Author: Yang Yang

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Preprints

A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx

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Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China

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  • Site-wide: 125
  • In epidemiology: 29
• Year to date:
  • Site-wide: 1,332
• Since beginning of last month:
  • Site-wide: 2,591

Laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections

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  • Site-wide: 199
  • In infectious diseases: 76
• Year to date:
  • Site-wide: 822
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  • Site-wide: 8,094

Viral Architecture of SARS-CoV-2 with Post-Fusion Spike Revealed by Cryo-EM

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  • Site-wide: 742
  • In microbiology: 76
• Year to date:
  • Site-wide: 1,063
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  • Site-wide: 8,652

Exuberant elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection is associated with disease severity and fatal outcome

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  • Site-wide: 887
  • In infectious diseases: 278
• Year to date:
  • Site-wide: 3,922
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  • Site-wide: 20,977

Predicting Enhancer-Promoter Interaction from Genomic Sequence with Deep Neural Networks

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  • Site-wide: 1,947
  • In bioinformatics: 141
• Year to date:
  • Site-wide: 40,296
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  • Site-wide: 82,658

Comprehensive Molecular Characterization of Mitochondrial Genomes in Human Cancers

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  • Site-wide: 5,758
  • In genomics: 604
• Year to date:
  • Site-wide: 66,163
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  • Site-wide: 71,298

Fluorogenic probe for fast 3D whole-cell DNA-PAINT

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  • Site-wide: 6,082
  • In biophysics: 102
• Year to date:
  • Site-wide: 5,128
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  • Site-wide: 3,478

Structure-based Classification of Tauopathies

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  • Site-wide: 7,490
  • In neuroscience: 718
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  • Site-wide: 1,067
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  • Site-wide: 271

Mid-Infrared Spectroscopy Study of Effects of Neonicotinoids on Forager Honey Bee (Apis mellifera) Fat Bodies and Their Connection to Colony Collapse Disorder

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  • Site-wide: 9,072
  • In pharmacology and toxicology: 52
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  • Site-wide: 63,645
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Increased anxiety and decreased sociability in adulthood following paternal deprivation involve oxytocin in the mPFC

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  • Site-wide: 10,046
  • In neuroscience: 1,043
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  • Site-wide: 35,534
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  • Site-wide: 23,830

Comparing 3D genome organization in multiple species using Phylo-HMRF

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  • Site-wide: 10,766
  • In bioinformatics: 1,258
• Year to date:
  • Site-wide: 104,802
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  • Site-wide: 24,003

Several FDA-approved drugs effectively inhibit SARS-CoV-2 infection in vitro

• Downloaded 1,340 times
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  • Site-wide: 15,848
  • In microbiology: 929
• Year to date:
  • Site-wide: 8,089
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  • Site-wide: 55,771

Predicting CTCF-mediated chromatin loops using CTCF-MP

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  • Site-wide: 25,230
  • In bioinformatics: 2,885
• Year to date:
  • Site-wide: 138,692
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The Epidemiology and Transmissibility of Zika Virus in Girardot and San Andres Island, Colombia

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  • Site-wide: 26,732
  • In epidemiology: 1,510
• Year to date:
  • Site-wide: 114,842
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  • Site-wide: 93,909

Predicting circRNA-RBP interaction sites using a codon-based encoding and hybrid deep neural networks

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  • Site-wide: 32,454
  • In bioinformatics: 3,612
• Year to date:
  • Site-wide: 97,432
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Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

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  • Site-wide: 35,070
  • In genomics: 2,966
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  • Site-wide: 133,005
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Methylglyoxal modification of TrkB promotes synaptic plasticity and enhances resilience to chronic stress

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  • Site-wide: 35,577
  • In neuroscience: 4,836
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  • Site-wide: 57,144
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The utility of native MS for understanding the mechanism of action of repurposed therapeutics in COVID-19: heparin as a disruptor of the SARS-CoV-2 interaction with its host cell receptor.

• Downloaded 724 times
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  • Site-wide: 38,515
  • In biochemistry: 943
• Year to date:
  • Site-wide: 70,644
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  • Site-wide: 109,198

Endothelial pannexin 1 channels control inflammation by regulating intracellular calcium

• Downloaded 603 times
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  • Site-wide: 48,729
  • In cell biology: 2,064
• Year to date:
  • Site-wide: 65,346
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  • Site-wide: 77,845

Comprehensive mapping of mammalian transcriptomes identifies conserved genes associated with different cell differentiation states

• Downloaded 594 times
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  • Site-wide: 49,664
  • In systems biology: 1,100
• Year to date:
  • Site-wide: 135,779
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  • Site-wide: None

The Mechanical of Organic Acids Secreted by Roots of Tartary Buckwheat under the Effects of Low Nitrogen Stress

