Author: Jun Chen

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Preprints

Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications

• Downloaded 134,243 times
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  • Site-wide: 30
  • In infectious diseases: 12
• Year to date:
  • Site-wide: 136
• Since beginning of last month:
  • Site-wide: 257

Clinical characteristics of the recovered COVID-19 patients with re-detectable positive RNA test

• Downloaded 20,614 times
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  • Site-wide: 374
  • In infectious diseases: 141
• Year to date:
  • Site-wide: 3,016
• Since beginning of last month:
  • Site-wide: 21,242

Deep learning-based model for detecting 2019 novel coronavirus pneumonia on high-resolution computed tomography: a prospective study in 27 patients

• Downloaded 19,546 times
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  • Site-wide: 398
  • In infectious diseases: 145
• Year to date:
  • Site-wide: 3,342
• Since beginning of last month:
  • Site-wide: 107,593

COVID-19 in a Designated Infectious Diseases HospitalOutside Hubei Province,China

• Downloaded 2,932 times
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  • Site-wide: 4,982
  • In public and global health: 149
• Year to date:
  • Site-wide: 31,710
• Since beginning of last month:
  • Site-wide: 107,803

Recurrence of SARS-CoV-2 PCR positivity in COVID-19 patients: a single center experience and potential implications

• Downloaded 2,160 times
• Download rankings, all-time:
  • Site-wide: 7,812
  • In infectious diseases: 1,179
• Year to date:
  • Site-wide: 20,876
• Since beginning of last month:
  • Site-wide: 56,721

No SARS-CoV-2 in expressed prostatic secretion of patients with coronavirus disease 2019: a descriptive multicentre study in China

• Downloaded 2,045 times
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  • Site-wide: 8,431
  • In urology: 3
• Year to date:
  • Site-wide: 5,458
• Since beginning of last month:
  • Site-wide: 29,535

Efficacy and tolerability of bevacizumab in patients with severe Covid -19

• Downloaded 2,006 times
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  • Site-wide: 8,701
  • In infectious diseases: 1,258
• Year to date:
  • Site-wide: 4,195
• Since beginning of last month:
  • Site-wide: 574

GMPR: A novel normalization method for microbiome sequencing data

• Downloaded 1,343 times
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  • Site-wide: 15,778
  • In bioinformatics: 1,851
• Year to date:
  • Site-wide: 95,475
• Since beginning of last month:
  • Site-wide: None

Small effect size leads to reproducibility failure in resting-state fMRI studies

• Downloaded 1,040 times
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  • Site-wide: 23,063
  • In neuroscience: 2,873
• Year to date:
  • Site-wide: 62,271
• Since beginning of last month:
  • Site-wide: 38,858

Human to yeast pathway transplantation: cross-species dissection of the adenine de novo pathway regulatory node

• Downloaded 912 times
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  • Site-wide: 27,810
  • In synthetic biology: 357
• Year to date:
  • Site-wide: 70,528
• Since beginning of last month:
  • Site-wide: None

Allosteric Inhibition of CRISPR-Cas9 by Bacteriophage-derived Peptides

• Downloaded 765 times
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  • Site-wide: 35,644
  • In genomics: 3,010
• Year to date:
  • Site-wide: 111,811
• Since beginning of last month:
  • Site-wide: 57,444

DeepViral: infectious disease phenotypes improve prediction of novel virus–host interactions

• Downloaded 729 times
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  • Site-wide: 38,070
  • In bioinformatics: 4,147
• Year to date:
  • Site-wide: 27,674
• Since beginning of last month:
  • Site-wide: 67,602

Large-scale Analysis of 2,152 dataset reveals key features of B cell biology and the antibody repertoire

• Downloaded 678 times
• Download rankings, all-time:
  • Site-wide: 41,918
  • In immunology: 1,287
• Year to date:
  • Site-wide: 75,696
• Since beginning of last month:
  • Site-wide: 90,935

