Author: Yan Wang

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Preprints

Age profile of susceptibility, mixing, and social distancing shape the dynamics of the novel coronavirus disease 2019 outbreak in China

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  • Site-wide: 996
  • In epidemiology: 137
• Year to date:
  • Site-wide: 13,631
• Since beginning of last month:
  • Site-wide: 32,082

Prevalence and Risk Factors for Acute Posttraumatic Stress Disorder during the COVID-19 Outbreak

• Downloaded 6,953 times
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  • Site-wide: 1,699
  • In psychiatry and clinical psychology: 8
• Year to date:
  • Site-wide: 4,371
• Since beginning of last month:
  • Site-wide: 15,515

Detection of 2019 novel coronavirus in semen and testicular biopsy specimen of COVID-19 patients

• Downloaded 4,669 times
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  • Site-wide: 2,931
  • In infectious diseases: 685
• Year to date:
  • Site-wide: 14,105
• Since beginning of last month:
  • Site-wide: 19,265

Evolving epidemiology of novel coronavirus diseases 2019 and possible interruption of local transmission outside Hubei Province in China: a descriptive and modeling study

• Downloaded 3,967 times
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  • Site-wide: 3,691
  • In infectious diseases: 790
• Year to date:
  • Site-wide: 26,486
• Since beginning of last month:
  • Site-wide: 46,926

Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China

• Downloaded 3,111 times
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  • Site-wide: 5,207
  • In infectious diseases: 994
• Year to date:
  • Site-wide: 7,479
• Since beginning of last month:
  • Site-wide: 20,229

MECAT: an ultra-fast mapping, error correction and de novo assembly tool for single-molecule sequencing reads

• Downloaded 2,759 times
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  • Site-wide: 6,193
  • In bioinformatics: 618
• Year to date:
  • Site-wide: 59,279
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  • Site-wide: 23,273

Case fatality risk of novel coronavirus diseases 2019 in China

• Downloaded 2,175 times
• Download rankings, all-time:
  • Site-wide: 8,803
  • In infectious diseases: 1,352
• Year to date:
  • Site-wide: 43,263
• Since beginning of last month:
  • Site-wide: 51,082

Dual midbrain and forebrain origins of thalamic inhibitory interneurons

• Downloaded 2,168 times
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  • Site-wide: 8,849
  • In neuroscience: 862
• Year to date:
  • Site-wide: 25,615
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  • Site-wide: 33,115

High risk of infection caused posttraumatic stress symptoms in individuals with poor sleep quality: A study on influence of coronavirus disease (COVID-19) in China

• Downloaded 2,070 times
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  • Site-wide: 9,450
  • In psychiatry and clinical psychology: 38
• Year to date:
  • Site-wide: 25,992
• Since beginning of last month:
  • Site-wide: 44,070

A genome-scale phylogeny of Fungi; insights into early evolution, radiations, and the relationship between taxonomy and phylogeny

• Downloaded 2,029 times
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  • Site-wide: 9,740
  • In evolutionary biology: 261
• Year to date:
  • Site-wide: 9,131
• Since beginning of last month:
  • Site-wide: 10,608

A statistical framework for mapping risk genes from de novo mutations in whole-genome sequencing studies

• Downloaded 1,930 times
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  • Site-wide: 10,521
  • In genetics: 439
• Year to date:
  • Site-wide: 76,823
• Since beginning of last month:
  • Site-wide: 36,246

Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2

• Downloaded 1,910 times
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  • Site-wide: 10,681
  • In epidemiology: 821
• Year to date:
  • Site-wide: 26,607
• Since beginning of last month:
  • Site-wide: 36,558

Simulating and Forecasting the Cumulative Confirmed Cases of SARS-CoV-2 in China by Boltzmann Function-based Regression Analyses

• Downloaded 1,766 times
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  • Site-wide: 12,003
  • In infectious diseases: 1,599
• Year to date:
  • Site-wide: 102,754
• Since beginning of last month:
  • Site-wide: 133,302

TET1 Modulates H4K16 Acetylation by Interacting with hMOF to Regulate Expression of DNA Repair Genes and Oncogenic Transformation

