Author: Veikko Salomaa

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Preprints

A reference panel of 64,976 haplotypes for genotype imputation

• Downloaded 4,620 times
• Download rankings, all-time:
  • Site-wide: 2,872
  • In genetics: 90
• Year to date:
  • Site-wide: 125,467
• Since beginning of last month:
  • Site-wide: 112,662

Taxonomic Signatures of Long-Term Mortality Risk in Human Gut Microbiota

• Downloaded 3,723 times
• Download rankings, all-time:
  • Site-wide: 3,880
  • In epidemiology: 391
• Year to date:
  • Site-wide: 16,562
• Since beginning of last month:
  • Site-wide: 51,445

Phenome-wide association studies (PheWAS) across large "real-world data" population cohorts support drug target validation

• Downloaded 3,632 times
• Download rankings, all-time:
  • Site-wide: 4,020
  • In genetics: 136
• Year to date:
  • Site-wide: 49,680
• Since beginning of last month:
  • Site-wide: 50,373

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,252 times
• Download rankings, all-time:
  • Site-wide: 4,700
  • In genetics: 176
• Year to date:
  • Site-wide: 41,305
• Since beginning of last month:
  • Site-wide: 63,774

Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers

• Downloaded 2,931 times
• Download rankings, all-time:
  • Site-wide: 5,446
  • In genomics: 547
• Year to date:
  • Site-wide: 32,404
• Since beginning of last month:
  • Site-wide: 50,142

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

• Downloaded 2,655 times
• Download rankings, all-time:
  • Site-wide: 6,288
  • In genetics: 257
• Year to date:
  • Site-wide: 25,196
• Since beginning of last month:
  • Site-wide: 37,298

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• Downloaded 2,539 times
• Download rankings, all-time:
  • Site-wide: 6,727
  • In genetics: 280
• Year to date:
  • Site-wide: 133,351
• Since beginning of last month:
  • Site-wide: 152,287

Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity

• Downloaded 2,456 times
• Download rankings, all-time:
  • Site-wide: 7,054
  • In microbiology: 425
• Year to date:
  • Site-wide: 6,189
• Since beginning of last month:
  • Site-wide: 22,090

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

• Downloaded 2,351 times
• Download rankings, all-time:
  • Site-wide: 7,506
  • In genetics: 320
• Year to date:
  • Site-wide: 118,519
• Since beginning of last month:
  • Site-wide: 112,655

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

• Downloaded 2,118 times
• Download rankings, all-time:
  • Site-wide: 8,750
  • In genomics: 875
• Year to date:
  • Site-wide: 151,219
• Since beginning of last month:
  • Site-wide: 153,165

Cell specific eQTL analysis without sorting cells

• Downloaded 2,025 times
• Download rankings, all-time:
  • Site-wide: 9,318
  • In genetics: 387
• Year to date:
  • Site-wide: 148,741
• Since beginning of last month:
  • Site-wide: 150,048

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,901 times
• Download rankings, all-time:
  • Site-wide: 10,224
  • In genetics: 433
• Year to date:
  • Site-wide: 111,161
• Since beginning of last month:
  • Site-wide: 112,599

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,855 times
• Download rankings, all-time:
  • Site-wide: 10,628
  • In genetics: 459
• Year to date:
  • Site-wide: 77,904
• Since beginning of last month:
  • Site-wide: 105,185

Elevated alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality

• Downloaded 1,802 times
• Download rankings, all-time:
  • Site-wide: 11,097
  • In systems biology: 194
• Year to date:
  • Site-wide: 43,109
• Since beginning of last month:
  • Site-wide: 111,580

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,755 times
• Download rankings, all-time:
  • Site-wide: 11,547
  • In genetics: 495
• Year to date:
  • Site-wide: 69,689
• Since beginning of last month:
  • Site-wide: 121,227

Refining fine-mapping: effect sizes and regional heritability

• Downloaded 1,641 times
• Download rankings, all-time:
  • Site-wide: 12,722
  • In genetics: 560
• Year to date:
  • Site-wide: 32,390
• Since beginning of last month:
  • Site-wide: 41,067

metaCCA: Summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis

• Downloaded 1,630 times
• Download rankings, all-time:
  • Site-wide: 12,846
  • In bioinformatics: 1,441
• Year to date:
  • Site-wide: 118,161
• Since beginning of last month:
  • Site-wide: 150,569

