Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 62,747 bioRxiv papers from 278,434 authors.

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Preprints

A reference panel of 64,976 haplotypes for genotype imputation

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  • In genetics: 55 out of 3,562
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Phenome-wide association studies (PheWAS) across large "real-world data" population cohorts support drug target validation

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  • In genetics: 95 out of 3,562
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  • Site-wide: 10,517 out of 62,747

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • In genetics: 121 out of 3,562
• Year to date:
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  • Site-wide: 26,734 out of 62,747

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • In genetics: 161 out of 3,562
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Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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  • In genetics: 184 out of 3,562
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Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

• Downloaded 1,970 times
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  • In genomics: 485 out of 4,316
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  • Site-wide: 36,488 out of 62,747
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  • Site-wide: 38,222 out of 62,747

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

• Downloaded 1,854 times
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  • In genetics: 236 out of 3,562
• Year to date:
  • Site-wide: 27,438 out of 62,747
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  • Site-wide: 21,557 out of 62,747

Cell specific eQTL analysis without sorting cells

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  • In genetics: 254 out of 3,562
• Year to date:
  • Site-wide: 19,408 out of 62,747
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  • Site-wide: 14,538 out of 62,747

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • In genetics: 270 out of 3,562
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  • Site-wide: 22,472 out of 62,747
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  • Site-wide: 32,897 out of 62,747

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • In genetics: 286 out of 3,562
• Year to date:
  • Site-wide: 45,916 out of 62,747
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  • Site-wide: 48,814 out of 62,747

Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers

• Downloaded 1,530 times
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  • In genomics: 664 out of 4,316
• Year to date:
  • Site-wide: 679 out of 62,747
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  • Site-wide: 923 out of 62,747

metaCCA: Summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis

• Downloaded 1,460 times
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  • In bioinformatics: 764 out of 6,251
• Year to date:
  • Site-wide: 52,766 out of 62,747
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  • Site-wide: 50,502 out of 62,747

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • In genomics: 839 out of 4,316
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  • Site-wide: 37,660 out of 62,747

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • In genetics: 488 out of 3,562
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  • Site-wide: 3,360 out of 62,747
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  • Site-wide: 15,294 out of 62,747

Genomic prediction of coronary heart disease

• Downloaded 1,061 times
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  • In genomics: 1,061 out of 4,316
• Year to date:
  • Site-wide: 55,446 out of 62,747
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  • Site-wide: 57,999 out of 62,747

Refining fine-mapping: effect sizes and regional heritability

• Downloaded 993 times
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  • Site-wide: 7,161 out of 62,747
  • In genetics: 560 out of 3,562
• Year to date:
  • Site-wide: 7,258 out of 62,747
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  • Site-wide: 12,734 out of 62,747

Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

• Downloaded 958 times
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  • In genomics: 1,201 out of 4,316
• Year to date:
  • Site-wide: 4,096 out of 62,747
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  • Site-wide: 21,052 out of 62,747

Haplotype sharing provides insights into fine-scale population history and disease in Finland

• Downloaded 938 times
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  • Site-wide: 7,833 out of 62,747
  • In genetics: 610 out of 3,562
• Year to date:
  • Site-wide: 37,704 out of 62,747
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  • Site-wide: 43,765 out of 62,747

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 887 times
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  • Site-wide: 8,586 out of 62,747
  • In genetics: 642 out of 3,562
• Year to date:
  • Site-wide: 15,849 out of 62,747
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  • Site-wide: 30,255 out of 62,747

Genetics of human plasma lipidome: Understanding lipid metabolism and its link to diseases beyond traditional lipids

• Downloaded 865 times
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  • In genetics: 667 out of 3,562
• Year to date:
  • Site-wide: 4,465 out of 62,747
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  • Site-wide: 4,695 out of 62,747

Geographic variation and bias in polygenic scores of complex diseases and traits in Finland

• Downloaded 829 times
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  • In genetics: 706 out of 3,562
• Year to date:
  • Site-wide: 4,957 out of 62,747
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  • Site-wide: 18,695 out of 62,747

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 808 times
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  • In genetics: 728 out of 3,562
• Year to date:
  • Site-wide: 2,137 out of 62,747
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  • Site-wide: 2,955 out of 62,747

