Author: Yi Wang

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Preprints

Inspiration of SARS-CoV-2 envelope protein mutations on pathogenicity of Omicron XBB

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Clinical Features of Patients Infected with the 2019 Novel Coronavirus (COVID-19) in Shanghai, China

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  • Site-wide: 1,346
  • In respiratory medicine: 6
• Year to date:
  • Site-wide: 9,904
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  • Site-wide: 24,650

Reverse transcription loop-mediated isothermal amplification combined with nanoparticles-based biosensor for diagnosis of COVID-19

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  • Site-wide: 3,267
  • In infectious diseases: 804
• Year to date:
  • Site-wide: 44,959
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  • Site-wide: 53,098

COVID-19 Epidemic Outside China: 34 Founders and Exponential Growth

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  • Site-wide: 3,661
  • In epidemiology: 386
• Year to date:
  • Site-wide: 128,958
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Safety, Tolerability, and Immunogenicity of COVID-19 Vaccines: A Systematic Review and Meta-Analysis

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  • Site-wide: 3,699
  • In infectious diseases: 855
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  • Site-wide: 44,134
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  • Site-wide: 16,601

Comparative performance of four nucleic acid amplification tests for SARS-CoV-2 virus

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  • Site-wide: 5,913
  • In molecular biology: 121
• Year to date:
  • Site-wide: 91,064
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  • Site-wide: 78,222

Promoter Or Enhancer Activation By CRISPRa Rescues Haploinsufficiency Caused Obesity

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  • Site-wide: 8,894
  • In genetics: 336
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  • Site-wide: 150,151

Co-expression analysis is biased by a mean-correlation relationship

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  • Site-wide: 14,956
  • In genomics: 1,359
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  • Site-wide: 35,156
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  • Site-wide: 77,798

Investigating the Evolutionary Importance of Denisovan Introgressions in Papua New Guineans and Australians

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  • Site-wide: 16,083
  • In genomics: 1,449
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  • Site-wide: 144,338

A Note on NCP Diagnosis Number Prediction Model

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  • Site-wide: 17,564
  • In epidemiology: 1,190
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  • Site-wide: 128,930
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  • Site-wide: 122,712

Structural basis for divergent and convergent evolution of catalytic machineries in plant aromatic amino acid decarboxylase proteins

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  • Site-wide: 21,093
  • In biochemistry: 448
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Increased antibiotic susceptibility in Neisseria gonorrhoeae through adaptation to the cervical environment

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  • Site-wide: 34,801
  • In microbiology: 2,003
• Year to date:
  • Site-wide: 183,609
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  • Site-wide: 162,339

Accurate estimation of cell-type resolution transcriptome in bulk tissue through matrix completion

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  • Site-wide: 34,753
  • In bioinformatics: 3,785
• Year to date:
  • Site-wide: 188,328
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  • Site-wide: 14,336

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damage and constitutes an antiviral target

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  • Site-wide: 35,214
  • In microbiology: 2,034
• Year to date:
  • Site-wide: 158,225
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  • Site-wide: 121,664

Automated literature mining and hypothesis generation through a network of Medical Subject Headings

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  • Site-wide: 39,692
  • In bioinformatics: 4,137
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  • Site-wide: 93,420

Impact of blood analysis and immune function on the prognosis of patients with COVID-19

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  • Site-wide: 40,106
  • In infectious diseases: 3,338
• Year to date:
  • Site-wide: 156,445
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  • Site-wide: 163,001

Why SARS-CoV-2 Omicron variant is milder? A single high-frequency mutation of structural envelope protein matters.

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  • Site-wide: 41,331
  • In microbiology: 2,468
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  • Site-wide: 51,092
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The brown alga Saccharina japonica features distinct vanadium-dependent bromoperoxidases and iodoperoxidases

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  • Site-wide: 46,745
  • In molecular biology: 1,293
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Time-resolved digital immunoassay for rapid and sensitive quantitation of procalcitonin with plasmonic imaging

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  • Site-wide: 53,970
  • In bioengineering: 1,064
• Year to date:
  • Site-wide: 108,787
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  • Site-wide: 179,319

RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates

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  • Site-wide: 56,407
  • In microbiology: 3,354
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  • Site-wide: None
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  • Site-wide: 91,292

Single-cell transcriptomic atlas of individuals receiving inactivated COVID-19 vaccines reveals distinct immunological responses between vaccine and natural SARS-CoV-2 infection

