Author: Veikko Salomaa

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Preprints

A reference panel of 64,976 haplotypes for genotype imputation

• Downloaded 4,562 times
• Download rankings, all-time:
  • Site-wide: 1,971
  • In genetics: 80
• Year to date:
  • Site-wide: 85,760
• Since beginning of last month:
  • Site-wide: 59,794

Phenome-wide association studies (PheWAS) across large "real-world data" population cohorts support drug target validation

• Downloaded 3,457 times
• Download rankings, all-time:
  • Site-wide: 2,949
  • In genetics: 125
• Year to date:
  • Site-wide: 34,466
• Since beginning of last month:
  • Site-wide: 39,847

Taxonomic Signatures of Long-Term Mortality Risk in Human Gut Microbiota

• Downloaded 3,326 times
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  • Site-wide: 3,124
  • In epidemiology: 296
• Year to date:
  • Site-wide: 11,356
• Since beginning of last month:
  • Site-wide: 11,226

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,052 times
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  • Site-wide: 3,553
  • In genetics: 163
• Year to date:
  • Site-wide: 18,990
• Since beginning of last month:
  • Site-wide: 42,061

Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers

• Downloaded 2,686 times
• Download rankings, all-time:
  • Site-wide: 4,221
  • In genomics: 502
• Year to date:
  • Site-wide: 17,457
• Since beginning of last month:
  • Site-wide: 15,142

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• Downloaded 2,489 times
• Download rankings, all-time:
  • Site-wide: 4,735
  • In genetics: 230
• Year to date:
  • Site-wide: 80,605
• Since beginning of last month:
  • Site-wide: 97,148

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

• Downloaded 2,369 times
• Download rankings, all-time:
  • Site-wide: 5,115
  • In genetics: 247
• Year to date:
  • Site-wide: 8,015
• Since beginning of last month:
  • Site-wide: 14,208

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

• Downloaded 2,284 times
• Download rankings, all-time:
  • Site-wide: 5,409
  • In genetics: 269
• Year to date:
  • Site-wide: 113,873
• Since beginning of last month:
  • Site-wide: 92,652

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

• Downloaded 2,083 times
• Download rankings, all-time:
  • Site-wide: 6,159
  • In genomics: 724
• Year to date:
  • Site-wide: 101,330
• Since beginning of last month:
  • Site-wide: 117,644

Cell specific eQTL analysis without sorting cells

• Downloaded 1,985 times
• Download rankings, all-time:
  • Site-wide: 6,600
  • In genetics: 333
• Year to date:
  • Site-wide: 122,113
• Since beginning of last month:
  • Site-wide: 80,115

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,833 times
• Download rankings, all-time:
  • Site-wide: 7,434
  • In genetics: 368
• Year to date:
  • Site-wide: 48,224
• Since beginning of last month:
  • Site-wide: 100,595

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,756 times
• Download rankings, all-time:
  • Site-wide: 7,923
  • In genetics: 399
• Year to date:
  • Site-wide: 15,809
• Since beginning of last month:
  • Site-wide: 40,739

Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity

• Downloaded 1,738 times
• Download rankings, all-time:
  • Site-wide: 8,055
  • In microbiology: 442
• Year to date:
  • Site-wide: 1,766
• Since beginning of last month:
  • Site-wide: 5,390

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,627 times
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  • Site-wide: 8,945
  • In genetics: 456
• Year to date:
  • Site-wide: 63,982
• Since beginning of last month:
  • Site-wide: 38,012

Elevated alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality

• Downloaded 1,620 times
• Download rankings, all-time:
  • Site-wide: 9,003
  • In systems biology: 175
• Year to date:
  • Site-wide: 9,505
• Since beginning of last month:
  • Site-wide: 16,283

metaCCA: Summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis

• Downloaded 1,566 times
• Download rankings, all-time:
  • Site-wide: 9,473
  • In bioinformatics: 1,193
• Year to date:
  • Site-wide: 82,582
• Since beginning of last month:
  • Site-wide: 116,064