• Downloaded 587 times
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  • Site-wide: 50,391
  • In plant biology: 1,158
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  • Site-wide: 76,439
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  • Site-wide: 71,993

Continuous-trait probabilistic model for comparing multi-species functional genomic data

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  • Site-wide: 51,041
  • In bioinformatics: 5,248
• Year to date:
  • Site-wide: 143,095
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Molecular mechanisms behind global distribution of earthworm revealed by the genome

• Downloaded 555 times
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  • Site-wide: 54,028
  • In genomics: 4,076
• Year to date:
  • Site-wide: 113,638
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High glucose-induced ubiquitylation of G6PD leads to the injury of podocyte

• Downloaded 536 times
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  • Site-wide: 56,346
  • In cell biology: 2,439
• Year to date:
  • Site-wide: 112,314
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  • Site-wide: 61,453

Effects of the anesthetic MS-222 on silver pomfret (Pampus argenteus) juveniles under aquaculture treatment stresses

• Downloaded 504 times
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  • Site-wide: 60,611
  • In animal behavior and cognition: 614
• Year to date:
  • Site-wide: 80,181
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  • Site-wide: 81,283

Variation benchmark datasets: update, criteria, quality and applications

• Downloaded 493 times
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  • Site-wide: 62,047
  • In bioinformatics: 6,128
• Year to date:
  • Site-wide: 125,820
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  • Site-wide: 71,315

Inhibiting Mycobacterium tuberculosis ClpP1P2 by addressing the equatorial handle domain of ClpP1 subunit

• Downloaded 491 times
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  • Site-wide: 62,292
  • In biochemistry: 1,639
• Year to date:
  • Site-wide: 48,885
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  • Site-wide: 65,985

Regeneration of Functional Retinal Ganglion Cells by Neuronal Identity Reprogramming

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  • Site-wide: 63,177
  • In neuroscience: 9,300
• Year to date:
  • Site-wide: 31,473
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  • Site-wide: 102,040

Label-free optical detection of bioelectric potentials using electrochromic thin films

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  • Site-wide: 66,171
  • In neuroscience: 9,815
• Year to date:
  • Site-wide: 84,483
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  • Site-wide: 95,431

Sorting liposomes of distinct sizes by DNA-brick assisted centrifugation

• Downloaded 463 times
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  • Site-wide: 66,572
  • In biophysics: 2,323
• Year to date:
  • Site-wide: 41,855
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  • Site-wide: 88,567

Inactivation of LCN2/EGR1 Promotes Oligodendrocyte Progenitor Cell Differentiation and Remyelination after White Matter Injury

• Downloaded 462 times
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  • Site-wide: 66,622
  • In neuroscience: 9,925
• Year to date:
  • Site-wide: 40,803
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  • Site-wide: None

Zinc finger protein SALL4 functions through an AT-rich motif to regulate gene expression

• Downloaded 462 times
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  • Site-wide: 66,639
  • In molecular biology: 1,886
• Year to date:
  • Site-wide: 59,935
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  • Site-wide: 56,519

Integrated analysis of the miRNA-mRNA network associated with LMP1 gene in nasopharyngeal carcinoma

• Downloaded 429 times
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  • Site-wide: 72,036
  • In microbiology: 4,863
• Year to date:
  • Site-wide: 95,914
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  • Site-wide: 35,460

A dynamic regulatory interface on SARS-CoV-2 RNA polymerase

• Downloaded 422 times
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  • Site-wide: 73,112
  • In molecular biology: 2,118
• Year to date:
  • Site-wide: 59,732
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  • Site-wide: 54,608

Microstructural plasticity in the bilingual brain

• Downloaded 421 times
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  • Site-wide: 73,228
  • In neuroscience: 10,953
• Year to date:
  • Site-wide: 104,363
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  • Site-wide: 16,710

Characterization of a gene-trap knockout mouse model of Scn2a encoding voltage-gated sodium channel Nav1.2

• Downloaded 393 times
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  • Site-wide: 78,239
  • In neuroscience: 11,799
• Year to date:
  • Site-wide: 63,138
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  • Site-wide: 49,299

Sodium channel Nav1.2-L1342P variant displaying complex biophysical properties renders hyperexcitability of cortical neurons derived fromhuman iPSCs

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  • Site-wide: 82,523
  • In physiology: 642
• Year to date:
  • Site-wide: 13,089
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  • Site-wide: 19,331

Transcriptome Profiling of different types of human respiratory tract cells infected by SARS-CoV-2 Highlight an unique Role for Inflammatory and Interferon Response

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  • Site-wide: 85,780
  • In immunology: 2,524
• Year to date:
  • Site-wide: 67,563
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  • Site-wide: 39,880

