Author: Yan Li

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Preprints

Prefrontal cortex melanocortin 4 receptors (MC4R) mediate food intake behavior in mice

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Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study

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  • Site-wide: 7
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• Year to date:
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  • Site-wide: 1,073

First 12 patients with coronavirus disease 2019 (COVID-19) in the United States

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  • Site-wide: 72
  • In public and global health: 5
• Year to date:
  • Site-wide: 2,445
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Time-varying transmission dynamics of Novel Coronavirus Pneumonia in China

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Viral infection and Transmission in a large well-traced outbreak caused by the Delta SARS-CoV-2 variant

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• Year to date:
  • Site-wide: 1,143
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Isolation and characterization of SARS-CoV-2 from the first US COVID-19 patient

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  • Site-wide: 334
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  • Site-wide: 3,722

Clinical diagnosis of 8274 samples with 2019-novel coronavirus in Wuhan

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  • Site-wide: 472
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Transmission dynamics and epidemiological characteristics of Delta variant infections in China

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Prevention and Attenuation of COVID-19 by BNT162b2 and mRNA-1273 Vaccines

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  • Site-wide: 1,446
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  • Site-wide: 23,806

Single Molecule Sequencing Of M13 Virus Genome Without Amplification

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Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening

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  • In pharmacology and toxicology: 8
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A Genomic Survey of SARS-CoV-2 Reveals Multiple Introductions into Northern California without a Predominant Lineage

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  • Site-wide: 1,974
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Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy

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  • Site-wide: 2,037
  • In microbiology: 161
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  • Site-wide: 22,141
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  • Site-wide: 96,175

Nanopore target sequencing for accurate and comprehensive detection of SARS-CoV-2 and other respiratory viruses

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  • Site-wide: 2,268
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Easy Hi-C: A simple efficient protocol for 3D genome mapping in small cell populations

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Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD protein vaccine against COVID-19 in adults: pooled analysis of two randomized, double-blind, placebo-controlled, phase 1 and 2 trials

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  • Site-wide: 3,105
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The production of antibodies for SARS-CoV-2 and its clinical implication

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An in-depth investigation of the safety and immunogenicity of an inactivated SARS-CoV-2 vaccine

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  • Site-wide: 5,596
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Immunodepletion with Hypoxemia: A Potential High Risk Subtype of Coronavirus Disease 2019

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Study on the expression levels of antibodies against SARS-CoV-2 at different period of disease and its related factors in 192 cases of COVID-19 patients

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  • Site-wide: 6,299
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  • Site-wide: 51,167

Mapping a Pandemic: SARS-CoV-2 Seropositivity in the United States

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  • Site-wide: 6,441
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  • Site-wide: 34,038
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  • Site-wide: 42,152

Resequencing the Escherichia coli genome by GenoCare single molecule sequencing platform

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SARS-CoV-2 infection does not significantly cause acute renal injury: an analysis of 116 hospitalized patients with COVID-19 in a single hospital, Wuhan, China

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  • Site-wide: 8,353
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Projected COVID-19 epidemic in the United States in the context of the effectiveness of a potential vaccine and implications for social distancing and face mask use

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  • Site-wide: 8,846
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  • Site-wide: 38,480

Multi-organ Proteomic Landscape of COVID-19 Autopsies

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  • Site-wide: 9,633
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  • Site-wide: 57,267
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  • Site-wide: 38,426

LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomes

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  • Site-wide: 10,517
  • In cell biology: 228
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  • Site-wide: 41,018

Genome sequence and analysis of the eggplant (Solanum melongena L.)

