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Author: George Church

Rankings

  • All-time downloads: 207,583 (rank: 244 )
  • Categories:
    • biochemistry: 5,258 (rank: 343 )
    • bioengineering: 7,654 (rank: 75 )
    • bioinformatics: 9,295 (rank: 796 )
    • cell biology: 25,994 (rank: 1 )
    • evolutionary biology: 2,280 (rank: 1,939 (tie) )
    • genetics: 2,219 (rank: 7,991 (tie) )
    • genomics: 42,776 (rank: 179 )
    • microbiology: 1,431 (rank: 8,861 (tie) )
    • molecular biology: 23,426 (rank: 38 )
    • neuroscience: 9,039 (rank: 1,329 (tie) )
    • synthetic biology: 75,425 (rank: 1 )
    • systems biology: 2,786 (rank: 1,259 (tie) )

Downloads per author, site-wide

Preprints

Vibrio natriegens, a new genomic powerhouse

genomics more details view paper
  • Downloaded 18,188 times
  • Download rankings, all-time:
    • Site-wide: 356
    • In genomics: 17
  • Year to date:
    • Site-wide: 2,887
  • Since beginning of last month:
    • Site-wide: 2,207

Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

molecular biology more details view paper
  • Downloaded 17,627 times
  • Download rankings, all-time:
    • Site-wide: 365
    • In molecular biology: 4
  • Year to date:
    • Site-wide: 759
  • Since beginning of last month:
    • Site-wide: 694

Unified rational protein engineering with sequence-only deep representation learning

synthetic biology more details view paper
  • Downloaded 10,773 times
  • Download rankings, all-time:
    • Site-wide: 679
    • In synthetic biology: 4
  • Year to date:
    • Site-wide: 4,548
  • Since beginning of last month:
    • Site-wide: None

Inter-homologue repair in fertilized human eggs?

cell biology more details view paper
  • Downloaded 10,311 times
  • Download rankings, all-time:
    • Site-wide: 723
    • In cell biology: 6
  • Year to date:
    • Site-wide: 48,584
  • Since beginning of last month:
    • Site-wide: 30,159

Expansion Sequencing: Spatially Precise In Situ Transcriptomics in Intact Biological Systems

genomics more details view paper
  • Downloaded 8,070 times
  • Download rankings, all-time:
    • Site-wide: 984
    • In genomics: 91
  • Year to date:
    • Site-wide: 501
  • Since beginning of last month:
    • Site-wide: 466

Conneconomics: The Economics of Dense, Large-Scale, High-Resolution Neural Connectomics

neuroscience more details view paper
  • Downloaded 6,532 times
  • Download rankings, all-time:
    • Site-wide: 1,279
    • In neuroscience: 62
  • Year to date:
    • Site-wide: 19,502
  • Since beginning of last month:
    • Site-wide: 26,738

Extensive sequencing of seven human genomes to characterize benchmark reference materials

genomics more details view paper
  • Downloaded 6,316 times
  • Download rankings, all-time:
    • Site-wide: 1,339
    • In genomics: 129
  • Year to date:
    • Site-wide: 33,118
  • Since beginning of last month:
    • Site-wide: 35,039

Highly-efficient Cas9-mediated transcriptional programming

synthetic biology more details view paper
  • Downloaded 6,216 times
  • Download rankings, all-time:
    • Site-wide: 1,367
    • In synthetic biology: 11
  • Year to date:
    • Site-wide: 8,502
  • Since beginning of last month:
    • Site-wide: 5,999

Rapidly evolving homing CRISPR barcodes

synthetic biology more details view paper
  • Downloaded 6,117 times
  • Download rankings, all-time:
    • Site-wide: 1,394
    • In synthetic biology: 12
  • Year to date:
    • Site-wide: 49,062
  • Since beginning of last month:
    • Site-wide: 39,718

Enabling large-scale genome editing by reducing DNA nicking

synthetic biology more details view paper
  • Downloaded 6,019 times
  • Download rankings, all-time:
    • Site-wide: 1,431
    • In synthetic biology: 13
  • Year to date:
    • Site-wide: 36,018
  • Since beginning of last month:
    • Site-wide: None

