Author: Xi Chen

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Preprints

Deep learning-based model for detecting 2019 novel coronavirus pneumonia on high-resolution computed tomography: a prospective study in 27 patients

• Downloaded 20,301 times
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  • Site-wide: 535
  • In infectious diseases: 192
• Year to date:
  • Site-wide: 11,381
• Since beginning of last month:
  • Site-wide: 26,530

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

• Downloaded 17,773 times
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  • Site-wide: 618
  • In cell biology: 4
• Year to date:
  • Site-wide: 214
• Since beginning of last month:
  • Site-wide: 386

A rapid and robust method for single cell chromatin accessibility profiling

• Downloaded 6,202 times
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  • Site-wide: 2,384
  • In genomics: 176
• Year to date:
  • Site-wide: 32,596
• Since beginning of last month:
  • Site-wide: 49,454

Impacts of social and economic factors on the transmission of coronavirus disease (COVID-19) in China

• Downloaded 5,694 times
• Download rankings, all-time:
  • Site-wide: 2,662
  • In epidemiology: 294
• Year to date:
  • Site-wide: 92,683
• Since beginning of last month:
  • Site-wide: 75,684

Evaluating Protein Transfer Learning with TAPE

• Downloaded 5,307 times
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  • Site-wide: 2,955
  • In synthetic biology: 26
• Year to date:
  • Site-wide: 6,413
• Since beginning of last month:
  • Site-wide: 17,681

Single-cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment

• Downloaded 5,040 times
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  • Site-wide: 3,146
  • In cancer biology: 35
• Year to date:
  • Site-wide: 28,990
• Since beginning of last month:
  • Site-wide: 28,350

ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells

• Downloaded 3,680 times
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  • Site-wide: 4,883
  • In genomics: 596
• Year to date:
  • Site-wide: 294
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  • Site-wide: 4,478

Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation

• Downloaded 3,617 times
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  • Site-wide: 4,994
  • In immunology: 179
• Year to date:
  • Site-wide: 73,044
• Since beginning of last month:
  • Site-wide: 49,026

Unsupervised clustering and epigenetic classification of single cells

• Downloaded 3,576 times
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  • Site-wide: 5,076
  • In bioinformatics: 418
• Year to date:
  • Site-wide: 162,366
• Since beginning of last month:
  • Site-wide: None

SARS-CoV-2 receptor networks in diabetic kidney disease, BK-Virus nephropathy and COVID-19 associated acute kidney injury

• Downloaded 3,561 times
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  • Site-wide: 5,106
  • In nephrology: 5
• Year to date:
  • Site-wide: 30,132
• Since beginning of last month:
  • Site-wide: 32,443

MultiMAP: Dimensionality Reduction and Integration of Multimodal Data

• Downloaded 3,560 times
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  • Site-wide: 5,110
  • In bioinformatics: 447
• Year to date:
  • Site-wide: 17,316
• Since beginning of last month:
  • Site-wide: 10,881

Detection of complex structural variation from paired-end sequencing data

• Downloaded 3,452 times
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  • Site-wide: 5,350
  • In bioinformatics: 459
• Year to date:
  • Site-wide: 42,310
• Since beginning of last month:
  • Site-wide: 70,902

Gene expression variability across cells and species shapes innate immunity

• Downloaded 2,845 times
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  • Site-wide: 7,099
  • In evolutionary biology: 133
• Year to date:
  • Site-wide: 160,217
• Since beginning of last month:
  • Site-wide: 182,285

Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease

• Downloaded 2,627 times
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  • Site-wide: 7,996
  • In biochemistry: 139
• Year to date:
  • Site-wide: 26,642
• Since beginning of last month:
  • Site-wide: 21,408

Belief in Conspiracy Theory about COVID-19 Predicts Mental Health and Well-being -- A Study of Healthcare Staff in Ecuador

• Downloaded 2,522 times
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  • Site-wide: 8,481
  • In psychiatry and clinical psychology: 31
• Year to date:
  • Site-wide: 21,885
• Since beginning of last month:
  • Site-wide: 64,893

Assessing real-time Zika risk in the United States

• Downloaded 2,262 times
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  • Site-wide: 9,915
  • In epidemiology: 759
• Year to date:
  • Site-wide: 115,941
• Since beginning of last month:
  • Site-wide: 138,977

Transcriptome Dynamics Reveals Progressive Transition from Effector to Memory in CD4+ T cells.

