Author: Yan Zhang

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Preprints

Memory in Repetitive Protein-Protein Interaction Series -- in Memory of the Late Professor Robert M. Nerem

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Clinical diagnosis of 8274 samples with 2019-novel coronavirus in Wuhan

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  • Site-wide: 485
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  • Site-wide: 6,861
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  • Site-wide: 7,555

Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection

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  • Site-wide: 917
  • In genomics: 50
• Year to date:
  • Site-wide: 2,088
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  • Site-wide: 2,129

Mapping Transcriptomic Vector Fields of Single Cells

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  • Site-wide: 1,107
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  • Site-wide: 1,972
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  • Site-wide: 12,239

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

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  • Site-wide: 1,805
  • In molecular biology: 29
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  • Site-wide: 23,991
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  • Site-wide: 50,299

ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism

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  • Site-wide: 1,947
  • In allergy and immunology: 17
• Year to date:
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  • Site-wide: 10,108

Fast and sensitive GCaMP calcium indicators for imaging neural populations

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  • Site-wide: 2,649
  • In neuroscience: 142
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  • Site-wide: 1,162

A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

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  • Site-wide: 6,058
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  • Site-wide: 37,149
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  • Site-wide: 51,004

Chaos theory applied to the outbreak of Covid-19: an ancillary approach to decision-making in pandemic context

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  • Site-wide: 6,162
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  • Site-wide: 81,286
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Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits and implications for the future

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  • Site-wide: 6,703
  • In genetics: 245
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  • Site-wide: 21,683

ElectroPen: An ultralow-cost piezoelectric electroporator

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  • Site-wide: 8,168
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  • Site-wide: 63,050
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  • Site-wide: 29,160

Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection

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  • Site-wide: 8,619
  • In genomics: 822
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  • Site-wide: 76,408
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HiCPlus: Resolution Enhancement of Hi-C interaction heatmap

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  • Site-wide: 10,191
  • In bioinformatics: 1,062
• Year to date:
  • Site-wide: 122,339
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  • Site-wide: 67,515

Integration of Mouse and Human Single-cell RNA Sequencing Infers Spatial Cell-type Composition in Human Brains

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  • Site-wide: 10,192
  • In bioinformatics: 1,080
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  • Site-wide: 33,632
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  • Site-wide: 10,352

Passenger mutations in 2500 cancer genomes: Overall molecular functional impact and consequences

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  • Site-wide: 10,563
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Comorbid Diabetes Mellitus was Associated with Poorer Prognosis in Patients with COVID-19: A Retrospective Cohort Study

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  • Site-wide: 13,646
  • In respiratory medicine: 46
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  • Site-wide: 32,843

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

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  • Site-wide: 13,782
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• Year to date:
  • Site-wide: 115,180
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  • Site-wide: 122,545

Cryo-EM structures of inactive and Gi-coupled GABAB heterodimer

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  • Site-wide: 14,358
  • In molecular biology: 352
• Year to date:
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  • Site-wide: 50,492

scTPA: A web tool for single-cell transcriptome analysis of pathway activation signatures

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  • Site-wide: 15,703
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  • Site-wide: 22,319
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  • Site-wide: 32,371

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

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  • Site-wide: 17,245
  • In genomics: 1,573
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  • Site-wide: 66,876
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  • Site-wide: 65,280

Giant African snail genomes provide insights into molluscan whole-genome duplication and aquatic-terrestrial transition

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  • Site-wide: 19,298
  • In genomics: 1,758
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  • Site-wide: 34,684

A complex structure of arrestin-2 bound to a G protein-coupled receptor

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  • Site-wide: 19,639
  • In biophysics: 467
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  • Site-wide: 129,575

Crystal structure of SARS-CoV-2 main protease in complex with a Chinese herb inhibitor shikonin

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  • Site-wide: 26,046
  • In biophysics: 696
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  • Site-wide: 62,533
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  • Site-wide: 81,649

HBP: an integrative and flexible pipeline for the interaction analysis of Hi-C dataset

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  • Site-wide: 26,275
  • In bioinformatics: 2,816
• Year to date:
  • Site-wide: 187,057
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  • Site-wide: 112,492

In vivo structure and dynamics of the RNA genome of SARS-Cov-2

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  • Site-wide: 27,516
  • In genomics: 2,360
• Year to date:
  • Site-wide: 64,481
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  • Site-wide: 23,699

Consensus interpretation of the Met34Thr and Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel

• Downloaded 1,188 times
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  • Site-wide: 28,164
  • In genetics: 1,131
• Year to date:
  • Site-wide: 159,301
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  • Site-wide: 127,294

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

• Downloaded 1,176 times
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  • Site-wide: 28,655
  • In genomics: 2,413
• Year to date:
  • Site-wide: 151,354
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  • Site-wide: 160,403