• Downloaded 789 times
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  • Site-wide: 57,313
  • In infectious diseases: 4,049
• Year to date:
  • Site-wide: 89,186
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  • Site-wide: 71,397

Monitoring and predicting viral dynamics in SARS-CoV-2-infected Patients

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  • Site-wide: 57,505
  • In infectious diseases: 4,058
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  • Site-wide: 55,094
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Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation

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  • Site-wide: 59,762
  • In genomics: 4,170
• Year to date:
  • Site-wide: 134,219
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  • Site-wide: 208,777

Using composite phenotypes to reveal hidden physiological heterogeneity and model oxygen saturation variation of high altitude acclimatization in a Chinese Han longitudinal cohort

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  • Site-wide: 61,441
  • In systems biology: 1,227
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  • Site-wide: 107,234
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  • Site-wide: 153,866

Renewable Fatty Acid Ester Production in Clostridium

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  • Site-wide: 67,044
  • In bioengineering: 1,345
• Year to date:
  • Site-wide: 158,163
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  • Site-wide: 98,687

HER2 Cancer Protrusion Growth Signaling Regulated by Unhindered, Localized Filopodial Dynamics

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  • Site-wide: 67,950
  • In cancer biology: 1,996
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  • Site-wide: 107,989
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  • Site-wide: 94,512

A follow-up study of children infected with SARS-CoV-2 from Western China

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  • Site-wide: 69,764
  • In infectious diseases: 4,446
• Year to date:
  • Site-wide: 185,492
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  • Site-wide: 163,074

The SC-SNc pathway boosts appetitive locomotion in predatory hunting

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  • Site-wide: 71,615
  • In neuroscience: 9,972
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  • Site-wide: 128,391
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  • Site-wide: 131,748

A mechanism for sensing of and adaptation to K+ deprivation in plants

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  • Site-wide: 73,929
  • In plant biology: 1,746
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  • Site-wide: 129,970
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  • Site-wide: 98,435

Mechanistic basis for the emergence of EPS1 as a catalyst in plant salicylic acid biosynthesis

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  • Site-wide: 77,108
  • In biochemistry: 2,088
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  • Site-wide: 67,533
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  • Site-wide: 68,033

A functional role for the epigenetic regulator ING1 in activity-induced gene expression in primary cortical neurons

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  • Site-wide: 82,338
  • In neuroscience: 11,670
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  • Site-wide: 174,192

Global Screening of Sentrin-Specific Protease Family Substrates in SUMOylation

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  • Site-wide: 83,840
  • In biochemistry: 2,271
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  • Site-wide: 215,565

Proteomic and metabolomic signatures associated with the immune response in healthy individuals immunized with an inactivated SARS-CoV-2 vaccine

• Downloaded 598 times
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  • Site-wide: 84,272
  • In infectious diseases: 4,936
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  • Site-wide: 120,638
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  • Site-wide: 67,855

Elucidating Mechanisms of Antitumor Immunity Mediated by Live Oncolytic Vaccinia and Heat-Inactivated Vaccinia

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  • Site-wide: 85,668
  • In immunology: 2,773
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  • Site-wide: 146,406
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  • Site-wide: 166,119

Impairment of dual-task gait dynamics in older adults with mild cognitive impairment: Relationships to neuropsychological status, fitness and brain morphology

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  • Site-wide: 87,434
  • In geriatric medicine: 64
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  • Site-wide: 131,843

Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against an acute vaccinia infection in the lungs

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  • Site-wide: 88,625
  • In immunology: 2,890
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  • Site-wide: 188,313

Selective Permeability of Carboxysome Shell Pores to Anionic Molecules

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  • Site-wide: 91,717
  • In biochemistry: 2,550
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  • Site-wide: 203,649

Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

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  • Site-wide: 99,730
  • In microbiology: 6,665
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  • Site-wide: 27,526
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  • Site-wide: 28,233

piggyBac-system-mediated genomic integration of large variant libraries for deep mutational scanning in mammalian cells

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  • Site-wide: 102,315
  • In bioengineering: 2,114
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Cortical and Subcortical Neuroanatomical Signatures of Schizotypy in 3,004 Individuals Assessed in a Worldwide ENIGMA Study

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  • Site-wide: 107,647
  • In psychiatry and clinical psychology: 566
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  • Site-wide: 110,807

Intratumoral delivery of engineered recombinant modified vaccinia virus Ankara express-ing Flt3L and OX40L generates potent antitumor immunity through activating the cGAS/STING pathway and depleting tumor-infiltrating regulatory T cells