• Downloaded 1,877 times
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  • Site-wide: 13,128
  • In immunology: 442
• Year to date:
  • Site-wide: 103,861
• Since beginning of last month:
  • Site-wide: 168,555

The IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

• Downloaded 1,765 times
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  • Site-wide: 14,407
  • In cell biology: 364
• Year to date:
  • Site-wide: 75,510
• Since beginning of last month:
  • Site-wide: 77,661

Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution

• Downloaded 1,651 times
• Download rankings, all-time:
  • Site-wide: 15,864
  • In neuroscience: 1,559
• Year to date:
  • Site-wide: 91,743
• Since beginning of last month:
  • Site-wide: 138,582

Spatial Transcriptional Mapping of the Human Nephrogenic Program

• Downloaded 1,592 times
• Download rankings, all-time:
  • Site-wide: 16,827
  • In cell biology: 470
• Year to date:
  • Site-wide: 51,678
• Since beginning of last month:
  • Site-wide: 90,366

Rora regulates activated T helper cells during inflammation

• Downloaded 1,457 times
• Download rankings, all-time:
  • Site-wide: 19,273
  • In immunology: 696
• Year to date:
  • Site-wide: 45,579
• Since beginning of last month:
  • Site-wide: 40,943

Immunogenicity and safety of the homogenous booster shot of a recombinant fusion protein vaccine (V-01) against COVID-19 in healthy adult participants primed with a two-dose regimen

• Downloaded 1,452 times
• Download rankings, all-time:
  • Site-wide: 19,401
  • In allergy and immunology: 136
• Year to date:
  • Site-wide: 2,162
• Since beginning of last month:
  • Site-wide: 5,780

The role of institutional trust in preventive and treatment-seeking behaviors during the 2019 novel coronavirus (2019-nCoV) outbreak among residents in Hubei, China

• Downloaded 1,351 times
• Download rankings, all-time:
  • Site-wide: 21,685
  • In health systems and quality improvement: 33
• Year to date:
  • Site-wide: 64,840
• Since beginning of last month:
  • Site-wide: 29,414

pathwayPCA: an R package for integrative pathway analysis with modern PCA methodology and gene selection

• Downloaded 1,344 times
• Download rankings, all-time:
  • Site-wide: 21,865
  • In bioinformatics: 2,338
• Year to date:
  • Site-wide: 70,579
• Since beginning of last month:
  • Site-wide: 107,486

One Year of Evidence on Mental Health Disorders in China during the COVID-19 Crisis - A Systematic Review and Meta-Analysis

• Downloaded 1,298 times
• Download rankings, all-time:
  • Site-wide: 23,070
  • In psychiatry and clinical psychology: 129
• Year to date:
  • Site-wide: 6,500
• Since beginning of last month:
  • Site-wide: 634

Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in Mycobacterium tuberculosis

• Downloaded 1,198 times
• Download rankings, all-time:
  • Site-wide: 26,193
  • In microbiology: 1,829
• Year to date:
  • Site-wide: 16,499
• Since beginning of last month:
  • Site-wide: 151,073

Re-investigation of classic T cell subsets and identification of novel cell subpopulations by single-cell RNA sequencing

• Downloaded 1,145 times
• Download rankings, all-time:
  • Site-wide: 28,044
  • In genomics: 2,694
• Year to date:
  • Site-wide: 21,115
• Since beginning of last month:
  • Site-wide: 6,754

Mocap: Large-scale inference of transcription factor binding sites from chromatin accessibility