Using structurally fungible biosensors to evolve improved alkaloid biosyntheses

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  • Site-wide: 29,842
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• Year to date:
  • Site-wide: 10,984
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  • Site-wide: 11,504

Cryo-EM structures reveal interactions of S-OPA1 with membrane and changes upon nucleotide binding

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  • Site-wide: 32,599
  • In biophysics: 931
• Year to date:
  • Site-wide: 151,553
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  • Site-wide: None

Structural basis for repurpose and design of nucleoside drugs for treating COVID-19

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  • Site-wide: 32,959
  • In biophysics: 1,031
• Year to date:
  • Site-wide: 22,954
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  • Site-wide: 9,561

Structural basis of bile acid receptor activation and Gs coupling

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  • Site-wide: 33,737
  • In biochemistry: 772
• Year to date:
  • Site-wide: 125,505
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  • Site-wide: 107,528

Comparative validation of breast cancer risk prediction models and projections for future risk stratification

• Downloaded 1,034 times
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  • Site-wide: 34,894
  • In epidemiology: 1,904
• Year to date:
  • Site-wide: 132,466
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  • Site-wide: 90,204

Imaging sensory transmission and neuronal plasticity in primary sensory neurons with genetically-encoded voltage indicators

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  • Site-wide: 36,106
  • In neuroscience: 4,722
• Year to date:
  • Site-wide: 26,570
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  • Site-wide: 40,285

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

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  • Site-wide: 36,727
  • In genetics: 1,464
• Year to date:
  • Site-wide: 179,580
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  • Site-wide: 118,652

Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

• Downloaded 982 times
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  • Site-wide: 37,749
  • In molecular biology: 1,017
• Year to date:
  • Site-wide: 36,996
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  • Site-wide: 85,447

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

• Downloaded 958 times
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  • Site-wide: 39,221
  • In molecular biology: 1,063
• Year to date:
  • Site-wide: 43,475
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  • Site-wide: 60,068

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease

• Downloaded 923 times
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  • Site-wide: 41,471
  • In genetics: 1,656
• Year to date:
  • Site-wide: 142,327
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  • Site-wide: 138,481

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

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  • Site-wide: 46,655
  • In molecular biology: 1,390
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  • Site-wide: 15,014
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  • Site-wide: 6,516

Molecular Mapping Of YrTZ2, A Stripe Rust Resistance Gene In Wild Emmer Accession TZ-2 And Its Comparative Analyses With Aegilops tauschii

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  • Site-wide: 51,249
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  • Site-wide: 164,270

Structural insights into the insecticidal Vip3A toxin of Bacillus thuringiensis

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  • Site-wide: 52,289
  • In microbiology: 3,082
• Year to date:
  • Site-wide: 80,511
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  • Site-wide: 141,452

Structure of SARS-CoV-2 main protease in the apo state reveals the inactive conformation

• Downloaded 756 times
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  • Site-wide: 55,712
  • In biochemistry: 1,427
• Year to date:
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Engineering a Functional small RNA Negative Autoregulation Network with Model-guided Design

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  • Site-wide: 55,830
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  • Site-wide: 126,842

A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo

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  • Site-wide: 60,005
  • In synthetic biology: 715
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  • Site-wide: 128,519

Diagnostic Evidence GAuge of Single cells (DEGAS): A flexible deep-transfer learning framework for prioritizing cells in relation to disease

• Downloaded 694 times
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  • Site-wide: 63,030
  • In bioinformatics: 6,092
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  • Site-wide: 56,332
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  • Site-wide: 86,169

Identification of Common Adulterants in Walnut Beverage Based on Plant DNA Barcode Technology

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  • Site-wide: 64,238
  • In molecular biology: 1,865
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  • Site-wide: 106,869
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  • Site-wide: 25,102

Electronic blood vessel

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  • Site-wide: 64,327
  • In bioengineering: 1,263
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  • Site-wide: 77,212
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  • Site-wide: 149,946

Altered Bacteria-Fungi Inter-Kingdom Network in Gut of Ankylosing Spondylitis Patients

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  • Site-wide: 65,234
  • In microbiology: 3,906
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Multiethnic Polygenic Risk Prediction in Diverse Populations through Transfer Learning

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  • Site-wide: 73,771
  • In genetics: 3,249
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  • Site-wide: 27,031

The loss of ATRX/DAXX complex disturbs rDNA heterochromatinization and promotes development of glioma

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  • Site-wide: 75,198
  • In cancer biology: 2,189
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  • Site-wide: 91,198

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

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  • Site-wide: 79,561
  • In molecular biology: 2,233
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A novel cryo-electron microscopy support film based on 2D crystal of HFBI protein

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  • Site-wide: 80,349
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  • Site-wide: 99,648

