Author: Yan Zhang

Downloads per author, site-wide

Preprints

Structural basis of bile acid receptor activation and Gs coupling

No bioRxiv download data for this paper yet.

A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

No bioRxiv download data for this paper yet.

Electronic blood vessel

No bioRxiv download data for this paper yet.

Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection

• Downloaded 7,308 times
• Download rankings, all-time:
  • Site-wide: 365 out of 83,873
  • In genomics: 77 out of 5,415
• Year to date:
  • Site-wide: 99 out of 83,873
• Since beginning of last month:
  • Site-wide: 196 out of 83,873

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

• Downloaded 6,485 times
• Download rankings, all-time:
  • Site-wide: 438 out of 83,873
  • In molecular biology: 15 out of 2,814
• Year to date:
  • Site-wide: 107 out of 83,873
• Since beginning of last month:
  • Site-wide: 55 out of 83,873

Mapping Vector Field of Single Cells

• Downloaded 4,542 times
• Download rankings, all-time:
  • Site-wide: 811 out of 83,873
  • In systems biology: 21 out of 2,222
• Year to date:
  • Site-wide: 1,050 out of 83,873
• Since beginning of last month:
  • Site-wide: 1,119 out of 83,873

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits and implications for the future

• Downloaded 2,134 times
• Download rankings, all-time:
  • Site-wide: 3,038 out of 83,873
  • In genetics: 240 out of 4,407
• Year to date:
  • Site-wide: 11,406 out of 83,873
• Since beginning of last month:
  • Site-wide: 12,835 out of 83,873

HiCPlus: Resolution Enhancement of Hi-C interaction heatmap

• Downloaded 2,062 times
• Download rankings, all-time:
  • Site-wide: 3,220 out of 83,873
  • In bioinformatics: 600 out of 8,043
• Year to date:
  • Site-wide: 59,658 out of 83,873
• Since beginning of last month:
  • Site-wide: 42,846 out of 83,873

Passenger mutations in 2500 cancer genomes: Overall molecular functional impact and consequences

• Downloaded 1,926 times
• Download rankings, all-time:
  • Site-wide: 3,598 out of 83,873
  • In genomics: 655 out of 5,415
• Year to date:
  • Site-wide: 8,922 out of 83,873
• Since beginning of last month:
  • Site-wide: 16,326 out of 83,873

ElectroPen: An ultralow-cost piezoelectric electroporator

• Downloaded 1,814 times
• Download rankings, all-time:
  • Site-wide: 3,968 out of 83,873
  • In bioengineering: 74 out of 1,826
• Year to date:
  • Site-wide: 4,074 out of 83,873
• Since beginning of last month:
  • Site-wide: 5,313 out of 83,873

Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection

• Downloaded 1,553 times
• Download rankings, all-time:
  • Site-wide: 5,136 out of 83,873
  • In genomics: 876 out of 5,415
• Year to date:
  • Site-wide: 512 out of 83,873
• Since beginning of last month:
  • Site-wide: 904 out of 83,873

Integration of Mouse and Human Single-cell RNA Sequencing Infers Spatial Cell-type Composition in Human Brains

• Downloaded 1,533 times
• Download rankings, all-time:
  • Site-wide: 5,250 out of 83,873
  • In bioinformatics: 960 out of 8,043
• Year to date:
  • Site-wide: 6,398 out of 83,873
• Since beginning of last month:
  • Site-wide: 7,020 out of 83,873

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

• Downloaded 1,492 times
• Download rankings, all-time:
  • Site-wide: 5,494 out of 83,873
  • In genetics: 418 out of 4,407
• Year to date:
  • Site-wide: 6,979 out of 83,873
• Since beginning of last month:
  • Site-wide: 11,972 out of 83,873

