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Author: John Hardy

Rankings

  • All-time downloads: 37,689 (rank: 3,881 )
  • Categories:
    • bioinformatics: 1,953 (rank: 7,406 (tie) )
    • genetic and genomic medicine: 1,699 (rank: 1,081 )
    • genetics: 10,130 (rank: 1,670 )
    • genomics: 2,573 (rank: 9,045 (tie) )
    • molecular biology: 294 (rank: 18,602 (tie) )
    • neurology: 4,296 (rank: 134 )
    • neuroscience: 12,404 (rank: 815 )
    • pathology: 4,111 (rank: 279 (tie) )
    • systems biology: 229 (rank: 12,171 (tie) )

Downloads per author, site-wide

Preprints

EXCEPTIONALLY LOW LIKELIHOOD OF ALZHEIMER'S DEMENTIA IN APOE2 HOMOZYGOTES

pathology more details view paper
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    • In pathology: 18
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New insights on the genetic etiology of Alzheimer and related dementia

neurology more details view paper
  • Downloaded 3,399 times
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    • Site-wide: 3,454
    • In neurology: 9
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    • Site-wide: 594
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    • Site-wide: 468

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

neuroscience more details view paper
  • Downloaded 3,249 times
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    • Site-wide: 3,683
    • In neuroscience: 294
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    • Site-wide: 13,386
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    • Site-wide: 20,905

G2P: Using machine learning to understand and predict genes causing rare neurological disorders

genetics more details view paper
  • Downloaded 1,980 times
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    • Site-wide: 7,557
    • In genetics: 355
  • Year to date:
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Genetic variability in response to Aβ deposition influences Alzheimer's risk

neuroscience more details view paper
  • Downloaded 1,878 times
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    • Site-wide: 8,186
    • In neuroscience: 852
  • Year to date:
    • Site-wide: 27,007
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    • Site-wide: 31,207

Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms

genetics more details view paper
  • Downloaded 1,370 times
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    • Site-wide: 13,081
    • In genetics: 644
  • Year to date:
    • Site-wide: 52,197
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    • Site-wide: 44,268

Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases

genomics more details view paper
  • Downloaded 1,223 times
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    • Site-wide: 15,580
    • In genomics: 1,607
  • Year to date:
    • Site-wide: 86,702
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    • Site-wide: 95,940

Exome sequencing identifies novel AD-associated genes.

genetic and genomic medicine more details view paper
  • Downloaded 1,084 times
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    • Site-wide: 18,606
    • In genetic and genomic medicine: 63
  • Year to date:
    • Site-wide: 10,658
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    • Site-wide: 12,851

Personalized genetic assessment of age associated Alzheimers disease risk

genetics more details view paper
  • Downloaded 976 times
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    • Site-wide: 21,613
    • In genetics: 1,039
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    • Site-wide: 76,402
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Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at Chr16q11.2 and on the MAPT H1 allele.

neuroscience more details view paper
  • Downloaded 940 times
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    • Site-wide: 22,897
    • In neuroscience: 2,961
  • Year to date:
    • Site-wide: 20,484
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    • Site-wide: 15,210

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of a-synuclein

neuroscience more details view paper
  • Downloaded 929 times
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    • Site-wide: 23,271
    • In neuroscience: 3,025
  • Year to date:
    • Site-wide: 32,892
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    • Site-wide: 42,275

Integration of eQTL and Parkinson's disease GWAS data implicates 11 disease genes

neuroscience more details view paper
  • Downloaded 923 times
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    • Site-wide: 23,478
    • In neuroscience: 3,069
  • Year to date:
    • Site-wide: 45,663
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A genome-wide genetic pleiotropy approach identified shared loci between multiple system atrophy and inflammatory bowel disease

genetics more details view paper
  • Downloaded 920 times
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    • Site-wide: 23,625
    • In genetics: 1,145
  • Year to date:
    • Site-wide: 69,747
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    • Site-wide: 55,235

Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability

genomics more details view paper
  • Downloaded 908 times
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    • Site-wide: 24,062
    • In genomics: 2,309
  • Year to date:
    • Site-wide: 108,636
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    • Site-wide: 109,240

Genetic modifiers of risk and age at onset in GBA associated Parkinson disease and Lewy body dementia

genetics more details view paper
  • Downloaded 829 times
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    • Site-wide: 27,327
    • In genetics: 1,328
  • Year to date:
    • Site-wide: 39,769
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    • Site-wide: 41,356

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

genetics more details view paper
  • Downloaded 825 times
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    • Site-wide: 27,490
    • In genetics: 1,333
  • Year to date:
    • Site-wide: 62,050
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    • Site-wide: 68,392

Common variation at the LRRK2 locus is associated with survival in the primary tauopathy progressive supranuclear palsy

genetics more details view paper
  • Downloaded 791 times
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    • Site-wide: 29,177
    • In genetics: 1,418
  • Year to date:
    • Site-wide: 49,130
  • Since beginning of last month:
    • Site-wide: 53,578

AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans

neuroscience more details view paper
  • Downloaded 791 times
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    • Site-wide: 29,176
    • In neuroscience: 3,944
  • Year to date:
    • Site-wide: 21,035
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    • Site-wide: 42,358

Incomplete annotation of disease-associated genes is limiting our understanding of Mendelian and complex neurogenetic disorders

bioinformatics more details view paper
  • Downloaded 738 times
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    • Site-wide: 32,207
    • In bioinformatics: 3,621
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    • Site-wide: 40,743
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    • Site-wide: 33,090

Heritability and genetic variance of dementia with Lewy bodies

neuroscience more details view paper
  • Downloaded 723 times
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    • Site-wide: 33,135
    • In neuroscience: 4,553
  • Year to date:
    • Site-wide: 86,703
  • Since beginning of last month:
    • Site-wide: 88,552

Parkinsons disease determinants, prediction and gene-environment interactions in the UK Biobank

genetics more details view paper
  • Downloaded 708 times
  • Download rankings, all-time:
    • Site-wide: 34,061
    • In genetics: 1,641
  • Year to date:
    • Site-wide: 43,255
  • Since beginning of last month:
    • Site-wide: 53,789

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

neurology more details view paper
  • Downloaded 685 times
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    • Site-wide: 35,605
    • In neurology: 64
  • Year to date:
    • Site-wide: 1,853
  • Since beginning of last month:
    • Site-wide: 515

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain

neuroscience more details view paper
  • Downloaded 613 times
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    • Site-wide: 41,093
    • In neuroscience: 5,867
  • Year to date:
    • Site-wide: 47,571
  • Since beginning of last month:
    • Site-wide: 74,911

Immune-related genetic enrichment in frontotemporal dementia

genetics more details view paper
  • Downloaded 603 times
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    • Site-wide: 41,988
    • In genetics: 1,994
  • Year to date:
    • Site-wide: 109,471
  • Since beginning of last month:
    • Site-wide: 119,857

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC--derived microglia

neuroscience more details view paper
  • Downloaded 586 times
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    • Site-wide: 43,487
    • In neuroscience: 6,260
  • Year to date:
    • Site-wide: 95,617
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    • Site-wide: 80,678

The Parkinsons Disease Mendelian Randomization Research Portal

neuroscience more details view paper
  • Downloaded 508 times
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    • Site-wide: 51,715
    • In neuroscience: 7,633
  • Year to date:
    • Site-wide: 115,547
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    • Site-wide: 129,769

Sequence of cognitive changes associated with development of Alzheimer's disease in Down syndrome - data driven analysis

neuroscience more details view paper
  • Downloaded 507 times
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    • Site-wide: 51,804
    • In neuroscience: 7,655
  • Year to date:
    • Site-wide: 77,105
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    • Site-wide: 102,545

Gene based Analysis in HRC Imputed Genome Wide Association Data Identifies Three Novel Genes for Alzheimer's Disease

genetics more details view paper
  • Downloaded 506 times
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    • Site-wide: 51,951
    • In genetics: 2,422
  • Year to date:
    • Site-wide: 120,465
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    • Site-wide: 127,369

