Author: Wei Zhou

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Preprints

Prognostic value of C-reactive protein in patients with COVID-19

• Downloaded 6,697 times
• Download rankings, all-time:
  • Site-wide: 2,136
  • In infectious diseases: 576
• Year to date:
  • Site-wide: 28,419
• Since beginning of last month:
  • Site-wide: 37,023

Systematic single-variant and gene-based association testing of thousands of phenotypes in 426,370 UK Biobank exomes

• Downloaded 5,751 times
• Download rankings, all-time:
  • Site-wide: 2,614
  • In genetic and genomic medicine: 15
• Year to date:
  • Site-wide: 967
• Since beginning of last month:
  • Site-wide: 339

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

• Downloaded 5,332 times
• Download rankings, all-time:
  • Site-wide: 2,911
  • In genomics: 236
• Year to date:
  • Site-wide: 63,711
• Since beginning of last month:
  • Site-wide: 50,345

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

• Downloaded 4,927 times
• Download rankings, all-time:
  • Site-wide: 3,222
  • In genetics: 128
• Year to date:
  • Site-wide: 197
• Since beginning of last month:
  • Site-wide: 867

Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

• Downloaded 3,554 times
• Download rankings, all-time:
  • Site-wide: 5,075
  • In genetic and genomic medicine: 24
• Year to date:
  • Site-wide: 7,656
• Since beginning of last month:
  • Site-wide: 10,523

Single-cell RNA-seq and V(D)J profiling of immune cells in COVID-19 patients

• Downloaded 3,495 times
• Download rankings, all-time:
  • Site-wide: 5,214
  • In infectious diseases: 1,072
• Year to date:
  • Site-wide: 6,971
• Since beginning of last month:
  • Site-wide: 11,820

Genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation

• Downloaded 3,473 times
• Download rankings, all-time:
  • Site-wide: 5,259
  • In genetics: 170
• Year to date:
  • Site-wide: 85,395
• Since beginning of last month:
  • Site-wide: 61,669

Characterizing the temporal dynamics of gene expression in single cells with sci-fate

• Downloaded 3,273 times
• Download rankings, all-time:
  • Site-wide: 5,741
  • In genomics: 519
• Year to date:
  • Site-wide: 104,809
• Since beginning of last month:
  • Site-wide: 86,107

Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts

• Downloaded 3,197 times
• Download rankings, all-time:
  • Site-wide: 5,947
  • In genetics: 211
• Year to date:
  • Site-wide: 30,796
• Since beginning of last month:
  • Site-wide: 21,544

Global Biobank Meta-analysis Initiative: powering genetic discovery across human diseases

• Downloaded 2,808 times
• Download rankings, all-time:
  • Site-wide: 7,161
  • In genetic and genomic medicine: 43
• Year to date:
  • Site-wide: 1,823
• Since beginning of last month:
  • Site-wide: 2,595

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.

• Downloaded 2,508 times
• Download rankings, all-time:
  • Site-wide: 8,487
  • In genetic and genomic medicine: 48
• Year to date:
  • Site-wide: 3,156
• Since beginning of last month:
  • Site-wide: 2,641

Comparative genetic architectures of schizophrenia in East Asian and European populations

• Downloaded 2,486 times
• Download rankings, all-time:
  • Site-wide: 8,576
  • In genetics: 330
• Year to date:
  • Site-wide: 71,998
• Since beginning of last month:
  • Site-wide: 76,906

Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases

• Downloaded 2,060 times
• Download rankings, all-time:
  • Site-wide: 11,357
  • In genetic and genomic medicine: 81
• Year to date:
  • Site-wide: 613
• Since beginning of last month:
  • Site-wide: 4,434

Large-scale single-cell analysis reveals critical immune characteristics of COVID-19 patients

• Downloaded 1,974 times
• Download rankings, all-time:
  • Site-wide: 12,089
  • In genomics: 1,125
• Year to date:
  • Site-wide: 43,959
• Since beginning of last month:
  • Site-wide: 28,998

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,840 times
• Download rankings, all-time:
  • Site-wide: 13,391
  • In genetics: 524
• Year to date:
  • Site-wide: 70,381
• Since beginning of last month:
  • Site-wide: 45,225

