Author: Veikko Salomaa

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Preprints

A reference panel of 64,976 haplotypes for genotype imputation

• Downloaded 4,601 times
• Download rankings, all-time:
  • Site-wide: 2,565
  • In genetics: 86
• Year to date:
  • Site-wide: 107,894
• Since beginning of last month:
  • Site-wide: 114,986

Taxonomic Signatures of Long-Term Mortality Risk in Human Gut Microbiota

• Downloaded 3,645 times
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  • Site-wide: 3,587
  • In epidemiology: 352
• Year to date:
  • Site-wide: 12,953
• Since beginning of last month:
  • Site-wide: 16,084

Phenome-wide association studies (PheWAS) across large "real-world data" population cohorts support drug target validation

• Downloaded 3,569 times
• Download rankings, all-time:
  • Site-wide: 3,695
  • In genetics: 132
• Year to date:
  • Site-wide: 46,549
• Since beginning of last month:
  • Site-wide: 62,448

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,214 times
• Download rankings, all-time:
  • Site-wide: 4,283
  • In genetics: 168
• Year to date:
  • Site-wide: 30,787
• Since beginning of last month:
  • Site-wide: 7,397

Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers

• Downloaded 2,874 times
• Download rankings, all-time:
  • Site-wide: 5,011
  • In genomics: 516
• Year to date:
  • Site-wide: 25,998
• Since beginning of last month:
  • Site-wide: 23,034

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

• Downloaded 2,570 times
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  • Site-wide: 5,891
  • In genetics: 254
• Year to date:
  • Site-wide: 22,126
• Since beginning of last month:
  • Site-wide: 36,465

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• Downloaded 2,527 times
• Download rankings, all-time:
  • Site-wide: 6,056
  • In genetics: 262
• Year to date:
  • Site-wide: 107,946
• Since beginning of last month:
  • Site-wide: 119,153

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

• Downloaded 2,328 times
• Download rankings, all-time:
  • Site-wide: 6,834
  • In genetics: 306
• Year to date:
  • Site-wide: 103,386
• Since beginning of last month:
  • Site-wide: 74,095

Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity

• Downloaded 2,266 times
• Download rankings, all-time:
  • Site-wide: 7,101
  • In microbiology: 418
• Year to date:
  • Site-wide: 5,465
• Since beginning of last month:
  • Site-wide: 11,533

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

• Downloaded 2,103 times
• Download rankings, all-time:
  • Site-wide: 7,919
  • In genomics: 835
• Year to date:
  • Site-wide: 137,567
• Since beginning of last month:
  • Site-wide: 143,079

Cell specific eQTL analysis without sorting cells

• Downloaded 2,013 times
• Download rankings, all-time:
  • Site-wide: 8,431
  • In genetics: 368
• Year to date:
  • Site-wide: 128,985
• Since beginning of last month:
  • Site-wide: 132,349

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,874 times
• Download rankings, all-time:
  • Site-wide: 9,407
  • In genetics: 416
• Year to date:
  • Site-wide: 99,308
• Since beginning of last month:
  • Site-wide: 116,365

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,823 times
• Download rankings, all-time:
  • Site-wide: 9,781
  • In genetics: 441
• Year to date:
  • Site-wide: 64,228
• Since beginning of last month:
  • Site-wide: 105,036

Elevated alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality

• Downloaded 1,772 times
• Download rankings, all-time:
  • Site-wide: 10,206
  • In systems biology: 186
• Year to date:
  • Site-wide: 30,494
• Since beginning of last month:
  • Site-wide: 62,754

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,716 times
• Download rankings, all-time:
  • Site-wide: 10,678
  • In genetics: 482
• Year to date:
  • Site-wide: 59,622
• Since beginning of last month:
  • Site-wide: 51,600

metaCCA: Summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis

• Downloaded 1,608 times
• Download rankings, all-time:
  • Site-wide: 11,782
  • In bioinformatics: 1,383
• Year to date:
  • Site-wide: 101,554
• Since beginning of last month:
  • Site-wide: 139,993

Refining fine-mapping: effect sizes and regional heritability

• Downloaded 1,556 times
• Download rankings, all-time:
  • Site-wide: 12,318
  • In genetics: 568
• Year to date:
  • Site-wide: 30,794
• Since beginning of last month:
  • Site-wide: 23,841

