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Author: Manolis Kellis

Rankings

  • All-time downloads: 92,545 (rank: 1,483 )
  • Categories:
    • bioinformatics: 11,319 (rank: 713 )
    • cancer biology: 5,522 (rank: 553 )
    • cell biology: 1,851 (rank: 3,824 (tie) )
    • developmental biology: 1,165 (rank: 3,535 (tie) )
    • epidemiology: 620 (rank: 14,687 (tie) )
    • evolutionary biology: 516 (rank: 14,058 (tie) )
    • genetic and genomic medicine: 748 (rank: 4,304 (tie) )
    • genetics: 10,691 (rank: 1,550 (tie) )
    • genomics: 42,664 (rank: 217 )
    • infectious diseases: 4,765 (rank: 8,999 (tie) )
    • molecular biology: 3,787 (rank: 1,062 )
    • neuroscience: 1,739 (rank: 14,281 (tie) )
    • psychiatry and clinical psychology: 3,137 (rank: 253 (tie) )
    • synthetic biology: 1,898 (rank: 826 (tie) )
    • systems biology: 2,123 (rank: 2,062 )

Downloads per author, site-wide

Preprints

Single-cell profiling of the human primary motor cortex in ALS and FTLD

neuroscience more details view paper

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Single-cell anatomical analysis of human hippocampus and entorhinal cortex uncovers early-stage molecular pathology in Alzheimer's disease

neuroscience more details view paper

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Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes

genomics more details view paper
  • Downloaded 5,597 times
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    • Site-wide: 1,953
    • In genomics: 175
  • Year to date:
    • Site-wide: 19,033
  • Since beginning of last month:
    • Site-wide: 21,881

Mathematical analysis of Cordoba calcifediol trial suggests strong role for Vitamin D in reducing ICU admissions of hospitalized COVID-19 patients

infectious diseases more details view paper
  • Downloaded 4,765 times
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    • Site-wide: 2,444
    • In infectious diseases: 563
  • Year to date:
    • Site-wide: 652
  • Since beginning of last month:
    • Site-wide: 1,494

Local genetic effects on gene expression across 44 human tissues

genomics more details view paper
  • Downloaded 4,476 times
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    • Site-wide: 2,669
    • In genomics: 276
  • Year to date:
    • Site-wide: 77,589
  • Since beginning of last month:
    • Site-wide: 95,517

Thousands of novel unannotated proteins expand the MHC I immunopeptidome in cancer

cancer biology more details view paper
  • Downloaded 4,321 times
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    • Site-wide: 2,804
    • In cancer biology: 40
  • Year to date:
    • Site-wide: 2,128
  • Since beginning of last month:
    • Site-wide: 2,406

High-resolution genome-wide functional dissection of transcriptional regulatory regions in human

genomics more details view paper
  • Downloaded 3,942 times
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    • Site-wide: 3,208
    • In genomics: 339
  • Year to date:
    • Site-wide: 80,313
  • Since beginning of last month:
    • Site-wide: 81,740

Phylogenetic Identification and Functional Characterization of Orthologs and Paralogs across Human, Mouse, Fly, and Worm

genomics more details view paper
  • Downloaded 3,697 times
  • Download rankings, all-time:
    • Site-wide: 3,519
    • In genomics: 375
  • Year to date:
    • Site-wide: 13,960
  • Since beginning of last month:
    • Site-wide: 14,333

Integrative analysis of 10,000 epigenomic maps across 800 samples for regulatory genomics and disease dissection

genomics more details view paper
  • Downloaded 3,644 times
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    • Site-wide: 3,587
    • In genomics: 382
  • Year to date:
    • Site-wide: 3,397
  • Since beginning of last month:
    • Site-wide: 9,456

A Bayesian approach to mediation analysis predicts 206 causal target genes in Alzheimer's disease

genetics more details view paper
  • Downloaded 3,495 times
  • Download rankings, all-time:
    • Site-wide: 3,799
    • In genetics: 140
  • Year to date:
    • Site-wide: 18,474
  • Since beginning of last month:
    • Site-wide: 17,033

Single-cell dissection of schizophrenia reveals neurodevelopmental-synaptic axis and transcriptional resilience

psychiatry and clinical psychology more details view paper
  • Downloaded 3,137 times
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    • Site-wide: 4,434
    • In psychiatry and clinical psychology: 16
  • Year to date:
    • Site-wide: 1,981
  • Since beginning of last month:
    • Site-wide: 3,182

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes

genomics more details view paper
  • Downloaded 2,824 times
  • Download rankings, all-time:
    • Site-wide: 5,154
    • In genomics: 533
  • Year to date:
    • Site-wide: 3,671
  • Since beginning of last month:
    • Site-wide: 3,122