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,455 times
• Download rankings, all-time:
  • Site-wide: 10,511
  • In genetics: 532
• Year to date:
  • Site-wide: 39,246
• Since beginning of last month:
  • Site-wide: 67,944

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,431 times
• Download rankings, all-time:
  • Site-wide: 10,808
  • In genomics: 1,227
• Year to date:
  • Site-wide: 69,425
• Since beginning of last month:
  • Site-wide: 103,094

Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

• Downloaded 1,403 times
• Download rankings, all-time:
  • Site-wide: 11,132
  • In genomics: 1,268
• Year to date:
  • Site-wide: 45,589
• Since beginning of last month:
  • Site-wide: 67,122

Refining fine-mapping: effect sizes and regional heritability

• Downloaded 1,386 times
• Download rankings, all-time:
  • Site-wide: 11,352
  • In genetics: 580
• Year to date:
  • Site-wide: 43,152
• Since beginning of last month:
  • Site-wide: 33,494

Genomic prediction of coronary heart disease

• Downloaded 1,150 times
• Download rankings, all-time:
  • Site-wide: 15,003
  • In genomics: 1,627
• Year to date:
  • Site-wide: 117,306
• Since beginning of last month:
  • Site-wide: 96,347

Genetics of human plasma lipidome: Understanding lipid metabolism and its link to diseases beyond traditional lipids

• Downloaded 1,138 times
• Download rankings, all-time:
  • Site-wide: 15,245
  • In genetics: 792
• Year to date:
  • Site-wide: 38,279
• Since beginning of last month:
  • Site-wide: 59,583

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,112 times
• Download rankings, all-time:
  • Site-wide: 15,796
  • In genetics: 818
• Year to date:
  • Site-wide: 60,242
• Since beginning of last month:
  • Site-wide: 69,991

Haplotype sharing provides insights into fine-scale population history and disease in Finland

• Downloaded 1,088 times
• Download rankings, all-time:
  • Site-wide: 16,358
  • In genetics: 845
• Year to date:
  • Site-wide: 61,107
• Since beginning of last month:
  • Site-wide: 70,457

Geographic variation and bias in polygenic scores of complex diseases and traits in Finland

• Downloaded 1,018 times
• Download rankings, all-time:
  • Site-wide: 18,066
  • In genetics: 923
• Year to date:
  • Site-wide: 99,164
• Since beginning of last month:
  • Site-wide: 61,877

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

• Downloaded 965 times
• Download rankings, all-time:
  • Site-wide: 19,521
  • In epidemiology: 1,103
• Year to date:
  • Site-wide: 94,558
• Since beginning of last month:
  • Site-wide: 41,648

The rate of false polymorphisms introduced when imputing genotypes from global imputation panels

• Downloaded 943 times
• Download rankings, all-time:
  • Site-wide: 20,164
  • In genetics: 1,013
• Year to date:
  • Site-wide: 94,135
• Since beginning of last month:
  • Site-wide: 79,175

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

• Downloaded 938 times
• Download rankings, all-time:
  • Site-wide: 20,337
  • In genomics: 2,072
• Year to date:
  • Site-wide: 60,120
• Since beginning of last month:
  • Site-wide: 50,910

Genome-wide association and Mendelian randomization analysis prioritizes bioactive metabolites with putative causal effects on common diseases

• Downloaded 792 times
• Download rankings, all-time:
  • Site-wide: 25,881
  • In genetic and genomic medicine: 64
• Year to date:
  • Site-wide: 17,777
• Since beginning of last month:
  • Site-wide: 18,068

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 764 times
• Download rankings, all-time:
  • Site-wide: 27,230
  • In genetics: 1,372
• Year to date:
  • Site-wide: 21,254
• Since beginning of last month:
  • Site-wide: 24,322

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

• Downloaded 754 times
• Download rankings, all-time:
  • Site-wide: 27,751
  • In genomics: 2,607
• Year to date:
  • Site-wide: 82,518
• Since beginning of last month:
  • Site-wide: 118,877

