Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 45,784 bioRxiv papers from 206,165 authors.

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Preprints

Population histories of the United States revealed through fine-scale migration and haplotype analysis

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Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinsons disease

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Analysis of protein-coding genetic variation in 60,706 humans

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  • In genomics: 5 out of 3,397
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  • Site-wide: 4,557 out of 45,813

New mutations, old statistical challenges

• Downloaded 6,586 times
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  • Site-wide: 13,180 out of 45,813

Analysis of shared heritability in common disorders of the brain

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  • In genetics: 20 out of 2,745
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Partitioning heritability by functional category using GWAS summary statistics

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  • Site-wide: 182 out of 45,813
  • In genetics: 22 out of 2,745
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Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • In genetics: 42 out of 2,745
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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

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  • In bioinformatics: 143 out of 4,918
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Haplotypes of common SNPs can explain missing heritability of complex diseases

• Downloaded 2,812 times
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  • In genetics: 85 out of 2,745
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  • Site-wide: 25,597 out of 45,813
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Phenome-wide association studies (PheWAS) across large "real-world data" population cohorts support drug target validation

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  • In genetics: 90 out of 2,745
• Year to date:
  • Site-wide: 5,066 out of 45,813
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  • Site-wide: 7,692 out of 45,813

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

• Downloaded 1,722 times
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  • In genetics: 195 out of 2,745
• Year to date:
  • Site-wide: 24,637 out of 45,813
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  • Site-wide: 20,896 out of 45,813

Genome-Wide Association Study Reveals First Locus for Anorexia Nervosa and Metabolic Correlations

• Downloaded 1,691 times
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  • In genomics: 435 out of 3,397
• Year to date:
  • Site-wide: 22,229 out of 45,813
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  • Site-wide: 24,537 out of 45,813

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,531 times
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  • In genetics: 226 out of 2,745
• Year to date:
  • Site-wide: 31,613 out of 45,813
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  • Site-wide: 36,907 out of 45,813

Quantifying the unobserved protein-coding variants in human populations provides a roadmap for large-scale sequencing projects

• Downloaded 1,454 times
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  • Site-wide: 2,563 out of 45,813
  • In genetics: 243 out of 2,745
• Year to date:
  • Site-wide: 23,065 out of 45,813
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  • Site-wide: 16,872 out of 45,813

De novo Variants In Neurodevelopmental Disorders With Epilepsy

• Downloaded 1,281 times
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  • In genetics: 293 out of 2,745
• Year to date:
  • Site-wide: 10,598 out of 45,813
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  • Site-wide: 8,384 out of 45,813

Refining the role of de novo protein truncating variants in neurodevelopmental disorders using population reference samples

• Downloaded 1,229 times
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  • In genetics: 308 out of 2,745
• Year to date:
  • Site-wide: 17,786 out of 45,813
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  • Site-wide: 15,163 out of 45,813

Whole Genome Sequencing in Psychiatric Disorders: the WGSPD Consortium

• Downloaded 1,168 times
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  • In genomics: 692 out of 3,397
• Year to date:
  • Site-wide: 21,693 out of 45,813
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  • Site-wide: 26,463 out of 45,813

Comparative genetic architectures of schizophrenia in East Asian and European populations

• Downloaded 858 times
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  • Site-wide: 5,914 out of 45,813
  • In genetics: 493 out of 2,745
• Year to date:
  • Site-wide: 2,365 out of 45,813
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  • Site-wide: 3,668 out of 45,813

Subtle stratification confounds estimates of heritability from rare variants

• Downloaded 848 times
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  • Site-wide: 6,015 out of 45,813
  • In genetics: 501 out of 2,745
• Year to date:
  • Site-wide: 35,518 out of 45,813
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  • Site-wide: 36,922 out of 45,813

Genome-wide association study implicates CHRNA2 in cannabis use disorder

• Downloaded 724 times
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  • Site-wide: 7,608 out of 45,813
  • In genomics: 1,185 out of 3,397
• Year to date:
  • Site-wide: 8,338 out of 45,813
• Since beginning of last month:
  • Site-wide: 7,876 out of 45,813

The rate of false polymorphisms introduced when imputing genotypes from global imputation panels

• Downloaded 635 times
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  • Site-wide: 9,123 out of 45,813
  • In genetics: 686 out of 2,745
• Year to date:
  • Site-wide: 22,949 out of 45,813
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  • Site-wide: 16,584 out of 45,813

Enrichment of rare protein truncating variants in amyotrophic lateral sclerosis patients

• Downloaded 618 times
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  • Site-wide: 9,469 out of 45,813
  • In genomics: 1,381 out of 3,397
• Year to date:
  • Site-wide: 7,788 out of 45,813
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  • Site-wide: 5,942 out of 45,813

The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders

• Downloaded 539 times
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  • Site-wide: 11,317 out of 45,813
  • In genetics: 830 out of 2,745
• Year to date:
  • Site-wide: 34,820 out of 45,813
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  • Site-wide: 34,716 out of 45,813

Whole genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

• Downloaded 352 times
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  • Site-wide: 18,200 out of 45,813
  • In genetics: 1,292 out of 2,745
• Year to date:
  • Site-wide: 32,598 out of 45,813
• Since beginning of last month:
  • Site-wide: 26,499 out of 45,813

A platform for case-control matching enables association studies without genotype sharing

• Downloaded 191 times
• Download rankings, all-time:
  • Site-wide: 29,026 out of 45,813
  • In genetics: 1,922 out of 2,745
• Year to date:
  • Site-wide: 17,449 out of 45,813
• Since beginning of last month:
  • Site-wide: 15,481 out of 45,813

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

• Downloaded 175 times
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  • Site-wide: 30,459 out of 45,813
  • In immunology: 518 out of 1,009
• Year to date:
  • Site-wide: 39,456 out of 45,813
• Since beginning of last month:
  • Site-wide: 42,035 out of 45,813

Reassessment Of Lesion-Associated Gene And Variant Pathogenicity In Focal Human Epilepsies

• Downloaded 120 times
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  • In genetics: 2,276 out of 2,745
• Year to date:
  • Site-wide: 41,351 out of 45,813
• Since beginning of last month:
  • Site-wide: 41,653 out of 45,813