Highly multiplexed in situ protein imaging with signal amplification by Immuno-SABER

cell biology more details view paper
  • Downloaded 5,635 times
  • Download rankings, all-time:
    • Site-wide: 1,593
    • In cell biology: 20
  • Year to date:
    • Site-wide: 20,000
  • Since beginning of last month:
    • Site-wide: 19,363

Barcoded oligonucleotides ligated on RNA amplified for multiplex and parallel in-situ analyses

cell biology more details view paper
  • Downloaded 5,344 times
  • Download rankings, all-time:
    • Site-wide: 1,703
    • In cell biology: 24
  • Year to date:
    • Site-wide: 6,377
  • Since beginning of last month:
    • Site-wide: 5,041

Daisy-chain gene drives for the alteration of local populations

synthetic biology more details view paper
  • Downloaded 5,319 times
  • Download rankings, all-time:
    • Site-wide: 1,712
    • In synthetic biology: 14
  • Year to date:
    • Site-wide: 82,689
  • Since beginning of last month:
    • Site-wide: None

The predictive power of the microbiome exceeds that of genome-wide association studies in the discrimination of complex human disease

bioinformatics more details view paper
  • Downloaded 5,091 times
  • Download rankings, all-time:
    • Site-wide: 1,801
    • In bioinformatics: 153
  • Year to date:
    • Site-wide: 6,620
  • Since beginning of last month:
    • Site-wide: 5,250

CasFinder: Flexible algorithm for identifying specific Cas9 targets in genomes

genomics more details view paper
  • Downloaded 5,083 times
  • Download rankings, all-time:
    • Site-wide: 1,804
    • In genomics: 185
  • Year to date:
    • Site-wide: 23,581
  • Since beginning of last month:
    • Site-wide: None

Enzymatic DNA synthesis for digital information storage

synthetic biology more details view paper
  • Downloaded 5,035 times
  • Download rankings, all-time:
    • Site-wide: 1,834
    • In synthetic biology: 16
  • Year to date:
    • Site-wide: 18,970
  • Since beginning of last month:
    • Site-wide: 14,903

Current CRISPR gene drive systems are likely to be highly invasive in wild populations

synthetic biology more details view paper
  • Downloaded 4,024 times
  • Download rankings, all-time:
    • Site-wide: 2,503
    • In synthetic biology: 23
  • Year to date:
    • Site-wide: 94,674
  • Since beginning of last month:
    • Site-wide: None

Accurate chromosome-scale haplotype-resolved assembly of human genomes

bioinformatics more details view paper
  • Downloaded 3,780 times
  • Download rankings, all-time:
    • Site-wide: 2,759
    • In bioinformatics: 267
  • Year to date:
    • Site-wide: 4,618
  • Since beginning of last month:
    • Site-wide: 6,550

Extensive Mammalian Germline Genome Engineering

synthetic biology more details view paper
  • Downloaded 3,411 times
  • Download rankings, all-time:
    • Site-wide: 3,217
    • In synthetic biology: 30
  • Year to date:
    • Site-wide: 19,193
  • Since beginning of last month:
    • Site-wide: None

A homing CRISPR mouse resource for barcoding and lineage tracing

synthetic biology more details view paper
  • Downloaded 3,272 times
  • Download rankings, all-time:
    • Site-wide: 3,416
    • In synthetic biology: 32
  • Year to date:
    • Site-wide: 103,828
  • Since beginning of last month:
    • Site-wide: None

Rapid Sequential In Situ Multiplexing With DNA-Exchange-Imaging

bioengineering more details view paper
  • Downloaded 3,187 times
  • Download rankings, all-time:
    • Site-wide: 3,548
    • In bioengineering: 35
  • Year to date:
    • Site-wide: 84,161
  • Since beginning of last month:
    • Site-wide: None

Evolutionary dynamics of CRISPR gene drives

synthetic biology more details view paper
  • Downloaded 2,715 times
  • Download rankings, all-time:
    • Site-wide: 4,427
    • In synthetic biology: 42
  • Year to date:
    • Site-wide: 71,955
  • Since beginning of last month:
    • Site-wide: None