• Downloaded 1,136 times
• Download rankings, all-time:
  • Site-wide: 28,424
  • In bioinformatics: 2,868
• Year to date:
  • Site-wide: 160,573
• Since beginning of last month:
  • Site-wide: 137,383

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

• Downloaded 1,134 times
• Download rankings, all-time:
  • Site-wide: 28,491
  • In immunology: 909
• Year to date:
  • Site-wide: 170,341
• Since beginning of last month:
  • Site-wide: 154,828

12h-clock control of central dogma information flow by XBP1s

• Downloaded 879 times
• Download rankings, all-time:
  • Site-wide: 41,600
  • In systems biology: 780
• Year to date:
  • Site-wide: 96,410
• Since beginning of last month:
  • Site-wide: 113,397

KAT7 is a therapeutic vulnerability of MLL-rearranged acute myeloid leukemia

• Downloaded 863 times
• Download rankings, all-time:
  • Site-wide: 42,809
  • In cancer biology: 1,145
• Year to date:
  • Site-wide: 47,241
• Since beginning of last month:
  • Site-wide: 52,155

Dual indexed design of in-Drop single-cell RNA-seq libraries improves sequencing quality and throughput

• Downloaded 860 times
• Download rankings, all-time:
  • Site-wide: 43,039
  • In molecular biology: 1,115
• Year to date:
  • Site-wide: 116,410
• Since beginning of last month:
  • Site-wide: 104,107

The effects of modified sialic acids on mucus and erythrocytes on influenza A virus HA and NA functions

• Downloaded 845 times
• Download rankings, all-time:
  • Site-wide: 44,223
  • In microbiology: 2,517
• Year to date:
  • Site-wide: 104,655
• Since beginning of last month:
  • Site-wide: 122,209

Localization free super-resolution microbubble velocimetry using a long short-term memory neural network

• Downloaded 793 times
• Download rankings, all-time:
  • Site-wide: 48,596
  • In bioengineering: 1,221
• Year to date:
  • Site-wide: 13,261
• Since beginning of last month:
  • Site-wide: 18,102

Robust transcriptional profiling and identification of differentially expressed genes with low input RNA sequencing of adult hippocampal neural stem and progenitor populations

• Downloaded 757 times
• Download rankings, all-time:
  • Site-wide: 51,921
  • In neuroscience: 7,028
• Year to date:
  • Site-wide: 46,420
• Since beginning of last month:
  • Site-wide: 92,051

Rap2 and TNIK control Plexin-dependent synaptic tiling in C. elegans

• Downloaded 747 times
• Download rankings, all-time:
  • Site-wide: 52,858
  • In neuroscience: 6,752
• Year to date:
  • Site-wide: 133,845
• Since beginning of last month:
  • Site-wide: 185,200

Integrative analysis of single cell genomics data by coupled nonnegative matrix factorizations

• Downloaded 743 times
• Download rankings, all-time:
  • Site-wide: 53,293
  • In bioinformatics: 4,932
• Year to date:
  • Site-wide: 190,060
• Since beginning of last month:
  • Site-wide: 181,412

Cholecystokinin release triggered by presynaptic NMDA receptors produces LTP and sound-sound associative memory formation

• Downloaded 609 times
• Download rankings, all-time:
  • Site-wide: 69,812
  • In neuroscience: 9,330
• Year to date:
  • Site-wide: 138,288
• Since beginning of last month:
  • Site-wide: 95,372

Quantitative Real-Time Imaging of Glutathione with Sub-Cellular Resolution

• Downloaded 604 times
• Download rankings, all-time:
  • Site-wide: 70,576
  • In cell biology: 2,832
• Year to date:
  • Site-wide: 181,491
• Since beginning of last month:
  • Site-wide: 187,826

Development and applications of sialoglycan-recognizing probes (SGRPs) with defined specificities: exploring the dynamic mammalian sialoglycome