Distant regulatory effects of genetic variation in multiple human tissues

genomics more details view paper
  • Downloaded 2,808 times
  • Download rankings, all-time:
    • Site-wide: 5,187
    • In genomics: 537
  • Year to date:
    • Site-wide: 70,223
  • Since beginning of last month:
    • Site-wide: 44,898

Simultaneous profiling of DNA methylation and chromatin architecture in mixed populations and in single cells

genomics more details view paper
  • Downloaded 2,484 times
  • Download rankings, all-time:
    • Site-wide: 6,218
    • In genomics: 673
  • Year to date:
    • Site-wide: 52,706
  • Since beginning of last month:
    • Site-wide: 50,387

DECODE-ing sparsity patterns in single-cell RNA-seq

bioinformatics more details view paper
  • Downloaded 2,275 times
  • Download rankings, all-time:
    • Site-wide: 7,064
    • In bioinformatics: 795
  • Year to date:
    • Site-wide: 87,131
  • Since beginning of last month:
    • Site-wide: 86,178

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

genomics more details view paper
  • Downloaded 2,103 times
  • Download rankings, all-time:
    • Site-wide: 7,914
    • In genomics: 835
  • Year to date:
    • Site-wide: 138,264
  • Since beginning of last month:
    • Site-wide: 141,676

A probabilistic framework to dissect functional cell-type-specific regulatory elements and risk loci underlying the genetics of complex traits

bioinformatics more details view paper
  • Downloaded 2,071 times
  • Download rankings, all-time:
    • Site-wide: 8,079
    • In bioinformatics: 929
  • Year to date:
    • Site-wide: 89,402
  • Since beginning of last month:
    • Site-wide: 58,854

Best practices for genome-wide RNA structure analysis: combination of mutational profiles and drop-off information

bioinformatics more details view paper
  • Downloaded 1,988 times
  • Download rankings, all-time:
    • Site-wide: 8,595
    • In bioinformatics: 998
  • Year to date:
    • Site-wide: 26,391
  • Since beginning of last month:
    • Site-wide: 16,565

mRNA structure dynamics identifies the embryonic RNA regulome

molecular biology more details view paper
  • Downloaded 1,950 times
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    • Site-wide: 8,857
    • In molecular biology: 227
  • Year to date:
    • Site-wide: 89,515
  • Since beginning of last month:
    • Site-wide: 103,797

A multiresolution framework to characterize single-cell state landscapes

genomics more details view paper
  • Downloaded 1,933 times
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    • Site-wide: 8,956
    • In genomics: 930
  • Year to date:
    • Site-wide: 42,061
  • Since beginning of last month:
    • Site-wide: 62,873

Single-cell deconvolution of 3,000 post-mortem brain samples for eQTL and GWAS dissection in mental disorders

genomics more details view paper
  • Downloaded 1,926 times
  • Download rankings, all-time:
    • Site-wide: 9,018
    • In genomics: 933
  • Year to date:
    • Site-wide: 1,136
  • Since beginning of last month:
    • Site-wide: 3,941

High-Throughput 5′ UTR Engineering for Enhanced Protein Production in Non-Viral Gene Therapies

synthetic biology more details view paper
  • Downloaded 1,898 times
  • Download rankings, all-time:
    • Site-wide: 9,220
    • In synthetic biology: 93
  • Year to date:
    • Site-wide: 8,157
  • Since beginning of last month:
    • Site-wide: 7,021

Modeling prediction error improves power of transcriptome-wide association studies

genetics more details view paper
  • Downloaded 1,887 times
  • Download rankings, all-time:
    • Site-wide: 9,297
    • In genetics: 411
  • Year to date:
    • Site-wide: 70,057
  • Since beginning of last month:
    • Site-wide: 73,857

Convergence of dispersed regulatory mutations predicts driver genes in prostate cancer

genomics more details view paper
  • Downloaded 1,868 times
  • Download rankings, all-time:
    • Site-wide: 9,445
    • In genomics: 979
  • Year to date:
    • Site-wide: 32,297
  • Since beginning of last month:
    • Site-wide: 39,870

Conserved epigenetic regulatory logic infers genes governing cell identity

cell biology more details view paper
  • Downloaded 1,851 times
  • Download rankings, all-time:
    • Site-wide: 9,561
    • In cell biology: 232
  • Year to date:
    • Site-wide: 44,131
  • Since beginning of last month:
    • Site-wide: 44,660

Single-cell interactomes of the human brain reveal cell-type specific convergence of brain disorders

systems biology more details view paper
  • Downloaded 1,837 times
  • Download rankings, all-time:
    • Site-wide: 9,675
    • In systems biology: 173
  • Year to date:
    • Site-wide: 66,224
  • Since beginning of last month:
    • Site-wide: 73,841