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  • Site-wide: 11,258
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Evolutionary history of the brown rat: out of southern East Asia and selection

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  • Site-wide: 11,496
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  • Site-wide: 26,754

Rapid, sensitive, full genome sequencing of Severe Acute Respiratory Syndrome Virus Coronavirus 2 (SARS-CoV-2)

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  • Site-wide: 11,871
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• Year to date:
  • Site-wide: 84,817
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  • Site-wide: 120,998

Discovery and Development of Human SARS-CoV-2 Neutralizing Antibodies using an Unbiased Phage Display Library Approach

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  • Site-wide: 14,791
  • In microbiology: 823
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  • Site-wide: 61,023
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  • Site-wide: 58,080

Robust Hi-C chromatin loop maps in human neurogenesis and brain tissues at high-resolution

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  • Site-wide: 16,060
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  • Site-wide: 59,028
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  • Site-wide: 77,781

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

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  • Site-wide: 16,248
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  • Site-wide: 846
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The Foundational data initiative for Parkinsons disease (FOUNDIN-PD): enabling efficient translation from genetic maps to mechanism

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  • Site-wide: 16,628
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  • Site-wide: 12,684

Efficacy and Safety of Leflunomide for Refractory COVID-19: An Open-label Controlled Study

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  • Site-wide: 17,688
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Proteomics Uncovers Immunosuppression in COVID-19 Patients with Long Disease Course

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  • Site-wide: 17,951
  • In respiratory medicine: 60
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  • Site-wide: 57,564
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  • Site-wide: 58,031

Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapse

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  • Site-wide: 18,281
  • In neuroscience: 2,175
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Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2

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  • Site-wide: 18,488
  • In biochemistry: 508
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Developmental trajectory of pre-hematopoietic stem cell formation from endothelium

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  • Site-wide: 18,558
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ACE2 expression in human dorsal root ganglion sensory neurons: implications for SARS-CoV-2 virus-induced neurological effects

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  • Site-wide: 19,012
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Building a sequence map of the pig pan-genome from multiple de novo assemblies and Hi-C data

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  • Site-wide: 20,119
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Genomic and phylogenetic analysis of Salmonella Typhimurium and its monophasic variants responsible for invasive endemic infections in Colombia

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Transmission Dynamics and Control Methodology of COVID-19: a Modeling Study

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  • Site-wide: 26,600
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Exploring genes of rectal cancer for new treatments based on protein interaction network

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  • Site-wide: 113,045

Neuroendocrine Modulation Sustains the C. elegans Forward Motor State

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  • Site-wide: 27,819
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  • Site-wide: 144,546

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

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  • Site-wide: 32,657
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Wiring logic of the early rodent olfactory system revealed by high-throughput sequencing of single neuron projections

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Recombinant Fc-fusion vaccine of RBD induced protection against SARS-CoV-2 in non-human primate and mice

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  • Site-wide: 36,997
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A novel network control model for identifying personalized driver genes in cancer

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Methylglyoxal modification of TrkB promotes synaptic plasticity and enhances resilience to chronic stress

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LCA robustly reveals subtle diversity in large-scale single-cell RNA-seq data

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Separate Fever Clinics Prevent the Spread of COVID-19 and Offload Emergency Resources: Analysis from a large tertiary hospital in China

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Cost-effectiveness analysis of BNT162b2 COVID-19 booster vaccination in the United States

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  • Site-wide: 43,138
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  • Site-wide: 40,240

TWO-SIGMA: a novel TWO-component SInGle cell Model-based Association method for single-cell RNA-seq data

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  • Site-wide: 43,366
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Convergent genomic signatures of high altitude adaptation among domestic mammals

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Nociceptor translational profiling reveals the RagA-mTORC1 network as a critical generator of neuropathic pain

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Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells

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Manipulation of Seedling Traits with Pulsed Light in Closed Controlled Environments

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A transferrable and interpretable multiple instance learning model for microsatellite instability prediction based on histopathology images

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RNA Profiling of Neuropathic Pain-Associated Human DRGs Reveal Sex-differences in Neuro-immune Interactions Promoting Pain

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RNF5 Regulation of RBBP4 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors

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Structure-based design of antisense oligonucleotides that inhibit SARS-CoV-2 replication

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A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo

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Same-Day Simultaneous Diagnosis of Bacterial and Fungal Infections in Clinical Practice by Nanopore Targeted Sequencing

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Genome structure and evolution of Antirrhnum majus L.