Set-based rare variant association tests for biobank scale sequencing data sets

• Downloaded 1,518 times
• Download rankings, all-time:
  • Site-wide: 17,929
  • In genetic and genomic medicine: 204
• Year to date:
  • Site-wide: 2,046
• Since beginning of last month:
  • Site-wide: 1,648

An enhanced characterization of the human skin microbiome: a new biodiversity of microbial interactions

• Downloaded 1,397 times
• Download rankings, all-time:
  • Site-wide: 20,369
  • In microbiology: 1,198
• Year to date:
  • Site-wide: 33,735
• Since beginning of last month:
  • Site-wide: 25,029

The Effect of Neutropenia and Filgrastim (G-CSF) in Cancer Patients With COVID-19 Infection

• Downloaded 1,330 times
• Download rankings, all-time:
  • Site-wide: 21,983
  • In infectious diseases: 2,339
• Year to date:
  • Site-wide: 28,165
• Since beginning of last month:
  • Site-wide: 42,589

Cryo-EM structure of the receptor-activated TRPC5 ion channel at 2.9 angstrom resolution

• Downloaded 1,214 times
• Download rankings, all-time:
  • Site-wide: 25,381
  • In biophysics: 622
• Year to date:
  • Site-wide: 129,726
• Since beginning of last month:
  • Site-wide: 114,735

Global biobank analyses provide lessons for computing polygenic risk scores across diverse cohorts

• Downloaded 1,213 times
• Download rankings, all-time:
  • Site-wide: 25,408
  • In genetic and genomic medicine: 176
• Year to date:
  • Site-wide: 3,818
• Since beginning of last month:
  • Site-wide: 4,690

FinnGen: Unique genetic insights from combining isolated population and national health register data

• Downloaded 1,212 times
• Download rankings, all-time:
  • Site-wide: 25,451
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 1,254
• Since beginning of last month:
  • Site-wide: 1,874

ReprDB and panDB: minimalist databases with maximal microbial representation

• Downloaded 1,202 times
• Download rankings, all-time:
  • Site-wide: 25,754
  • In bioinformatics: 2,627
• Year to date:
  • Site-wide: 170,034
• Since beginning of last month:
  • Site-wide: 163,878

Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in Mycobacterium tuberculosis

• Downloaded 1,198 times
• Download rankings, all-time:
  • Site-wide: 25,874
  • In microbiology: 1,829
• Year to date:
  • Site-wide: 14,895
• Since beginning of last month:
  • Site-wide: 12,020

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

• Downloaded 1,166 times
• Download rankings, all-time:
  • Site-wide: 26,951
  • In genomics: 2,592
• Year to date:
  • Site-wide: 9,612
• Since beginning of last month:
  • Site-wide: 36,447

An efficient and accurate frailty model approach for genome-wide survival association analysis controlling for population structure and relatedness in large-scale biobanks

• Downloaded 1,121 times
• Download rankings, all-time:
  • Site-wide: 28,629
  • In genomics: 2,771
• Year to date:
  • Site-wide: 12,545
• Since beginning of last month:
  • Site-wide: 12,019

An Exon Skipping Screen Identifies Antitumor Drugs That Are Potent Modulators of Pre-mRNA Splicing, Suggesting New Therapeutic Applications

• Downloaded 1,119 times
• Download rankings, all-time:
  • Site-wide: 28,702
  • In cancer biology: 691
• Year to date:
  • Site-wide: 60,127
• Since beginning of last month:
  • Site-wide: 61,819

Analysis of genetic dominance in the UK Biobank

• Downloaded 1,074 times
• Download rankings, all-time:
  • Site-wide: 30,568
  • In genetics: 1,619
• Year to date:
  • Site-wide: 2,421
• Since beginning of last month:
  • Site-wide: 11,418

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

• Downloaded 1,025 times
• Download rankings, all-time:
  • Site-wide: 32,733
  • In cancer biology: 2,540
• Year to date:
  • Site-wide: 3,157
• Since beginning of last month:
  • Site-wide: 633

A practical guideline of genomics-driven drug discovery in the era of global biobank meta-analysis

• Downloaded 1,013 times
• Download rankings, all-time:
  • Site-wide: 33,327
  • In genetic and genomic medicine: 257
• Year to date:
  • Site-wide: 4,415
• Since beginning of last month:
  • Site-wide: 5,041

