Author: John R Mascola

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Preprints

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

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  • In immunology: 10
• Year to date:
  • Site-wide: 1,523
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  • Site-wide: 2,997

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

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  • Site-wide: 271
  • In immunology: 13
• Year to date:
  • Site-wide: 1,424
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  • Site-wide: 3,545

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

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  • Site-wide: 1,671
  • In immunology: 67
• Year to date:
  • Site-wide: 19,458
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  • Site-wide: 13,129

Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains

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  • Site-wide: 3,180
  • In immunology: 132
• Year to date:
  • Site-wide: 28,412
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  • Site-wide: 13,912

Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants

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  • Site-wide: 9,253
  • In immunology: 357
• Year to date:
  • Site-wide: 59,882
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  • Site-wide: 50,307

Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines

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  • Site-wide: 14,046
  • In immunology: 535
• Year to date:
  • Site-wide: 19,384
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  • Site-wide: 102,877

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

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  • Site-wide: 14,111
  • In immunology: 548
• Year to date:
  • Site-wide: 42,788
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  • Site-wide: 15,110

A Platform Incorporating Trimeric Antigens into Self-Assembling Nanoparticles Reveals SARS-CoV-2-Spike Nanoparticles to Elicit Substantially Higher Neutralizing Responses than Spike Alone

• Downloaded 1,664 times
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  • Site-wide: 17,860
  • In immunology: 663
• Year to date:
  • Site-wide: 36,626
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  • Site-wide: 38,552

Real-time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles

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  • Site-wide: 17,956
  • In microbiology: 1,029
• Year to date:
  • Site-wide: 183,949
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  • Site-wide: 53,648

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

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  • Site-wide: 20,591
  • In immunology: 756
• Year to date:
  • Site-wide: 83,755
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  • Site-wide: 81,421

Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

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  • Site-wide: 21,209
  • In immunology: 795
• Year to date:
  • Site-wide: 52,603
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  • Site-wide: 50,137

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

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  • Site-wide: 27,073
  • In immunology: 989
• Year to date:
  • Site-wide: 133,886
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  • Site-wide: 149,502

Human antibody immune responses are personalized by selective removal of MHC-II peptide epitopes

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  • Site-wide: 35,296
  • In immunology: 1,298
• Year to date:
  • Site-wide: 9,314
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  • Site-wide: 70,871

A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

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  • Site-wide: 55,002
  • In immunology: 1,885
• Year to date:
  • Site-wide: 85,236
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  • Site-wide: 64,708

Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

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  • Site-wide: 68,056
  • In immunology: 2,255
• Year to date:
  • Site-wide: 84,236
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  • Site-wide: 64,548

Structural survey of HIV-1-neutralizing antibodies targeting Env trimer delineates epitope categories and suggests vaccine templates

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  • Site-wide: 80,389
  • In bioinformatics: 7,327
• Year to date:
  • Site-wide: 131,732
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  • Site-wide: 173,910

Protection of rhesus macaques against vaginal SHIV challenges by VRC01 and an anti-α4β7 antibody

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  • Site-wide: 81,692
  • In immunology: 2,649
• Year to date:
  • Site-wide: 112,834
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  • Site-wide: 118,440

Accurate Prediction of Antibody Resistance in Clinical HIV-1 Isolates

• Downloaded 607 times
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  • Site-wide: 82,476
  • In bioinformatics: 7,560
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  • Site-wide: None
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  • Site-wide: 209,844

Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV

• Downloaded 556 times
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  • Site-wide: 92,136
  • In immunology: 2,969
• Year to date:
  • Site-wide: 192,710
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  • Site-wide: 144,108

Design of nanoparticulate group 2 influenza hemagglutinin stem antigens that activate unmutated ancestor B cell receptors of broadly neutralizing antibody lineages

• Downloaded 477 times
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  • Site-wide: 109,749
  • In immunology: 3,508
• Year to date:
  • Site-wide: 192,469
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  • Site-wide: 141,081

Extensive CD8β depletion does not prevent control of viral replication or protection from challenge in macaques chronically infected with a live attenuated simian immunodeficiency virus

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  • Site-wide: 136,560
  • In immunology: 4,275
• Year to date:
  • Site-wide: 138,309
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  • Site-wide: 203,674

Virus-Like Particle Based-Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide

• Downloaded 308 times
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  • Site-wide: 157,432
  • In immunology: 4,938
• Year to date:
  • Site-wide: 149,110
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  • Site-wide: 162,647

Structurally related but genetically unrelated antibody lineages converge on an immunodominantHIV-1 Env neutralizing determinant following trimer immunization

• Downloaded 265 times
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  • Site-wide: 170,315
  • In biochemistry: 5,321
• Year to date:
  • Site-wide: 105,634
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  • Site-wide: 156,645