Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 52,519 bioRxiv papers from 243,473 authors.

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Preprints

Recording temporal data onto DNA with minutes resolution

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Vibrio natriegens, a new genomic powerhouse

• Downloaded 14,271 times
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  • In genomics: 12 out of 3,756
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  • Site-wide: 344 out of 52,519
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  • Site-wide: 450 out of 52,519

Inter-homologue repair in fertilized human eggs?

• Downloaded 9,790 times
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  • Site-wide: 93 out of 52,519
  • In cell biology: 4 out of 2,472
• Year to date:
  • Site-wide: 11,336 out of 52,519
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  • Site-wide: 13,030 out of 52,519

RNA-guided gene drives can efficiently and reversibly bias inheritance in wild yeast

• Downloaded 6,858 times
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  • Site-wide: 181 out of 52,519
  • In synthetic biology: 3 out of 504
• Year to date:
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  • Site-wide: 21,808 out of 52,519

Tumor-infiltrating immune repertoires captured by single-cell barcoding in emulsion

• Downloaded 5,944 times
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  • Site-wide: 232 out of 52,519
  • In immunology: 4 out of 1,212
• Year to date:
  • Site-wide: 3,219 out of 52,519
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  • Site-wide: 4,706 out of 52,519

Conneconomics: The Economics of Dense, Large-Scale, High-Resolution Neural Connectomics

• Downloaded 5,876 times
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  • Site-wide: 239 out of 52,519
  • In neuroscience: 35 out of 9,207
• Year to date:
  • Site-wide: 4,961 out of 52,519
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  • Site-wide: 7,201 out of 52,519

Rapidly evolving homing CRISPR barcodes

• Downloaded 5,729 times
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  • Site-wide: 252 out of 52,519
  • In synthetic biology: 5 out of 504
• Year to date:
  • Site-wide: 14,908 out of 52,519
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  • Site-wide: 14,615 out of 52,519

Extensive sequencing of seven human genomes to characterize benchmark reference materials

• Downloaded 5,641 times
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  • In genomics: 72 out of 3,756
• Year to date:
  • Site-wide: 19,107 out of 52,519
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  • Site-wide: 17,358 out of 52,519

Highly-efficient Cas9-mediated transcriptional programming

• Downloaded 5,430 times
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  • Site-wide: 283 out of 52,519
  • In synthetic biology: 6 out of 504
• Year to date:
  • Site-wide: 16,067 out of 52,519
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  • Site-wide: 16,352 out of 52,519

Daisy-chain gene drives for the alteration of local populations

• Downloaded 4,885 times
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  • Site-wide: 346 out of 52,519
  • In synthetic biology: 8 out of 504
• Year to date:
  • Site-wide: 1,399 out of 52,519
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  • Site-wide: 17,698 out of 52,519

Enabling large-scale genome editing by reducing DNA nicking

• Downloaded 4,507 times
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  • Site-wide: 403 out of 52,519
  • In synthetic biology: 9 out of 504
• Year to date:
  • Site-wide: 37 out of 52,519
• Since beginning of last month:
  • Site-wide: 393 out of 52,519

CasFinder: Flexible algorithm for identifying specific Cas9 targets in genomes

• Downloaded 4,257 times
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  • Site-wide: 457 out of 52,519
  • In genomics: 125 out of 3,756
• Year to date:
  • Site-wide: 7,860 out of 52,519
• Since beginning of last month:
  • Site-wide: 6,974 out of 52,519

Toward machine-guided design of proteins

• Downloaded 3,898 times
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  • Site-wide: 545 out of 52,519
  • In synthetic biology: 10 out of 504
• Year to date:
  • Site-wide: 361 out of 52,519
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  • Site-wide: 358 out of 52,519

Enzymatic DNA synthesis for digital information storage

• Downloaded 3,832 times
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  • Site-wide: 558 out of 52,519
  • In synthetic biology: 11 out of 504
• Year to date:
  • Site-wide: 356 out of 52,519
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  • Site-wide: 944 out of 52,519