Mono- and bi-allelic effects of coding variants on disease in 176,899 Finns

• Downloaded 943 times
• Download rankings, all-time:
  • Site-wide: 37,101
  • In genetic and genomic medicine: 212
• Year to date:
  • Site-wide: 14,681
• Since beginning of last month:
  • Site-wide: 18,744

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 859 times
• Download rankings, all-time:
  • Site-wide: 42,543
  • In genomics: 3,180
• Year to date:
  • Site-wide: 160,440
• Since beginning of last month:
  • Site-wide: 173,478

Meta-analysis fine-mapping is often miscalibrated at single-variant resolution

• Downloaded 858 times
• Download rankings, all-time:
  • Site-wide: 42,655
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 2,158
• Since beginning of last month:
  • Site-wide: 3,058

UK-Biobank Whole Exome Sequence Binary Phenome Analysis with Robust Region-based Rare Variant Test

• Downloaded 798 times
• Download rankings, all-time:
  • Site-wide: 47,432
  • In genetics: 1,902
• Year to date:
  • Site-wide: 111,303
• Since beginning of last month:
  • Site-wide: 94,130

Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing

• Downloaded 797 times
• Download rankings, all-time:
  • Site-wide: 47,554
  • In genomics: 3,667
• Year to date:
  • Site-wide: 47,217
• Since beginning of last month:
  • Site-wide: 47,082

Best practices for multi-ancestry, meta-analytic transcriptome-wide association studies: lessons from the Global Biobank Meta-analysis Initiative

• Downloaded 775 times
• Download rankings, all-time:
  • Site-wide: 49,506
  • In genetic and genomic medicine: 352
• Year to date:
  • Site-wide: 9,292
• Since beginning of last month:
  • Site-wide: 23,998

Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity

• Downloaded 728 times
• Download rankings, all-time:
  • Site-wide: 54,091
  • In allergy and immunology: 174
• Year to date:
  • Site-wide: 6,867
• Since beginning of last month:
  • Site-wide: 14,041

Endoplasmic reticulum stress may activate NLRP3 inflammasomes via TXNIP in preeclampsia

• Downloaded 723 times
• Download rankings, all-time:
  • Site-wide: 54,661
  • In cell biology: 2,299
• Year to date:
  • Site-wide: 71,929
• Since beginning of last month:
  • Site-wide: 54,098

Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

• Downloaded 703 times
• Download rankings, all-time:
  • Site-wide: 56,773
  • In genetics: 2,206
• Year to date:
  • Site-wide: 153,614
• Since beginning of last month:
  • Site-wide: 116,711

Efficient mixed model approach for large-scale genome-wide association studies of ordinal categorical phenotypes

• Downloaded 674 times
• Download rankings, all-time:
  • Site-wide: 60,360
  • In genetics: 2,380
• Year to date:
  • Site-wide: 116,163
• Since beginning of last month:
  • Site-wide: 96,332

Pharmacological rescue of tumor intrinsic STING expression and immune response in LKB1-mutant lung cancer via the IAP-JAK regulatory axis

• Downloaded 663 times
• Download rankings, all-time:
  • Site-wide: 61,612
  • In cancer biology: 2,099
• Year to date:
  • Site-wide: 20,455
• Since beginning of last month:
  • Site-wide: 15,925

Identification of Common Adulterants in Walnut Beverage Based on Plant DNA Barcode Technology

• Downloaded 653 times
• Download rankings, all-time:
  • Site-wide: 62,830
  • In molecular biology: 1,704
• Year to date:
  • Site-wide: 117,230
• Since beginning of last month:
  • Site-wide: 65,712

Genome-wide association meta-analysis identifies novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation

• Downloaded 604 times
• Download rankings, all-time:
  • Site-wide: 69,649
  • In genetic and genomic medicine: 602
• Year to date:
  • Site-wide: 6,088
• Since beginning of last month:
  • Site-wide: 12,746

Genome-wide analysis yields new loci associating with aortic valve stenosis

• Downloaded 587 times
• Download rankings, all-time:
  • Site-wide: 72,082
  • In genetics: 2,744
• Year to date:
  • Site-wide: 181,545
• Since beginning of last month:
  • Site-wide: 170,084

