Author: John R Mascola

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Preprints

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

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SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

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LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

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Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains

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Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants

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Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines

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Real-time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles

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Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

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A Platform Incorporating Trimeric Antigens into Self-Assembling Nanoparticles Reveals SARS-CoV-2-Spike Nanoparticles to Elicit Substantially Higher Neutralizing Responses than Spike Alone

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Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

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Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

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  • Site-wide: 40,513
  • In immunology: 1,209
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  • Site-wide: 3,648
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  • Site-wide: 1,752

Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

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  • In immunology: 1,236
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A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

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  • Site-wide: 42,699
  • In immunology: 1,265
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  • Site-wide: 24,560
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Human antibody immune responses are personalized by selective removal of MHC-II peptide epitopes

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  • In immunology: 1,358
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Accurate Prediction of Antibody Resistance in Clinical HIV-1 Isolates

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Structural survey of HIV-1-neutralizing antibodies targeting Env trimer delineates epitope categories and suggests vaccine templates

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  • Site-wide: 54,203
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Protection of rhesus macaques against vaginal SHIV challenges by VRC01 and an anti-α4β7 antibody

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Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV

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  • Site-wide: 59,962
  • In immunology: 1,731
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  • Site-wide: 137,488
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  • Site-wide: 124,122

Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

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  • In immunology: 1,901
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Design of nanoparticulate group 2 influenza hemagglutinin stem antigens that activate unmutated ancestor B cell receptors of broadly neutralizing antibody lineages

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  • Site-wide: 71,407
  • In immunology: 2,062
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Extensive CD8β depletion does not prevent control of viral replication or protection from challenge in macaques chronically infected with a live attenuated simian immunodeficiency virus

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  • In immunology: 2,711
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Virus-Like Particle Based-Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide

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  • Site-wide: 114,846
  • In immunology: 3,337
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Structurally related but genetically unrelated antibody lineages converge on an immunodominantHIV-1 Env neutralizing determinant following trimer immunization

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  • Site-wide: 135,988
  • In biochemistry: 4,112
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  • Site-wide: 38,882