Cryo-EM structures of inactive and Gi-coupled GABAB heterodimer

• Downloaded 1,154 times
• Download rankings, all-time:
  • Site-wide: 8,437 out of 83,873
  • In molecular biology: 281 out of 2,814
• Year to date:
  • Site-wide: 781 out of 83,873
• Since beginning of last month:
  • Site-wide: 399 out of 83,873

A complex structure of arrestin-2 bound to a G protein-coupled receptor

• Downloaded 1,120 times
• Download rankings, all-time:
  • Site-wide: 8,873 out of 83,873
  • In biophysics: 265 out of 3,595
• Year to date:
  • Site-wide: 10,881 out of 83,873
• Since beginning of last month:
  • Site-wide: 13,675 out of 83,873

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

• Downloaded 1,003 times
• Download rankings, all-time:
  • Site-wide: 10,598 out of 83,873
  • In genomics: 1,526 out of 5,415
• Year to date:
  • Site-wide: 60,132 out of 83,873
• Since beginning of last month:
  • Site-wide: 67,324 out of 83,873

HBP: an integrative and flexible pipeline for the interaction analysis of Hi-C dataset

• Downloaded 911 times
• Download rankings, all-time:
  • Site-wide: 12,346 out of 83,873
  • In bioinformatics: 1,989 out of 8,043
• Year to date:
  • Site-wide: 78,121 out of 83,873
• Since beginning of last month:
  • Site-wide: 72,444 out of 83,873

Cryo-EM structures reveal interactions of S-OPA1 with membrane and changes upon nucleotide binding

• Downloaded 812 times
• Download rankings, all-time:
  • Site-wide: 14,676 out of 83,873
  • In biophysics: 476 out of 3,595
• Year to date:
  • Site-wide: 25,783 out of 83,873
• Since beginning of last month:
  • Site-wide: 26,717 out of 83,873

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

• Downloaded 804 times
• Download rankings, all-time:
  • Site-wide: 14,908 out of 83,873
  • In genomics: 1,953 out of 5,415
• Year to date:
  • Site-wide: 1,294 out of 83,873
• Since beginning of last month:
  • Site-wide: 567 out of 83,873

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

• Downloaded 739 times
• Download rankings, all-time:
  • Site-wide: 16,998 out of 83,873
  • In genetics: 1,108 out of 4,407
• Year to date:
  • Site-wide: 16,495 out of 83,873
• Since beginning of last month:
  • Site-wide: 17,440 out of 83,873

Consensus interpretation of the Met34Thr and Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel

• Downloaded 716 times
• Download rankings, all-time:
  • Site-wide: 17,808 out of 83,873
  • In genetics: 1,152 out of 4,407
• Year to date:
  • Site-wide: 20,929 out of 83,873
• Since beginning of last month:
  • Site-wide: 23,392 out of 83,873

Comparative validation of breast cancer risk prediction models and projections for future risk stratification

• Downloaded 705 times
• Download rankings, all-time:
  • Site-wide: 18,205 out of 83,873
  • In epidemiology: 206 out of 1,556
• Year to date:
  • Site-wide: 17,775 out of 83,873
• Since beginning of last month:
  • Site-wide: 21,027 out of 83,873

Molecular Mapping Of YrTZ2, A Stripe Rust Resistance Gene In Wild Emmer Accession TZ-2 And Its Comparative Analyses With Aegilops tauschii

• Downloaded 607 times
• Download rankings, all-time:
  • Site-wide: 22,642 out of 83,873
  • In plant biology: 556 out of 2,550
• Year to date:
  • Site-wide: 75,996 out of 83,873
• Since beginning of last month:
  • Site-wide: 71,674 out of 83,873

Engineering a Functional small RNA Negative Autoregulation Network with Model-guided Design

• Downloaded 530 times
• Download rankings, all-time:
  • Site-wide: 27,107 out of 83,873
  • In synthetic biology: 420 out of 781
• Year to date:
  • Site-wide: 59,285 out of 83,873
• Since beginning of last month:
  • Site-wide: 63,968 out of 83,873

scTPA: A web tool for single-cell transcriptome analysis of pathway activation signatures

