Author: Yan Zhang

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Preprints

Atmospheric particulate matter aggravates CNS demyelination via TLR-4/NF-κB-mediated microglia pathogenic activities

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Clinical diagnosis of 8274 samples with 2019-novel coronavirus in Wuhan

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  • Site-wide: 374
  • In infectious diseases: 142
• Year to date:
  • Site-wide: 5,905
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  • Site-wide: 41,582

Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection

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  • Site-wide: 806
  • In genomics: 53
• Year to date:
  • Site-wide: 1,643
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Mapping Transcriptomic Vector Fields of Single Cells

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  • Site-wide: 1,110
  • In systems biology: 14
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  • Site-wide: 8,638

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

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  • Site-wide: 1,393
  • In molecular biology: 26
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  • Site-wide: 19,441
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  • Site-wide: 18,643

ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism

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  • Site-wide: 1,537
  • In allergy and immunology: 11
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  • Site-wide: 32,179

Chaos theory applied to the outbreak of Covid-19: an ancillary approach to decision-making in pandemic context

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  • Site-wide: 4,831
  • In epidemiology: 460
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  • Site-wide: 23,335
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A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

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  • Site-wide: 5,016
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  • Site-wide: 15,714
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  • Site-wide: 32,649

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits and implications for the future

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  • Site-wide: 5,687
  • In genetics: 241
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  • Site-wide: 22,222
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  • Site-wide: 68,253

ElectroPen: An ultralow-cost piezoelectric electroporator

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  • Site-wide: 6,605
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  • Site-wide: 22,575
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Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection

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  • Site-wide: 6,947
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  • Site-wide: 19,912

HiCPlus: Resolution Enhancement of Hi-C interaction heatmap

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  • Site-wide: 7,751
  • In bioinformatics: 872
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  • Site-wide: 95,211
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  • Site-wide: 31,203

Passenger mutations in 2500 cancer genomes: Overall molecular functional impact and consequences

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  • Site-wide: 8,020
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  • Site-wide: 63,394
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Integration of Mouse and Human Single-cell RNA Sequencing Infers Spatial Cell-type Composition in Human Brains

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  • Site-wide: 8,938
  • In bioinformatics: 1,026
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Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

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  • Site-wide: 10,716
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Cryo-EM structures of inactive and Gi-coupled GABAB heterodimer

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  • Site-wide: 11,277
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Comorbid Diabetes Mellitus was Associated with Poorer Prognosis in Patients with COVID-19: A Retrospective Cohort Study

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  • Site-wide: 13,690
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  • Site-wide: 42,912

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

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  • Site-wide: 14,488
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  • Site-wide: 88,013

A complex structure of arrestin-2 bound to a G protein-coupled receptor

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  • Site-wide: 14,759
  • In biophysics: 344
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  • Site-wide: 14,715

scTPA: A web tool for single-cell transcriptome analysis of pathway activation signatures

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  • Site-wide: 17,719
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  • Site-wide: 14,037
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  • Site-wide: 113,033

HBP: an integrative and flexible pipeline for the interaction analysis of Hi-C dataset

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  • Site-wide: 20,618
  • In bioinformatics: 2,367
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5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

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  • Site-wide: 21,426
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Giant African snail genomes provide insights into molluscan whole-genome duplication and aquatic-terrestrial transition

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  • Site-wide: 21,804
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Consensus interpretation of the Met34Thr and Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel

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  • Site-wide: 22,614
  • In genetics: 1,033
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  • Site-wide: 68,000

Crystal structure of SARS-CoV-2 main protease in complex with a Chinese herb inhibitor shikonin

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  • Site-wide: 24,528
  • In biophysics: 668
• Year to date:
  • Site-wide: 13,178
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  • Site-wide: 72,372

Cryo-EM structures reveal interactions of S-OPA1 with membrane and changes upon nucleotide binding

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  • Site-wide: 24,688
  • In biophysics: 671
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  • Site-wide: 63,428
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  • Site-wide: 28,212

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

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  • Site-wide: 27,092
  • In genetics: 1,237
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  • Site-wide: 71,514
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  • Site-wide: 98,112

Structural basis of bile acid receptor activation and Gs coupling

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  • Site-wide: 27,141
  • In biochemistry: 613
• Year to date:
  • Site-wide: 83,035
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Comparative validation of breast cancer risk prediction models and projections for future risk stratification

• Downloaded 930 times
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  • Site-wide: 27,463
  • In epidemiology: 1,533
• Year to date:
  • Site-wide: 65,090
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  • Site-wide: 17,399

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease

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  • Site-wide: 33,084
  • In genetics: 1,523
• Year to date:
  • Site-wide: 35,167
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  • Site-wide: 41,077

In vivo structure and dynamics of the RNA genome of SARS-Cov-2

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  • Site-wide: 37,193
  • In genomics: 3,091
• Year to date:
  • Site-wide: 4,993
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  • Site-wide: 74,199

Molecular Mapping Of YrTZ2, A Stripe Rust Resistance Gene In Wild Emmer Accession TZ-2 And Its Comparative Analyses With Aegilops tauschii