A dynamic regulatory interface on SARS-CoV-2 RNA polymerase

• Downloaded 538 times
• Download rankings, all-time:
  • Site-wide: 80,242
  • In molecular biology: 2,207
• Year to date:
  • Site-wide: 103,986
• Since beginning of last month:
  • Site-wide: 96,353

Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis

• Downloaded 502 times
• Download rankings, all-time:
  • Site-wide: 87,155
  • In genomics: 5,344
• Year to date:
  • Site-wide: 155,215
• Since beginning of last month:
  • Site-wide: 104,630

Leveraging global multi-ancestry meta-analysis in the study of Idiopathic Pulmonary Fibrosis genetics

• Downloaded 463 times
• Download rankings, all-time:
  • Site-wide: 95,250
  • In genetic and genomic medicine: 753
• Year to date:
  • Site-wide: 5,971
• Since beginning of last month:
  • Site-wide: 27,061

A general role of zinc binding domain revealed by structures of σ28-dependent transcribing complexes

• Downloaded 448 times
• Download rankings, all-time:
  • Site-wide: 98,716
  • In molecular biology: 2,721
• Year to date:
  • Site-wide: 158,119
• Since beginning of last month:
  • Site-wide: 107,551

Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

• Downloaded 447 times
• Download rankings, all-time:
  • Site-wide: 98,949
  • In epidemiology: 4,204
• Year to date:
  • Site-wide: 86,163
• Since beginning of last month:
  • Site-wide: 75,379

Transcriptional re-wiring by mutation of the yeast Hsf1 oligomerization domain

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 100,387
  • In genomics: 5,982
• Year to date:
  • Site-wide: 86,898
• Since beginning of last month:
  • Site-wide: 63,158

Minor QTLs mining through the combination of GWAS and machine learning feature selection

• Downloaded 437 times
• Download rankings, all-time:
  • Site-wide: 101,196
  • In bioinformatics: 8,441
• Year to date:
  • Site-wide: 102,040
• Since beginning of last month:
  • Site-wide: 61,999

Utility of family history in disease prediction in the era of polygenic scores

• Downloaded 435 times
• Download rankings, all-time:
  • Site-wide: 101,662
  • In genetic and genomic medicine: 559
• Year to date:
  • Site-wide: 87,823
• Since beginning of last month:
  • Site-wide: 81,940

The HUNT Study: a population-based cohort for genetic research

• Downloaded 410 times
• Download rankings, all-time:
  • Site-wide: 107,845
  • In epidemiology: 5,616
• Year to date:
  • Site-wide: 8,762
• Since beginning of last month:
  • Site-wide: 19,348

Genetic variant in SPDL1 reveals novel mechanism linking pulmonary fibrosis risk and cancer protection

• Downloaded 409 times
• Download rankings, all-time:
  • Site-wide: 108,042
  • In genetic and genomic medicine: 699
• Year to date:
  • Site-wide: 47,440
• Since beginning of last month:
  • Site-wide: 50,057

Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors

• Downloaded 405 times
• Download rankings, all-time:
  • Site-wide: 108,999
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 6,794
• Since beginning of last month:
  • Site-wide: 12,860

The reduced prevalence of macrolide resistance in Mycoplasma pneumoniae clinical isolates from pediatric patients in Beijing in 2016

• Downloaded 398 times
• Download rankings, all-time:
  • Site-wide: 110,627
  • In microbiology: 7,042
• Year to date:
  • Site-wide: 163,470
• Since beginning of last month:
  • Site-wide: 163,984

Minor QTLs mining through the combination of GWAS and machine learning feature selection

• Downloaded 389 times
• Download rankings, all-time:
  • Site-wide: 112,830
  • In bioinformatics: 9,012
• Year to date:
  • Site-wide: 142,669
• Since beginning of last month:
  • Site-wide: 112,628

Species and strain cultivation of skin, oral, and gut microbiota

• Downloaded 380 times
• Download rankings, all-time:
  • Site-wide: 115,443
  • In microbiology: 7,738
• Year to date:
  • Site-wide: 105,577
• Since beginning of last month:
  • Site-wide: 100,561