Recombineering in Vibrio natriegens

synthetic biology more details view paper
  • Downloaded 2,695 times
  • Download rankings, all-time:
    • Site-wide: 4,482
    • In synthetic biology: 43
  • Year to date:
    • Site-wide: 18,975
  • Since beginning of last month:
    • Site-wide: 25,705

Assembly of Radically Recoded E. coli Genome Segments

synthetic biology more details view paper
  • Downloaded 2,652 times
  • Download rankings, all-time:
    • Site-wide: 4,606
    • In synthetic biology: 46
  • Year to date:
    • Site-wide: 76,766
  • Since beginning of last month:
    • Site-wide: None

Multiplexed in situ protein imaging using DNA-barcoded antibodies with extended hybridization chain reactions

cell biology more details view paper
  • Downloaded 2,621 times
  • Download rankings, all-time:
    • Site-wide: 4,696
    • In cell biology: 90
  • Year to date:
    • Site-wide: 5,838
  • Since beginning of last month:
    • Site-wide: 4,205

Precise Cas9 targeting enables genomic mutation prevention

synthetic biology more details view paper
  • Downloaded 2,588 times
  • Download rankings, all-time:
    • Site-wide: 4,763
    • In synthetic biology: 50
  • Year to date:
    • Site-wide: 67,509
  • Since beginning of last month:
    • Site-wide: 62,528

Rapid and scalable in vitro production of single-stranded DNA

molecular biology more details view paper
  • Downloaded 2,488 times
  • Download rankings, all-time:
    • Site-wide: 5,061
    • In molecular biology: 111
  • Year to date:
    • Site-wide: 36,047
  • Since beginning of last month:
    • Site-wide: 29,704

The experimental design and data interpretation in ‘Unexpected mutations after CRISPR Cas9 editing in vivo’ by Schaefer et al. are insufficient to support the conclusions drawn by the authors

genetics more details view paper
  • Downloaded 2,219 times
  • Download rankings, all-time:
    • Site-wide: 5,980
    • In genetics: 288
  • Year to date:
    • Site-wide: 43,692
  • Since beginning of last month:
    • Site-wide: 47,583

Efficient in situ barcode sequencing using padlock probe-based BaristaSeq

molecular biology more details view paper
  • Downloaded 1,950 times
  • Download rankings, all-time:
    • Site-wide: 7,211
    • In molecular biology: 176
  • Year to date:
    • Site-wide: 41,938
  • Since beginning of last month:
    • Site-wide: None

Genetic design automation for autonomous formation of multicellular shapes from a single cell progenitor

synthetic biology more details view paper
  • Downloaded 1,771 times
  • Download rankings, all-time:
    • Site-wide: 8,338
    • In synthetic biology: 88
  • Year to date:
    • Site-wide: 17,860
  • Since beginning of last month:
    • Site-wide: None

High-throughput creation and functional profiling of eukaryotic DNA sequence variant libraries using CRISPR/Cas9

bioengineering more details view paper
  • Downloaded 1,770 times
  • Download rankings, all-time:
    • Site-wide: 8,346
    • In bioengineering: 136
  • Year to date:
    • Site-wide: 71,580
  • Since beginning of last month:
    • Site-wide: 59,370

An orthogonal differentiation platform for genomically programming stem cells, organoids, and bioprinted tissues

bioengineering more details view paper
  • Downloaded 1,741 times
  • Download rankings, all-time:
    • Site-wide: 8,567
    • In bioengineering: 140
  • Year to date:
    • Site-wide: 10,244
  • Since beginning of last month:
    • Site-wide: None

The whale shark genome reveals how genomic and physiological properties scale with body size

genomics more details view paper
  • Downloaded 1,708 times
  • Download rankings, all-time:
    • Site-wide: 8,834
    • In genomics: 994
  • Year to date:
    • Site-wide: 77,190
  • Since beginning of last month:
    • Site-wide: 73,877