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,493 times
• Download rankings, all-time:
  • Site-wide: 13,089
  • In genetics: 606
• Year to date:
  • Site-wide: 100,102
• Since beginning of last month:
  • Site-wide: 95,638

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,476 times
• Download rankings, all-time:
  • Site-wide: 13,318
  • In genomics: 1,379
• Year to date:
  • Site-wide: 96,509
• Since beginning of last month:
  • Site-wide: 106,026

Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

• Downloaded 1,462 times
• Download rankings, all-time:
  • Site-wide: 13,510
  • In genomics: 1,393
• Year to date:
  • Site-wide: 78,716
• Since beginning of last month:
  • Site-wide: 73,441

Genetics of human plasma lipidome: Understanding lipid metabolism and its link to diseases beyond traditional lipids

• Downloaded 1,194 times
• Download rankings, all-time:
  • Site-wide: 18,343
  • In genetics: 861
• Year to date:
  • Site-wide: 80,394
• Since beginning of last month:
  • Site-wide: 74,379

Genomic prediction of coronary heart disease

• Downloaded 1,181 times
• Download rankings, all-time:
  • Site-wide: 18,647
  • In genomics: 1,832
• Year to date:
  • Site-wide: 121,679
• Since beginning of last month:
  • Site-wide: 97,677

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,160 times
• Download rankings, all-time:
  • Site-wide: 19,147
  • In genetics: 899
• Year to date:
  • Site-wide: 92,251
• Since beginning of last month:
  • Site-wide: 81,983

Haplotype sharing provides insights into fine-scale population history and disease in Finland

• Downloaded 1,148 times
• Download rankings, all-time:
  • Site-wide: 19,466
  • In genetics: 914
• Year to date:
  • Site-wide: 80,230
• Since beginning of last month:
  • Site-wide: 106,178

Genome-wide association and Mendelian randomization analysis prioritizes bioactive metabolites with putative causal effects on common diseases

• Downloaded 1,054 times
• Download rankings, all-time:
  • Site-wide: 22,038
  • In genetic and genomic medicine: 86
• Year to date:
  • Site-wide: 17,257
• Since beginning of last month:
  • Site-wide: 25,239

Geographic variation and bias in polygenic scores of complex diseases and traits in Finland

• Downloaded 1,044 times
• Download rankings, all-time:
  • Site-wide: 22,381
  • In genetics: 1,036
• Year to date:
  • Site-wide: 128,607
• Since beginning of last month:
  • Site-wide: 139,885

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

• Downloaded 1,041 times
• Download rankings, all-time:
  • Site-wide: 22,502
  • In epidemiology: 1,335
• Year to date:
  • Site-wide: 69,103
• Since beginning of last month:
  • Site-wide: 59,327

OGUs enable effective, phylogeny-aware analysis of even shallow metagenome community structures

• Downloaded 1,012 times
• Download rankings, all-time:
  • Site-wide: 23,387
  • In bioinformatics: 2,697
• Year to date:
  • Site-wide: 2,725
• Since beginning of last month:
  • Site-wide: 4,568

Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort

• Downloaded 997 times
• Download rankings, all-time:
  • Site-wide: 23,876
  • In genetic and genomic medicine: 94
• Year to date:
  • Site-wide: 16,353
• Since beginning of last month:
  • Site-wide: 19,880

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 983 times
• Download rankings, all-time:
  • Site-wide: 24,428
  • In genetics: 1,133
• Year to date:
  • Site-wide: 21,813
• Since beginning of last month:
  • Site-wide: 30,384

The rate of false polymorphisms introduced when imputing genotypes from global imputation panels

• Downloaded 983 times
• Download rankings, all-time:
  • Site-wide: 24,415
  • In genetics: 1,132
• Year to date:
  • Site-wide: 105,459
• Since beginning of last month:
  • Site-wide: 104,530

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

• Downloaded 979 times
• Download rankings, all-time:
  • Site-wide: 24,564
  • In genomics: 2,299
• Year to date:
  • Site-wide: 100,510
• Since beginning of last month:
  • Site-wide: 80,834

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

• Downloaded 792 times
• Download rankings, all-time:
  • Site-wide: 33,129
  • In genomics: 2,864
• Year to date:
  • Site-wide: 107,913
• Since beginning of last month:
  • Site-wide: 94,164

