Author: Mika Kähönen

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Preprints

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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  • Site-wide: 779
  • In genomics: 68
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  • Site-wide: 3,552

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 3,246
  • In genetics: 146
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  • Site-wide: 14,084
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  • Site-wide: 32,492

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,519
  • In genetics: 165
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Integrative approaches for large-scale transcriptome-wide association studies

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  • Site-wide: 3,815
  • In genetics: 185
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  • Site-wide: 18,576
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  • Site-wide: 29,750

Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

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  • Site-wide: 6,013
  • In genetics: 305
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  • Site-wide: 8,814

The Polygenic and Monogenic Basis of Blood Traits and Diseases

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  • Site-wide: 6,935
  • In genetic and genomic medicine: 17
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New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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  • Site-wide: 9,510
  • In genomics: 1,082
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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 11,188
  • In genetics: 581
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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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  • Site-wide: 14,446
  • In genetics: 757
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  • Site-wide: 12,595
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  • Site-wide: 60,070

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

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  • Site-wide: 19,147
  • In epidemiology: 1,074
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  • Site-wide: 57,137
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An epigenome-wide association study of educational attainment (n = 10,767)

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  • In genetics: 990
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Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

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  • Site-wide: 20,491
  • In genomics: 2,096
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  • Site-wide: 101,197

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 23,392
  • In genetics: 1,187
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  • Site-wide: 21,224

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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  • In genetics: 1,312
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Lower hemoglobin levels associate with lower body mass index and healthier metabolic profile

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  • Site-wide: 25,985
  • In epidemiology: 1,319
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  • Site-wide: 45,870
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  • Site-wide: 17,573

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

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  • Site-wide: 27,197
  • In genomics: 2,576
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  • Site-wide: 42,650
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  • Site-wide: 104,588

Genetic and environmental perturbations lead to regulatory decoherence

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  • Site-wide: 28,368
  • In genomics: 2,647
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  • Site-wide: 66,430
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  • Site-wide: 66,536

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 28,661
  • In genomics: 2,669
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  • Site-wide: 113,754

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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  • Site-wide: 37,911
  • In genetics: 1,886
• Year to date:
  • Site-wide: 44,339
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  • Site-wide: 48,841

Metabolic Effects Of Risk Alleles In PNPLA3, TM6SF2, GCKR, And LYPLAL1 Inform About Heterogeneity Of Non-Alcoholic Fatty Liver Disease

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  • Site-wide: 38,323
  • In epidemiology: 1,774
• Year to date:
  • Site-wide: 35,754
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  • Site-wide: 71,814

Metabolic profiling of alcohol consumption in 9778 young adults

• Downloaded 568 times
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  • Site-wide: 39,534
  • In systems biology: 940
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  • Site-wide: 114,256

Discovering patterns of pleiotropy in genome-wide association studies

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  • Site-wide: 40,135
  • In genetics: 1,980
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  • Site-wide: 108,374

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

• Downloaded 548 times
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  • Site-wide: 41,361
  • In genetics: 2,045
• Year to date:
  • Site-wide: 67,015
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  • Site-wide: 77,275

Metabolic signatures of birth weight in 18288 adolescents and adults

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  • Site-wide: 42,534
  • In systems biology: 1,019
• Year to date:
  • Site-wide: 65,773
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  • Site-wide: 83,369

Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

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  • Site-wide: 44,860
  • In genomics: 3,675
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  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 109,364

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 460 times
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  • Site-wide: 50,704
  • In genetics: 2,475
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  • Site-wide: 112,094

The landscape of incident disease risk for the biomarker GlycA and its mortality stratification in angiography patients

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  • Site-wide: 53,082
  • In epidemiology: 2,232
• Year to date:
  • Site-wide: 49,430
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  • Site-wide: 90,522

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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  • Site-wide: 66,395
  • In genetics: 3,168
• Year to date:
  • Site-wide: 51,091
• Since beginning of last month:
  • Site-wide: 96,568

Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease

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  • Site-wide: 72,943
  • In epidemiology: 2,947
• Year to date:
  • Site-wide: 48,184
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  • Site-wide: 102,503

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 183 times
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  • Site-wide: 99,548
  • In genomics: 5,912
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  • Site-wide: None
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  • Site-wide: 96,817

Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two European cohort studies

• Downloaded 140 times
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  • Site-wide: 107,646
  • In epidemiology: 4,316
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  • Site-wide: None
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  • Site-wide: 106,970

Elevated glycoprotein acetyl levels in adolescence and early adulthood predict adverse cardiometabolic profiles and risk of metabolic syndrome in up to 10 year follow-up

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  • Site-wide: 109,865
  • In cardiovascular medicine: 247
• Year to date:
  • Site-wide: 32,888
• Since beginning of last month:
  • Site-wide: 56,796