• Downloaded 587 times
• Download rankings, all-time:
  • Site-wide: 73,127
  • In molecular biology: 2,078
• Year to date:
  • Site-wide: 58,393
• Since beginning of last month:
  • Site-wide: 84,518

coMethDMR: Accurate identification of co-methylated and differentially methylated regions in epigenome-wide association studies

• Downloaded 560 times
• Download rankings, all-time:
  • Site-wide: 77,678
  • In bioinformatics: 6,729
• Year to date:
  • Site-wide: 151,954
• Since beginning of last month:
  • Site-wide: 158,959

Unconsciously Implanted Visuoauditory Memory in the Presence of Cholecystokinin Retrieved in Behavioral Contexts

• Downloaded 550 times
• Download rankings, all-time:
  • Site-wide: 79,281
  • In neuroscience: 10,564
• Year to date:
  • Site-wide: 163,185
• Since beginning of last month:
  • Site-wide: 138,581

Knowledge-guided analysis of 'omics' data using the KnowEnG cloud platform

• Downloaded 541 times
• Download rankings, all-time:
  • Site-wide: 80,982
  • In cancer biology: 2,178
• Year to date:
  • Site-wide: 171,372
• Since beginning of last month:
  • Site-wide: 112,256

Proteomic and metabolomic signatures associated with the immune response in healthy individuals immunized with an inactivated SARS-CoV-2 vaccine

• Downloaded 529 times
• Download rankings, all-time:
  • Site-wide: 83,212
  • In infectious diseases: 4,736
• Year to date:
  • Site-wide: 43,853
• Since beginning of last month:
  • Site-wide: 41,577

Progressive chromatin silencing of ABA biosynthesis gene permits seed germination in Arabidopsis

• Downloaded 509 times
• Download rankings, all-time:
  • Site-wide: 86,951
  • In plant biology: 3,262
• Year to date:
  • Site-wide: 16,372
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  • Site-wide: 44,267

Disentangling the contribution of childhood and adulthood circumstances and genetics to phenotypic aging: prospective cohort study

• Downloaded 505 times
• Download rankings, all-time:
  • Site-wide: 87,777
  • In epidemiology: 3,581
• Year to date:
  • Site-wide: 126,314
• Since beginning of last month:
  • Site-wide: 187,579

Growth Factor Independent 1 is a tumor suppressor gene in colorectal cancer

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 88,604
  • In cancer biology: 2,454
• Year to date:
  • Site-wide: 119,127
• Since beginning of last month:
  • Site-wide: 70,703

The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the lateral amygdala via cholecystokinin

• Downloaded 493 times
• Download rankings, all-time:
  • Site-wide: 90,303
  • In neuroscience: 14,617
• Year to date:
  • Site-wide: 39,706
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  • Site-wide: 146,709

MassComp, a lossless compressor for mass spectrometry data

• Downloaded 485 times
• Download rankings, all-time:
  • Site-wide: 91,945
  • In bioinformatics: 7,596
• Year to date:
  • Site-wide: 163,842
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  • Site-wide: 188,080

Fear memory-associated synaptic and mitochondrial changes revealed by deep learning-based processing of electron microscopy data

• Downloaded 482 times
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  • Site-wide: 92,461
  • In neuroscience: 13,357
• Year to date:
  • Site-wide: 68,846
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  • Site-wide: 133,794

Selectivity and engineering of the sialoglycan-binding spectrum in Siglec-like adhesins

• Downloaded 470 times
• Download rankings, all-time:
  • Site-wide: 95,123
  • In biochemistry: 2,572
• Year to date:
  • Site-wide: 113,087
• Since beginning of last month:
  • Site-wide: 106,816

Aging-related cerebral microvascular changes visualized using Ultrasound Localization Microscopy in the living mouse

• Downloaded 468 times
• Download rankings, all-time:
  • Site-wide: 95,668
  • In neuroscience: 13,223
• Year to date:
  • Site-wide: 107,901
• Since beginning of last month:
  • Site-wide: 189,390