A systematic comparison of error correction enzymes by next-generation sequencing

synthetic biology more details view paper
  • Downloaded 1,646 times
  • Download rankings, all-time:
    • Site-wide: 9,341
    • In synthetic biology: 97
  • Year to date:
    • Site-wide: 36,395
  • Since beginning of last month:
    • Site-wide: 27,107

Photon-directed Multiplexed Enzymatic DNA Synthesis for Molecular Digital Data Storage

synthetic biology more details view paper
  • Downloaded 1,576 times
  • Download rankings, all-time:
    • Site-wide: 9,965
    • In synthetic biology: 106
  • Year to date:
    • Site-wide: 26,540
  • Since beginning of last month:
    • Site-wide: None

A DNA nanoscope that identifies and precisely localizes over a hundred unique molecular features with nanometer accuracy

biochemistry more details view paper
  • Downloaded 1,563 times
  • Download rankings, all-time:
    • Site-wide: 10,072
    • In biochemistry: 195
  • Year to date:
    • Site-wide: 5,820
  • Since beginning of last month:
    • Site-wide: 4,201

Improved bacterial recombineering by parallelized protein discovery

microbiology more details view paper
  • Downloaded 1,431 times
  • Download rankings, all-time:
    • Site-wide: 11,468
    • In microbiology: 640
  • Year to date:
    • Site-wide: 35,577
  • Since beginning of last month:
    • Site-wide: 40,788

Reprogramming protein kinase substrate specificity through synthetic mutations

biochemistry more details view paper
  • Downloaded 1,427 times
  • Download rankings, all-time:
    • Site-wide: 11,511
    • In biochemistry: 219
  • Year to date:
    • Site-wide: 69,961
  • Since beginning of last month:
    • Site-wide: None

Induced Pluripotent Stem Cell-derived CAR-Macrophage Cells with Antigen-dependent Anti-Cancer Cell Functions for Liquid and Solid Tumors

cell biology more details view paper
  • Downloaded 1,413 times
  • Download rankings, all-time:
    • Site-wide: 11,664
    • In cell biology: 327
  • Year to date:
    • Site-wide: 5,101
  • Since beginning of last month:
    • Site-wide: 5,339

Concerning RNA-Guided Gene Drives for the Alteration of Wild Populations

synthetic biology more details view paper
  • Downloaded 1,411 times
  • Download rankings, all-time:
    • Site-wide: 11,708
    • In synthetic biology: 130
  • Year to date:
    • Site-wide: 84,624
  • Since beginning of last month:
    • Site-wide: 93,251

Multi-pronged human protein mimicry by SARS-CoV-2 reveals bifurcating potential for MHC detection and immune evasion

evolutionary biology more details view paper
  • Downloaded 1,405 times
  • Download rankings, all-time:
    • Site-wide: 11,783
    • In evolutionary biology: 419
  • Year to date:
    • Site-wide: 4,822
  • Since beginning of last month:
    • Site-wide: None

CRISPR-mediated biocontainment

synthetic biology more details view paper
  • Downloaded 1,381 times
  • Download rankings, all-time:
    • Site-wide: 12,117
    • In synthetic biology: 139
  • Year to date:
    • Site-wide: 33,564
  • Since beginning of last month:
    • Site-wide: 23,916

Enhanced bacterial immunity and mammalian genome editing via RNA polymerase-mediated dislodging of Cas9 from double strand DNA breaks.

molecular biology more details view paper
  • Downloaded 1,361 times
  • Download rankings, all-time:
    • Site-wide: 12,363
    • In molecular biology: 340
  • Year to date:
    • Site-wide: 88,545
  • Since beginning of last month:
    • Site-wide: None

Engineering post-translational proofreading to discriminate non-standard amino acids

synthetic biology more details view paper
  • Downloaded 1,282 times
  • Download rankings, all-time:
    • Site-wide: 13,533
    • In synthetic biology: 160
  • Year to date:
    • Site-wide: 67,521
  • Since beginning of last month:
    • Site-wide: 47,097

Systemic post-translational control of bacterial metabolism regulates adaptation in dynamic environments

systems biology more details view paper
  • Downloaded 1,242 times
  • Download rankings, all-time:
    • Site-wide: 14,175
    • In systems biology: 286
  • Year to date:
    • Site-wide: 30,581
  • Since beginning of last month:
    • Site-wide: 17,255