• Downloaded 1,689 times
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  • Site-wide: 12,832
  • In molecular biology: 346
• Year to date:
  • Site-wide: 89,538
• Since beginning of last month:
  • Site-wide: 71,963

A two-stage ECG signal denoising method based on deep convolutional network

• Downloaded 1,618 times
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  • Site-wide: 13,661
  • In bioengineering: 230
• Year to date:
  • Site-wide: 5,723
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  • Site-wide: 21,386

Organizing Pneumonia of COVID-19: Time-dependent Evolution and Outcome in CT Findings

• Downloaded 1,329 times
• Download rankings, all-time:
  • Site-wide: 18,559
  • In radiology and imaging: 42
• Year to date:
  • Site-wide: 81,312
• Since beginning of last month:
  • Site-wide: 124,538

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

• Downloaded 1,239 times
• Download rankings, all-time:
  • Site-wide: 20,621
  • In biophysics: 521
• Year to date:
  • Site-wide: 85,087
• Since beginning of last month:
  • Site-wide: 119,778

Cleavage of a pathogen apoplastic protein by plant subtilases activates immunity

• Downloaded 1,085 times
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  • Site-wide: 25,250
  • In plant biology: 382
• Year to date:
  • Site-wide: 73,015
• Since beginning of last month:
  • Site-wide: 81,436

The landscape of DNA methylation associated with the transcriptomic network in laying hens and broilers generates insight into embryonic muscle development in chicken

• Downloaded 1,031 times
• Download rankings, all-time:
  • Site-wide: 27,283
  • In bioinformatics: 3,019
• Year to date:
  • Site-wide: 48,082
• Since beginning of last month:
  • Site-wide: 43,520

N-Acetyl Cysteine Alleviates Coxsackievirus B-Induced Myocarditis by Suppressing caspase-1

• Downloaded 1,014 times
• Download rankings, all-time:
  • Site-wide: 27,960
  • In microbiology: 1,631
• Year to date:
  • Site-wide: 27,884
• Since beginning of last month:
  • Site-wide: 13,071

The YdiU Domain Modulates Bacterial Stress Signaling through Mn2+-dependent UMPylation

• Downloaded 998 times
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  • Site-wide: 28,630
  • In biochemistry: 661
• Year to date:
  • Site-wide: 121,884
• Since beginning of last month:
  • Site-wide: 118,327

Positive feedback loop of regulating ERK phosphorylation in mESCs mediated by Etv5-Tet2-Fgfr2 axis

• Downloaded 953 times
• Download rankings, all-time:
  • Site-wide: 30,622
  • In developmental biology: 583
• Year to date:
  • Site-wide: 83,348
• Since beginning of last month:
  • Site-wide: 93,042

Molecular dating of the emergence of anaerobic rumen fungi and the impact of laterally acquired genes

• Downloaded 905 times
• Download rankings, all-time:
  • Site-wide: 33,084
  • In evolutionary biology: 1,409
• Year to date:
  • Site-wide: 100,155
• Since beginning of last month:
  • Site-wide: 119,541

Wuhan and Hubei COVID-19 mortality analysis reveals the critical role of timely supply of medical resources

• Downloaded 777 times
• Download rankings, all-time:
  • Site-wide: 41,116
  • In epidemiology: 2,091
• Year to date:
  • Site-wide: 114,938
• Since beginning of last month:
  • Site-wide: 133,335

Negligible Risk of the COVID-19 Resurgence Caused by Work Resuming in China (outside Hubei): a Statistical Probability Study

• Downloaded 761 times
• Download rankings, all-time:
  • Site-wide: 42,460
  • In epidemiology: 2,134
• Year to date:
  • Site-wide: 114,974
• Since beginning of last month:
  • Site-wide: 134,985

Transcriptional Inactivation of TP53 and the BMP Pathway Mediates Therapy-induced Dedifferentiation and Metastasis in Prostate Cancer

• Downloaded 761 times
• Download rankings, all-time:
  • Site-wide: 42,430
  • In cancer biology: 1,167
• Year to date:
  • Site-wide: 8,233
• Since beginning of last month:
  • Site-wide: 3,859

