Author: Yan Zhang

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Preprints

Clinical diagnosis of 8274 samples with 2019-novel coronavirus in Wuhan

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  • Site-wide: 313
  • In infectious diseases: 119
• Year to date:
  • Site-wide: 4,960
• Since beginning of last month:
  • Site-wide: 4,459

Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection

• Downloaded 10,267 times
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  • Site-wide: 732
  • In genomics: 58
• Year to date:
  • Site-wide: 1,423
• Since beginning of last month:
  • Site-wide: 1,350

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

• Downloaded 7,271 times
• Download rankings, all-time:
  • Site-wide: 1,134
  • In molecular biology: 17
• Year to date:
  • Site-wide: 14,422
• Since beginning of last month:
  • Site-wide: None

ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism

• Downloaded 6,566 times
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  • Site-wide: 1,276
  • In allergy and immunology: 7
• Year to date:
  • Site-wide: 8,955
• Since beginning of last month:
  • Site-wide: 8,129

Mapping Transcriptomic Vector Fields of Single Cells

• Downloaded 5,633 times
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  • Site-wide: 1,601
  • In systems biology: 22
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Chaos theory applied to the outbreak of Covid-19: an ancillary approach to decision-making in pandemic context

• Downloaded 2,851 times
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  • Site-wide: 4,138
  • In epidemiology: 385
• Year to date:
  • Site-wide: 16,015
• Since beginning of last month:
  • Site-wide: 10,044

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits and implications for the future

• Downloaded 2,515 times
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  • Site-wide: 4,997
  • In genetics: 230
• Year to date:
  • Site-wide: 14,441
• Since beginning of last month:
  • Site-wide: 11,064

A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

• Downloaded 2,501 times
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  • Site-wide: 5,046
  • In bioengineering: 67
• Year to date:
  • Site-wide: None
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  • Site-wide: None

ElectroPen: An ultralow-cost piezoelectric electroporator

• Downloaded 2,224 times
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  • Site-wide: 5,982
  • In bioengineering: 82
• Year to date:
  • Site-wide: 31,258
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  • Site-wide: None

Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection

• Downloaded 2,196 times
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  • Site-wide: 6,093
  • In genomics: 701
• Year to date:
  • Site-wide: 10,701
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  • Site-wide: 10,560

HiCPlus: Resolution Enhancement of Hi-C interaction heatmap

• Downloaded 2,135 times
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  • Site-wide: 6,360
  • In bioinformatics: 761
• Year to date:
  • Site-wide: 91,986
• Since beginning of last month:
  • Site-wide: 82,253

Passenger mutations in 2500 cancer genomes: Overall molecular functional impact and consequences

• Downloaded 2,089 times
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  • Site-wide: 6,535
  • In genomics: 740
• Year to date:
  • Site-wide: 23,582
• Since beginning of last month:
  • Site-wide: 62,412

Integration of Mouse and Human Single-cell RNA Sequencing Infers Spatial Cell-type Composition in Human Brains

• Downloaded 1,822 times
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  • Site-wide: 8,020
  • In bioinformatics: 985
• Year to date:
  • Site-wide: 25,002
• Since beginning of last month:
  • Site-wide: 20,196

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

• Downloaded 1,658 times
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  • Site-wide: 9,305
  • In genetics: 458
• Year to date:
  • Site-wide: 47,606
• Since beginning of last month:
  • Site-wide: 62,751

Cryo-EM structures of inactive and Gi-coupled GABAB heterodimer

• Downloaded 1,576 times
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  • Site-wide: 10,013
  • In molecular biology: 270
• Year to date:
  • Site-wide: 27,127
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  • Site-wide: 21,423

A complex structure of arrestin-2 bound to a G protein-coupled receptor

• Downloaded 1,305 times
• Download rankings, all-time:
  • Site-wide: 13,217
  • In biophysics: 318
• Year to date:
  • Site-wide: 74,395
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  • Site-wide: None

