Author: Mika Ala-Korpela

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Preprints

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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Elevated alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality

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  • In systems biology: 178
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Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

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Efficient estimation and applications of cross-validated genetic predictions

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Machine Learning in Multi-Omics Data to Assess Longitudinal Predictors of Glycaemic Health

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Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

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  • In epidemiology: 1,223
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Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

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Lower hemoglobin levels associate with lower body mass index and healthier metabolic profile

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High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease

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An interaction map of circulating metabolites, immune gene networks and their genetic regulation

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Genetic and environmental perturbations lead to regulatory decoherence

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Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

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  • In epidemiology: 1,836
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Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

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  • In epidemiology: 1,965
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Metabolic Effects Of Risk Alleles In PNPLA3, TM6SF2, GCKR, And LYPLAL1 Inform About Heterogeneity Of Non-Alcoholic Fatty Liver Disease

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Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics

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Metabolic signatures of birth weight in 18288 adolescents and adults

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Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

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Direct estimation of HDL-mediated cholesterol efflux capacity from serum

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The landscape of incident disease risk for the biomarker GlycA and its mortality stratification in angiography patients

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  • Site-wide: 58,494
  • In epidemiology: 2,522
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Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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  • In genetics: 3,295
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The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

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  • Site-wide: 72,189
  • In epidemiology: 3,029
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Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

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Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease

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  • Site-wide: 80,353
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Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis

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  • Site-wide: 96,871
  • In cardiovascular medicine: 180
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Metabolic biomarkers for peripheral artery disease compared with coronary artery disease: Lipoprotein and metabolite profiling of 31,657 individuals from five prospective cohorts

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  • In epidemiology: 4,068
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A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation

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  • In epidemiology: 4,080
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Apt interpretation of comprehensive lipoprotein data in large-scale epidemiology - disclosure of fundamental structural and metabolic relationships

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  • In epidemiology: 4,815
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Elevated glycoprotein acetyl levels in adolescence and early adulthood predict adverse cardiometabolic profiles and risk of metabolic syndrome in up to 10 year follow-up

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  • Site-wide: 117,408
  • In cardiovascular medicine: 279
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Metabolic subgroups and cardiometabolic multimorbidity in the UK Biobank

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