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  • Site-wide: 41,185
  • In plant biology: 853
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  • Site-wide: 136,686
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  • Site-wide: None

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

• Downloaded 632 times
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  • Site-wide: 46,530
  • In molecular biology: 1,336
• Year to date:
  • Site-wide: 6,393
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  • Site-wide: 65,723

Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

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  • Site-wide: 46,833
  • In molecular biology: 1,341
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  • Site-wide: 6,427
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  • Site-wide: 123,896

A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo

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  • Site-wide: 46,844
  • In synthetic biology: 582
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  • Site-wide: 39,603

Structure of SARS-CoV-2 main protease in the apo state reveals the inactive conformation

• Downloaded 627 times
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  • Site-wide: 47,043
  • In biochemistry: 1,191
• Year to date:
  • Site-wide: 55,956
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  • Site-wide: 40,807

Engineering a Functional small RNA Negative Autoregulation Network with Model-guided Design

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  • Site-wide: 47,215
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  • Site-wide: 52,086

Structural insights into the insecticidal Vip3A toxin of Bacillus thuringiensis

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  • Site-wide: 49,401
  • In microbiology: 3,056
• Year to date:
  • Site-wide: 56,924
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  • Site-wide: 96,927

Structural basis for repurpose and design of nucleoside drugs for treating COVID-19

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  • Site-wide: 49,395
  • In biophysics: 1,625
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  • Site-wide: 18,930
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  • Site-wide: 29,391

Imaging sensory transmission and neuronal plasticity in primary sensory neurons with genetically-encoded voltage indicators

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  • Site-wide: 50,418
  • In neuroscience: 7,153
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  • Site-wide: 2,024

Altered Bacteria-Fungi Inter-Kingdom Network in Gut of Ankylosing Spondylitis Patients

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  • Site-wide: 53,306
  • In microbiology: 3,341
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Identification of Common Adulterants in Walnut Beverage Based on Plant DNA Barcode Technology

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  • Site-wide: 55,736
  • In molecular biology: 1,564
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  • Site-wide: 51,786

Electronic blood vessel

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  • Site-wide: 66,327
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  • Site-wide: 69,559

The loss of ATRX/DAXX complex disturbs rDNA heterochromatinization and promotes development of glioma

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  • Site-wide: 67,457
  • In cancer biology: 1,947
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  • Site-wide: 99,085

Tyr1 phosphorylation promotes the phosphorylation of Ser2 on the C-terminal domain of RNA polymerase II by P-TEFb

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  • Site-wide: 67,865
  • In biochemistry: 1,825
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  • Site-wide: 49,443

SARS-Cov-2-, HIV-1-, Ebola-neutralizing and anti-PD1 clones are predisposed

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LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesis

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  • Site-wide: 69,927
  • In molecular biology: 1,992
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  • Site-wide: 102,923

Using structurally fungible biosensors to evolve improved alkaloid biosyntheses

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  • Site-wide: 71,517
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  • Site-wide: 80,176

Integrated analysis of the miRNA-mRNA network associated with LMP1 gene in nasopharyngeal carcinoma

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  • Site-wide: 72,959
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  • Site-wide: 77,626

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

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  • Site-wide: 84,691
  • In molecular biology: 2,482
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  • Site-wide: 127,433

Verification of the phenylpropanoid pinoresinol biosynthetic pathway and its glycosides in Phomopsis sp. XP-8 using 13C stable isotope labeling and liquid chromatography coupled with time-of-flight mass spectrometry

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  • Site-wide: 84,620
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  • Site-wide: 50,344

Diagnostic Evidence GAuge of Single cells (DEGAS): A flexible deep-transfer learning framework for prioritizing cells in relation to disease

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  • Site-wide: 85,200
  • In bioinformatics: 7,650
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  • Site-wide: 35,734
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  • Site-wide: 14,264

Source-Sink Modifications Affect Leaf Senescence and Grain Mass in Wheat

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  • Site-wide: 90,574
  • In physiology: 758
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  • Site-wide: 124,737
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  • Site-wide: 35,477

Altered brain function in anorexia nervosa and bulimia nervosa: A hierarchical series of task-based fMRI meta-analyses

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  • Site-wide: 90,565
  • In neuroscience: 13,597
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  • Site-wide: 122,558
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  • Site-wide: 95,782

MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice

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  • Site-wide: 94,890
  • In developmental biology: 2,548
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  • Site-wide: 98,775
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  • Site-wide: 19,039

Proto-sex locus in large yellow croaker provides insights into early evolution of the sex chromosome

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  • Site-wide: 97,516
  • In evolutionary biology: 5,008
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  • Site-wide: 48,187

Inferring novel lncRNA associated with Ventricular septal defect by DNA methylation interaction network

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  • Site-wide: 100,084
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  • Site-wide: 40,212

Protocell Arrays for Simultaneous Detection of Diverse Analytes

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  • Site-wide: 105,449
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  • Site-wide: 21,381
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  • Site-wide: 124,361

Distinct impact of IgG subclass and Fc-FcγR interaction on autoantibody pathogenicity in different IgG4-mediated diseases