• Downloaded 505 times
• Download rankings, all-time:
  • Site-wide: 28,734 out of 83,873
  • In genomics: 2,967 out of 5,415
• Year to date:
  • Site-wide: 2,598 out of 83,873
• Since beginning of last month:
  • Site-wide: 4,202 out of 83,873

Altered Bacteria-Fungi Inter-Kingdom Network in Gut of Ankylosing Spondylitis Patients

• Downloaded 457 times
• Download rankings, all-time:
  • Site-wide: 32,439 out of 83,873
  • In microbiology: 2,115 out of 7,145
• Year to date:
  • Site-wide: 51,330 out of 83,873
• Since beginning of last month:
  • Site-wide: 47,629 out of 83,873

Giant African snail genomes provide insights into molluscan whole-genome duplication and aquatic-terrestrial transition

• Downloaded 439 times
• Download rankings, all-time:
  • Site-wide: 33,999 out of 83,873
  • In genomics: 3,309 out of 5,415
• Year to date:
  • Site-wide: 3,212 out of 83,873
• Since beginning of last month:
  • Site-wide: 6,824 out of 83,873

Identification of Common Adulterants in Walnut Beverage Based on Plant DNA Barcode Technology

• Downloaded 384 times
• Download rankings, all-time:
  • Site-wide: 39,343 out of 83,873
  • In molecular biology: 1,257 out of 2,814
• Year to date:
  • Site-wide: 46,328 out of 83,873
• Since beginning of last month:
  • Site-wide: 56,158 out of 83,873

A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo

• Downloaded 340 times
• Download rankings, all-time:
  • Site-wide: 44,318 out of 83,873
  • In synthetic biology: 600 out of 781
• Year to date:
  • Site-wide: 28,398 out of 83,873
• Since beginning of last month:
  • Site-wide: 17,009 out of 83,873

Tyr1 phosphorylation promotes the phosphorylation of Ser2 on the C-terminal domain of RNA polymerase II by P-TEFb

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 48,242 out of 83,873
  • In biochemistry: 1,409 out of 2,718
• Year to date:
  • Site-wide: 50,583 out of 83,873
• Since beginning of last month:
  • Site-wide: 39,265 out of 83,873

Integrated analysis of the miRNA-mRNA network associated with LMP1 gene in nasopharyngeal carcinoma

• Downloaded 278 times
• Download rankings, all-time:
  • Site-wide: 52,753 out of 83,873
  • In microbiology: 3,837 out of 7,145
• Year to date:
  • Site-wide: 43,646 out of 83,873
• Since beginning of last month:
  • Site-wide: 49,007 out of 83,873

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease

• Downloaded 277 times
• Download rankings, all-time:
  • Site-wide: 52,829 out of 83,873
  • In genetics: 3,032 out of 4,407
• Year to date:
  • Site-wide: 6,635 out of 83,873
• Since beginning of last month:
  • Site-wide: 1,904 out of 83,873

Structure of SARS-CoV-2 main protease in the apo state reveals the inactive conformation

• Downloaded 258 times
• Download rankings, all-time:
  • Site-wide: 55,634 out of 83,873
  • In biochemistry: 1,667 out of 2,718
• Year to date:
  • Site-wide: 7,384 out of 83,873
• Since beginning of last month:
  • Site-wide: 2,098 out of 83,873

LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesis

• Downloaded 258 times
• Download rankings, all-time:
  • Site-wide: 55,639 out of 83,873
  • In molecular biology: 1,801 out of 2,814
• Year to date:
  • Site-wide: 30,472 out of 83,873
• Since beginning of last month:
  • Site-wide: 50,868 out of 83,873

Altered brain function in anorexia nervosa and bulimia nervosa: A hierarchical series of task-based fMRI meta-analyses