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  • Site-wide: 109,505
  • In immunology: 3,620
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  • Site-wide: 36,429

Mechanistic basis for the evolution of chalcone synthase catalytic cysteine reactivity in land plants

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  • Site-wide: 110,640
  • In biochemistry: 3,161
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  • Site-wide: 201,638

The primary cilium is required for MC4R control of food intake and body weight

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  • Site-wide: 110,724
  • In physiology: 919
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  • Site-wide: 101,423

Inheritance of neural substrates for motivation and pleasure experience

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  • Site-wide: 119,927
  • In neuroscience: 17,465
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  • Site-wide: 144,916

Whole Human-Brain Mapping of Single Cortical Neurons for Profiling Morphological Diversity and Stereotypy

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  • Site-wide: 123,083
  • In neuroscience: 18,805
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Scellseg: a style-aware cell instance segmentation tool with pre-training and contrastive fine-tuning

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  • Site-wide: 123,886
  • In bioinformatics: 10,275
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  • Site-wide: 56,910

Antibiotic concentrations in the sinonasal secretions and tissue in CRS patients after oral therapy: a randomized trial

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  • Site-wide: 125,124
  • In pharmacology and toxicology: 918
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  • Site-wide: 65,240

Robust Reference Powered Association Test of genome-wide association studies

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  • Site-wide: 125,400
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  • Site-wide: 196,157
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  • Site-wide: 151,961

Quantitative susceptibility mapping captures chronic multiple sclerosis rim lesions with greater myelin damage: Comparison with high-pass filtered phase MRI

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  • Site-wide: 127,443
  • In radiology and imaging: 287
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Biofilm Formation and Virulence of Shigella flexneri is Modulated by pH of Gastrointestinal Tract

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Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13

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  • Site-wide: 132,951
  • In biophysics: 4,998
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  • Site-wide: 180,305

Increased Risk for Cerebral Small Vessel Disease is Associated with Quantitative Susceptibility Mapping in HIV Infected and Uninfected Individuals

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  • Site-wide: 140,618
  • In pathology: 747
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  • Site-wide: 188,373
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  • Site-wide: 170,312

Dose-effect relationship of ginger interposed moxibustion for allergic rhinitis: study protocol for a randomised, placebo-controlled and parallel clinical trial

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  • Site-wide: 141,493
  • In otolaryngology: 107
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  • Site-wide: 41,459
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  • Site-wide: 32,374

Structural insight into the mechanism of 4-aminoquinolines selectivity for the alpha2A-adrenoceptor

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  • Site-wide: 144,474
  • In pharmacology and toxicology: 1,082
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  • Site-wide: 174,899
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  • Site-wide: 155,794

BREAst screening Tailored for HEr (BREATHE) - A Study Protocol On Personalised Risk-based Breast Cancer Screening Programme

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  • Site-wide: 150,255
  • In public and global health: 2,264
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  • Site-wide: 23,725
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  • Site-wide: 15,719

Bioactive constituents of Verbena officinalis alleviate inflammation and enhance killing efficiency of natural killer cells

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  • Site-wide: 152,959
  • In immunology: 5,013
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  • Site-wide: 28,722

Structural disconnectivity from quantitative susceptibility mapping rim+ lesions is related to disability in people with multiple sclerosis

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  • Site-wide: 154,712
  • In radiology and imaging: 375
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  • Site-wide: 95,204
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  • Site-wide: 139,577

Zebrafish airinemes optimize their shape between ballistic and diffusive search

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  • Site-wide: 163,811
  • In systems biology: 3,297
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  • Site-wide: 47,667
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  • Site-wide: 108,024

Disease correlates of quantitative susceptibility mapping rim lesions in multiple sclerosis

• Downloaded 281 times
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  • Site-wide: 166,094
  • In neurology: 1,026
• Year to date:
  • Site-wide: 149,439
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  • Site-wide: 48,717

Wear and Tear of the Intestinal Visceral Musculature by Intrinsic and Extrinsic Factors

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  • Site-wide: 167,857
  • In developmental biology: 4,487
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  • Site-wide: 51,323
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  • Site-wide: 110,567

Exosomal MFGE8 from high glucose induced endothelial cells is involved in calcification/senescence of vascular smooth muscle cells

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  • Site-wide: 173,386
  • In molecular biology: 5,239
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  • Site-wide: 32,095
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  • Site-wide: 166,533