Highly multiplexed in situ protein imaging with signal amplification by Immuno-SABER

• Downloaded 3,793 times
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  • Site-wide: 575 out of 52,519
  • In cell biology: 18 out of 2,472
• Year to date:
  • Site-wide: 73 out of 52,519
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  • Site-wide: 103 out of 52,519

Current CRISPR gene drive systems are likely to be highly invasive in wild populations

• Downloaded 3,628 times
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  • Site-wide: 627 out of 52,519
  • In synthetic biology: 13 out of 504
• Year to date:
  • Site-wide: 10,915 out of 52,519
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  • Site-wide: 12,862 out of 52,519

Barcoded oligonucleotides ligated on RNA amplified for multiplex and parallel in-situ analyses

• Downloaded 3,367 times
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  • Site-wide: 717 out of 52,519
  • In cell biology: 20 out of 2,472
• Year to date:
  • Site-wide: 1,007 out of 52,519
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  • Site-wide: 1,136 out of 52,519

Unified rational protein engineering with sequence-only deep representation learning

• Downloaded 3,220 times
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  • Site-wide: 789 out of 52,519
  • In synthetic biology: 16 out of 504
• Year to date:
  • Site-wide: 66 out of 52,519
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  • Site-wide: 75 out of 52,519

Rapid Sequential In Situ Multiplexing With DNA-Exchange-Imaging

• Downloaded 2,937 times
• Download rankings, all-time:
  • Site-wide: 927 out of 52,519
  • In bioengineering: 12 out of 976
• Year to date:
  • Site-wide: 19,093 out of 52,519
• Since beginning of last month:
  • Site-wide: 18,555 out of 52,519

A homing CRISPR mouse resource for barcoding and lineage tracing

• Downloaded 2,911 times
• Download rankings, all-time:
  • Site-wide: 945 out of 52,519
  • In synthetic biology: 18 out of 504
• Year to date:
  • Site-wide: 6,290 out of 52,519
• Since beginning of last month:
  • Site-wide: 18,356 out of 52,519

Precise Cas9 targeting enables genomic mutation prevention

• Downloaded 2,394 times
• Download rankings, all-time:
  • Site-wide: 1,347 out of 52,519
  • In synthetic biology: 25 out of 504
• Year to date:
  • Site-wide: 27,115 out of 52,519
• Since beginning of last month:
  • Site-wide: 41,168 out of 52,519

Assembly of Radically Recoded E. coli Genome Segments

• Downloaded 2,287 times
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  • Site-wide: 1,469 out of 52,519
  • In synthetic biology: 27 out of 504
• Year to date:
  • Site-wide: 13,517 out of 52,519
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  • Site-wide: 12,608 out of 52,519

The experimental design and data interpretation in ‘Unexpected mutations after CRISPR Cas9 editing in vivo’ by Schaefer et al. are insufficient to support the conclusions drawn by the authors

• Downloaded 1,955 times
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  • Site-wide: 1,916 out of 52,519
  • In genetics: 190 out of 3,067
• Year to date:
  • Site-wide: 25,122 out of 52,519
• Since beginning of last month:
  • Site-wide: 36,091 out of 52,519

Recombineering in Vibrio natriegens

• Downloaded 1,944 times
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  • Site-wide: 1,938 out of 52,519
  • In synthetic biology: 35 out of 504
• Year to date:
  • Site-wide: 4,616 out of 52,519
• Since beginning of last month:
  • Site-wide: 4,928 out of 52,519

Single-cell sequencing reveals αβ chain pairing shapes the T cell repertoire

• Downloaded 1,553 times
• Download rankings, all-time:
  • Site-wide: 2,820 out of 52,519
  • In immunology: 31 out of 1,212
• Year to date:
  • Site-wide: 10,083 out of 52,519
• Since beginning of last month:
  • Site-wide: 13,048 out of 52,519