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,533 times
• Download rankings, all-time:
  • Site-wide: 14,063
  • In genetics: 622
• Year to date:
  • Site-wide: 100,284
• Since beginning of last month:
  • Site-wide: 53,153

Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

• Downloaded 1,498 times
• Download rankings, all-time:
  • Site-wide: 14,610
  • In genomics: 1,446
• Year to date:
  • Site-wide: 87,659
• Since beginning of last month:
  • Site-wide: 73,105

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,495 times
• Download rankings, all-time:
  • Site-wide: 14,651
  • In genomics: 1,451
• Year to date:
  • Site-wide: 117,239
• Since beginning of last month:
  • Site-wide: 111,377

Genetics of human plasma lipidome: Understanding lipid metabolism and its link to diseases beyond traditional lipids

• Downloaded 1,221 times
• Download rankings, all-time:
  • Site-wide: 19,885
  • In genetics: 896
• Year to date:
  • Site-wide: 96,543
• Since beginning of last month:
  • Site-wide: 121,350

Genomic prediction of coronary heart disease

• Downloaded 1,193 times
• Download rankings, all-time:
  • Site-wide: 20,583
  • In genomics: 1,956
• Year to date:
  • Site-wide: 144,327
• Since beginning of last month:
  • Site-wide: 128,105

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,190 times
• Download rankings, all-time:
  • Site-wide: 20,667
  • In genetics: 926
• Year to date:
  • Site-wide: 102,659
• Since beginning of last month:
  • Site-wide: 97,208

Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort

• Downloaded 1,187 times
• Download rankings, all-time:
  • Site-wide: 20,745
  • In genetic and genomic medicine: 93
• Year to date:
  • Site-wide: 13,633
• Since beginning of last month:
  • Site-wide: 14,009

Genome-wide association and Mendelian randomization analysis prioritizes bioactive metabolites with putative causal effects on common diseases

• Downloaded 1,181 times
• Download rankings, all-time:
  • Site-wide: 20,879
  • In genetic and genomic medicine: 94
• Year to date:
  • Site-wide: 17,526
• Since beginning of last month:
  • Site-wide: 34,274

Haplotype sharing provides insights into fine-scale population history and disease in Finland

• Downloaded 1,170 times
• Download rankings, all-time:
  • Site-wide: 21,173
  • In genetics: 943
• Year to date:
  • Site-wide: 99,212
• Since beginning of last month:
  • Site-wide: 136,257

OGUs enable effective, phylogeny-aware analysis of even shallow metagenome community structures

• Downloaded 1,165 times
• Download rankings, all-time:
  • Site-wide: 21,315
  • In bioinformatics: 2,440
• Year to date:
  • Site-wide: 3,609
• Since beginning of last month:
  • Site-wide: 21,222

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

• Downloaded 1,075 times
• Download rankings, all-time:
  • Site-wide: 24,013
  • In epidemiology: 1,436
• Year to date:
  • Site-wide: 81,447
• Since beginning of last month:
  • Site-wide: 84,106

Geographic variation and bias in polygenic scores of complex diseases and traits in Finland

• Downloaded 1,062 times
• Download rankings, all-time:
  • Site-wide: 24,458
  • In genetics: 1,089
• Year to date:
  • Site-wide: 141,521
• Since beginning of last month:
  • Site-wide: 135,498

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 1,043 times
• Download rankings, all-time:
  • Site-wide: 25,159
  • In genetics: 1,123
• Year to date:
  • Site-wide: 27,948
• Since beginning of last month:
  • Site-wide: 44,448

The rate of false polymorphisms introduced when imputing genotypes from global imputation panels

• Downloaded 1,010 times
• Download rankings, all-time:
  • Site-wide: 26,321
  • In genetics: 1,168
• Year to date:
  • Site-wide: 115,684
• Since beginning of last month:
  • Site-wide: 112,646

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

• Downloaded 993 times
• Download rankings, all-time:
  • Site-wide: 27,081
  • In genomics: 2,443
• Year to date:
  • Site-wide: 125,517
• Since beginning of last month:
  • Site-wide: 135,467

An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease

• Downloaded 804 times
• Download rankings, all-time:
  • Site-wide: 36,532
  • In genetics: 1,613
• Year to date:
  • Site-wide: 31,859
• Since beginning of last month:
  • Site-wide: 31,575

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

• Downloaded 800 times
• Download rankings, all-time:
  • Site-wide: 36,792
  • In genomics: 3,044
• Year to date:
  • Site-wide: 138,200
• Since beginning of last month:
  • Site-wide: 156,302