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Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes

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Pathway-Structured Predictive Model for Cancer Survival Prediction: A Two-Stage Approach

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Associations between state-level healthcare access and COVID-19 case trajectories in the United States

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IRESbase: a Comprehensive Database of Experimentally Validated Internal Ribosome Entry Sites

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Fine-tuning of ABA responses by the protein kinase WNK8

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The RhoGEF Cysts couples apical polarity proteins to Rho and myosin activity at adherens junctions

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Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

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Plasticity in structure and assembly of SARS-CoV-2 nucleocapsid protein

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CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors

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Formation of tRNA wobble inosine in humans is perturbed by a millennia-old mutation linked to intellectual disability

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The endoplasmic reticulum-resident protein TMEM-120/TMEM120A promotes fat storage in C. elegans and mammalian cells

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Local 5-HT signal bi-directionally regulates the coincidence time window of associative learning

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Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1

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PGC-1α coordinates with Bcl-2 to control cell cycle in U251 cells through reducing ROS

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Lrfn2-mutant mice display suppressed synaptic plasticity and inhibitory synapse development and abnormal social communication and startle response

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Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

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Two Color Single Molecule Sequencing on GenoCare 1600 Platform to Facilitate Clinical Applications

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Effects of New York's Executive Order on Face Mask Use on COVID-19 Infections and Mortality: A Modeling Study

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  • Site-wide: 155,004

Base pair editing of goat embryos: nonsense codon introgression into FGF5 to improve cashmere yield

• Downloaded 478 times
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  • Site-wide: 92,084
  • In genetics: 3,588
• Year to date:
  • Site-wide: 126,535
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  • Site-wide: 93,379

OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy

• Downloaded 459 times
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  • Site-wide: 96,247
  • In cell biology: 5,326
• Year to date:
  • Site-wide: 10,786
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  • Site-wide: 20,116

In-depth analysis reveals complex molecular etiology of idiopathic cerebral palsy

• Downloaded 455 times
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  • Site-wide: 97,177
  • In genetics: 3,761
• Year to date:
  • Site-wide: 95,975
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  • Site-wide: 120,378

Genomic analyses provide insights into genetic architecture of three-way crossbred pigs

• Downloaded 449 times
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  • Site-wide: 98,469
  • In genomics: 5,764
• Year to date:
  • Site-wide: 124,607
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  • Site-wide: 115,462

Time courses of COVID-19 infection and local variation in socioeconomic and health disparities in England

• Downloaded 446 times
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  • Site-wide: 99,265
  • In public and global health: 1,401
• Year to date:
  • Site-wide: 88,835
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  • Site-wide: 58,191

Myt Transcription Factors prevent stress-response gene over-activation to enable postnatal pancreatic β cell proliferation and function

• Downloaded 432 times
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  • Site-wide: 102,436
  • In developmental biology: 2,524
• Year to date:
  • Site-wide: 162,656
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  • Site-wide: 137,048

Dietary disparities of urban immigrant schoolchildren in New York City: Results from a mixed-methods pilot study

• Downloaded 423 times
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  • Site-wide: 104,566
  • In public and global health: 1,518
• Year to date:
  • Site-wide: 51,190
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  • Site-wide: 55,596

Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response

• Downloaded 417 times
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  • Site-wide: 105,996
  • In cell biology: 4,583
• Year to date:
  • Site-wide: 146,923
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  • Site-wide: 185,816

Projecting the impact of SARS-CoV-2 variants on the COVID-19 epidemic and social restoration in the United States: a mathematical modelling study

• Downloaded 388 times
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  • Site-wide: 113,321
  • In infectious diseases: 5,279
• Year to date:
  • Site-wide: 97,626
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  • Site-wide: 137,825