Multi-tissue polygenic models for transcriptome-wide association studies

genetics more details view paper
  • Downloaded 1,834 times
  • Download rankings, all-time:
    • Site-wide: 9,695
    • In genetics: 433
  • Year to date:
    • Site-wide: 86,111
  • Since beginning of last month:
    • Site-wide: 85,896

Nearly all new protein-coding predictions in the CHESS database are not protein-coding

genomics more details view paper
  • Downloaded 1,793 times
  • Download rankings, all-time:
    • Site-wide: 10,022
    • In genomics: 1,043
  • Year to date:
    • Site-wide: 39,275
  • Since beginning of last month:
    • Site-wide: 44,999

Genome-wide regulatory model from MPRA data predicts functional regions, eQTLs, and GWAS hits

bioinformatics more details view paper
  • Downloaded 1,665 times
  • Download rankings, all-time:
    • Site-wide: 11,183
    • In bioinformatics: 1,313
  • Year to date:
    • Site-wide: 72,568
  • Since beginning of last month:
    • Site-wide: 111,132

Functional enrichments of disease variants across thousands of independent loci in eight diseases

genetics more details view paper
  • Downloaded 1,284 times
  • Download rankings, all-time:
    • Site-wide: 16,479
    • In genetics: 776
  • Year to date:
    • Site-wide: 103,812
  • Since beginning of last month:
    • Site-wide: 87,793

Single-cell dissection of the human cerebrovasculature in health and disease

neuroscience more details view paper
  • Downloaded 1,219 times
  • Download rankings, all-time:
    • Site-wide: 17,793
    • In neuroscience: 2,151
  • Year to date:
    • Site-wide: 2,095
  • Since beginning of last month:
    • Site-wide: 4,692

A gene expression atlas of embryonic neurogenesis in Drosophila reveals complex spatiotemporal regulation of lncRNAs.

developmental biology more details view paper
  • Downloaded 1,165 times
  • Download rankings, all-time:
    • Site-wide: 19,023
    • In developmental biology: 313
  • Year to date:
    • Site-wide: 34,455
  • Since beginning of last month:
    • Site-wide: 58,729

Single-cell dissection of live human hearts in ischemic heart disease and heart failure reveals cell-type-specific driver genes and pathways

molecular biology more details view paper
  • Downloaded 1,072 times
  • Download rankings, all-time:
    • Site-wide: 21,464
    • In molecular biology: 572
  • Year to date:
    • Site-wide: 2,499
  • Since beginning of last month:
    • Site-wide: 341

Structural variant selection for high-altitude adaptation using single-molecule long-read sequencing

genomics more details view paper
  • Downloaded 1,041 times
  • Download rankings, all-time:
    • Site-wide: 22,477
    • In genomics: 2,153
  • Year to date:
    • Site-wide: 2,600
  • Since beginning of last month:
    • Site-wide: 15,424

Predicting trait regulators by identifying co-localization of DNA binding and GWAS variants in regulatory regions

bioinformatics more details view paper
  • Downloaded 954 times
  • Download rankings, all-time:
    • Site-wide: 25,480
    • In bioinformatics: 2,920
  • Year to date:
    • Site-wide: 95,656
  • Since beginning of last month:
    • Site-wide: 97,967

A causal inference framework for estimating genetic variance and pleiotropy from GWAS summary data

bioinformatics more details view paper
  • Downloaded 946 times
  • Download rankings, all-time:
    • Site-wide: 25,801
    • In bioinformatics: 2,958
  • Year to date:
    • Site-wide: 64,001
  • Since beginning of last month:
    • Site-wide: 93,134

Evidence of a recombination rate valley in human regulatory domains

genomics more details view paper
  • Downloaded 932 times
  • Download rankings, all-time:
    • Site-wide: 26,350
    • In genomics: 2,436
  • Year to date:
    • Site-wide: 114,257
  • Since beginning of last month:
    • Site-wide: 124,930

Genus-wide characterization of bumblebee genomes reveals variation associated with key ecological and behavioral traits of pollinators

genomics more details view paper
  • Downloaded 854 times
  • Download rankings, all-time:
    • Site-wide: 29,785
    • In genomics: 2,653
  • Year to date:
    • Site-wide: 38,145
  • Since beginning of last month:
    • Site-wide: 89,399

Evolutionary dynamics of abundant stop codon readthrough in Anopheles and Drosophila

molecular biology more details view paper
  • Downloaded 765 times
  • Download rankings, all-time:
    • Site-wide: 34,683
    • In molecular biology: 968
  • Year to date:
    • Site-wide: 103,591
  • Since beginning of last month:
    • Site-wide: 125,921

Counterfactual inference for single-cell gene expression analysis

genetic and genomic medicine more details view paper
  • Downloaded 748 times
  • Download rankings, all-time:
    • Site-wide: 35,801
    • In genetic and genomic medicine: 136
  • Year to date:
    • Site-wide: 4,169
  • Since beginning of last month:
    • Site-wide: 17,285

