Author: Wei Zhou

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Preprints

Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT

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Pharmacological rescue of tumor intrinsic STING expression and immune response in LKB1-mutant lung cancer via the IAP-JAK regulatory axis

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Prognostic value of C-reactive protein in patients with COVID-19

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Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

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Genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation

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Systematic single-variant and gene-based association testing of 3,700 phenotypes in 281,850 UK Biobank exomes

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Characterizing the temporal dynamics of gene expression in single cells with sci-fate

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Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts

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Single-cell RNA-seq and V(D)J profiling of immune cells in COVID-19 patients

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Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

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Comparative genetic architectures of schizophrenia in East Asian and European populations

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Large-scale single-cell analysis reveals critical immune characteristics of COVID-19 patients

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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.

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ReprDB and panDB: minimalist databases with maximal microbial representation

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Cryo-EM structure of the receptor-activated TRPC5 ion channel at 2.9 angstrom resolution

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An enhanced characterization of the human skin microbiome: a new biodiversity of microbial interactions

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The Effect of Neutropenia and Filgrastim (G-CSF) in Cancer Patients With COVID-19 Infection

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An Exon Skipping Screen Identifies Antitumor Drugs That Are Potent Modulators of Pre-mRNA Splicing, Suggesting New Therapeutic Applications

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Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

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Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in Mycobacterium tuberculosis

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UK-Biobank Whole Exome Sequence Binary Phenome Analysis with Robust Region-based Rare Variant Test

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Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

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An efficient and accurate frailty model approach for genome-wide survival association analysis controlling for population structure and relatedness in large-scale biobanks

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  • In genomics: 3,673
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Efficient mixed model approach for large-scale genome-wide association studies of ordinal categorical phenotypes

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  • Site-wide: 53,028
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Genome-wide analysis yields new loci associating with aortic valve stenosis

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Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing

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Identification of Common Adulterants in Walnut Beverage Based on Plant DNA Barcode Technology

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  • In molecular biology: 1,578
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Endoplasmic reticulum stress may activate NLRP3 inflammasomes via TXNIP in preeclampsia

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Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis

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A dynamic regulatory interface on SARS-CoV-2 RNA polymerase

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  • In molecular biology: 1,998
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A general role of zinc binding domain revealed by structures of σ28-dependent transcribing complexes

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  • In molecular biology: 2,542
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The reduced prevalence of macrolide resistance in Mycoplasma pneumoniae clinical isolates from pediatric patients in Beijing in 2016

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Transcriptional re-wiring by mutation of the yeast Hsf1 oligomerization domain

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Set-based rare variant association tests for biobank scale sequencing data sets

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Minor QTLs mining through the combination of GWAS and machine learning feature selection

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Minor QTLs mining through the combination of GWAS and machine learning feature selection

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Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

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Utility of family history in disease prediction in the era of polygenic scores

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Species and strain cultivation of skin, oral, and gut microbiota

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Genetic variant in SPDL1 reveals novel mechanism linking pulmonary fibrosis risk and cancer protection

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Analysis of genetic dominance in the UK Biobank

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Dynein/Sunday driver mediate disorders of dynamic profiles of Golgi outposts induced by amyloid precursor protein

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Network pharmacology and chemoproteomics unveil the mechanism of Total Flavonoid Aglycones Extract inhibiting EMT in A549 cell line

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Incorporating family disease history and controlling case-control imbalance for population based genetic association studies

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A comparative transcriptional landscape of two castor cultivars obtained by single-molecule sequencing comparative analysis

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Changes in nitrogen pools in the maize-soil system after urea or straw application to a typical intensive agricultural soil: A 15N tracer study

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The effect of histone deacetylase inhibitor Trichostatin A on IL-17A-induced transformation of MRC5 into myofibroblasts and its mechanism

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