Comorbid Diabetes Mellitus was Associated with Poorer Prognosis in Patients with COVID-19: A Retrospective Cohort Study

• Downloaded 1,302 times
• Download rankings, all-time:
  • Site-wide: 13,261
  • In respiratory medicine: 45
• Year to date:
  • Site-wide: 28,954
• Since beginning of last month:
  • Site-wide: 22,362

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

• Downloaded 1,288 times
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  • Site-wide: 13,490
  • In genomics: 1,463
• Year to date:
  • Site-wide: 16,299
• Since beginning of last month:
  • Site-wide: 13,460

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

• Downloaded 1,068 times
• Download rankings, all-time:
  • Site-wide: 17,875
  • In genomics: 1,852
• Year to date:
  • Site-wide: 81,936
• Since beginning of last month:
  • Site-wide: 75,587

scTPA: A web tool for single-cell transcriptome analysis of pathway activation signatures

• Downloaded 985 times
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  • Site-wide: 20,148
  • In genomics: 2,041
• Year to date:
  • Site-wide: 12,123
• Since beginning of last month:
  • Site-wide: 8,255

Consensus interpretation of the Met34Thr and Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel

• Downloaded 960 times
• Download rankings, all-time:
  • Site-wide: 20,912
  • In genetics: 1,029
• Year to date:
  • Site-wide: 22,195
• Since beginning of last month:
  • Site-wide: 22,130

HBP: an integrative and flexible pipeline for the interaction analysis of Hi-C dataset

• Downloaded 950 times
• Download rankings, all-time:
  • Site-wide: 21,232
  • In bioinformatics: 2,547
• Year to date:
  • Site-wide: 107,761
• Since beginning of last month:
  • Site-wide: 103,884

Cryo-EM structures reveal interactions of S-OPA1 with membrane and changes upon nucleotide binding

• Downloaded 912 times
• Download rankings, all-time:
  • Site-wide: 22,516
  • In biophysics: 625
• Year to date:
  • Site-wide: 67,119
• Since beginning of last month:
  • Site-wide: None

Structural basis of bile acid receptor activation and Gs coupling

• Downloaded 892 times
• Download rankings, all-time:
  • Site-wide: 23,253
  • In biochemistry: 536
• Year to date:
  • Site-wide: 42,156
• Since beginning of last month:
  • Site-wide: 41,033

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

• Downloaded 872 times
• Download rankings, all-time:
  • Site-wide: 24,014
  • In genetics: 1,195
• Year to date:
  • Site-wide: 49,868
• Since beginning of last month:
  • Site-wide: 33,167

Comparative validation of breast cancer risk prediction models and projections for future risk stratification

• Downloaded 845 times
• Download rankings, all-time:
  • Site-wide: 25,125
  • In epidemiology: 1,345
• Year to date:
  • Site-wide: 66,809
• Since beginning of last month:
  • Site-wide: 49,562

Giant African snail genomes provide insights into molluscan whole-genome duplication and aquatic-terrestrial transition

• Downloaded 801 times
• Download rankings, all-time:
  • Site-wide: 27,009
  • In genomics: 2,548
• Year to date:
  • Site-wide: 21,997
• Since beginning of last month:
  • Site-wide: 18,495

Crystal structure of SARS-CoV-2 main protease in complex with a Chinese herb inhibitor shikonin

• Downloaded 736 times
• Download rankings, all-time:
  • Site-wide: 30,411
  • In biophysics: 931
• Year to date:
  • Site-wide: 9,937
• Since beginning of last month:
  • Site-wide: 11,885

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease

• Downloaded 694 times
• Download rankings, all-time:
  • Site-wide: 32,994
  • In genetics: 1,626
• Year to date:
  • Site-wide: 20,365
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  • Site-wide: None

Molecular Mapping Of YrTZ2, A Stripe Rust Resistance Gene In Wild Emmer Accession TZ-2 And Its Comparative Analyses With Aegilops tauschii