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 788 times
• Download rankings, all-time:
  • Site-wide: 37,603
  • In genomics: 3,094
• Year to date:
  • Site-wide: 128,153
• Since beginning of last month:
  • Site-wide: 145,216

Early prediction of liver disease using conventional risk factors and gut microbiome-augmented gradient boosting

• Downloaded 777 times
• Download rankings, all-time:
  • Site-wide: 38,341
  • In genetic and genomic medicine: 167
• Year to date:
  • Site-wide: 25,072
• Since beginning of last month:
  • Site-wide: 38,391

Links between gut microbiome composition and fatty liver disease in a large population sample

• Downloaded 769 times
• Download rankings, all-time:
  • Site-wide: 38,987
  • In gastroenterology: 37
• Year to date:
  • Site-wide: 23,915
• Since beginning of last month:
  • Site-wide: 57,889

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

• Downloaded 754 times
• Download rankings, all-time:
  • Site-wide: 40,029
  • In genomics: 3,231
• Year to date:
  • Site-wide: 157,348
• Since beginning of last month:
  • Site-wide: 158,384

Communicating polygenic and non-genetic risk for atherosclerotic cardiovascular disease - An observational follow-up study

• Downloaded 705 times
• Download rankings, all-time:
  • Site-wide: 43,880
  • In genetic and genomic medicine: 191
• Year to date:
  • Site-wide: 24,852
• Since beginning of last month:
  • Site-wide: 23,697

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

• Downloaded 684 times
• Download rankings, all-time:
  • Site-wide: 45,801
  • In epidemiology: 2,241
• Year to date:
  • Site-wide: 143,080
• Since beginning of last month:
  • Site-wide: 139,130

Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

• Downloaded 677 times
• Download rankings, all-time:
  • Site-wide: 46,360
  • In genomics: 3,625
• Year to date:
  • Site-wide: 94,465
• Since beginning of last month:
  • Site-wide: 90,147

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

• Downloaded 676 times
• Download rankings, all-time:
  • Site-wide: 46,419
  • In genomics: 3,627
• Year to date:
  • Site-wide: 72,731
• Since beginning of last month:
  • Site-wide: 68,288

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 664 times
• Download rankings, all-time:
  • Site-wide: 47,525
  • In genetics: 2,084
• Year to date:
  • Site-wide: 105,469
• Since beginning of last month:
  • Site-wide: 72,855

Metabolic profiling of alcohol consumption in 9778 young adults

• Downloaded 631 times
• Download rankings, all-time:
  • Site-wide: 50,797
  • In systems biology: 1,095
• Year to date:
  • Site-wide: 126,242
• Since beginning of last month:
  • Site-wide: 154,002

Contribution of rare and common variants to intellectual disability in a high-risk population sub-isolate of Northern Finland

• Downloaded 625 times
• Download rankings, all-time:
  • Site-wide: 51,428
  • In genetics: 2,228
• Year to date:
  • Site-wide: 127,597
• Since beginning of last month:
  • Site-wide: 126,720

A Comprehensive Evaluation of the Genetic Architecture of Sudden Cardiac Arrest

• Downloaded 608 times
• Download rankings, all-time:
  • Site-wide: 53,291
  • In genetics: 2,295
• Year to date:
  • Site-wide: 127,659
• Since beginning of last month:
  • Site-wide: 128,162

Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 60,105
  • In genomics: 4,386
• Year to date:
  • Site-wide: 152,434
• Since beginning of last month:
  • Site-wide: 152,810

Whole genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

• Downloaded 500 times
• Download rankings, all-time:
  • Site-wide: 67,313
  • In genetics: 2,895
• Year to date:
  • Site-wide: 157,635
• Since beginning of last month:
  • Site-wide: 155,492

Direct estimation of HDL-mediated cholesterol efflux capacity from serum

• Downloaded 495 times
• Download rankings, all-time:
  • Site-wide: 68,160
  • In epidemiology: 3,033
• Year to date:
  • Site-wide: 144,398
• Since beginning of last month:
  • Site-wide: 143,319

The landscape of incident disease risk for the biomarker GlycA and its mortality stratification in angiography patients

• Downloaded 486 times
• Download rankings, all-time:
  • Site-wide: 69,605
  • In epidemiology: 3,082
• Year to date:
  • Site-wide: 138,744
• Since beginning of last month:
  • Site-wide: 159,388