Efficient in situ barcode sequencing using padlock probe-based BaristaSeq

• Downloaded 1,493 times
• Download rankings, all-time:
  • Site-wide: 3,014 out of 52,519
  • In molecular biology: 81 out of 1,586
• Year to date:
  • Site-wide: 14,343 out of 52,519
• Since beginning of last month:
  • Site-wide: 18,472 out of 52,519

Multiplexed imaging using same species primary antibodies with signal amplification

• Downloaded 1,318 times
• Download rankings, all-time:
  • Site-wide: 3,689 out of 52,519
  • In cell biology: 97 out of 2,472
• Year to date:
  • Site-wide: 4,957 out of 52,519
• Since beginning of last month:
  • Site-wide: 7,475 out of 52,519

Concerning RNA-Guided Gene Drives for the Alteration of Wild Populations

• Downloaded 1,259 times
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  • Site-wide: 3,977 out of 52,519
  • In synthetic biology: 59 out of 504
• Year to date:
  • Site-wide: 36,037 out of 52,519
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  • Site-wide: 45,431 out of 52,519

A systematic comparison of error correction enzymes by next-generation sequencing

• Downloaded 1,243 times
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  • Site-wide: 4,053 out of 52,519
  • In synthetic biology: 62 out of 504
• Year to date:
  • Site-wide: 24,855 out of 52,519
• Since beginning of last month:
  • Site-wide: 26,388 out of 52,519

Enhanced bacterial immunity and mammalian genome editing via RNA polymerase-mediated dislodging of Cas9 from double strand DNA breaks.

• Downloaded 1,180 times
• Download rankings, all-time:
  • Site-wide: 4,396 out of 52,519
  • In molecular biology: 123 out of 1,586
• Year to date:
  • Site-wide: 12,218 out of 52,519
• Since beginning of last month:
  • Site-wide: 17,065 out of 52,519

Reprogramming protein kinase substrate specificity through synthetic mutations

• Downloaded 1,155 times
• Download rankings, all-time:
  • Site-wide: 4,548 out of 52,519
  • In biochemistry: 79 out of 1,474
• Year to date:
  • Site-wide: 24,370 out of 52,519
• Since beginning of last month:
  • Site-wide: 26,448 out of 52,519

Optimizing complex phenotypes through model-guided multiplex genome engineering

• Downloaded 1,029 times
• Download rankings, all-time:
  • Site-wide: 5,471 out of 52,519
  • In synthetic biology: 83 out of 504
• Year to date:
  • Site-wide: 38,865 out of 52,519
• Since beginning of last month:
  • Site-wide: 30,101 out of 52,519

Circularization of genes and chromosome by CRISPR in human cells

• Downloaded 1,028 times
• Download rankings, all-time:
  • Site-wide: 5,485 out of 52,519
  • In genomics: 936 out of 3,756
• Year to date:
  • Site-wide: 16,249 out of 52,519
• Since beginning of last month:
  • Site-wide: 17,884 out of 52,519

Engineering post-translational proofreading to discriminate non-standard amino acids

• Downloaded 1,024 times
• Download rankings, all-time:
  • Site-wide: 5,525 out of 52,519
  • In synthetic biology: 84 out of 504
• Year to date:
  • Site-wide: 31,126 out of 52,519
• Since beginning of last month:
  • Site-wide: 40,213 out of 52,519

Establishing a cell-free Vibrio natriegens expression system

• Downloaded 949 times
• Download rankings, all-time:
  • Site-wide: 6,257 out of 52,519
  • In synthetic biology: 96 out of 504
• Year to date:
  • Site-wide: 10,381 out of 52,519
• Since beginning of last month:
  • Site-wide: 21,514 out of 52,519

Biosensor libraries harness large classes of binding domains for allosteric transcription regulators