Distinct Microbes, Metabolites, and Ecologies Define the Microbiome in Deficient and Proficient Mismatch Repair Colorectal Cancers

• Downloaded 640 times
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  • Site-wide: 45,210
  • In cancer biology: 1,246
• Year to date:
  • Site-wide: 104,181
• Since beginning of last month:
  • Site-wide: None

Genomic data provides new insights on the demographic history and the extent of recent material transfers in Norway spruce

• Downloaded 634 times
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  • Site-wide: 45,734
  • In evolutionary biology: 2,241
• Year to date:
  • Site-wide: 111,166
• Since beginning of last month:
  • Site-wide: None

Hyaluronic acid particle hydrogels decrease cerebral atrophy and promote pro-reparative astrocyte/axonal infiltration after ischemic stroke

• Downloaded 615 times
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  • Site-wide: 47,526
  • In bioengineering: 876
• Year to date:
  • Site-wide: 34,204
• Since beginning of last month:
  • Site-wide: 60,482

From drift to draft: How much do beneficial mutations actually contribute to predictions of Ohta’s slightly deleterious model of molecular evolution?

• Downloaded 578 times
• Download rankings, all-time:
  • Site-wide: 51,431
  • In evolutionary biology: 2,599
• Year to date:
  • Site-wide: 133,096
• Since beginning of last month:
  • Site-wide: None

Selective germline genome edited pigs and their long immune tolerance in Non Human Primates

• Downloaded 575 times
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  • Site-wide: 51,807
  • In synthetic biology: 634
• Year to date:
  • Site-wide: 69,014
• Since beginning of last month:
  • Site-wide: 23,408

Parental legacy, demography, and introgression influenced the evolution of the two subgenomes of the tetraploid Capsella bursa-pastoris (Brassicaceae)

• Downloaded 535 times
• Download rankings, all-time:
  • Site-wide: 56,515
  • In evolutionary biology: 2,917
• Year to date:
  • Site-wide: 79,132
• Since beginning of last month:
  • Site-wide: None

Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer

• Downloaded 534 times
• Download rankings, all-time:
  • Site-wide: 56,552
  • In cancer biology: 1,582
• Year to date:
  • Site-wide: 29,379
• Since beginning of last month:
  • Site-wide: 16,058

Empathic contagious pain and consolation in laboratory rodents: species and sex comparisons

• Downloaded 528 times
• Download rankings, all-time:
  • Site-wide: 57,427
  • In animal behavior and cognition: 566
• Year to date:
  • Site-wide: 65,634
• Since beginning of last month:
  • Site-wide: 88,748

Gut microbiome meta-analysis reveals dysbiosis is independent of body mass index in predicting risk of obesity-associated CRC

• Downloaded 427 times
• Download rankings, all-time:
  • Site-wide: 72,210
  • In cancer biology: 2,085
• Year to date:
  • Site-wide: 140,460
• Since beginning of last month:
  • Site-wide: None

Let-7i-5p regulation of cell morphology and migration through distinct signaling pathways in normal and pathogenic fibroblasts from urethra

• Downloaded 425 times
• Download rankings, all-time:
  • Site-wide: 72,515
  • In molecular biology: 2,093
• Year to date:
  • Site-wide: 87,402
• Since beginning of last month:
  • Site-wide: 58,344

Estradiol modulates gut microbiota in female ob/ob mice fed a high fat diet

• Downloaded 420 times
• Download rankings, all-time:
  • Site-wide: 73,497
  • In microbiology: 4,987
• Year to date:
  • Site-wide: 90,060
• Since beginning of last month:
  • Site-wide: 13,124

Asymmetrical cleavages of Sleeping Beauty transposons generate multiple excised transposon fragments during transposition

• Downloaded 416 times
• Download rankings, all-time:
  • Site-wide: 74,113
  • In molecular biology: 2,149
• Year to date:
  • Site-wide: 84,309
• Since beginning of last month:
  • Site-wide: 86,010