Time-resolved digital immunoassay for rapid and sensitive quantitation of procalcitonin with plasmonic imaging

• Downloaded 748 times
• Download rankings, all-time:
  • Site-wide: 43,503
  • In bioengineering: 818
• Year to date:
  • Site-wide: 76,127
• Since beginning of last month:
  • Site-wide: 45,567

2019 Association of Biomolecular Resource Facilities Multi-Laboratory Data-Independent Acquisition Study

• Downloaded 708 times
• Download rankings, all-time:
  • Site-wide: 46,952
  • In bioinformatics: 4,855
• Year to date:
  • Site-wide: 17,704
• Since beginning of last month:
  • Site-wide: 59,421

CNS antigen-specific control of early B-lineage development in the meninges

• Downloaded 673 times
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  • Site-wide: 50,396
  • In immunology: 1,584
• Year to date:
  • Site-wide: 9,984
• Since beginning of last month:
  • Site-wide: 6,267

Integrative molecular and clinical profiling of acral melanoma identifies LZTR1 as a key tumor promoter and therapeutic target

• Downloaded 618 times
• Download rankings, all-time:
  • Site-wide: 56,547
  • In cancer biology: 1,624
• Year to date:
  • Site-wide: 11,483
• Since beginning of last month:
  • Site-wide: 12,455

Plasticity and the role of mass-scaling in allocation, morphology and anatomical trait responses to above and belowground resource limitation in cultivated sunflower (Helianthus annuus L.)

• Downloaded 588 times
• Download rankings, all-time:
  • Site-wide: 60,210
  • In plant biology: 1,422
• Year to date:
  • Site-wide: 50,677
• Since beginning of last month:
  • Site-wide: 72,255

An overexpressed Q allele leads to increased spike density and improved processing quality

• Downloaded 587 times
• Download rankings, all-time:
  • Site-wide: 60,398
  • In genetics: 2,566
• Year to date:
  • Site-wide: 141,768
• Since beginning of last month:
  • Site-wide: 154,485

T-bet+ CD11c+ B Cells Are Critical For Anti-Chromatin IgG Production In The Development Of Lupus

• Downloaded 585 times
• Download rankings, all-time:
  • Site-wide: 60,579
  • In immunology: 1,859
• Year to date:
  • Site-wide: 151,484
• Since beginning of last month:
  • Site-wide: 134,463

TSD: A computational tool to study the complex structural variants using PacBio targeted sequencing data

• Downloaded 581 times
• Download rankings, all-time:
  • Site-wide: 61,125
  • In bioinformatics: 5,958
• Year to date:
  • Site-wide: 147,538
• Since beginning of last month:
  • Site-wide: 143,364

A spatiotemporal translatome of mouse tissue development

• Downloaded 576 times
• Download rankings, all-time:
  • Site-wide: 61,694
  • In bioinformatics: 6,010
• Year to date:
  • Site-wide: 74,969
• Since beginning of last month:
  • Site-wide: 111,114

A pattern categorization of CT findings to predict outcome of COVID-19 pneumonia

• Downloaded 518 times
• Download rankings, all-time:
  • Site-wide: 70,149
  • In infectious diseases: 3,890
• Year to date:
  • Site-wide: 105,056
• Since beginning of last month:
  • Site-wide: 111,994

Hypercholesterolemia risk associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol level in human and mouse

• Downloaded 511 times
• Download rankings, all-time:
  • Site-wide: 71,326
  • In genetics: 3,031
• Year to date:
  • Site-wide: 92,188
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  • Site-wide: 106,839

Single cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis)

• Downloaded 510 times
• Download rankings, all-time:
  • Site-wide: 71,428
  • In developmental biology: 1,800
• Year to date:
  • Site-wide: 90,481
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  • Site-wide: 120,465

Tracking and predicting the African COVID-19 pandemic

• Downloaded 487 times
• Download rankings, all-time:
  • Site-wide: 75,314
  • In infectious diseases: 4,020
• Year to date:
  • Site-wide: 34,074
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  • Site-wide: 27,132

Coevolution-based prediction of protein-protein interactions in polyketide biosynthetic assembly lines