• Downloaded 670 times
• Download rankings, all-time:
  • Site-wide: 34,644
  • In plant biology: 720
• Year to date:
  • Site-wide: 113,681
• Since beginning of last month:
  • Site-wide: 79,425

Engineering a Functional small RNA Negative Autoregulation Network with Model-guided Design

• Downloaded 570 times
• Download rankings, all-time:
  • Site-wide: 42,535
  • In synthetic biology: 530
• Year to date:
  • Site-wide: 113,655
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  • Site-wide: None

A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo

• Downloaded 539 times
• Download rankings, all-time:
  • Site-wide: 45,653
  • In synthetic biology: 562
• Year to date:
  • Site-wide: 72,451
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  • Site-wide: None

Altered Bacteria-Fungi Inter-Kingdom Network in Gut of Ankylosing Spondylitis Patients

• Downloaded 539 times
• Download rankings, all-time:
  • Site-wide: 45,568
  • In microbiology: 2,850
• Year to date:
  • Site-wide: 95,630
• Since beginning of last month:
  • Site-wide: 94,896

Structure of SARS-CoV-2 main protease in the apo state reveals the inactive conformation

• Downloaded 524 times
• Download rankings, all-time:
  • Site-wide: 47,155
  • In biochemistry: 1,202
• Year to date:
  • Site-wide: 69,106
• Since beginning of last month:
  • Site-wide: None

Structural insights into the insecticidal Vip3A toxin of Bacillus thuringiensis

• Downloaded 517 times
• Download rankings, all-time:
  • Site-wide: 47,813
  • In microbiology: 3,000
• Year to date:
  • Site-wide: 40,532
• Since beginning of last month:
  • Site-wide: 50,466

In vivo structure and dynamics of the RNA genome of SARS-Cov-2

• Downloaded 515 times
• Download rankings, all-time:
  • Site-wide: 48,081
  • In genomics: 3,844
• Year to date:
  • Site-wide: 1,278
• Since beginning of last month:
  • Site-wide: None

Identification of Common Adulterants in Walnut Beverage Based on Plant DNA Barcode Technology

• Downloaded 486 times
• Download rankings, all-time:
  • Site-wide: 51,508
  • In molecular biology: 1,473
• Year to date:
  • Site-wide: 80,401
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  • Site-wide: None

Tyr1 phosphorylation promotes the phosphorylation of Ser2 on the C-terminal domain of RNA polymerase II by P-TEFb

• Downloaded 418 times
• Download rankings, all-time:
  • Site-wide: 60,487
  • In biochemistry: 1,627
• Year to date:
  • Site-wide: 79,752
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  • Site-wide: None

LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesis

• Downloaded 409 times
• Download rankings, all-time:
  • Site-wide: 61,779
  • In molecular biology: 1,791
• Year to date:
  • Site-wide: 54,143
• Since beginning of last month:
  • Site-wide: 45,287

Electronic blood vessel

• Downloaded 402 times
• Download rankings, all-time:
  • Site-wide: 62,878
  • In bioengineering: 1,148
• Year to date:
  • Site-wide: 58,842
• Since beginning of last month:
  • Site-wide: 39,416

Structural basis for repurpose and design of nucleoside drugs for treating COVID-19

• Downloaded 402 times
• Download rankings, all-time:
  • Site-wide: 62,844
  • In biophysics: 2,268
• Year to date:
  • Site-wide: 12,319
• Since beginning of last month:
  • Site-wide: None

The loss of ATRX/DAXX complex disturbs rDNA heterochromatinization and promotes development of glioma

• Downloaded 392 times
• Download rankings, all-time:
  • Site-wide: 64,398
  • In cancer biology: 1,839
• Year to date:
  • Site-wide: 28,102
• Since beginning of last month:
  • Site-wide: 26,563