SARS-Cov-2-, HIV-1-, Ebola-neutralizing and anti-PD1 clones are predisposed

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  • Site-wide: 81,312
  • In immunology: 2,616
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  • Site-wide: 65,994

High-throughput, label-free and slide-free histological imaging by computational microscopy and unsupervised learning

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  • Site-wide: 81,657
  • In bioengineering: 1,609
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  • Site-wide: 68,537
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  • Site-wide: 57,989

Protocell Arrays for Simultaneous Detection of Diverse Analytes

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  • Site-wide: 83,812
  • In synthetic biology: 958
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  • Site-wide: 52,397
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LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesis

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  • Site-wide: 84,574
  • In molecular biology: 2,449
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  • Site-wide: 109,949
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  • Site-wide: 29,167

Tyr1 phosphorylation promotes the phosphorylation of Ser2 on the C-terminal domain of RNA polymerase II by P-TEFb

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  • Site-wide: 86,198
  • In biochemistry: 2,312
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Integrated analysis of the miRNA-mRNA network associated with LMP1 gene in nasopharyngeal carcinoma

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  • Site-wide: 91,008
  • In microbiology: 5,784
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  • Site-wide: 154,025
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  • Site-wide: 128,897

Fast, live-cell imaging of 15 intracellular compartments by deep learning segmentation of super-resolution data

• Downloaded 480 times
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  • Site-wide: 99,856
  • In cell biology: 4,797
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  • Site-wide: 27,322
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  • Site-wide: 20,044

Verification of the phenylpropanoid pinoresinol biosynthetic pathway and its glycosides in Phomopsis sp. XP-8 using 13C stable isotope labeling and liquid chromatography coupled with time-of-flight mass spectrometry

• Downloaded 469 times
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  • Site-wide: 102,499
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  • Site-wide: 121,753
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  • Site-wide: 92,575

Proto-sex locus in large yellow croaker provides insights into early evolution of the sex chromosome

• Downloaded 464 times
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  • Site-wide: 103,595
  • In evolutionary biology: 4,822
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  • Site-wide: 94,210
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  • Site-wide: 106,895

Structural basis of peptidomimetic agonism revealed by small molecule GLP-1R agonists Boc5 and WB4-24

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  • Site-wide: 104,312
  • In molecular biology: 3,031
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  • Site-wide: 133,970

Structural insights into ligand recognition and activation of the melanocortin-4 receptor

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  • Site-wide: 106,841
  • In molecular biology: 3,197
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  • Site-wide: 55,586
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  • Site-wide: 26,309

Distinct impact of IgG subclass and Fc-FcγR interaction on autoantibody pathogenicity in different IgG4-mediated diseases

• Downloaded 426 times
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  • Site-wide: 112,720
  • In allergy and immunology: 239
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  • Site-wide: 91,951
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  • Site-wide: None

MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice

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  • Site-wide: 113,269
  • In developmental biology: 2,985
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  • Site-wide: 113,125
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  • Site-wide: 118,779

Point-of-care analyte quantification and digital readout via lysate-based cell-free biosensors interfaced with personal glucose monitors

• Downloaded 412 times
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  • Site-wide: 116,083
  • In synthetic biology: 1,187
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  • Site-wide: 89,880
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  • Site-wide: 134,029

Altered brain function in anorexia nervosa and bulimia nervosa: A hierarchical series of task-based fMRI meta-analyses

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  • Site-wide: 117,511
  • In neuroscience: 16,986
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  • Site-wide: 175,633

Mast cell-specific receptor/corticotropin-releasing factor axis regulates alcohol withdrawal-associated headache

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  • Site-wide: 118,099
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  • Site-wide: 79,044

Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors

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  • In molecular biology: 3,620
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  • Site-wide: 23,166

Source-Sink Modifications Affect Leaf Senescence and Grain Mass in Wheat

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  • Site-wide: 119,438
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  • Site-wide: 151,878
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  • Site-wide: 92,614

Structures of full-length glycoprotein hormone receptor signaling complexes

• Downloaded 398 times
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  • Site-wide: 120,003
  • In molecular biology: 3,560
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  • Site-wide: 68,627
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  • Site-wide: 95,661

Three-dimensional Multicolor Subcellular Imaging by Fast Serial Sectioning Tomography for Centimeter-scale Specimens

• Downloaded 385 times
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  • Site-wide: 123,444
  • In bioengineering: 2,458
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  • Site-wide: 37,485
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The mediating role of epigenetic clocks underlying educational inequalities in mortality: a multi-cohort study

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  • Site-wide: 125,091
  • In epidemiology: 5,583
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  • Site-wide: 30,763
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  • Site-wide: 12,980

Inferring novel lncRNA associated with Ventricular septal defect by DNA methylation interaction network