Amplification lags nonlinearity in the recovery from reduced endocochlear potential

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  • Site-wide: 174,014
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  • Site-wide: 185,146

Structural variation, functional differentiation and expression characteristics of the AP2/ERF gene family and its response to cold stress and methyl jasmonate in Panax ginseng C.A. Meyer

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  • Site-wide: 174,417
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  • Site-wide: 212,640

Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-based fMRI Meta-analysis

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  • Site-wide: 178,212
  • In psychiatry and clinical psychology: 1,159
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  • Site-wide: 61,931

A novel attention-based peptide language model for dipeptidyl peptidase-IV inhibitory peptides mining

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  • Site-wide: 178,245
  • In bioinformatics: 13,483
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  • Site-wide: 192,915
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  • Site-wide: 31,473

Quantitative susceptibility mapping improves the detection of calcified carotid vessels by multi-contrast MRI using computed tomography angiography as the reference standard

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  • Site-wide: 178,790
  • In radiology and imaging: 430
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  • Site-wide: 150,550
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  • Site-wide: 67,737

Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack

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  • Site-wide: 179,041
  • In biophysics: 6,835
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  • Site-wide: 193,029
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  • Site-wide: 172,847

Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment and confers resistance to immunotherapy

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  • Site-wide: 179,750
  • In cancer biology: 5,570
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  • Site-wide: 124,380
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  • Site-wide: 133,515

Selective degradation of an ER stress-induced protein by ER-associated degradation mechanism during stress recovery

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  • Site-wide: 184,611
  • In biochemistry: 5,790
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  • Site-wide: 194,245

Molecular atlas reveals the tri-sectional spinning mechanism of spider dragline silk

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  • Site-wide: 184,526
  • In genomics: 8,898
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  • Site-wide: 68,989
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  • Site-wide: 41,297

Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation

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  • Site-wide: 186,799
  • In biochemistry: 5,838
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  • Site-wide: 73,681

The natural compound TMYX reduces SAN cells rate by antagonizing the cAMP modulation of f-channels

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  • Site-wide: 190,331
  • In physiology: 2,243
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  • Site-wide: 147,641
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  • Site-wide: 170,896

QSMRim-Net: Imbalance-Aware Learning for Identification of Chronic Active Multiple Sclerosis Lesions on Quantitative Susceptibility Maps

• Downloaded 178 times
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  • Site-wide: 192,801
  • In bioinformatics: 14,236
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  • Site-wide: 134,249

Flagellin FLiC Enhances Resistance of Upland Cotton to Verticillium dahliae

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  • Site-wide: 198,278
  • In pathology: 1,182
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  • Site-wide: 119,199
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  • Site-wide: 102,477

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

• Downloaded 144 times
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  • Site-wide: 199,683
  • In immunology: 6,860
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  • Site-wide: 4,786
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  • Site-wide: 2,316

IL-12-expressing highly immunogenic recombinant modified vaccinia virus Ankara reprograms tumor-infiltrating myeloid cells to overcome immune resistance

• Downloaded 121 times
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  • Site-wide: 204,032
  • In immunology: 6,605
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  • Site-wide: 56,763
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  • Site-wide: 40,163

Multiple NTS Neuron Populations Synergistically Suppress Physiologic Food Intake but are Dispensable for the Response to VSG

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  • Site-wide: 209,389
  • In neuroscience: None
• Year to date:
  • Site-wide: 4,590
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  • Site-wide: 7,663

Identification of Biomarker Genes Based on Multi-Omics Analysis in Non-Small Cell Lung Cancer

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  • Site-wide: 210,178
  • In molecular biology: 6,414
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  • Site-wide: 25,364
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  • Site-wide: 74,118

Benzidine Induces Proliferation of UMUC3 Bladder Cancer Cells Through Activation of ERK5 Pathway

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  • Site-wide: 211,975
  • In biochemistry: 6,563
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  • Site-wide: 63,247

The expression and function of 28s5-rtsRNA: an update

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  • Site-wide: 212,225
  • In biochemistry: 6,528
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  • Site-wide: 122,088
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  • Site-wide: 194,939

Rho of plant GTPase MxROP1 regulates Fe deficiency responses by targeting Zinc Ribbon 3 in apple rootstock

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  • Site-wide: 214,965
  • In plant biology: 5,969
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Development and Validation of a Deep Learning System for the Diagnosis of Pediatric Diseases: A Large-Scale Real-World Data Study in Shanghai

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