Polygenic risk score from a multi-ancestry GWAS uncovers susceptibility of heart failure

• Downloaded 349 times
• Download rankings, all-time:
  • Site-wide: 123,926
  • In cardiovascular medicine: 485
• Year to date:
  • Site-wide: 18,204
• Since beginning of last month:
  • Site-wide: 42,250

Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT

• Downloaded 345 times
• Download rankings, all-time:
  • Site-wide: 124,823
  • In epidemiology: 6,216
• Year to date:
  • Site-wide: 21,412
• Since beginning of last month:
  • Site-wide: 16,202

Incorporating family disease history and controlling case-control imbalance for population based genetic association studies

• Downloaded 303 times
• Download rankings, all-time:
  • Site-wide: 137,188
  • In genetic and genomic medicine: 887
• Year to date:
  • Site-wide: 56,478
• Since beginning of last month:
  • Site-wide: 49,694

Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

• Downloaded 300 times
• Download rankings, all-time:
  • Site-wide: 138,096
  • In cancer biology: 4,291
• Year to date:
  • Site-wide: 39,353
• Since beginning of last month:
  • Site-wide: 109,911

The compound of baicalein, wogonin, and oroxylin-A inhibiting EMT in A549 cell line via PI3K/AKT-TWIST1-glycolysis pathway

• Downloaded 270 times
• Download rankings, all-time:
  • Site-wide: 146,897
  • In pharmacology and toxicology: 1,215
• Year to date:
  • Site-wide: 61,725
• Since beginning of last month:
  • Site-wide: 44,796

Insulated expression of periplasmic uricase in E. coli Nissle 1917 for the treatment of hyperuricemia

• Downloaded 258 times
• Download rankings, all-time:
  • Site-wide: 150,781
  • In synthetic biology: None
• Year to date:
  • Site-wide: 13,438
• Since beginning of last month:
  • Site-wide: 9,586

Dynein/Sunday driver mediate disorders of dynamic profiles of Golgi outposts induced by amyloid precursor protein

• Downloaded 236 times
• Download rankings, all-time:
  • Site-wide: 156,914
  • In neuroscience: 22,373
• Year to date:
  • Site-wide: 128,687
• Since beginning of last month:
  • Site-wide: 78,707

Cortical encoding during word reading in bilinguals: parallel interdigitated distributed networks support convergent linguistic functioning

• Downloaded 224 times
• Download rankings, all-time:
  • Site-wide: 160,324
  • In neuroscience: 23,844
• Year to date:
  • Site-wide: 37,704
• Since beginning of last month:
  • Site-wide: 58,825

Mice with a humanized immune system are resilient to transplantation of human microbiota

• Downloaded 204 times
• Download rankings, all-time:
  • Site-wide: 165,597
  • In microbiology: 12,437
• Year to date:
  • Site-wide: 65,549
• Since beginning of last month:
  • Site-wide: 110,804

Multi-ancestry meta-analysis identifies 2 novel loci associated with ischemic stroke and reveals heterogeneity of effects between sexes and ancestries

• Downloaded 174 times
• Download rankings, all-time:
  • Site-wide: 173,002
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 23,545
• Since beginning of last month:
  • Site-wide: 35,525

A comparative transcriptional landscape of two castor cultivars obtained by single-molecule sequencing comparative analysis

• Downloaded 152 times
• Download rankings, all-time:
  • Site-wide: 177,624
  • In genomics: 8,163
• Year to date:
  • Site-wide: 161,767
• Since beginning of last month:
  • Site-wide: 153,149

The effect of histone deacetylase inhibitor Trichostatin A on IL-17A-induced transformation of MRC5 into myofibroblasts and its mechanism

• Downloaded 139 times
• Download rankings, all-time:
  • Site-wide: 180,050
  • In cell biology: 7,818
• Year to date:
  • Site-wide: 114,878
• Since beginning of last month:
  • Site-wide: 155,645

Changes in nitrogen pools in the maize-soil system after urea or straw application to a typical intensive agricultural soil: A 15N tracer study

• Downloaded 127 times
• Download rankings, all-time:
  • Site-wide: 182,025
  • In plant biology: 4,819
• Year to date:
  • Site-wide: 142,190
• Since beginning of last month:
  • Site-wide: 128,447