Author: John R Mascola

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Preprints

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

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SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

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LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

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  • Site-wide: 1,508
  • In immunology: 47
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  • Site-wide: 850
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Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains

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Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants

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  • In immunology: 358
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  • Site-wide: 16,108

Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines

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  • In immunology: 426
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Real-time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles

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  • In microbiology: 890
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Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

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• Year to date:
  • Site-wide: 3,064
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  • Site-wide: 1,652

A Platform Incorporating Trimeric Antigens into Self-Assembling Nanoparticles Reveals SARS-CoV-2-Spike Nanoparticles to Elicit Substantially Higher Neutralizing Responses than Spike Alone

• Downloaded 1,411 times
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  • Site-wide: 16,978
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• Year to date:
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Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

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• Year to date:
  • Site-wide: 55,152
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  • Site-wide: 114,805

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

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  • Site-wide: 21,328
  • In immunology: 743
• Year to date:
  • Site-wide: 130,980
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  • Site-wide: 144,043

Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

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  • Site-wide: 24,414
  • In immunology: 846
• Year to date:
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  • Site-wide: 8,280

Human antibody immune responses are personalized by selective removal of MHC-II peptide epitopes

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  • Site-wide: 38,073
  • In immunology: 1,236
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A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

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  • Site-wide: 44,823
  • In immunology: 1,424
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  • Site-wide: 39,582
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  • Site-wide: 36,878

Accurate Prediction of Antibody Resistance in Clinical HIV-1 Isolates

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  • Site-wide: 62,790
  • In bioinformatics: 6,082
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  • Site-wide: 149,939
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Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

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  • Site-wide: 63,710
  • In immunology: 1,963
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  • Site-wide: 36,097
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  • Site-wide: 41,849

Structural survey of HIV-1-neutralizing antibodies targeting Env trimer delineates epitope categories and suggests vaccine templates

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  • Site-wide: 65,333
  • In bioinformatics: 6,257
• Year to date:
  • Site-wide: 138,145
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  • Site-wide: 159,385

Protection of rhesus macaques against vaginal SHIV challenges by VRC01 and an anti-α4β7 antibody

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  • Site-wide: 67,548
  • In immunology: 2,056
• Year to date:
  • Site-wide: 132,146
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Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV

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  • Site-wide: 73,979
  • In immunology: 2,248
• Year to date:
  • Site-wide: 162,122
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  • Site-wide: 150,808

Design of nanoparticulate group 2 influenza hemagglutinin stem antigens that activate unmutated ancestor B cell receptors of broadly neutralizing antibody lineages

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  • Site-wide: 84,644
  • In immunology: 2,557
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Extensive CD8β depletion does not prevent control of viral replication or protection from challenge in macaques chronically infected with a live attenuated simian immunodeficiency virus

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  • Site-wide: 110,619
  • In immunology: 3,316
• Year to date:
  • Site-wide: 148,519
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  • Site-wide: 142,504

Virus-Like Particle Based-Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide

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  • Site-wide: 126,542
  • In immunology: 3,764
• Year to date:
  • Site-wide: 100,560
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  • Site-wide: 115,901

Structurally related but genetically unrelated antibody lineages converge on an immunodominantHIV-1 Env neutralizing determinant following trimer immunization

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  • Site-wide: 139,550
  • In biochemistry: 4,239
• Year to date:
  • Site-wide: 54,436
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  • Site-wide: 50,422