SARS-Cov-2-, HIV-1-, Ebola-neutralizing and anti-PD1 clones are predisposed

• Downloaded 391 times
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  • Site-wide: 64,526
  • In immunology: 1,736
• Year to date:
  • Site-wide: 37,141
• Since beginning of last month:
  • Site-wide: 46,510

Integrated analysis of the miRNA-mRNA network associated with LMP1 gene in nasopharyngeal carcinoma

• Downloaded 389 times
• Download rankings, all-time:
  • Site-wide: 64,882
  • In microbiology: 4,352
• Year to date:
  • Site-wide: 67,005
• Since beginning of last month:
  • Site-wide: 73,605

Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

• Downloaded 324 times
• Download rankings, all-time:
  • Site-wide: 75,954
  • In molecular biology: 2,245
• Year to date:
  • Site-wide: 2,415
• Since beginning of last month:
  • Site-wide: 740

Source-Sink Modifications Affect Leaf Senescence and Grain Mass in Wheat

• Downloaded 315 times
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  • Site-wide: 77,888
  • In physiology: 632
• Year to date:
  • Site-wide: 70,234
• Since beginning of last month:
  • Site-wide: 91,756

Verification of the phenylpropanoid pinoresinol biosynthetic pathway and its glycosides in Phomopsis sp. XP-8 using 13C stable isotope labeling and liquid chromatography coupled with time-of-flight mass spectrometry

• Downloaded 313 times
• Download rankings, all-time:
  • Site-wide: 78,206
  • In microbiology: 5,457
• Year to date:
  • Site-wide: 62,419
• Since beginning of last month:
  • Site-wide: 74,289

Altered brain function in anorexia nervosa and bulimia nervosa: A hierarchical series of task-based fMRI meta-analyses

• Downloaded 303 times
• Download rankings, all-time:
  • Site-wide: 80,190
  • In neuroscience: 12,409
• Year to date:
  • Site-wide: 108,690
• Since beginning of last month:
  • Site-wide: 105,625

Inferring novel lncRNA associated with Ventricular septal defect by DNA methylation interaction network

• Downloaded 267 times
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  • Site-wide: 87,617
  • In developmental biology: 2,393
• Year to date:
  • Site-wide: 121,845
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  • Site-wide: None

MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice

• Downloaded 264 times
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  • Site-wide: 88,277
  • In developmental biology: 2,399
• Year to date:
  • Site-wide: 115,159
• Since beginning of last month:
  • Site-wide: 105,863

Proto-sex locus in large yellow croaker provides insights into early evolution of the sex chromosome

• Downloaded 240 times
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  • Site-wide: 93,272
  • In evolutionary biology: 5,043
• Year to date:
  • Site-wide: 69,236
• Since beginning of last month:
  • Site-wide: 46,908

Diagnostic Evidence GAuge of Single cells (DEGAS): A transfer learning framework to infer impressions of cellular and patient phenotypes between patients and single cells

• Downloaded 206 times
• Download rankings, all-time:
  • Site-wide: 100,800
  • In bioinformatics: 8,632
• Year to date:
  • Site-wide: 51,017
• Since beginning of last month:
  • Site-wide: 100,293

Calcium ion chelation preserves platelet function during cold storage

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 106,647
  • In cell biology: 4,949
• Year to date:
  • Site-wide: 31,943
• Since beginning of last month:
  • Site-wide: 39,816

Adaptive Expansion of Taste Neuron Response Profiles by Congruent Aroma in Drosophila

• Downloaded 177 times
• Download rankings, all-time:
  • Site-wide: 106,845
  • In neuroscience: 16,690
• Year to date:
  • Site-wide: 103,869
• Since beginning of last month:
  • Site-wide: 74,634

Distinct impact of IgG subclass and Fc-FcγR interaction on autoantibody pathogenicity in different IgG4-mediated diseases