Predicting candidate genes from phenotypes, functions, and anatomical site of expression

• Downloaded 394 times
• Download rankings, all-time:
  • Site-wide: 78,167
  • In bioinformatics: 7,257
• Year to date:
  • Site-wide: 85,830
• Since beginning of last month:
  • Site-wide: 18,354

Zebrafish hhex null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1

• Downloaded 351 times
• Download rankings, all-time:
  • Site-wide: 86,511
  • In developmental biology: 2,260
• Year to date:
  • Site-wide: 79,207
• Since beginning of last month:
  • Site-wide: 68,143

Comparative Genome Analysis of Scutellaria baicalensis and Scutellaria barbata Reveals the Evolution of Active Flavonoid Biosynthesis

• Downloaded 318 times
• Download rankings, all-time:
  • Site-wide: 93,455
  • In genomics: 5,823
• Year to date:
  • Site-wide: 108,839
• Since beginning of last month:
  • Site-wide: 23,393

Assessing the potential for assisted gene flow using past introduction of Norway spruce in Southern Sweden: Local adaptation and genetic basis of quantitative traits in trees.

• Downloaded 261 times
• Download rankings, all-time:
  • Site-wide: 106,863
  • In evolutionary biology: 5,429
• Year to date:
  • Site-wide: 151,896
• Since beginning of last month:
  • Site-wide: None

Precision Genome and Base Editing by Regulating mRNA Nuclear Export Using Selective Inhibitors of Nuclear Export

• Downloaded 227 times
• Download rankings, all-time:
  • Site-wide: 115,379
  • In biochemistry: 3,395
• Year to date:
  • Site-wide: 25,777
• Since beginning of last month:
  • Site-wide: 51,467

CTCF-binding element regulates ESC differentiation via orchestrating long-range chromatin interaction between enhancers and HoxA

• Downloaded 217 times
• Download rankings, all-time:
  • Site-wide: 117,864
  • In developmental biology: 3,163
• Year to date:
  • Site-wide: 112,712
• Since beginning of last month:
  • Site-wide: 49,236

Selective Germline Genome Edited Pig Meninges Grafts for the Abdominal Wall Closure in Damage Control Surgery

• Downloaded 195 times
• Download rankings, all-time:
  • Site-wide: 123,152
  • In synthetic biology: 1,093
• Year to date:
  • Site-wide: 116,484
• Since beginning of last month:
  • Site-wide: 65,007

Genome-wide evolutionary response of European oakssince the Little Ice Age

• Downloaded 164 times
• Download rankings, all-time:
  • Site-wide: 130,604
  • In evolutionary biology: 6,478
• Year to date:
  • Site-wide: 38,107
• Since beginning of last month:
  • Site-wide: 53,193

Protein kinase D1 phosphorylates CBX8 to facilitate the disassociation of PRC1 complex from p16 promoter and promotes cell senescence

• Downloaded 145 times
• Download rankings, all-time:
  • Site-wide: 134,811
  • In cell biology: 6,173
• Year to date:
  • Site-wide: 99,467
• Since beginning of last month:
  • Site-wide: 112,952

Reproducible abnormalities of functional gradient reliably predict clinical and cognitive symptoms in schizophrenia

• Downloaded 128 times
• Download rankings, all-time:
  • Site-wide: 138,491
  • In neuroscience: 21,000
• Year to date:
  • Site-wide: 113,033
• Since beginning of last month:
  • Site-wide: 110,610

Long-range gene regulation network of the MGMT enhancer in modulating glioma cell sensitivity to temozolomide

• Downloaded 114 times
• Download rankings, all-time:
  • Site-wide: 141,290
  • In genetics: 5,634
• Year to date:
  • Site-wide: 114,304
• Since beginning of last month:
  • Site-wide: 113,143