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  • Site-wide: 128,697
  • In developmental biology: 3,354
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Calcium ion chelation preserves platelet function during cold storage

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  • Site-wide: 131,646
  • In cell biology: 6,099
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  • Site-wide: 130,819
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  • Site-wide: 135,528

Seasonal variations in soil fungal communities and co-occurrence networks along an altitudinal gradient in the cold temperate zone of China: A case study on Oakley Mountain

• Downloaded 344 times
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  • Site-wide: 135,143
  • In ecology: 4,179
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  • Site-wide: 79,313
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  • Site-wide: 88,013

Metabolic Dynamics in Escherichia coli-based Cell-Free Systems

• Downloaded 325 times
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  • Site-wide: 140,740
  • In systems biology: 2,884
• Year to date:
  • Site-wide: 137,068
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  • Site-wide: 78,754

Meclizine and metabotropic glutamate receptor agonists attenuate severe pain and primary sensory neuron Ca2+ activity in chemotherapy-induced peripheral neuropathy

• Downloaded 322 times
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  • Site-wide: 141,603
  • In neuroscience: 21,132
• Year to date:
  • Site-wide: 75,570
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  • Site-wide: None

Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response

• Downloaded 322 times
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  • Site-wide: 141,601
  • In immunology: 4,616
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  • Site-wide: 55,557
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  • Site-wide: 26,700

Altered O-glycosylation Level of SARS-CoV-2 Spike Protein by Host O-glycosyltransferase Strengthens Its Trimeric Structure

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  • Site-wide: 145,153
  • In biochemistry: 4,364
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  • Site-wide: 120,877
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Vitamin B12 and Risk of Diabetes: New insight from Cross-Sectional and Longitudinal Analyses of the China Stroke Primary Prevention Trial (CSPPT)

• Downloaded 305 times
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  • Site-wide: 146,766
  • In epidemiology: 6,096
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  • Site-wide: 116,139
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  • Site-wide: 145,356

Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy

• Downloaded 289 times
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  • Site-wide: 151,350
  • In biochemistry: 4,663
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  • Site-wide: 67,486
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  • Site-wide: 77,376

Extracellular histones trigger disseminated intravascular coagulation by lytic cell death

• Downloaded 287 times
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  • Site-wide: 152,038
  • In immunology: 4,726
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  • Site-wide: 156,655
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  • Site-wide: 143,347

DMLDA-LocLIFT: Identification of multi-label protein subcellular localization using DMLDA dimensionality reduction and LIFT classifier

• Downloaded 287 times
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  • Site-wide: 172,452

Adaptive Expansion of Taste Neuron Response Profiles by Congruent Aroma in Drosophila

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Speckle illumination microscopy enables slide-free and non-destructive pathology of human lung adenocarcinoma

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Three-dimensional label-free histological imaging of whole organs by microtomy-assisted autofluorescence tomography

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The GR2D2 Estimator for the Precision Matrices

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Constitutive signal bias mediated by the human GHRHR splice variant 1

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Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis

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Novel Vβ specific germline contacts shape an elite controller T cell response

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Capsaicin pretreatment alleviates postoperative pain and reduces primary sensory neuron Ca2+ activity

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dbGSRV: a manually curated database of genetic susceptibility to respiratory virus

• Downloaded 231 times
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  • Site-wide: 167,822
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Conversion between 100-million-year-old duplicated genes contributes to rice subspecies divergence

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Impact of serum calcium levels on local and total body bone mineral density: A Mendelian randomization study and an age stratum analysis

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Characterisation of bacteriophage JD419, a Staphylococcal phage with an unusual morphology and broad host range

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  • Site-wide: 52,459

An integrative analysis of clinical and epigenetic biomarkers of mortality

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  • Site-wide: 75,667

Escape Steering by Cholecystokinin Peptidergic Signaling

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Transcriptome analysis of an albino mutant in Haworthia cooperi var. pilifera

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Grace-AKO: A Novel and Stable Knockoff Filter for Variable Selection Incorporating Gene Network Structures

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The genome sequence of Sorbus pohuashanensis provides insights into population evolution and leaf sunburn response

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Scavenger receptor A1 participates in the phagocytosis of Leptospira interrogans and leads to subsequent high inflammatory responses and bacterial dissemination in leptospirosis

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Hurricane Harvey Impacts on Water Quality and Microbial Communities in Houston, TX Waterbodies

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Atmospheric particulate matter aggravates CNS demyelination via TLR-4/NF-κB-mediated microglia pathogenic activities

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  • Site-wide: 61,287

Mapping Multiple Factors Mediated Chromatin Interactions to Assess Regulatory Network and Dysregulation of Lung Cancer-Related Genes

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  • Site-wide: 39,549