NOGEA: Network-Oriented Gene Entropy Approach for Dissecting Disease Comorbidity and Drug Repositioning

• Downloaded 360 times
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  • Site-wide: 120,865
  • In systems biology: 2,405
• Year to date:
  • Site-wide: 177,922
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  • Site-wide: 134,340

The collective influence of 1, 25-dihydroxyvitamin D3 with physiological fluid shear stress on osteoblasts

• Downloaded 354 times
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  • Site-wide: 122,552
  • In cell biology: 5,409
• Year to date:
  • Site-wide: 133,994
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  • Site-wide: 141,473

Bifunctional enzyme SpoT is involved in biofilm formation of Helicobacter pylori with multidrug resistance by upregulating efflux pump Hp1174 (gluP)

• Downloaded 352 times
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  • Site-wide: 123,054
  • In microbiology: 8,107
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  • Site-wide: 165,754
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  • Site-wide: 117,611

A variant in SMOC2, inhibiting BMP signaling by competitively binding to BMPR1B, causes multiple epiphyseal dysplasia

• Downloaded 343 times
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  • Site-wide: 125,488
  • In genomics: 6,782
• Year to date:
  • Site-wide: 112,577
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  • Site-wide: 108,841

Genetic interaction between two unlinked loci underlies the loss of self-incompatibility in Arabidopsis lyrata

• Downloaded 340 times
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  • Site-wide: 126,243
  • In genetics: 4,799
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  • Site-wide: 112,632
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  • Site-wide: 88,378

The regulation of mammalian maternal-to-embryonic transition by Eukaryotic translation initiation factor 4E

• Downloaded 336 times
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  • Site-wide: 127,444
  • In developmental biology: 3,220
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  • Site-wide: 177,812
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  • Site-wide: 156,499

Exploring the impact of inoculum dose on host immunity and morbidity to inform model-based vaccine design

• Downloaded 336 times
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  • Site-wide: 127,572
  • In systems biology: 2,521
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  • Site-wide: 186,643
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  • Site-wide: 171,893

Insights into the susceptibility of rice to a floral disease

• Downloaded 316 times
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  • Site-wide: 133,385
  • In plant biology: 3,591
• Year to date:
  • Site-wide: 76,860
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  • Site-wide: 81,043

Trans-ethnic polygenic analysis supports genetic overlaps of lumbar disc degeneration with height, body mass index, and bone mineral density

• Downloaded 311 times
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  • Site-wide: 134,707
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  • Site-wide: 165,892
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  • Site-wide: 187,669

Abnormal nitration and S-sulfhydration of Sp1-CSE-H2S pathway contribute to the progress of HHcy

• Downloaded 311 times
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  • Site-wide: 134,801
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• Year to date:
  • Site-wide: 167,112
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  • Site-wide: 157,868

WBC-Profiler: an Unsupervised Feature Learning System for Leukocytes Characterization and Classification

• Downloaded 295 times
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  • Site-wide: 139,650
  • In bioinformatics: 10,549
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  • Site-wide: 152,934
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  • Site-wide: 161,477

Maximizing the Reusability of Gene Expression Data by Predicting Missing Metadata

• Downloaded 280 times
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  • Site-wide: 144,022
  • In bioinformatics: 10,625
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  • Site-wide: 189,535
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  • Site-wide: 181,890

Clinical Significance of C4d Deposition in Renal Tissues from Patients with Primary Sj&oumlgren's Syndrome--A Preliminary Study

• Downloaded 279 times
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  • Site-wide: 144,463
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• Year to date:
  • Site-wide: 145,079
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  • Site-wide: 111,708

Fusobacterium nucleatum facilitates cetuximab resistance in colorectal cancer via the PI3K/AKT and JAK/STAT3 pathways