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 769 times
• Download rankings, all-time:
  • Site-wide: 34,472
  • In genomics: 2,943
• Year to date:
  • Site-wide: 109,682
• Since beginning of last month:
  • Site-wide: 80,620

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

• Downloaded 742 times
• Download rankings, all-time:
  • Site-wide: 36,247
  • In genomics: 3,055
• Year to date:
  • Site-wide: 144,101
• Since beginning of last month:
  • Site-wide: 146,215

An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease

• Downloaded 739 times
• Download rankings, all-time:
  • Site-wide: 36,473
  • In genetics: 1,681
• Year to date:
  • Site-wide: 26,543
• Since beginning of last month:
  • Site-wide: 38,310

Links between gut microbiome composition and fatty liver disease in a large population sample

• Downloaded 693 times
• Download rankings, all-time:
  • Site-wide: 39,755
  • In gastroenterology: 37
• Year to date:
  • Site-wide: 19,761
• Since beginning of last month:
  • Site-wide: 35,528

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

• Downloaded 671 times
• Download rankings, all-time:
  • Site-wide: 41,492
  • In epidemiology: 2,033
• Year to date:
  • Site-wide: 122,362
• Since beginning of last month:
  • Site-wide: 104,195

Early prediction of liver disease using conventional risk factors and gut microbiome-augmented gradient boosting

• Downloaded 654 times
• Download rankings, all-time:
  • Site-wide: 42,844
  • In genetic and genomic medicine: 164
• Year to date:
  • Site-wide: 27,519
• Since beginning of last month:
  • Site-wide: 16,362

Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

• Downloaded 641 times
• Download rankings, all-time:
  • Site-wide: 43,961
  • In genomics: 3,534
• Year to date:
  • Site-wide: 87,602
• Since beginning of last month:
  • Site-wide: 124,330

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 636 times
• Download rankings, all-time:
  • Site-wide: 44,466
  • In genetics: 2,011
• Year to date:
  • Site-wide: 93,156
• Since beginning of last month:
  • Site-wide: 81,019

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

• Downloaded 634 times
• Download rankings, all-time:
  • Site-wide: 44,599
  • In genomics: 3,572
• Year to date:
  • Site-wide: 64,369
• Since beginning of last month:
  • Site-wide: 69,136

Metabolic profiling of alcohol consumption in 9778 young adults

• Downloaded 623 times
• Download rankings, all-time:
  • Site-wide: 45,563
  • In systems biology: 1,011
• Year to date:
  • Site-wide: 94,488
• Since beginning of last month:
  • Site-wide: 137,357

Contribution of rare and common variants to intellectual disability in a high-risk population sub-isolate of Northern Finland

• Downloaded 596 times
• Download rankings, all-time:
  • Site-wide: 48,126
  • In genetics: 2,169
• Year to date:
  • Site-wide: 125,642
• Since beginning of last month:
  • Site-wide: 88,585

A Comprehensive Evaluation of the Genetic Architecture of Sudden Cardiac Arrest

• Downloaded 589 times
• Download rankings, all-time:
  • Site-wide: 48,885
  • In genetics: 2,199
• Year to date:
  • Site-wide: 109,848
• Since beginning of last month:
  • Site-wide: 114,167

Communicating polygenic and non-genetic risk for atherosclerotic cardiovascular disease - An observational follow-up study

• Downloaded 577 times
• Download rankings, all-time:
  • Site-wide: 50,125
  • In genetic and genomic medicine: 194
• Year to date:
  • Site-wide: 28,135
• Since beginning of last month:
  • Site-wide: 46,918

Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

• Downloaded 535 times
• Download rankings, all-time:
  • Site-wide: 54,987
  • In genomics: 4,161
• Year to date:
  • Site-wide: 142,213
• Since beginning of last month:
  • Site-wide: 138,207

Whole genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

• Downloaded 486 times
• Download rankings, all-time:
  • Site-wide: 61,449
  • In genetics: 2,752
• Year to date:
  • Site-wide: 146,027
• Since beginning of last month:
  • Site-wide: 131,405

Direct estimation of HDL-mediated cholesterol efflux capacity from serum

• Downloaded 478 times
• Download rankings, all-time:
  • Site-wide: 62,494
  • In epidemiology: 2,750
• Year to date:
  • Site-wide: 129,995
• Since beginning of last month:
  • Site-wide: 142,026