Three-dimensional ATUM-SEM reconstruction and analysis of hepatic endoplasmic reticulum-organelle interactions

• Downloaded 463 times
• Download rankings, all-time:
  • Site-wide: 96,759
  • In cell biology: 4,285
• Year to date:
  • Site-wide: 106,662
• Since beginning of last month:
  • Site-wide: 126,202

Amelioration of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration

• Downloaded 454 times
• Download rankings, all-time:
  • Site-wide: 98,915
  • In bioengineering: 2,261
• Year to date:
  • Site-wide: 33,284
• Since beginning of last month:
  • Site-wide: 13,091

Longitudinal Evaluation of mRNA Vaccinated Subjects using a Quidel Multianalyte Point-of-Care SARS-CoV-2 IgG Immunoassay

• Downloaded 430 times
• Download rankings, all-time:
  • Site-wide: 104,431
  • In public and global health: 1,639
• Year to date:
  • Site-wide: 45,257
• Since beginning of last month:
  • Site-wide: 8,620

A SMAD4-modulated gene profile predicts disease-free survival in stage II and III colorectal cancer

• Downloaded 429 times
• Download rankings, all-time:
  • Site-wide: 104,546
  • In oncology: 226
• Year to date:
  • Site-wide: 116,800
• Since beginning of last month:
  • Site-wide: 103,057

Alternative splicing and translation play important roles in parallel with transcriptional regulation during rice hypoxic germination

• Downloaded 405 times
• Download rankings, all-time:
  • Site-wide: 110,477
  • In plant biology: 2,725
• Year to date:
  • Site-wide: 157,294
• Since beginning of last month:
  • Site-wide: 116,279

Dopaminergic Neurodegeneration Induced by Parkinson's Disease-Linked G2019S LRRK2 is Dependent on Kinase and GTPase Activity

• Downloaded 401 times
• Download rankings, all-time:
  • Site-wide: 111,420
  • In neuroscience: 15,360
• Year to date:
  • Site-wide: 165,938
• Since beginning of last month:
  • Site-wide: 172,709

Inferring active cis-regulatory modules to predict functional regulatory elements

• Downloaded 389 times
• Download rankings, all-time:
  • Site-wide: 114,670
  • In bioinformatics: 9,125
• Year to date:
  • Site-wide: 138,089
• Since beginning of last month:
  • Site-wide: 142,875

stLFRsv: a germline SV analysis pipeline using co-barcoded reads

• Downloaded 389 times
• Download rankings, all-time:
  • Site-wide: 114,515
  • In bioinformatics: 9,174
• Year to date:
  • Site-wide: 121,929
• Since beginning of last month:
  • Site-wide: 103,519

A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

• Downloaded 384 times
• Download rankings, all-time:
  • Site-wide: 115,800
  • In developmental biology: 3,038
• Year to date:
  • Site-wide: 106,773
• Since beginning of last month:
  • Site-wide: 59,175

scMoMaT: Mosaic integration of single cell multi-omics matrices using matrix trifactorization

• Downloaded 364 times
• Download rankings, all-time:
  • Site-wide: 121,475
  • In bioinformatics: None
• Year to date:
  • Site-wide: 8,762
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  • Site-wide: 20,472

Cellular heterogeneity-adjusted clonal methylation (CHALM) provides better prediction of gene expression

• Downloaded 360 times
• Download rankings, all-time:
  • Site-wide: 122,450
  • In bioinformatics: 9,398
• Year to date:
  • Site-wide: 177,365
• Since beginning of last month:
  • Site-wide: 175,525

Biomolecular recognition of the glycan neoantigen CA19-9 by distinct antibodies

• Downloaded 353 times
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  • Site-wide: 124,345
  • In molecular biology: 3,929
• Year to date:
  • Site-wide: 58,341
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  • Site-wide: 16,454

Phage-Derived Depolymerase as an Antibiotic Adjuvant Against Multidrug-Resistant Acinetobacter Baumannii