Transgenerational inheritance of betaine-induced epigenetic alterations in estrogen-responsive IGF-2/IGFBP2 genes in rat hippocampus

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  • Site-wide: 88,400
  • In genetics: 3,831
• Year to date:
  • Site-wide: 62,712
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D1, not D2, dopamine receptor activation dramatically improves MPTP-induced parkinsonism unresponsive to levodopa

• Downloaded 327 times
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  • Site-wide: 91,520
  • In neuroscience: 13,897
• Year to date:
  • Site-wide: 33,650
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  • Site-wide: 101,242

The MarR Family Regulator BmrR is involved in Bile Tolerance of Bifidobacterium longum BBMN68 via Controlling the Expression of an ABC-Transporter

• Downloaded 287 times
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  • Site-wide: 100,600
  • In microbiology: 7,255
• Year to date:
  • Site-wide: 142,190
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Severe deficiency of voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice

• Downloaded 279 times
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  • Site-wide: 102,569
  • In neuroscience: 15,681
• Year to date:
  • Site-wide: 19,621
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  • Site-wide: 49,424

Androgen Promotes Differentiation of PLZF+ Spermatogonia pool via Indirect Regulatory Pattern

• Downloaded 274 times
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  • Site-wide: 103,691
  • In developmental biology: 2,769
• Year to date:
  • Site-wide: 142,475
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A fast image processing toolbox for all-optical closed-loop control of neuronal activities

• Downloaded 268 times
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  • Site-wide: 105,196
  • In neuroscience: 16,109
• Year to date:
  • Site-wide: 51,295
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  • Site-wide: 112,112

RNF219 interacts with CCR4-NOT in regulating stem cell differentiation

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  • Site-wide: 107,119
  • In molecular biology: 3,164
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  • Site-wide: 74,484
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HIV-1 Nef interacts with LMP7 to attenuate immunoproteasome formation and MHC-I antigen presentation

• Downloaded 246 times
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  • Site-wide: 110,626
  • In microbiology: 8,080
• Year to date:
  • Site-wide: 134,202
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  • Site-wide: 65,851

O-GlcNAcylation of SAMHD1 Indicating a Link between Metabolic Reprogramming and Anti-HBV Immunity

• Downloaded 238 times
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  • Site-wide: 112,554
  • In microbiology: 8,250
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  • Site-wide: 119,967
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Mutational signatures of complex genomic rearrangements in human cancer

• Downloaded 222 times
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  • Site-wide: 116,556
  • In genomics: 6,586
• Year to date:
  • Site-wide: 26,563
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  • Site-wide: 54,036

SPOCK1 promotes breast cancer progression via interacting with SIX1 and activating AKT/mTOR signaling pathway

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  • Site-wide: 120,098
  • In cancer biology: 3,619
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  • Site-wide: 98,476
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  • Site-wide: 26,199

The challenge of structural heterogeneity in the native mass spectrometry studies of the SARS-CoV-2 spike protein interactions with its host cell-surface receptor

• Downloaded 201 times
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  • Site-wide: 121,797
  • In biochemistry: 3,601
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  • Site-wide: 30,099
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  • Site-wide: 45,085

A mathematical investigation of chemotherapy-induced peripheral neuropathy

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  • Site-wide: 123,462
  • In neuroscience: 18,857
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  • Site-wide: 132,221
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  • Site-wide: None

Interannual variability of net ecosystem carbon production and its climatic and biotic mechanism during 2005-2018 in a rain-fed maize ecosystem

• Downloaded 141 times
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  • Site-wide: 135,573
  • In ecology: 4,746
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  • Site-wide: 84,521
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  • Site-wide: None

Systematic characterization of short intronic splicing-regulatory elements

• Downloaded 116 times
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  • Site-wide: 140,798
  • In molecular biology: 4,184
• Year to date:
  • Site-wide: 55,030
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  • Site-wide: 54,129

Olanzapine leads to nonalcoholic fatty liver disease through the apolipoprotein A5 pathway

• Downloaded 102 times
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  • Site-wide: 143,504
  • In pathology: 869
• Year to date:
  • Site-wide: 62,406
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  • Site-wide: 116,023

Oncomodulin Delays Age-Related Hearing Loss in C57 and CBA Mice

• Downloaded 98 times
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  • Site-wide: 144,248
  • In neuroscience: 21,779
• Year to date:
  • Site-wide: 64,314
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  • Site-wide: 55,298

E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis

• Downloaded 88 times
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  • Site-wide: 145,806
  • In immunology: 4,354
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  • Site-wide: 107,755

A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis

• Downloaded 85 times
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  • Site-wide: 146,190
  • In cell biology: 6,654
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  • Site-wide: 72,865
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  • Site-wide: 107,973