• Downloaded 484 times
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  • Site-wide: 75,769
  • In bioinformatics: 6,981
• Year to date:
  • Site-wide: 104,148
• Since beginning of last month:
  • Site-wide: 134,866

RNA-seq analysis of laser micro-dissected Arabidopsis thaliana leaf epidermis, mesophyll and vasculature defines tissue-specific transcriptional responses to multiple stress treatments

• Downloaded 462 times
• Download rankings, all-time:
  • Site-wide: 79,690
  • In plant biology: 2,038
• Year to date:
  • Site-wide: 38,416
• Since beginning of last month:
  • Site-wide: 51,611

Left ventricular geometry during unloading and the end-systolic pressure volume relationship: Measurement with a modified real-time MRI-based method in normal sheep

• Downloaded 462 times
• Download rankings, all-time:
  • Site-wide: 79,738
  • In bioengineering: 1,521
• Year to date:
  • Site-wide: 117,829
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  • Site-wide: 83,765

Role of PARP1 in oligodendrocyte differentiation during developmental myelination and remyelination after myelin damage

• Downloaded 454 times
• Download rankings, all-time:
  • Site-wide: 81,316
  • In neuroscience: 12,008
• Year to date:
  • Site-wide: 18,488
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  • Site-wide: 6,942

Mapping fetal brain development based on automated segmentation and 4D brain atlasing

• Downloaded 448 times
• Download rankings, all-time:
  • Site-wide: 82,536
  • In neuroscience: 12,194
• Year to date:
  • Site-wide: 68,030
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  • Site-wide: 111,740

The LIM-Only Protein FHL2 is Involved in Autophagy to Regulate the Development of Skeletal Muscle

• Downloaded 443 times
• Download rankings, all-time:
  • Site-wide: 83,504
  • In molecular biology: 2,439
• Year to date:
  • Site-wide: 132,964
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  • Site-wide: 146,635

HIFα regulates developmental myelination independent of autocrine Wnt signaling

• Downloaded 442 times
• Download rankings, all-time:
  • Site-wide: 83,672
  • In neuroscience: 12,369
• Year to date:
  • Site-wide: 46,822
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  • Site-wide: 42,149

Structural insights into the Ca 2+-dependent gating of the human mitochondrial calcium uniporter

• Downloaded 404 times
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  • Site-wide: 91,346
  • In biochemistry: 2,601
• Year to date:
  • Site-wide: 102,649
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  • Site-wide: 56,438

Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer

• Downloaded 394 times
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  • Site-wide: 93,528
  • In genomics: 5,826
• Year to date:
  • Site-wide: 143,397
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  • Site-wide: 151,190

CD44 inhibits α-SMA gene expression via a novel G-actin/MRTF mediated pathway that requires TGFβR/p38MAPK activity in murine skin fibroblasts.

• Downloaded 381 times
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  • Site-wide: 96,563
  • In cell biology: 4,445
• Year to date:
  • Site-wide: 106,447
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  • Site-wide: 103,603

Differences of clinical and imaging findings in multiple generations of secondary COVID-19 infection in Xi'an, China

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 97,765
  • In radiology and imaging: 182
• Year to date:
  • Site-wide: 101,637
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  • Site-wide: 59,458

Larger organ size caused by obesity is a mechanism for higher cancer risk.

• Downloaded 366 times
• Download rankings, all-time:
  • Site-wide: 99,929
  • In cancer biology: 3,022
• Year to date:
  • Site-wide: 54,618
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  • Site-wide: 77,246

Assessing deep learning algorithms in cis-regulatory motif finding based on genomic sequencing data

• Downloaded 365 times
• Download rankings, all-time:
  • Site-wide: 100,159
  • In bioinformatics: 8,603
• Year to date:
  • Site-wide: 58,455
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  • Site-wide: 82,785

Kaposi's Sarcoma-associated Herpesvirus vFLIP Promotes MEndT to Generate Hybrid M/E State for Tumorigenesis

• Downloaded 351 times
• Download rankings, all-time:
  • Site-wide: 103,655
  • In microbiology: 7,215
• Year to date:
  • Site-wide: 27,300
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  • Site-wide: 3,166