• Downloaded 329 times
• Download rankings, all-time:
  • Site-wide: 131,044
  • In microbiology: 8,966
• Year to date:
  • Site-wide: 93,742
• Since beginning of last month:
  • Site-wide: 94,929

ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach

• Downloaded 316 times
• Download rankings, all-time:
  • Site-wide: 134,945
  • In bioinformatics: 10,027
• Year to date:
  • Site-wide: 190,320
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  • Site-wide: 167,373

MethReg: estimating the regulatory potential of DNA methylation in gene transcription

• Downloaded 316 times
• Download rankings, all-time:
  • Site-wide: 135,061
  • In bioinformatics: 10,540
• Year to date:
  • Site-wide: 89,125
• Since beginning of last month:
  • Site-wide: 93,558

Quantitative Control of Noise in Mammalian Gene Expression by Dynamic Histone Regulations

• Downloaded 309 times
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  • Site-wide: 137,287
  • In molecular biology: 3,817
• Year to date:
  • Site-wide: 150,020
• Since beginning of last month:
  • Site-wide: 134,072

Acidosis, Zinc and HMGB1 in Sepsis: A Common Connection Involving Sialoglycan Recognition

• Downloaded 309 times
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  • Site-wide: 137,022
  • In immunology: 4,005
• Year to date:
  • Site-wide: 112,991
• Since beginning of last month:
  • Site-wide: 59,359

American older adults in COVID-19 Times: Vulnerability types, aging attitudes and emotional responses

• Downloaded 306 times
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  • Site-wide: 138,111
  • In psychiatry and clinical psychology: 842
• Year to date:
  • Site-wide: 48,148
• Since beginning of last month:
  • Site-wide: 12,822

GIP: A Gene network-based integrative approach for Inferring disease-associated signaling Pathways

• Downloaded 300 times
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  • Site-wide: 139,904
  • In bioinformatics: 10,376
• Year to date:
  • Site-wide: 175,500
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  • Site-wide: 166,589

Sialoglycan microarray encoding reveals differential sialoglycan binding of phylogenetically-related bacterial AB5 toxin B subunits

• Downloaded 299 times
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  • Site-wide: 140,112
  • In molecular biology: 4,140
• Year to date:
  • Site-wide: 71,686
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  • Site-wide: 47,524

Impact of Prior Cancer on Outcomes in Nasopharyngeal Carcinoma

• Downloaded 298 times
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  • Site-wide: 140,323
  • In epidemiology: 5,495
• Year to date:
  • Site-wide: 180,721
• Since beginning of last month:
  • Site-wide: 114,270

Sex-specific DNA methylation changes in Alzheimer's disease pathology

• Downloaded 293 times
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  • Site-wide: 141,883
  • In neurology: 842
• Year to date:
  • Site-wide: 56,673
• Since beginning of last month:
  • Site-wide: 15,678

Bayesian inference of differentially expressed transcripts and their abundance from multi-condition RNA-seq data

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 143,829
  • In bioinformatics: 10,462
• Year to date:
  • Site-wide: 189,639
• Since beginning of last month:
  • Site-wide: 187,147

MSIGNET: a Metropolis sampling-based method for global optimal significant network identification

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 145,167
  • In bioinformatics: 10,558
• Year to date:
  • Site-wide: 191,404
• Since beginning of last month:
  • Site-wide: 167,337

BICORN: An R package for integrative inference of de novo cis-regulatory modules

• Downloaded 274 times
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  • Site-wide: 147,427
  • In bioinformatics: 10,738
• Year to date:
  • Site-wide: 188,917
• Since beginning of last month:
  • Site-wide: None

Serious Workplace Violence against healthcare providers in China in the past 15 years

• Downloaded 273 times
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  • Site-wide: 147,754
  • In public and global health: 1,953
• Year to date:
  • Site-wide: 131,003
• Since beginning of last month:
  • Site-wide: 130,766