Genome-wide association studies of cognitive and motor progression in Parkinson's disease

genetic and genomic medicine more details view paper
  • Downloaded 505 times
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    • Site-wide: 52,017
    • In genetic and genomic medicine: 166
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    • Site-wide: 53,014
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    • Site-wide: 73,025

A comprehensive assessment of benign genetic variability for neurodegenerative disorders

genomics more details view paper
  • Downloaded 442 times
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    • Site-wide: 60,304
    • In genomics: 4,440
  • Year to date:
    • Site-wide: 120,545
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    • Site-wide: 109,447

Regulatory sites for known and novel splicing in human basal ganglia are enriched for disease-relevant information

bioinformatics more details view paper
  • Downloaded 413 times
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    • Site-wide: 64,555
    • In bioinformatics: 6,298
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    • Site-wide: 99,817
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    • Site-wide: 117,332

Human-lineage-specific genomic elements: relevance to neurodegenerative disease and APOE transcript usage

neuroscience more details view paper
  • Downloaded 382 times
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    • Site-wide: 69,496
    • In neuroscience: 10,586
  • Year to date:
    • Site-wide: 57,727
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    • Site-wide: 57,326

Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasome

neuroscience more details view paper
  • Downloaded 375 times
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    • Site-wide: 70,768
    • In neuroscience: 10,768
  • Year to date:
    • Site-wide: 16,258
  • Since beginning of last month:
    • Site-wide: 9,511

Transcriptomic analysis of dystonia-associated genes reveals functional convergence within specific cell types and shared neurobiology with psychiatric disorders

genetics more details view paper
  • Downloaded 372 times
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    • Site-wide: 71,285
    • In genetics: 3,253
  • Year to date:
    • Site-wide: 48,733
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    • Site-wide: 53,522

CoExp Web, a web tool for the exploitation of co-expression networks

bioinformatics more details view paper
  • Downloaded 351 times
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    • Site-wide: 75,030
    • In bioinformatics: 6,992
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    • Site-wide: 25,520
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    • Site-wide: 19,692

ERASE: Extended Randomization for assessment of annotation enrichment in ASE datasets

bioinformatics more details view paper
  • Downloaded 330 times
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    • Site-wide: 78,878
    • In bioinformatics: 7,261
  • Year to date:
    • Site-wide: 115,471
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    • Site-wide: 78,754

Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome

molecular biology more details view paper
  • Downloaded 294 times
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    • Site-wide: 86,165
    • In molecular biology: 2,558
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    • Site-wide: 126,382
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    • Site-wide: 102,589

Genetic variability associated with OAS1 expression in myeloid cells increases the risk of Alzheimer's disease and severe COVID-19 outcomes

genetics more details view paper
  • Downloaded 250 times
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    • Site-wide: 95,701
    • In genetics: 4,292
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    • Site-wide: 7,801
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    • Site-wide: 2,142

Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias

systems biology more details view paper
  • Downloaded 229 times
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    • Site-wide: 100,350
    • In systems biology: 2,332
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Heritability enrichment implicates microglia in Parkinson's disease pathogenesis

neurology more details view paper
  • Downloaded 212 times
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    • Site-wide: 104,371
    • In neurology: 328
  • Year to date:
    • Site-wide: 40,100
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    • Site-wide: 39,313

Modeling multifunctionality of genes with secondary gene co-expression networks in human brain provides novel disease insights

bioinformatics more details view paper
  • Downloaded 121 times
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    • Site-wide: 123,244
    • In bioinformatics: 9,910
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    • Site-wide: 78,043
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    • Site-wide: 100,679

Investigation of Autosomal Genetic Sex Differences in Parkinsons disease

genetic and genomic medicine more details view paper
  • Downloaded 110 times
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    • Site-wide: 125,304
    • In genetic and genomic medicine: 608
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    • Site-wide: 22,650
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    • Site-wide: 14,587

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