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  • Site-wide: 111,727
  • In allergy and immunology: 170
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  • Site-wide: 32,207

Calcium ion chelation preserves platelet function during cold storage

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  • Site-wide: 113,016
  • In cell biology: 5,222
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  • Site-wide: 63,634
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  • Site-wide: 123,160

High-throughput, label-free and slide-free histological imaging by computational microscopy and unsupervised learning

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  • Site-wide: 116,712
  • In bioengineering: 2,308
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  • Site-wide: 127,196

Extracellular histones trigger disseminated intravascular coagulation by lytic cell death

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  • Site-wide: 123,187
  • In immunology: 3,640
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  • Site-wide: 16,750

Altered O-glycosylation Level of SARS-CoV-2 Spike Protein by Host O-glycosyltransferase Strengthens Its Trimeric Structure

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  • Site-wide: 123,745
  • In biochemistry: 3,685
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  • Site-wide: 17,869

Adaptive Expansion of Taste Neuron Response Profiles by Congruent Aroma in Drosophila

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  • Site-wide: 124,595
  • In neuroscience: 18,849
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Dynamics of synthetic yeast chromosome evolution shaped by hierarchical chromatin organization

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  • Site-wide: 124,851
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  • Site-wide: 32,984
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  • Site-wide: 127,173

Vitamin B12 and Risk of Diabetes: New insight from Cross-Sectional and Longitudinal Analyses of the China Stroke Primary Prevention Trial (CSPPT)

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  • Site-wide: 126,780
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DMLDA-LocLIFT: Identification of multi-label protein subcellular localization using DMLDA dimensionality reduction and LIFT classifier

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  • Site-wide: 130,339
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Structural insights into ligand recognition and activation of the melanocortin-4 receptor

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  • Site-wide: 130,857
  • In molecular biology: 3,895
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  • Site-wide: 81,230

Seasonal variations in soil fungal communities and co-occurrence networks along an altitudinal gradient in the cold temperate zone of China: A case study on Oakley Mountain

• Downloaded 168 times
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  • Site-wide: 131,133
  • In ecology: 4,495
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  • Site-wide: 71,763
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  • Site-wide: 88,261

Novel Vβ specific germline contacts shape an elite controller T cell response

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  • Site-wide: 131,776
  • In immunology: 3,904
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  • Site-wide: 99,293
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  • Site-wide: 25,721

Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis

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  • Site-wide: 133,734
  • In biochemistry: 4,038
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  • Site-wide: 18,318

Point-of-care analyte quantification and digital readout via lysate-based cell-free biosensors interfaced with personal glucose monitors

• Downloaded 148 times
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  • Site-wide: 135,587
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Conversion between 100-million-year-old duplicated genes contributes to rice subspecies divergence

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  • Site-wide: 25,716

Impact of serum calcium levels on local and total body bone mineral density: A Mendelian randomization study and an age stratum analysis

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  • Site-wide: 136,772
  • In genetics: 5,517
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  • Site-wide: 149,399
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Metabolic Dynamics in Escherichia coli-based Cell-Free Systems

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  • Site-wide: 138,365
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  • Site-wide: 68,552

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

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  • Site-wide: 142,961
  • In molecular biology: 4,276
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  • Site-wide: 60,033
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  • Site-wide: 64,799

Transcriptome analysis of an albino mutant in Haworthia cooperi var. pilifera

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  • Site-wide: 143,653
  • In genetics: 5,709
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Mast cell-specific receptor/corticotropin-releasing factor axis regulates alcohol withdrawal-associated headache

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  • Site-wide: 143,833
  • In neuroscience: 21,566
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  • Site-wide: 62,346
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  • Site-wide: 64,744

Characterisation of bacteriophage JD419, a Staphylococcal phage with an unusual morphology and broad host range

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  • Site-wide: 144,917
  • In microbiology: 11,039
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  • Site-wide: 131,626
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Capsaicin pretreatment alleviates postoperative pain and reduces primary sensory neuron Ca2+ activity

• Downloaded 94 times
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  • Site-wide: 146,406
  • In neuroscience: 21,937
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  • Site-wide: 71,139
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  • Site-wide: 81,839

The mediating role of epigenetic clocks underlying educational inequalities in mortality: a multi-cohort study

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  • Site-wide: 147,183
  • In epidemiology: 6,078
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  • Site-wide: 74,286
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  • Site-wide: 10,899

Scavenger receptor A1 participates in the phagocytosis of Leptospira interrogans and leads to subsequent high inflammatory responses and bacterial dissemination in leptospirosis

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  • Site-wide: 147,223
  • In microbiology: 11,294
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  • Site-wide: 118,846

Meclizine and metabotropic glutamate receptor agonists attenuate severe pain and primary sensory neuron Ca2+ activity in chemotherapy-induced peripheral neuropathy

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Three-dimensional label-free histological imaging of whole organs by microtomy-assisted autofluorescence tomography

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Constitutive signal bias mediated by the human GHRHR splice variant 1

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The genome sequence of Sorbus pohuashanensis provides insights into population evolution and leaf sunburn response

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Structures of full-length glycoprotein hormone receptor signaling complexes

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