Life course circumstances contribute to the acceleration of phenotypic and functional aging in Chinese middle-aged and older adults

• Downloaded 270 times
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  • Site-wide: 148,833
  • In geriatric medicine: 101
• Year to date:
  • Site-wide: 79,624
• Since beginning of last month:
  • Site-wide: 120,561

A LAMP-based microfluidic chip for rapid detection of pathogen in Cryptococcal meningitis

• Downloaded 269 times
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  • Site-wide: 149,059
  • In microbiology: 10,149
• Year to date:
  • Site-wide: 131,573
• Since beginning of last month:
  • Site-wide: 126,164

20-hydroxyecdysone (20E) signaling regulates amnioserosa morphogenesis during Drosophila dorsal closure: Ecdysone receptor modulates gene expression in a complex with the AP-1 component, Jun

• Downloaded 265 times
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  • Site-wide: 150,283
  • In developmental biology: 3,822
• Year to date:
  • Site-wide: 124,544
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  • Site-wide: 101,406

Lipidomic and Ultrastructural Characterization of Cell Envelope of Staphylococcus aureus Grown in the Presence of Human Serum

• Downloaded 261 times
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  • Site-wide: 151,349
  • In microbiology: 10,263
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  • Site-wide: 155,837
• Since beginning of last month:
  • Site-wide: 175,615

Retrieval Practice Facilitates Judgments of Learning Through Multiple Mechanisms

• Downloaded 259 times
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  • Site-wide: 151,877
  • In neuroscience: 20,897
• Year to date:
  • Site-wide: 182,792
• Since beginning of last month:
  • Site-wide: 184,822

Neuron-glia Integrity: Functional Assessment, Molecular Underpinnings, and Implication for Higher Brain Functions

• Downloaded 250 times
• Download rankings, all-time:
  • Site-wide: 154,484
  • In neuroscience: 21,243
• Year to date:
  • Site-wide: 187,376
• Since beginning of last month:
  • Site-wide: 179,484

Development and validation of FootNet; a new kinematic algorithm to improve foot-strike and toe-off detection in treadmill running

• Downloaded 249 times
• Download rankings, all-time:
  • Site-wide: 154,922
  • In bioinformatics: 11,305
• Year to date:
  • Site-wide: 145,879
• Since beginning of last month:
  • Site-wide: 135,039

Pyruvate:ferredoxin oxidoreductase and low abundant ferredoxins support aerobic photomixotrophic growth in cyanobacteria

• Downloaded 248 times
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  • Site-wide: 155,077
  • In evolutionary biology: 7,503
• Year to date:
  • Site-wide: 45,302
• Since beginning of last month:
  • Site-wide: 74,837

Long-term Services and Supports, Cognitive Impairment, and Disease Management among Older Chinese Adults

• Downloaded 237 times
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  • Site-wide: 158,252
  • In health policy: 391
• Year to date:
  • Site-wide: 66,423
• Since beginning of last month:
  • Site-wide: 93,972

Rapid evolution of bacterial AB5 toxin B subunits independent of A subunits: sialic acid binding preferences correlate with host range and toxicity

• Downloaded 235 times
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  • Site-wide: 158,829
  • In molecular biology: 4,749
• Year to date:
  • Site-wide: 67,005
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  • Site-wide: 100,534

Early-Life Circumstances and Racial Disparities in Cognition among US Older Adults

• Downloaded 233 times
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  • Site-wide: 159,329
  • In neurology: 905
• Year to date:
  • Site-wide: 42,627
• Since beginning of last month:
  • Site-wide: 73,233

Alzheimer’s pathology is associated with dedifferentiation of functional memory networks in aging

• Downloaded 232 times
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  • Site-wide: 159,651
  • In neuroscience: 22,113
• Year to date:
  • Site-wide: 178,569
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  • Site-wide: 180,138

Evolution of Human-specific Alleles Protecting Cognitive Function of Grandmothers