Optimizing complex phenotypes through model-guided multiplex genome engineering

synthetic biology more details view paper
  • Downloaded 1,201 times
  • Download rankings, all-time:
    • Site-wide: 14,931
    • In synthetic biology: 185
  • Year to date:
    • Site-wide: 83,361
  • Since beginning of last month:
    • Site-wide: None

Fluorescent in situ sequencing of DNA barcoded antibodies

neuroscience more details view paper
  • Downloaded 1,096 times
  • Download rankings, all-time:
    • Site-wide: 17,165
    • In neuroscience: 2,156
  • Year to date:
    • Site-wide: 8,625
  • Since beginning of last month:
    • Site-wide: 5,530

Biosensor libraries harness large classes of binding domains for allosteric transcription regulators

synthetic biology more details view paper
  • Downloaded 1,094 times
  • Download rankings, all-time:
    • Site-wide: 17,210
    • In synthetic biology: 214
  • Year to date:
    • Site-wide: 101,951
  • Since beginning of last month:
    • Site-wide: 73,212

Massively parallel quantification of CRISPR editing in cells by TRAP-seq enables better design of Cas9, ABE, CBE gRNAs of high efficiency and accuracy

systems biology more details view paper
  • Downloaded 1,030 times
  • Download rankings, all-time:
    • Site-wide: 18,836
    • In systems biology: 391
  • Year to date:
    • Site-wide: 23,765
  • Since beginning of last month:
    • Site-wide: 33,266

Characterizing the portability of RecT-mediated oligonucleotide recombination

synthetic biology more details view paper
  • Downloaded 1,017 times
  • Download rankings, all-time:
    • Site-wide: 19,169
    • In synthetic biology: 242
  • Year to date:
    • Site-wide: 16,647
  • Since beginning of last month:
    • Site-wide: 15,320

Significant abundance of cis configurations of mutations in diploid human genomes

genomics more details view paper
  • Downloaded 1,013 times
  • Download rankings, all-time:
    • Site-wide: 19,310
    • In genomics: 1,979
  • Year to date:
    • Site-wide: 35,880
  • Since beginning of last month:
    • Site-wide: 33,740

Citizen-Centered, Auditable, and Privacy-Preserving Population Genomics

genomics more details view paper
  • Downloaded 976 times
  • Download rankings, all-time:
    • Site-wide: 20,315
    • In genomics: 2,052
  • Year to date:
    • Site-wide: 18,736
  • Since beginning of last month:
    • Site-wide: 19,122

Dissecting limiting factors of the Protein synthesis Using Recombinant Elements (PURE) system

bioengineering more details view paper
  • Downloaded 956 times
  • Download rankings, all-time:
    • Site-wide: 20,941
    • In bioengineering: 352
  • Year to date:
    • Site-wide: 118,193
  • Since beginning of last month:
    • Site-wide: None

Attribution of genetic engineering: a practical and accurate machine learning toolkit for biosecurity

synthetic biology more details view paper
  • Downloaded 947 times
  • Download rankings, all-time:
    • Site-wide: 21,236
    • In synthetic biology: 270
  • Year to date:
    • Site-wide: 31,246
  • Since beginning of last month:
    • Site-wide: 27,317

Long-term adaptive evolution of genomically recoded Escherichia coli

evolutionary biology more details view paper
  • Downloaded 875 times
  • Download rankings, all-time:
    • Site-wide: 23,801
    • In evolutionary biology: 1,114
  • Year to date:
    • Site-wide: 96,694
  • Since beginning of last month:
    • Site-wide: 72,791

Ethnically relevant consensus Korean reference genome towards personal reference genomes

genomics more details view paper
  • Downloaded 854 times
  • Download rankings, all-time:
    • Site-wide: 24,634
    • In genomics: 2,375
  • Year to date:
    • Site-wide: 77,909
  • Since beginning of last month:
    • Site-wide: 75,332

