Author: Aki S Havulinna

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Preprints

Association of Structural Variation with Cardiometabolic Traits in Finns

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Taxonomic Signatures of Long-Term Mortality Risk in Human Gut Microbiota

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers

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Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

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Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity

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Elevated alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality

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Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

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Refining fine-mapping: effect sizes and regional heritability

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Genomic prediction of coronary heart disease

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Genetics of human plasma lipidome: Understanding lipid metabolism and its link to diseases beyond traditional lipids

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Haplotype sharing provides insights into fine-scale population history and disease in Finland

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  • Site-wide: 16,027
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Geographic variation and bias in polygenic scores of complex diseases and traits in Finland

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Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

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Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

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Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma

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An interaction map of circulating metabolites, immune gene networks and their genetic regulation

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Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort

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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

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The landscape of incident disease risk for the biomarker GlycA and its mortality stratification in angiography patients

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Links between gut microbiome composition and fatty liver disease in a large population sample

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Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease

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Polygenic Hyperlipidemias and Coronary Artery Disease Risk

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Coronary artery disease risk and lipidomic profiles are similar in familial and population-ascertained hyperlipidemias

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High Density Lipoprotein pathway as a therapeutic target for coronary heart disease: individual participant meta-analysis in 28,597 individuals with 4197 coronary events

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  • Site-wide: 83,957
  • In cardiovascular medicine: 128
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An efficient and accurate frailty model approach for genome-wide survival association analysis controlling for population structure and relatedness in large-scale biobanks

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Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health

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  • Site-wide: 90,541
  • In genetics: 4,205
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Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal Structure

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  • In genetic and genomic medicine: 463
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