The landscape of incident disease risk for the biomarker GlycA and its mortality stratification in angiography patients

• Downloaded 471 times
• Download rankings, all-time:
  • Site-wide: 63,530
  • In epidemiology: 2,792
• Year to date:
  • Site-wide: 119,313
• Since beginning of last month:
  • Site-wide: 142,319

Eicosanoid Inflammatory Mediators Are Robustly Associated with Blood Pressure in the General Population

• Downloaded 431 times
• Download rankings, all-time:
  • Site-wide: 69,786
  • In cardiovascular medicine: 111
• Year to date:
  • Site-wide: 69,709
• Since beginning of last month:
  • Site-wide: 43,630

Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 71,148
  • In genetics: 3,169
• Year to date:
  • Site-wide: 133,661
• Since beginning of last month:
  • Site-wide: 143,073

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 79,418
  • In genetics: 3,507
• Year to date:
  • Site-wide: 128,820
• Since beginning of last month:
  • Site-wide: 131,528

ANGPTL8 protein-truncating variant and the risk of coronary disease, type 2 diabetes and adverse effects

• Downloaded 364 times
• Download rankings, all-time:
  • Site-wide: 81,723
  • In genetic and genomic medicine: 341
• Year to date:
  • Site-wide: 76,652
• Since beginning of last month:
  • Site-wide: 83,407

Metabolic biomarkers for peripheral artery disease compared with coronary artery disease: Lipoprotein and metabolite profiling of 31,657 individuals from five prospective cohorts

• Downloaded 356 times
• Download rankings, all-time:
  • Site-wide: 83,305
  • In epidemiology: 3,500
• Year to date:
  • Site-wide: 37,729
• Since beginning of last month:
  • Site-wide: 13,527

Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease

• Downloaded 334 times
• Download rankings, all-time:
  • Site-wide: 87,818
  • In epidemiology: 3,669
• Year to date:
  • Site-wide: 133,547
• Since beginning of last month:
  • Site-wide: 116,705

High-resolution population-specific recombination rates and their effect on phasing and genotype imputation

• Downloaded 334 times
• Download rankings, all-time:
  • Site-wide: 87,837
  • In genomics: 5,589
• Year to date:
  • Site-wide: 124,978
• Since beginning of last month:
  • Site-wide: 107,686

Polygenic Hyperlipidemias and Coronary Artery Disease Risk

• Downloaded 331 times
• Download rankings, all-time:
  • Site-wide: 88,399
  • In genomics: 5,606
• Year to date:
  • Site-wide: 87,313
• Since beginning of last month:
  • Site-wide: 99,310

Genetic study of circulating cytokines offers insight into the determinants, cascades and effects of systemic inflammation

• Downloaded 330 times
• Download rankings, all-time:
  • Site-wide: 88,686
  • In epidemiology: 3,692
• Year to date:
  • Site-wide: 30,747
• Since beginning of last month:
  • Site-wide: 34,332

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health

• Downloaded 318 times
• Download rankings, all-time:
  • Site-wide: 91,233
  • In genetics: 3,973
• Year to date:
  • Site-wide: 60,113
• Since beginning of last month:
  • Site-wide: 60,601

High Density Lipoprotein pathway as a therapeutic target for coronary heart disease: individual participant meta-analysis in 28,597 individuals with 4197 coronary events

• Downloaded 313 times
• Download rankings, all-time:
  • Site-wide: 92,478
  • In cardiovascular medicine: 180
• Year to date:
  • Site-wide: 85,062
• Since beginning of last month:
  • Site-wide: 65,928

Coronary artery disease risk and lipidomic profiles are similar in familial and population-ascertained hyperlipidemias

• Downloaded 295 times
• Download rankings, all-time:
  • Site-wide: 96,411
  • In epidemiology: 4,031
• Year to date:
  • Site-wide: 117,623
• Since beginning of last month:
  • Site-wide: 123,377

Circulating metabolic biomarkers consistently predict incident type 2 diabetes in Asian and European populations - a plasma metabolomics analysis of four ethnic groups

• Downloaded 60 times
• Download rankings, all-time:
  • Site-wide: 146,334
  • In epidemiology: 6,005
• Year to date:
  • Site-wide: 85,511
• Since beginning of last month:
  • Site-wide: 17,069