Toward D-Peptide Biosynthesis: Elongation Factor P Enables Ribosomal Incorporation Of Consecutive D-Amino Acids

biochemistry more details view paper
  • Downloaded 791 times
  • Download rankings, all-time:
    • Site-wide: 27,369
    • In biochemistry: 649
  • Year to date:
    • Site-wide: 66,563
  • Since beginning of last month:
    • Site-wide: 57,716

Towards Practical and Robust DNA-based Data Archiving by Codec System Named ‘Yin-Yang’

synthetic biology more details view paper
  • Downloaded 764 times
  • Download rankings, all-time:
    • Site-wide: 28,718
    • In synthetic biology: 369
  • Year to date:
    • Site-wide: 30,309
  • Since beginning of last month:
    • Site-wide: 20,829

Spatial Information in Large-Scale Neural Recordings

neuroscience more details view paper
  • Downloaded 759 times
  • Download rankings, all-time:
    • Site-wide: 29,013
    • In neuroscience: 3,969
  • Year to date:
    • Site-wide: 102,689
  • Since beginning of last month:
    • Site-wide: 77,926

Cushing's Syndrome mutant PKAL205R exhibits altered substrate specificity

biochemistry more details view paper
  • Downloaded 729 times
  • Download rankings, all-time:
    • Site-wide: 30,711
    • In biochemistry: 737
  • Year to date:
    • Site-wide: 104,438
  • Since beginning of last month:
    • Site-wide: 57,593

Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA

cell biology more details view paper
  • Downloaded 670 times
  • Download rankings, all-time:
    • Site-wide: 34,453
    • In cell biology: 1,383
  • Year to date:
    • Site-wide: 44,424
  • Since beginning of last month:
    • Site-wide: 36,670

L1CAM is not Associated with Extracellular Vesicles in Human Cerebrospinal Fluid or Plasma

neuroscience more details view paper
  • Downloaded 652 times
  • Download rankings, all-time:
    • Site-wide: 35,744
    • In neuroscience: 5,035
  • Year to date:
    • Site-wide: 7,568
  • Since beginning of last month:
    • Site-wide: 10,011

Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli

genomics more details view paper
  • Downloaded 568 times
  • Download rankings, all-time:
    • Site-wide: 42,549
    • In genomics: 3,495
  • Year to date:
    • Site-wide: 115,928
  • Since beginning of last month:
    • Site-wide: None

Simulating serial-target antibacterial drug synergies using flux balance analysis

systems biology more details view paper
  • Downloaded 514 times
  • Download rankings, all-time:
    • Site-wide: 48,028
    • In systems biology: 1,126
  • Year to date:
    • Site-wide: 84,343
  • Since beginning of last month:
    • Site-wide: 59,141

Multiplex single-molecule kinetics of nanopore-coupled polymerases

synthetic biology more details view paper
  • Downloaded 499 times
  • Download rankings, all-time:
    • Site-wide: 49,689
    • In synthetic biology: 601
  • Year to date:
    • Site-wide: 34,173
  • Since beginning of last month:
    • Site-wide: 43,589

Physiological Assembly Of Functionally Active 30S Ribosomal Subunits From In Vitro Synthesized Parts

biochemistry more details view paper
  • Downloaded 447 times
  • Download rankings, all-time:
    • Site-wide: 56,167
    • In biochemistry: 1,481
  • Year to date:
    • Site-wide: 108,244
  • Since beginning of last month:
    • Site-wide: None

TBDB: A database of structurally annotated T-box riboswitch-tRNA pairs

bioinformatics more details view paper
  • Downloaded 424 times
  • Download rankings, all-time:
    • Site-wide: 59,281
    • In bioinformatics: 5,916
  • Year to date:
    • Site-wide: 38,998
  • Since beginning of last month:
    • Site-wide: 28,984

Comparison of Extracellular Vesicle Isolation Methods from Human Biofluids using Single Molecule Arrays

biochemistry more details view paper
  • Downloaded 301 times
  • Download rankings, all-time:
    • Site-wide: 80,119
    • In biochemistry: 2,302
  • Year to date:
    • Site-wide: 12,119
  • Since beginning of last month:
    • Site-wide: 12,483

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