• Downloaded 246 times
• Download rankings, all-time:
  • Site-wide: 57,418 out of 83,873
  • In neuroscience: 10,213 out of 14,943
• Year to date:
  • Site-wide: 50,403 out of 83,873
• Since beginning of last month:
  • Site-wide: 34,077 out of 83,873

Structural insights into the insecticidal Vip3A toxin of Bacillus thuringiensis

• Downloaded 237 times
• Download rankings, all-time:
  • Site-wide: 58,972 out of 83,873
  • In microbiology: 4,443 out of 7,145
• Year to date:
  • Site-wide: 8,479 out of 83,873
• Since beginning of last month:
  • Site-wide: 14,514 out of 83,873

Verification of the phenylpropanoid pinoresinol biosynthetic pathway and its glycosides in Phomopsis sp. XP-8 using 13C stable isotope labeling and liquid chromatography coupled with time-of-flight mass spectrometry

• Downloaded 233 times
• Download rankings, all-time:
  • Site-wide: 59,590 out of 83,873
  • In microbiology: 4,512 out of 7,145
• Year to date:
  • Site-wide: 50,115 out of 83,873
• Since beginning of last month:
  • Site-wide: 47,603 out of 83,873

The loss of ATRX/DAXX complex disturbs rDNA heterochromatinization and promotes development of glioma

• Downloaded 220 times
• Download rankings, all-time:
  • Site-wide: 61,660 out of 83,873
  • In cancer biology: 2,033 out of 2,926
• Year to date:
  • Site-wide: 60,363 out of 83,873
• Since beginning of last month:
  • Site-wide: 57,844 out of 83,873

Source-Sink Modifications Affect Leaf Senescence and Grain Mass in Wheat

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 61,980 out of 83,873
  • In physiology: 619 out of 1,130
• Year to date:
  • Site-wide: 48,448 out of 83,873
• Since beginning of last month:
  • Site-wide: 36,990 out of 83,873

Inferring novel lncRNA associated with Ventricular septal defect by DNA methylation interaction network

• Downloaded 211 times
• Download rankings, all-time:
  • Site-wide: 63,248 out of 83,873
  • In developmental biology: 1,975 out of 2,497
• Year to date:
  • Site-wide: 63,106 out of 83,873
• Since beginning of last month:
  • Site-wide: 80,428 out of 83,873

MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice

• Downloaded 187 times
• Download rankings, all-time:
  • Site-wide: 67,259 out of 83,873
  • In developmental biology: 2,087 out of 2,497
• Year to date:
  • Site-wide: 49,656 out of 83,873
• Since beginning of last month:
  • Site-wide: 51,808 out of 83,873

Adaptive Expansion of Taste Neuron Response Profiles by Congruent Aroma in Drosophila

• Downloaded 129 times
• Download rankings, all-time:
  • Site-wide: 75,862 out of 83,873
  • In neuroscience: 13,614 out of 14,943
• Year to date:
  • Site-wide: 58,445 out of 83,873
• Since beginning of last month:
  • Site-wide: 74,032 out of 83,873

Impact of serum calcium levels on local and total body bone mineral density: A Mendelian randomization study and an age stratum analysis

• Downloaded 98 times
• Download rankings, all-time:
  • Site-wide: 78,987 out of 83,873
  • In genetics: 4,227 out of 4,407
• Year to date:
  • Site-wide: 67,399 out of 83,873
• Since beginning of last month:
  • Site-wide: 49,107 out of 83,873

DMLDA-LocLIFT: Identification of multi-label protein subcellular localization using DMLDA dimensionality reduction and LIFT classifier

• Downloaded 77 times
• Download rankings, all-time:
  • Site-wide: 80,430 out of 83,873
  • In bioinformatics: 7,775 out of 8,043
• Year to date:
  • Site-wide: 37,946 out of 83,873
• Since beginning of last month:
  • Site-wide: 36,970 out of 83,873