Drosophila larval epidermal cells only exhibit epidermal aging when they persist to the adult stage

• Downloaded 350 times
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  • Site-wide: 103,790
  • In cell biology: 4,812
• Year to date:
  • Site-wide: 107,655
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  • Site-wide: 95,708

PBN-PVT projection modulates negative affective states in mice

• Downloaded 348 times
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  • Site-wide: 104,374
  • In neuroscience: 15,557
• Year to date:
  • Site-wide: 27,684
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  • Site-wide: 64,119

Phylogenomic analyses of non-Dikarya fungi supports horizontal gene transfer driving diversification of secondary metabolism in the amphibian gastrointestinal symbiont, Basidiobolus

• Downloaded 332 times
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  • Site-wide: 108,291
  • In genomics: 6,354
• Year to date:
  • Site-wide: 149,121
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  • Site-wide: 156,118

RNF219 interacts with CCR4-NOT in regulating stem cell differentiation

• Downloaded 317 times
• Download rankings, all-time:
  • Site-wide: 112,052
  • In molecular biology: 3,339
• Year to date:
  • Site-wide: 85,773
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  • Site-wide: 85,289

The role of BMP6 in the proliferation and differentiation of chicken cartilage cells

• Downloaded 311 times
• Download rankings, all-time:
  • Site-wide: 113,660
  • In cell biology: 5,291
• Year to date:
  • Site-wide: 131,127
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  • Site-wide: 58,323

Decoding regulatory specificity of human ribosomal proteins

• Downloaded 299 times
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  • Site-wide: 116,575
  • In cell biology: 5,444
• Year to date:
  • Site-wide: 34,355
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  • Site-wide: 60,058

The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signaling

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 119,869
  • In neuroscience: 18,002
• Year to date:
  • Site-wide: 70,719
• Since beginning of last month:
  • Site-wide: 115,235

Site-specific covalent labeling of large RNAs with nanoparticles empowered by expanded genetic alphabet transcription

• Downloaded 283 times
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  • Site-wide: 120,961
  • In biophysics: 4,632
• Year to date:
  • Site-wide: 100,718
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  • Site-wide: 141,369

Mutant Zp1 results in Zona Pellucida Lacking and Female Infertility in Rats and Humans

• Downloaded 275 times
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  • Site-wide: 123,097
  • In genetics: 4,991
• Year to date:
  • Site-wide: 120,051
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  • Site-wide: 94,354

Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways

• Downloaded 265 times
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  • Site-wide: 125,869
  • In neuroscience: 18,915
• Year to date:
  • Site-wide: 150,328
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  • Site-wide: 156,269

Individual-level and neighborhood-level factors associated with longitudinal changes in cardiometabolic measures in participants of a care coordination program

• Downloaded 260 times
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  • Site-wide: 126,930
  • In primary care research: 111
• Year to date:
  • Site-wide: 41,596
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  • Site-wide: 102,078

Genome-scale phylogenetic analyses confirm Olpidium as the closest living zoosporic fungus to the non-flagellated, terrestrial fungi

• Downloaded 254 times
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  • Site-wide: 128,684
  • In evolutionary biology: 6,248
• Year to date:
  • Site-wide: 120,030
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  • Site-wide: 148,666

Phytophthora sojae effector Avr1d functions as E2 competitor and inhibits ubiquitination activity of GmPUB13 to facilitate infection

• Downloaded 252 times
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  • Site-wide: 129,084
  • In microbiology: 9,380
• Year to date:
  • Site-wide: 93,383
• Since beginning of last month:
  • Site-wide: 124,027

Development of an electronic frailty index for predicting mortality in patients undergoing transcatheter aortic valve replacement using machine learning

• Downloaded 248 times
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  • Site-wide: 130,109
  • In cardiovascular medicine: 352
• Year to date:
  • Site-wide: 64,088
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  • Site-wide: 91,821

Dicer1 is reduced in APPswe/PSEN1dE9 mice and is regulated by Nrf2

• Downloaded 241 times
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  • Site-wide: 131,919
  • In neuroscience: 19,847
• Year to date:
  • Site-wide: 130,206
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  • Site-wide: 97,514