Eicosanoid Inflammatory Mediators Are Robustly Associated with Blood Pressure in the General Population

• Downloaded 458 times
• Download rankings, all-time:
  • Site-wide: 74,186
  • In cardiovascular medicine: 134
• Year to date:
  • Site-wide: 86,718
• Since beginning of last month:
  • Site-wide: 123,197

Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

• Downloaded 433 times
• Download rankings, all-time:
  • Site-wide: 78,674
  • In genetics: 3,369
• Year to date:
  • Site-wide: 153,453
• Since beginning of last month:
  • Site-wide: 150,998

Genetic study of circulating cytokines offers insight into the determinants, cascades and effects of systemic inflammation

• Downloaded 430 times
• Download rankings, all-time:
  • Site-wide: 79,165
  • In epidemiology: 3,439
• Year to date:
  • Site-wide: 30,084
• Since beginning of last month:
  • Site-wide: 39,394

Metabolic biomarkers for peripheral artery disease compared with coronary artery disease: Lipoprotein and metabolite profiling of 31,657 individuals from five prospective cohorts

• Downloaded 417 times
• Download rankings, all-time:
  • Site-wide: 81,657
  • In epidemiology: 3,529
• Year to date:
  • Site-wide: 42,803
• Since beginning of last month:
  • Site-wide: 42,107

ANGPTL8 protein-truncating variant and the risk of coronary disease, type 2 diabetes and adverse effects

• Downloaded 411 times
• Download rankings, all-time:
  • Site-wide: 82,803
  • In genetic and genomic medicine: 376
• Year to date:
  • Site-wide: 78,810
• Since beginning of last month:
  • Site-wide: 66,794

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

• Downloaded 392 times
• Download rankings, all-time:
  • Site-wide: 86,589
  • In genetics: 3,690
• Year to date:
  • Site-wide: 144,664
• Since beginning of last month:
  • Site-wide: 150,194

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health

• Downloaded 372 times
• Download rankings, all-time:
  • Site-wide: 90,751
  • In genetics: 3,855
• Year to date:
  • Site-wide: 63,510
• Since beginning of last month:
  • Site-wide: 62,431

High-resolution population-specific recombination rates and their effect on phasing and genotype imputation

• Downloaded 360 times
• Download rankings, all-time:
  • Site-wide: 93,418
  • In genomics: 5,838
• Year to date:
  • Site-wide: 130,517
• Since beginning of last month:
  • Site-wide: 109,048

Polygenic Hyperlipidemias and Coronary Artery Disease Risk

• Downloaded 358 times
• Download rankings, all-time:
  • Site-wide: 93,945
  • In genomics: 5,849
• Year to date:
  • Site-wide: 101,767
• Since beginning of last month:
  • Site-wide: 150,833

High Density Lipoprotein pathway as a therapeutic target for coronary heart disease: individual participant meta-analysis in 28,597 individuals with 4197 coronary events

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 95,090
  • In cardiovascular medicine: 196
• Year to date:
  • Site-wide: 90,045
• Since beginning of last month:
  • Site-wide: 77,484

Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease

• Downloaded 350 times
• Download rankings, all-time:
  • Site-wide: 95,731
  • In epidemiology: 4,075
• Year to date:
  • Site-wide: 147,993
• Since beginning of last month:
  • Site-wide: 125,734

Coronary artery disease risk and lipidomic profiles are similar in familial and population-ascertained hyperlipidemias

• Downloaded 327 times
• Download rankings, all-time:
  • Site-wide: 101,271
  • In epidemiology: 4,297
• Year to date:
  • Site-wide: 118,825
• Since beginning of last month:
  • Site-wide: 120,390

Circulating metabolic biomarkers are consistently associated with incident type 2 diabetes in Asian and European populations - a metabolomics analysis in five prospective cohorts

• Downloaded 135 times
• Download rankings, all-time:
  • Site-wide: 148,522
  • In epidemiology: 6,135
• Year to date:
  • Site-wide: 68,817
• Since beginning of last month:
  • Site-wide: 29,937

A plasma metabolite score of three eicosanoids predicts incident type 2 diabetes - a prospective study in three independent cohorts

• Downloaded 103 times
• Download rankings, all-time:
  • Site-wide: 154,167
  • In epidemiology: 6,356
• Year to date:
  • Site-wide: 88,015
• Since beginning of last month:
  • Site-wide: 98,981