Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 66,973 bioRxiv papers from 294,811 authors.

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Preprints

An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease

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A reference panel of 64,976 haplotypes for genotype imputation

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Phenome-wide association studies (PheWAS) across large "real-world data" population cohorts support drug target validation

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • In genetics: 165 out of 3,772
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Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

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Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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Cell specific eQTL analysis without sorting cells

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Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers

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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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metaCCA: Summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis

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  • In bioinformatics: 810 out of 6,609
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 3,331 out of 67,014

Genomic prediction of coronary heart disease

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Refining fine-mapping: effect sizes and regional heritability

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  • In genetics: 555 out of 3,772
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Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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  • In genetics: 571 out of 3,772
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  • Site-wide: 1,721 out of 67,014

Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

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Haplotype sharing provides insights into fine-scale population history and disease in Finland

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• Year to date:
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Narrow-sense heritability estimation of complex traits using identity-by-descent information.

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  • In genetics: 661 out of 3,772
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  • Site-wide: 23,165 out of 67,014

Genetics of human plasma lipidome: Understanding lipid metabolism and its link to diseases beyond traditional lipids

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  • In genetics: 675 out of 3,772
• Year to date:
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  • Site-wide: 17,207 out of 67,014

Geographic variation and bias in polygenic scores of complex diseases and traits in Finland

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  • In genetics: 729 out of 3,772
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  • Site-wide: 25,345 out of 67,014

Elevated alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality

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  • In systems biology: 292 out of 1,861
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  • Site-wide: 4,398 out of 67,014
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  • Site-wide: 9,545 out of 67,014

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

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  • In epidemiology: 118 out of 1,556
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  • Site-wide: 2,889 out of 67,014
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  • Site-wide: 22,783 out of 67,014

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

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  • In genomics: 1,676 out of 4,553
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  • Site-wide: 5,624 out of 67,014

The rate of false polymorphisms introduced when imputing genotypes from global imputation panels

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  • Site-wide: 35,922 out of 67,014

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

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Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

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  • Site-wide: 22,695 out of 67,014

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 35,130 out of 67,014

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

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  • In epidemiology: 222 out of 1,556
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  • Site-wide: 58,551 out of 67,014

Metabolic profiling of alcohol consumption in 9778 young adults

• Downloaded 496 times
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  • In systems biology: 622 out of 1,861
• Year to date:
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Contribution of rare and common variants to intellectual disability in a high-risk population sub-isolate of Northern Finland

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Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

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A Comprehensive Evaluation of the Genetic Architecture of Sudden Cardiac Arrest

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Whole genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

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Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

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  • Site-wide: 17,830 out of 67,014

Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

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  • Site-wide: 16,614 out of 67,014

Direct estimation of HDL-mediated cholesterol efflux capacity from serum

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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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The landscape of incident disease risk for the biomarker GlycA and its mortality stratification in angiography patients

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Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

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Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease

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Coronary artery disease risk and lipidomic profiles are similar in familial and population-ascertained hyperlipidemias

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Polygenic Hyperlipidemias and Coronary Artery Disease Risk

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