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

genomics more details view paper
  • Downloaded 742 times
  • Download rankings, all-time:
    • Site-wide: 36,254
    • In genomics: 3,050
  • Year to date:
    • Site-wide: 144,374
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    • Site-wide: 146,483

RiVIERA-beta: Joint Bayesian inference of risk variants and tissue-specific epigenomic enrichments across multiple complex human diseases

bioinformatics more details view paper
  • Downloaded 716 times
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    • Site-wide: 38,052
    • In bioinformatics: 4,123
  • Year to date:
    • Site-wide: 138,127
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    • Site-wide: 143,219

Plasma-derived exosomal analysis and deconvolution enables prediction and tracking of melanoma checkpoint blockade response

cancer biology more details view paper
  • Downloaded 664 times
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    • Site-wide: 42,037
    • In cancer biology: 1,146
  • Year to date:
    • Site-wide: 52,176
  • Since beginning of last month:
    • Site-wide: 84,216

Evidence for secondary-variant genetic burden and non-random distribution across biological modules in a recessive ciliopathy

genetics more details view paper
  • Downloaded 631 times
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    • Site-wide: 44,813
    • In genetics: 2,033
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    • Site-wide: 72,682
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    • Site-wide: 50,502

Analysis of Genetically Regulated Gene Expression identifies a trauma type specific PTSD gene, SNRNP35

genetics more details view paper
  • Downloaded 627 times
  • Download rankings, all-time:
    • Site-wide: 45,240
    • In genetics: 2,055
  • Year to date:
    • Site-wide: 130,264
  • Since beginning of last month:
    • Site-wide: 103,910

Integrative construction of regulatory region networks in 127 human reference epigenomes by matrix factorization

epidemiology more details view paper
  • Downloaded 620 times
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    • Site-wide: 45,858
    • In epidemiology: 2,187
  • Year to date:
    • Site-wide: 147,254
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    • Site-wide: 141,639

Correlating predicted epigenetic marks with expression data to find interactions between SNPs and genes

bioinformatics more details view paper
  • Downloaded 591 times
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    • Site-wide: 48,628
    • In bioinformatics: 5,018
  • Year to date:
    • Site-wide: 98,465
  • Since beginning of last month:
    • Site-wide: 107,320

Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival

cancer biology more details view paper
  • Downloaded 537 times
  • Download rankings, all-time:
    • Site-wide: 54,768
    • In cancer biology: 1,538
  • Year to date:
    • Site-wide: 147,863
  • Since beginning of last month:
    • Site-wide: 142,211

Exome-wide age-of-onset analysis reveals exonic variants in ERN1, TACR3 and SPPL2C associated with Alzheimer's disease

neuroscience more details view paper
  • Downloaded 520 times
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    • Site-wide: 56,922
    • In neuroscience: 8,280
  • Year to date:
    • Site-wide: 81,915
  • Since beginning of last month:
    • Site-wide: 91,845

Elucidation of Codon Usage Signatures across the Domains of Life

evolutionary biology more details view paper
  • Downloaded 516 times
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    • Site-wide: 57,476
    • In evolutionary biology: 2,987
  • Year to date:
    • Site-wide: 111,787
  • Since beginning of last month:
    • Site-wide: 102,569

Various localized epigenetic marks predict expression across 54 samples and reveal underlying chromatin state enrichments

genetics more details view paper
  • Downloaded 514 times
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    • Site-wide: 57,683
    • In genetics: 2,578
  • Year to date:
    • Site-wide: 143,411
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    • Site-wide: 104,273

Leveraging single-cell ATAC-seq to identify disease-critical fetal and adult brain cell types

genetics more details view paper
  • Downloaded 419 times
  • Download rankings, all-time:
    • Site-wide: 71,815
    • In genetics: 3,189
  • Year to date:
    • Site-wide: 9,766
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    • Site-wide: 3,249

Cellular intelligence: dynamic specialization through non-equilibrium multi-scale compartmentalization

systems biology more details view paper
  • Downloaded 191 times
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    • Site-wide: 121,355
    • In systems biology: 2,684
  • Year to date:
    • Site-wide: 28,228
  • Since beginning of last month:
    • Site-wide: 3,404

Comparison of human and mouse tissues with focus on genes with no 1-to-1 homology

bioinformatics more details view paper
  • Downloaded 113 times
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    • Site-wide: 138,463
    • In bioinformatics: 10,752
  • Year to date:
    • Site-wide: 50,448
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    • Site-wide: 35,541

Metabolic resilience is encoded in genome plasticity

systems biology more details view paper
  • Downloaded 95 times
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    • Site-wide: 141,824
    • In systems biology: 2,989
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