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 738 times
• Download rankings, all-time:
  • Site-wide: 28,596
  • In genomics: 2,655
• Year to date:
  • Site-wide: 41,602
• Since beginning of last month:
  • Site-wide: 110,739

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

• Downloaded 731 times
• Download rankings, all-time:
  • Site-wide: 28,969
  • In genomics: 2,676
• Year to date:
  • Site-wide: 56,711
• Since beginning of last month:
  • Site-wide: 115,813

Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort

• Downloaded 729 times
• Download rankings, all-time:
  • Site-wide: 29,033
  • In genetic and genomic medicine: 75
• Year to date:
  • Site-wide: 11,777
• Since beginning of last month:
  • Site-wide: 5,244

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

• Downloaded 639 times
• Download rankings, all-time:
  • Site-wide: 34,732
  • In epidemiology: 1,637
• Year to date:
  • Site-wide: 119,998
• Since beginning of last month:
  • Site-wide: 107,557

Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

• Downloaded 589 times
• Download rankings, all-time:
  • Site-wide: 38,472
  • In genomics: 3,270
• Year to date:
  • Site-wide: 58,877
• Since beginning of last month:
  • Site-wide: 97,986

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 587 times
• Download rankings, all-time:
  • Site-wide: 38,658
  • In genetics: 1,908
• Year to date:
  • Site-wide: 85,090
• Since beginning of last month:
  • Site-wide: 63,706

Metabolic profiling of alcohol consumption in 9778 young adults

• Downloaded 571 times
• Download rankings, all-time:
  • Site-wide: 40,018
  • In systems biology: 950
• Year to date:
  • Site-wide: 121,398
• Since beginning of last month:
  • Site-wide: 110,501

Contribution of rare and common variants to intellectual disability in a high-risk population sub-isolate of Northern Finland

• Downloaded 570 times
• Download rankings, all-time:
  • Site-wide: 40,146
  • In genetics: 1,953
• Year to date:
  • Site-wide: 84,388
• Since beginning of last month:
  • Site-wide: 104,329

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 41,804
  • In genomics: 3,462
• Year to date:
  • Site-wide: 82,352
• Since beginning of last month:
  • Site-wide: 76,151

A Comprehensive Evaluation of the Genetic Architecture of Sudden Cardiac Arrest

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 41,793
  • In genetics: 2,043
• Year to date:
  • Site-wide: 87,849
• Since beginning of last month:
  • Site-wide: 81,647

An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease

• Downloaded 551 times
• Download rankings, all-time:
  • Site-wide: 41,906
  • In genetics: 2,050
• Year to date:
  • Site-wide: 25,802
• Since beginning of last month:
  • Site-wide: 36,562

Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

• Downloaded 517 times
• Download rankings, all-time:
  • Site-wide: 45,232
  • In genomics: 3,682
• Year to date:
  • Site-wide: 115,055
• Since beginning of last month:
  • Site-wide: 104,461

Early prediction of liver disease using conventional risk factors and gut microbiome-augmented gradient boosting

• Downloaded 475 times
• Download rankings, all-time:
  • Site-wide: 49,871
  • In genetic and genomic medicine: 127
• Year to date:
  • Site-wide: 19,634
• Since beginning of last month:
  • Site-wide: 19,040

Whole genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

• Downloaded 471 times
• Download rankings, all-time:
  • Site-wide: 50,364
  • In genetics: 2,444
• Year to date:
  • Site-wide: 120,640
• Since beginning of last month:
  • Site-wide: 109,618

Direct estimation of HDL-mediated cholesterol efflux capacity from serum

• Downloaded 457 times
• Download rankings, all-time:
  • Site-wide: 52,113
  • In epidemiology: 2,231
• Year to date:
  • Site-wide: 59,945
• Since beginning of last month:
  • Site-wide: 117,208

Links between gut microbiome composition and fatty liver disease in a large population sample

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 54,144
  • In gastroenterology: 41
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 8,336

The landscape of incident disease risk for the biomarker GlycA and its mortality stratification in angiography patients

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 54,092
  • In epidemiology: 2,290
• Year to date:
  • Site-wide: 75,593
• Since beginning of last month:
  • Site-wide: 110,999

Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

• Downloaded 399 times
• Download rankings, all-time:
  • Site-wide: 59,939
  • In genetics: 2,869
• Year to date:
  • Site-wide: 115,417
• Since beginning of last month:
  • Site-wide: 59,068

Communicating polygenic and non-genetic risk for atherosclerotic cardiovascular disease - An observational follow-up study

• Downloaded 393 times
• Download rankings, all-time:
  • Site-wide: 60,889
  • In genetic and genomic medicine: 167
• Year to date:
  • Site-wide: 45,016
• Since beginning of last month:
  • Site-wide: 31,402

Eicosanoid Inflammatory Mediators Are Robustly Associated with Blood Pressure in the General Population

• Downloaded 355 times
• Download rankings, all-time:
  • Site-wide: 66,895
  • In cardiovascular medicine: 95
• Year to date:
  • Site-wide: 102,576
• Since beginning of last month:
  • Site-wide: 47,410

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

• Downloaded 351 times
• Download rankings, all-time:
  • Site-wide: 67,549
  • In genetics: 3,203
• Year to date:
  • Site-wide: 89,881
• Since beginning of last month:
  • Site-wide: 115,785

Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease

• Downloaded 313 times
• Download rankings, all-time:
  • Site-wide: 74,322
  • In epidemiology: 3,022
• Year to date:
  • Site-wide: 78,117
• Since beginning of last month:
  • Site-wide: 117,654

High-resolution population-specific recombination rates and their effect on phasing and genotype imputation

• Downloaded 306 times
• Download rankings, all-time:
  • Site-wide: 75,564
  • In genomics: 5,082
• Year to date:
  • Site-wide: 99,280
• Since beginning of last month:
  • Site-wide: 38,987

ANGPTL8 protein-truncating variant and the risk of coronary disease, type 2 diabetes and adverse effects

• Downloaded 301 times
• Download rankings, all-time:
  • Site-wide: 76,486
  • In genetic and genomic medicine: 215
• Year to date:
  • Site-wide: 50,981
• Since beginning of last month:
  • Site-wide: 27,314

Polygenic Hyperlipidemias and Coronary Artery Disease Risk

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 81,904
  • In genomics: 5,318
• Year to date:
  • Site-wide: 112,783
• Since beginning of last month:
  • Site-wide: 73,347

Coronary artery disease risk and lipidomic profiles are similar in familial and population-ascertained hyperlipidemias

• Downloaded 263 times
• Download rankings, all-time:
  • Site-wide: 84,107
  • In epidemiology: 3,394
• Year to date:
  • Site-wide: 90,787
• Since beginning of last month:
  • Site-wide: 103,186

High Density Lipoprotein pathway as a therapeutic target for coronary heart disease: individual participant meta-analysis in 28,597 individuals with 4197 coronary events

• Downloaded 257 times
• Download rankings, all-time:
  • Site-wide: 85,469
  • In cardiovascular medicine: 128
• Year to date:
  • Site-wide: 84,853
• Since beginning of last month:
  • Site-wide: 63,360

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health

• Downloaded 226 times
• Download rankings, all-time:
  • Site-wide: 91,859
  • In genetics: 4,255
• Year to date:
  • Site-wide: 113,098
• Since beginning of last month:
  • Site-wide: 24,486

Metabolic biomarkers for peripheral artery disease compared with coronary artery disease: Lipoprotein and metabolite profiling of 31,657 individuals from five prospective cohorts

• Downloaded 212 times
• Download rankings, all-time:
  • Site-wide: 94,807
  • In epidemiology: 3,814
• Year to date:
  • Site-wide: 72,272
• Since beginning of last month:
  • Site-wide: 51,316

Genetic study of circulating cytokines offers insight into the determinants, cascades and effects of systemic inflammation

• Downloaded 180 times
• Download rankings, all-time:
  • Site-wide: 101,639
  • In epidemiology: 4,110
• Year to date:
  • Site-wide: 9,134
• Since beginning of last month:
  • Site-wide: 22,264