• Downloaded 165 times
• Download rankings, all-time:
  • Site-wide: 109,220
  • In allergy and immunology: 111
• Year to date:
  • Site-wide: 16,248
• Since beginning of last month:
  • Site-wide: 19,386

Extracellular histones trigger disseminated intravascular coagulation by lytic cell death

• Downloaded 147 times
• Download rankings, all-time:
  • Site-wide: 112,911
  • In immunology: 3,157
• Year to date:
  • Site-wide: 69,016
• Since beginning of last month:
  • Site-wide: 57,168

DMLDA-LocLIFT: Identification of multi-label protein subcellular localization using DMLDA dimensionality reduction and LIFT classifier

• Downloaded 145 times
• Download rankings, all-time:
  • Site-wide: 113,160
  • In bioinformatics: 9,351
• Year to date:
  • Site-wide: 99,377
• Since beginning of last month:
  • Site-wide: 70,013

Impact of serum calcium levels on local and total body bone mineral density: A Mendelian randomization study and an age stratum analysis

• Downloaded 129 times
• Download rankings, all-time:
  • Site-wide: 116,263
  • In genetics: 5,050
• Year to date:
  • Site-wide: 115,081
• Since beginning of last month:
  • Site-wide: 82,615

Novel Vβ specific germline contacts shape an elite controller T cell response

• Downloaded 124 times
• Download rankings, all-time:
  • Site-wide: 117,054
  • In immunology: 3,295
• Year to date:
  • Site-wide: 64,302
• Since beginning of last month:
  • Site-wide: 39,596

Vitamin B12 and Risk of Diabetes: New insight from Cross-Sectional and Longitudinal Analyses of the China Stroke Primary Prevention Trial (CSPPT)

• Downloaded 116 times
• Download rankings, all-time:
  • Site-wide: 118,605
  • In epidemiology: 4,778
• Year to date:
  • Site-wide: 90,686
• Since beginning of last month:
  • Site-wide: 47,951

Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis

• Downloaded 114 times
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  • Site-wide: 118,960
  • In biochemistry: 3,580
• Year to date:
  • Site-wide: 104,952
• Since beginning of last month:
  • Site-wide: None

Protocell Arrays for Simultaneous Detection of Diverse Analytes

• Downloaded 104 times
• Download rankings, all-time:
  • Site-wide: 120,698
  • In synthetic biology: 1,000
• Year to date:
  • Site-wide: 11,512
• Since beginning of last month:
  • Site-wide: 3,522

Conversion between 100-million-year-old duplicated genes contributes to rice subspecies divergence

• Downloaded 90 times
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  • Site-wide: 122,996
  • In bioinformatics: 9,879
• Year to date:
  • Site-wide: 48,088
• Since beginning of last month:
  • Site-wide: 101,863

Seasonal variations in soil fungal communities and co-occurrence networks along an altitudinal gradient in the cold temperate zone of China: A case study on Oakley Mountain

• Downloaded 86 times
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  • Site-wide: 123,465
  • In ecology: 4,616
• Year to date:
  • Site-wide: 97,895
• Since beginning of last month:
  • Site-wide: 100,123

Characterisation of bacteriophage JD419, a Staphylococcal phage with an unusual morphology and broad host range

• Downloaded 68 times
• Download rankings, all-time:
  • Site-wide: 125,846
  • In microbiology: 9,786
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Transcriptome analysis of an albino mutant in Haworthia cooperi var. pilifera

• Downloaded 68 times
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  • Site-wide: 125,885
  • In genetics: 5,313
• Year to date:
  • Site-wide: 87,026
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  • Site-wide: 84,466

Scavenger receptor A1 participates in the phagocytosis of Leptospira interrogans and leads to subsequent high inflammatory responses and bacterial dissemination in leptospirosis

• Downloaded 52 times
• Download rankings, all-time:
  • Site-wide: 127,173
  • In microbiology: 9,937
• Year to date:
  • Site-wide: 98,345
• Since beginning of last month:
  • Site-wide: 84,863