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

• Downloaded 760 times
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  • Site-wide: 10,828 out of 62,747
  • In epidemiology: 119 out of 1,556
• Year to date:
  • Site-wide: 2,374 out of 62,747
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  • Site-wide: 8,786 out of 62,747

Elevated alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality

• Downloaded 748 times
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  • In systems biology: 316 out of 1,783
• Year to date:
  • Site-wide: 4,245 out of 62,747
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  • Site-wide: 5,214 out of 62,747

The rate of false polymorphisms introduced when imputing genotypes from global imputation panels

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  • In genetics: 859 out of 3,562
• Year to date:
  • Site-wide: 43,757 out of 62,747
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  • Site-wide: 34,231 out of 62,747

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

• Downloaded 686 times
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  • In genomics: 1,728 out of 4,316
• Year to date:
  • Site-wide: 2,842 out of 62,747
• Since beginning of last month:
  • Site-wide: 9,879 out of 62,747

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

• Downloaded 663 times
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  • In genomics: 1,784 out of 4,316
• Year to date:
  • Site-wide: 57,381 out of 62,747
• Since beginning of last month:
  • Site-wide: 53,225 out of 62,747

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

• Downloaded 616 times
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  • Site-wide: 14,552 out of 62,747
  • In genomics: 1,902 out of 4,316
• Year to date:
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  • Site-wide: 60,596 out of 62,747

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 588 times
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  • Site-wide: 15,553 out of 62,747
  • In genomics: 1,971 out of 4,316
• Year to date:
  • Site-wide: 41,584 out of 62,747
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  • Site-wide: 45,656 out of 62,747

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

• Downloaded 549 times
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  • Site-wide: 17,060 out of 62,747
  • In epidemiology: 208 out of 1,556
• Year to date:
  • Site-wide: 25,875 out of 62,747
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  • Site-wide: 56,723 out of 62,747

Metabolic profiling of alcohol consumption in 9778 young adults

• Downloaded 488 times
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  • Site-wide: 19,771 out of 62,747
  • In systems biology: 598 out of 1,783
• Year to date:
  • Site-wide: 56,833 out of 62,747
• Since beginning of last month:
  • Site-wide: 57,411 out of 62,747

Contribution of rare and common variants to intellectual disability in a high-risk population sub-isolate of Northern Finland

• Downloaded 468 times
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  • In genetics: 1,395 out of 3,562
• Year to date:
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  • Site-wide: 39,592 out of 62,747

Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

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  • In genomics: 2,501 out of 4,316
• Year to date:
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  • Site-wide: 58,159 out of 62,747

A Comprehensive Evaluation of the Genetic Architecture of Sudden Cardiac Arrest

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  • In genetics: 1,537 out of 3,562
• Year to date:
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  • Site-wide: 57,108 out of 62,747

Whole genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

• Downloaded 399 times
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  • In genetics: 1,631 out of 3,562
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  • Site-wide: 58,517 out of 62,747

Direct estimation of HDL-mediated cholesterol efflux capacity from serum

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  • In epidemiology: 421 out of 1,556
• Year to date:
  • Site-wide: 31,531 out of 62,747
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  • Site-wide: 43,652 out of 62,747

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

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  • In genomics: 2,894 out of 4,316
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  • Site-wide: 9,043 out of 62,747
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  • Site-wide: 21,826 out of 62,747

Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

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  • In genomics: 2,972 out of 4,316
• Year to date:
  • Site-wide: 9,782 out of 62,747
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  • Site-wide: 17,377 out of 62,747

The landscape of incident disease risk for the biomarker GlycA and its mortality stratification in angiography patients

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  • In epidemiology: 488 out of 1,556
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  • Site-wide: 43,120 out of 62,747
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  • Site-wide: 50,374 out of 62,747

Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

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  • In genetics: 2,159 out of 3,562
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  • Site-wide: 45,638 out of 62,747

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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  • Site-wide: 10,514 out of 62,747

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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  • Site-wide: 45,449 out of 62,747

Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease

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  • In epidemiology: 785 out of 1,556
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  • Site-wide: 37,496 out of 62,747

Coronary artery disease risk and lipidomic profiles are similar in familial and population-ascertained hyperlipidemias

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  • In epidemiology: 898 out of 1,556
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  • Site-wide: 49,074 out of 62,747

Polygenic Hyperlipidemias and Coronary Artery Disease Risk

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  • In genomics: 4,103 out of 4,316
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  • Site-wide: 22,758 out of 62,747