• Downloaded 226 times
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  • Site-wide: 161,398
  • In evolutionary biology: 7,341
• Year to date:
  • Site-wide: 79,272
• Since beginning of last month:
  • Site-wide: 53,888

Temperature and Low-stakes Cognitive Performance

• Downloaded 225 times
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  • Site-wide: 161,672
  • In health economics: 242
• Year to date:
  • Site-wide: 79,614
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  • Site-wide: 57,193

Curvelet Transform-based Sparsity Promoting Algorithm for Fast Ultrasound Localization Microscopy

• Downloaded 215 times
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  • Site-wide: 164,382
  • In bioengineering: 3,690
• Year to date:
  • Site-wide: 19,566
• Since beginning of last month:
  • Site-wide: 46,564

Improving robustness of 3D multi-shot EPI by structured low-rank reconstruction of segmented CAIPI sampling for fMRI at 7T

• Downloaded 210 times
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  • Site-wide: 165,680
  • In neuroscience: 24,971
• Year to date:
  • Site-wide: 48,018
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  • Site-wide: 47,043

The Morbidity Costs of Air Pollution through the Lens of Health Spending in China

• Downloaded 207 times
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  • Site-wide: 166,400
  • In health policy: 414
• Year to date:
  • Site-wide: 82,619
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  • Site-wide: 73,924

Deep Learning-based Microbubble Localization for Ultrasound Localization Microscopy

• Downloaded 196 times
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  • Site-wide: 169,188
  • In bioengineering: 3,660
• Year to date:
  • Site-wide: 22,283
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  • Site-wide: 55,989

Distinct Mechanisms of Innate and Adaptive Immune Regulation Underlie Poor Oncologic Outcomes Associated with KRAS-TP53 Co-Alteration in Pancreatic Cancer

• Downloaded 191 times
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  • Site-wide: 170,348
  • In cancer biology: None
• Year to date:
  • Site-wide: 23,302
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  • Site-wide: 36,621

Identification of mutations associated with Macozinone-resistant in Mycobacterium Tuberculosis

• Downloaded 189 times
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  • Site-wide: 170,832
  • In molecular biology: 4,879
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  • Site-wide: 102,471
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  • Site-wide: 135,175

Co-expression of recombinant human collagen α1(III) chain with viral prolyl 4-Hydroxylase in P. pastoris GS115

• Downloaded 135 times
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  • Site-wide: 181,900
  • In biochemistry: None
• Year to date:
  • Site-wide: 36,847
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  • Site-wide: 24,892

Life course traumas, phenotypic aging, and cardiovascular disease: retrospective analysis of 104,939 UKB participants

• Downloaded 129 times
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  • Site-wide: 182,806
  • In epidemiology: 7,145
• Year to date:
  • Site-wide: 66,924
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  • Site-wide: 102,327

Metacognition, cortical thickness, and tauopathy in aging

• Downloaded 120 times
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  • Site-wide: 184,188
  • In neuroscience: 25,696
• Year to date:
  • Site-wide: 91,247
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  • Site-wide: 84,005

Accelerated Aging Mediates the Associations of Unhealthy Lifestyles with Cardiovascular Disease, Cancer, and Mortality: Two Large Prospective Cohort Studies

• Downloaded 73 times
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  • Site-wide: 189,559
  • In epidemiology: None
• Year to date:
  • Site-wide: 69,806
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  • Site-wide: 28,840

Grandfathers and Grandsons: Social Security Expansion and Child Health in China

• Downloaded 63 times
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  • Site-wide: 190,368
  • In health economics: None
• Year to date:
  • Site-wide: 78,924
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  • Site-wide: 56,293

Unhealthy Lifestyle Mediates the Adverse Influence of Childhood Traumas on Acceleration of Aging: Analysis of 110,596 UK Biobank Participants

• Downloaded 59 times
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  • Site-wide: 190,667
  • In geriatric medicine: None
• Year to date:
  • Site-wide: 83,409
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  • Site-wide: 42,559