1,330
• Year to date:
  • Site-wide: 9,482
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  • Site-wide: 44,300

The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish

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  • Site-wide: 54,698
  • In developmental biology: 1,344
• Year to date:
  • Site-wide: 101,675
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  • Site-wide: 109,396

Amplification-free Library Preparation Improves Quality of Hi-C Analysis

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  • Site-wide: 57,254
  • In genomics: 4,289
• Year to date:
  • Site-wide: 125,452
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  • Site-wide: 109,586

Relative genomic impacts of translocation history, hatchery practices, and farm selection in Pacific oyster Crassostrea gigas throughout the Northern Hemisphere

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  • Site-wide: 57,420
  • In genetics: 2,672
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  • Site-wide: 89,894
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  • Site-wide: 81,786

Human Chrysomya bezziana myiasis: A systematic review

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  • Site-wide: 59,314
  • In epidemiology: 2,559
• Year to date:
  • Site-wide: 80,546
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  • Site-wide: 59,772

Multi-site co-mutations and 5’UTR CpG immunity escape drive the evolution of SARS-CoV-2

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  • Site-wide: 60,686
  • In evolutionary biology: 3,323
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  • Site-wide: 67,677

Proliferation impairs cell viability via energy depletion

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  • Site-wide: 62,474
  • In cell biology: 2,789
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  • Site-wide: 22,709
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  • Site-wide: 17,834

Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis

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  • Site-wide: 70,175
  • In genetics: 3,215
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  • Site-wide: 114,490
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  • Site-wide: 106,458

HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development

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  • Site-wide: 70,387
  • In genetics: 3,224
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Anti-BP180 Autoantibodies Are Present in Stroke and Recognize Human Cutaneous BP180 and BP180-NC16A

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  • Site-wide: 70,925
  • In neuroscience: 10,790
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  • Site-wide: 113,793

Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex

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  • Site-wide: 74,143
  • In biochemistry: 2,049
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  • Site-wide: 78,969

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

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  • Site-wide: 75,525
  • In epidemiology: 3,157
• Year to date:
  • Site-wide: 78,831
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  • Site-wide: 67,483

Age-dependent characterization of the carotid and cerebral artery morphologies in a transgenic mouse model of sickle cell anemia using ultrasound and microcomputed tomography

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  • Site-wide: 77,303
  • In pathology: 388
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  • Site-wide: 73,461
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Comparative analysis of the Accelerated Aged seed transcriptome profiles of maize CSSLs (I178 and X178)

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  • Site-wide: 80,455
  • In plant biology: 2,154
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  • Site-wide: 110,522

Depression and Anxiety in Healthcare Staffs in A Tertiary University Hospital in Luoyang, Henan Province: A Cross-Sectional Observational Study

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  • Site-wide: 80,989
  • In scientific communication and education: 466
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  • Site-wide: 125,150

Continuous cis-regulatory changes in an advantageous gene are linked with adaptive radiation in cichlid fishes

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  • Site-wide: 85,441
  • In evolutionary biology: 4,626
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  • Site-wide: 26,030

Crystallographic observation of nonenzymatic RNA primer extension

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  • Site-wide: 87,935
  • In biochemistry: 2,547
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  • Site-wide: 113,476
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  • Site-wide: 96,642

Di-Ras2 Promotes Renal Cell Carcinoma Formation by Activating the MAPK Pathway in the Absence of VHL

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  • Site-wide: 90,782
  • In cancer biology: 2,736
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  • Site-wide: 74,106
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  • Site-wide: 90,254

Identification and quantification of Lyme pathogen strains by deep sequencing of outer surface protein C (ospC) amplicons

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  • Site-wide: 91,528
  • In microbiology: 6,561
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  • Site-wide: 128,545
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  • Site-wide: 121,244

Identification and genetic validation of drug-comorbidity interactions in type 2 diabetes using data-driven disease trajectory analysis

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  • Site-wide: 96,620
  • In bioinformatics: 8,394
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  • Site-wide: 60,602

Ab initio Spillover Compensation in CyTOF Data

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  • Site-wide: 97,133
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Genetic architectures of proximal and distal colorectal cancer are partly distinct

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  • Site-wide: 97,313
  • In genetic and genomic medicine: 381
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  • Site-wide: 56,930

Noncanonical WNT activation in human right ventricular heart failure

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  • Site-wide: 100,238
  • In cardiovascular medicine: 194
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5-HAYED peptide can protect AD brain by scavenging the redundant iron ions and the catalyzed radicals

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  • Site-wide: 101,681
  • In neuroscience: 15,781
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  • Site-wide: 113,990
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  • Site-wide: 116,599

Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosis

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  • Site-wide: 102,632
  • In cell biology: 4,762
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Structural and Functional Analyses of Hub MicroRNAs in an Integrated Gene Regulatory Network of Arabidopsis

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  • Site-wide: 103,124
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Antigenicity and Potential Use of A Novel Brucella Multiepitope Recombinant Protein in the Diagnosis of Brucellosis

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  • Site-wide: 103,272
  • In zoology: 447
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Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia

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  • Site-wide: 103,255
  • In neuroscience: 16,021
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  • Site-wide: 118,625

Optimal fertigation for high yield and fruit quality of greenhouse strawberry

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  • Site-wide: 105,321
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The Mitochondrial Calcium Uniporter of Pulmonary Type 2 Cells Determines Severity of ARDS

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Resolving a Systematic Error in STARR-seq for Quantitative Enhancer Activity Mapping

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A comprehensive digital phenotype for postpartum hemorrhage

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  • Site-wide: 112,568
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  • Site-wide: 3,224

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

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  • In cancer biology: 3,466
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The Histone Methyltransferase SETD2 Modulates Oxidative Stress to Attenuate Colonic Inflammation and Tumorigenesis in Mice

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A novel nonsense mutation c.424G>T (p. G142X) in the first exon of XLas leading to osteopetrosis

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Primary pterygium was not associated with corneal endothelial cell decrease in a rural Chinese population

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  • In epidemiology: 4,769
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Inhibition of HSP90 reversed STAT3 mediated muscle wasting induced by cancer cachexia

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Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance

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Structural variation, functional differentiation and expression characteristics of the AP2/ERF gene family and its response to cold stress and methyl jasmonate in Panax ginseng C.A. Meyer

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  • Site-wide: 120,122
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SETD2 deficiency impairs β-catenin destruction complex to facilitate renal cell carcinoma formation

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  • Site-wide: 121,850
  • In cancer biology: 3,783
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  • Site-wide: 106,202

Transcriptome profiling reveals the mechanism of ripening and epidermal senescence in passionfruit (Passiflora edulia Sims)

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  • Site-wide: 123,285
  • In plant biology: 3,472
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ESD1 Affects Seed Setting Rate in Rice by Controlling Embryo Sac Development

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  • In plant biology: 3,603
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Quantitative proteomics reveals the protective effects of ESD against osteoarthritis via attenuating inflammation and modulating immune response

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  • Site-wide: 129,145
  • In pharmacology and toxicology: 1,140
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Improving postpartum hemorrhage risk prediction using longitudinal electronic medical records

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  • Site-wide: 129,712
  • In obstetrics and gynecology: 124
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  • Site-wide: 30,922
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  • Site-wide: 9,252

Actin fence therapy with exogenous V12Rac1 protects against Acute Lung Injury

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  • Site-wide: 131,260
  • In physiology: 1,644
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Improving Pre-eclampsia Risk Prediction by Modeling Individualized Pregnancy Trajectories Derived from Routinely Collected Electronic Medical Record Data

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  • In obstetrics and gynecology: 128
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