• Downloaded 937 times
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  • Site-wide: 6,385 out of 52,519
  • In synthetic biology: 103 out of 504
• Year to date:
  • Site-wide: 32,195 out of 52,519
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  • Site-wide: 33,447 out of 52,519

The whale shark genome reveals how genomic and physiological properties scale with body size

• Downloaded 932 times
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  • Site-wide: 6,441 out of 52,519
  • In genomics: 1,065 out of 3,756
• Year to date:
  • Site-wide: 3,646 out of 52,519
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  • Site-wide: 5,706 out of 52,519

Dissecting limiting factors of the Protein synthesis Using Recombinant Elements (PURE) system

• Downloaded 839 times
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  • Site-wide: 7,552 out of 52,519
  • In bioengineering: 119 out of 976
• Year to date:
  • Site-wide: 50,069 out of 52,519
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  • Site-wide: 50,932 out of 52,519

Systemic post-translational control of bacterial metabolism regulates adaptation in dynamic environments

• Downloaded 799 times
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  • Site-wide: 8,148 out of 52,519
  • In systems biology: 226 out of 1,534
• Year to date:
  • Site-wide: 16,001 out of 52,519
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  • Site-wide: 21,209 out of 52,519

Long-term adaptive evolution of genomically recoded Escherichia coli

• Downloaded 747 times
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  • Site-wide: 9,027 out of 52,519
  • In evolutionary biology: 636 out of 3,671
• Year to date:
  • Site-wide: 45,116 out of 52,519
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  • Site-wide: 47,681 out of 52,519

Ethnically relevant consensus Korean reference genome towards personal reference genomes

• Downloaded 666 times
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  • Site-wide: 10,598 out of 52,519
  • In genomics: 1,514 out of 3,756
• Year to date:
  • Site-wide: 39,569 out of 52,519
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  • Site-wide: 46,213 out of 52,519

Spatial Information in Large-Scale Neural Recordings

• Downloaded 630 times
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  • Site-wide: 11,438 out of 52,519
  • In neuroscience: 1,813 out of 9,207
• Year to date:
  • Site-wide: 46,820 out of 52,519
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  • Site-wide: 42,628 out of 52,519

Significant abundance of cis configurations of mutations in diploid human genomes

• Downloaded 580 times
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  • Site-wide: 12,722 out of 52,519
  • In genomics: 1,724 out of 3,756
• Year to date:
  • Site-wide: 14,277 out of 52,519
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  • Site-wide: 13,329 out of 52,519

Cushing's Syndrome mutant PKAL205R exhibits altered substrate specificity

• Downloaded 571 times
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  • Site-wide: 12,966 out of 52,519
  • In biochemistry: 251 out of 1,474
• Year to date:
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  • Site-wide: 40,995 out of 52,519

Toward D-Peptide Biosynthesis: Elongation Factor P Enables Ribosomal Incorporation Of Consecutive D-Amino Acids

• Downloaded 552 times
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  • In biochemistry: 261 out of 1,474
• Year to date:
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  • Site-wide: 31,055 out of 52,519

Millstone: Software for Multiplex Microbial Genome Analysis and Engineering

• Downloaded 511 times
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  • Site-wide: 15,035 out of 52,519
  • In synthetic biology: 244 out of 504
• Year to date:
  • Site-wide: 41,924 out of 52,519
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  • Site-wide: 34,529 out of 52,519

Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli

• Downloaded 420 times
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  • In genomics: 2,215 out of 3,756
• Year to date:
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  • Site-wide: 41,919 out of 52,519

Simulating serial-target antibacterial drug synergies using flux balance analysis

• Downloaded 397 times
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  • Site-wide: 20,040 out of 52,519
  • In systems biology: 621 out of 1,534
• Year to date:
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  • Site-wide: 50,516 out of 52,519

Physiological Assembly Of Functionally Active 30S Ribosomal Subunits From In Vitro Synthesized Parts

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  • In biochemistry: 610 out of 1,474
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  • Site-wide: 45,613 out of 52,519