• Downloaded 277 times
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  • Site-wide: 145,010
  • In cancer biology: 4,336
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  • Site-wide: 93,112
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  • Site-wide: 59,364

INFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants

• Downloaded 249 times
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  • Site-wide: 153,241
  • In bioinformatics: 11,383
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  • Site-wide: 122,844
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  • Site-wide: 137,582

Impact of Kuntai Capsules on LIF, IGF-1 and EGF Expression in the Implantation Window of Endometrium in Mice

• Downloaded 248 times
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  • Site-wide: 153,473
  • In pharmacology and toxicology: 1,135
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  • Site-wide: 184,349
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  • Site-wide: 172,895

Biogenesis of a bacterial metabolosome for propanediol utilization

• Downloaded 248 times
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  • Site-wide: 153,625
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  • Site-wide: 30,959
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  • Site-wide: 56,043

A study on the protective effects of CpG ODN-induced mucosal immunity against lung injury in a mouse ARDS model

• Downloaded 235 times
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  • Site-wide: 157,215
  • In immunology: 4,541
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  • Site-wide: 174,042
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  • Site-wide: 140,540

Proteasome maturation factor UMP1 confers broad-spectrum disease resistance by modulating H2O2 accumulation in rice

• Downloaded 225 times
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  • Site-wide: 160,053
  • In plant biology: 4,259
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  • Site-wide: 115,124
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  • Site-wide: 155,491

MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo

• Downloaded 218 times
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  • Site-wide: 161,908
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  • Site-wide: 82,159
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  • Site-wide: 75,798

Repeated introduction of micropollutants enhances microbial succession despite stable degradation patterns

• Downloaded 209 times
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  • Site-wide: 164,340
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  • Site-wide: 30,504
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  • Site-wide: 36,459

The addition of antibiotics to embryo culture media caused altered expression of genes in pathways governing DNA integrity in mouse blastocysts

• Downloaded 186 times
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  • Site-wide: 170,152
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• Year to date:
  • Site-wide: 21,523
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  • Site-wide: 17,783

mRNA-based COVID-19 booster vaccination is highly effective and cost-effective in Australia

• Downloaded 172 times
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  • Site-wide: 173,293
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• Year to date:
  • Site-wide: 23,997
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  • Site-wide: 3,293

Multi-omics analysis combining pyroptosis-related signatures for building a prognosis prediction model in hepatocellular carcinoma

• Downloaded 172 times
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  • Site-wide: 173,273
  • In cancer biology: 5,216
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  • Site-wide: 23,971
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  • Site-wide: 79,556

Biophysical, Molecular and Proteomic profiling of Human Retinal Organoids derived Exosomes

• Downloaded 160 times
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  • Site-wide: 176,042
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• Year to date:
  • Site-wide: 26,373
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  • Site-wide: 8,902

Class 1 integrons in clinical and swine industry isolates of Salmonella Typhimurium from Colombia, dating 1997 to 2017

• Downloaded 155 times
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  • Site-wide: 176,962
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  • Site-wide: 27,398
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  • Site-wide: 37,295

Statistical analysis of spatially resolved transcriptomic data by incorporating multi-omics auxiliary information

• Downloaded 152 times
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  • Site-wide: 177,713
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• Year to date:
  • Site-wide: 28,091
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  • Site-wide: 37,120

Fucoidan but not 2'-Fucosyllactose could inhibit human norovirus replication in zebrafish larvae

• Downloaded 147 times
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  • Site-wide: 178,560
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  • Site-wide: 181,040
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  • Site-wide: 181,389

Multinuclear MRI reveals early efficacy of stem cell therapy in stroke

• Downloaded 119 times
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  • Site-wide: 183,180
  • In bioengineering: 3,778
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  • Site-wide: 37,977
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  • Site-wide: 58,336

Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1

• Downloaded 65 times
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  • Site-wide: 188,956
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  • Site-wide: 70,177
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  • Site-wide: 16,375