SARS-CoV-2 Exploits Sexually Dimorphic and Adaptive IFN and TNFa Signaling to Gain Entry into Alveolar Epithelium

• Downloaded 237 times
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  • Site-wide: 133,112
  • In immunology: 3,975
• Year to date:
  • Site-wide: 47,010
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  • Site-wide: 131,765

The size of helical pitch is important for microtubule plus end dynamic instability

• Downloaded 228 times
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  • Site-wide: 135,401
  • In cell biology: 6,271
• Year to date:
  • Site-wide: 57,880
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  • Site-wide: 67,629

Dicer1 promotes Aβ clearance via blocking B2 RNA-mediated repression of apolipoprotein E

• Downloaded 222 times
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  • Site-wide: 136,882
  • In neuroscience: 20,460
• Year to date:
  • Site-wide: 96,086
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  • Site-wide: 124,125

Rationale, protocol and baseline characteristics of the metabolome, microbiome, and dietary salt intervention study (MetaSalt)

• Downloaded 200 times
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  • Site-wide: 142,136
  • In epidemiology: 5,919
• Year to date:
  • Site-wide: 57,990
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  • Site-wide: 57,828

Pvr and downstream signaling factors are required for spreading of Drosophila hemocytes at larval wound sites

• Downloaded 195 times
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  • Site-wide: 143,525
  • In genetics: 5,640
• Year to date:
  • Site-wide: 59,999
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  • Site-wide: 52,105

Mutations in PIKFYVE cause autosomal dominant congenital cataract

• Downloaded 189 times
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  • Site-wide: 144,910
  • In genomics: 7,490
• Year to date:
  • Site-wide: 62,218
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  • Site-wide: 67,732

Effectiveness of Joint Species Distribution Models in the Presence of Imperfect Detection

• Downloaded 184 times
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  • Site-wide: 146,054
  • In ecology: 5,041
• Year to date:
  • Site-wide: 64,007
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  • Site-wide: 74,126

Tree-based automated machine learning to predict biogas production for anaerobic co-digestion of organic waste

• Downloaded 179 times
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  • Site-wide: 147,093
  • In bioinformatics: 11,283
• Year to date:
  • Site-wide: 66,016
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  • Site-wide: 74,609

Activin B Promotes the Initiation and Progression of Liver Fibrosis

• Downloaded 178 times
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  • Site-wide: 147,366
  • In pathology: 878
• Year to date:
  • Site-wide: 66,662
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  • Site-wide: 33,864

riboCIRC: a comprehensive database of translatable circRNAs

• Downloaded 177 times
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  • Site-wide: 147,585
  • In bioinformatics: 11,305
• Year to date:
  • Site-wide: 67,164
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  • Site-wide: 127,713

Kaposi's Sarcoma-associated Herpesvirus Promotes Mesenchymal-to-Endothelial Transition by Resolving the Bivalent Chromatin of PROX1 Gene

• Downloaded 167 times
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  • Site-wide: 149,623
  • In microbiology: 11,289
• Year to date:
  • Site-wide: 71,395
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  • Site-wide: 34,162

Large-scale characterisation of the pregnancy vaginal microbiome and sialidase activity in a low-risk Chinese population

• Downloaded 163 times
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  • Site-wide: 150,368
  • In systems biology: 3,120
• Year to date:
  • Site-wide: 73,391
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  • Site-wide: 91,498

Blocking of EGFR Signaling is a Latent Strategy for the Improvement of Prognosis of HPV Induced Cancer

• Downloaded 162 times
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  • Site-wide: 150,592
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Geraniol Enhances Inhibitory Inputs to Paraventricular Thalamic Nucleus and Induces Sedation in Mice

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Keap1 recognizes EIAV early accessory protein Rev to promote antiviral defense

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Engineered neuron-targeting, placental mesenchymal stromal cell-derived extracellular vesicles for in utero treatment of myelomeningocele

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EBV LMP1-activated mTORC1 and mTORC2 Coordinately Promote Nasopharyngeal Cancer Stem Cell Properties

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