Author: George M. Church

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Preprints

TBDB: A database of structurally annotated T-box riboswitch-tRNA pairs

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Accurate chromosome-scale haplotype-resolved assembly of human genomes

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Vibrio natriegens, a new genomic powerhouse

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Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

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Inter-homologue repair in fertilized human eggs?

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Unified rational protein engineering with sequence-only deep representation learning

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Tumor-infiltrating immune repertoires captured by single-cell barcoding in emulsion

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Extensive sequencing of seven human genomes to characterize benchmark reference materials

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Toward machine-guided design of proteins

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Enabling large-scale genome editing by reducing DNA nicking

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Highly-efficient Cas9-mediated transcriptional programming

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Highly multiplexed in situ protein imaging with signal amplification by Immuno-SABER

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Barcoded oligonucleotides ligated on RNA amplified for multiplex and parallel in-situ analyses

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CasFinder: Flexible algorithm for identifying specific Cas9 targets in genomes

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Low-N protein engineering with data-efficient deep learning

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Enzymatic DNA synthesis for digital information storage

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Expansion Sequencing: Spatially Precise In Situ Transcriptomics in Intact Biological Systems

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The predictive power of the microbiome exceeds that of genome-wide association studies in the discrimination of complex human disease

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Current CRISPR gene drive systems are likely to be highly invasive in wild populations

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A homing CRISPR mouse resource for barcoding and lineage tracing

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Rapid Sequential In Situ Multiplexing With DNA-Exchange-Imaging

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Precise Cas9 targeting enables genomic mutation prevention

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Extensive Mammalian Germline Genome Engineering

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Recombineering in Vibrio natriegens

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Rapid and scalable in vitro production of single-stranded DNA

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The experimental design and data interpretation in ‘Unexpected mutations after CRISPR Cas9 editing in vivo’ by Schaefer et al. are insufficient to support the conclusions drawn by the authors

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Multiplexed in situ protein imaging using DNA-barcoded antibodies with extended hybridization chain reactions

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Single-cell sequencing reveals αβ chain pairing shapes the T cell repertoire

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Efficient in situ barcode sequencing using padlock probe-based BaristaSeq

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High-throughput creation and functional profiling of eukaryotic DNA sequence variant libraries using CRISPR/Cas9

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A systematic comparison of error correction enzymes by next-generation sequencing

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High throughput functional variant screens via in-vivo production of single-stranded DNA

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The whale shark genome reveals how genomic and physiological properties scale with body size

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Concerning RNA-Guided Gene Drives for the Alteration of Wild Populations

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Reprogramming protein kinase substrate specificity through synthetic mutations

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Enhanced bacterial immunity and mammalian genome editing via RNA polymerase-mediated dislodging of Cas9 from double strand DNA breaks.

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Establishing a cell-free Vibrio natriegens expression system

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Genetic design automation for autonomous formation of multicellular shapes from a single cell progenitor

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Circularization of genes and chromosome by CRISPR in human cells

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Photon-directed Multiplexed Enzymatic DNA Synthesis for Molecular Digital Data Storage

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Improved bacterial recombineering by parallelized protein discovery

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Systemic post-translational control of bacterial metabolism regulates adaptation in dynamic environments

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Biosensor libraries harness large classes of binding domains for allosteric transcription regulators

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CRISPR-mediated biocontainment

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Dissecting limiting factors of the Protein synthesis Using Recombinant Elements (PURE) system

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Significant abundance of cis configurations of mutations in diploid human genomes

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Long-term adaptive evolution of genomically recoded Escherichia coli

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Ethnically relevant consensus Korean reference genome towards personal reference genomes

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Toward D-Peptide Biosynthesis: Elongation Factor P Enables Ribosomal Incorporation Of Consecutive D-Amino Acids

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Spatial Information in Large-Scale Neural Recordings

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Citizen-Centered, Auditable, and Privacy-Preserving Population Genomics

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Massively parallel quantification of CRISPR editing in cells by TRAP-seq enables better design of Cas9, ABE, CBE gRNAs of high efficiency and accuracy

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Cushing's Syndrome mutant PKAL205R exhibits altered substrate specificity

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Millstone: Software for Multiplex Microbial Genome Analysis and Engineering

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Characterizing the portability of RecT-mediated oligonucleotide recombination

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Fluorescent in situ sequencing of DNA barcoded antibodies

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Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli

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Towards Practical and Robust DNA-based Data Archiving by Codec System Named ‘Yin-Yang’

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Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA

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Simulating serial-target antibacterial drug synergies using flux balance analysis

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Physiological Assembly Of Functionally Active 30S Ribosomal Subunits From In Vitro Synthesized Parts

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Multiplex single-molecule kinetics of nanopore-coupled polymerases

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