Author: Erez Lieberman Aiden

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Preprints

Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations

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  • Site-wide: 1,343
  • In genetics: 26
• Year to date:
  • Site-wide: 19,256
• Since beginning of last month:
  • Site-wide: 14,895

A rapid, low cost, and highly sensitive SARS-CoV-2 diagnostic based on whole genome sequencing

• Downloaded 10,162 times
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  • Site-wide: 1,348
  • In genomics: 84
• Year to date:
  • Site-wide: 8,351
• Since beginning of last month:
  • Site-wide: 14,948

The Juicebox Assembly Tools module facilitates de novo assembly of mammalian genomes with chromosome-length scaffolds for under $1000

• Downloaded 6,715 times
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  • Site-wide: 2,342
  • In genomics: 174
• Year to date:
  • Site-wide: 6,365
• Since beginning of last month:
  • Site-wide: 6,001

Genetic determinants of co-accessible chromatin regions in T cell activation across humans

• Downloaded 5,266 times
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  • Site-wide: 3,266
  • In genomics: 276
• Year to date:
  • Site-wide: 111,509
• Since beginning of last month:
  • Site-wide: 174,624

Cohesin Loss Eliminates All Loop Domains, Leading To Links Among Superenhancers And Downregulation Of Nearby Genes

• Downloaded 5,250 times
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  • Site-wide: 3,279
  • In genomics: 279
• Year to date:
  • Site-wide: 147,619
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  • Site-wide: 143,361

Improved Aedes aegypti mosquito reference genome assembly enables biological discovery and vector control

• Downloaded 3,950 times
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  • Site-wide: 4,891
  • In genomics: 446
• Year to date:
  • Site-wide: 112,940
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  • Site-wide: 61,098

Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling

• Downloaded 3,199 times
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  • Site-wide: 6,677
  • In genetics: 234
• Year to date:
  • Site-wide: 182,818
• Since beginning of last month:
  • Site-wide: 119,632

A Cell Type-Specific Class of Chromatin Loops Anchored at Large DNA Methylation Nadirs

• Downloaded 2,257 times
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  • Site-wide: 11,196
  • In genomics: 1,031
• Year to date:
  • Site-wide: 14,225
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  • Site-wide: 59,394

Polycomb-Mediated Chromatin Loops Revealed by a Sub-Kilobase Resolution Chromatin Interaction Map

• Downloaded 2,075 times
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  • Site-wide: 12,704
  • In molecular biology: 303
• Year to date:
  • Site-wide: 145,936
• Since beginning of last month:
  • Site-wide: 152,502

Static And Dynamic DNA Loops Form AP-1 Bound Activation Hubs During Macrophage Development

• Downloaded 1,873 times
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  • Site-wide: 14,851
  • In genomics: 1,332
• Year to date:
  • Site-wide: 160,956
• Since beginning of last month:
  • Site-wide: 149,277

The Hi-Culfite assay reveals relationships between chromatin contacts and DNA methylation state

• Downloaded 1,414 times
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  • Site-wide: 23,165
  • In genomics: 2,020
• Year to date:
  • Site-wide: 82,896
• Since beginning of last month:
  • Site-wide: 59,293

Convergent selection on juvenile hormone signaling is associated with the evolution of eusociality in bees

• Downloaded 1,393 times
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  • Site-wide: 23,724
  • In evolutionary biology: 818
• Year to date:
  • Site-wide: 5,580
• Since beginning of last month:
  • Site-wide: 7,835

ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

• Downloaded 1,268 times
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  • Site-wide: 27,575
  • In cell biology: 976
• Year to date:
  • Site-wide: 155,882
• Since beginning of last month:
  • Site-wide: 192,734

Chromosome size affects sequence divergence between species through the interplay of recombination and selection

• Downloaded 1,205 times
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  • Site-wide: 29,848
  • In evolutionary biology: 1,053
• Year to date:
  • Site-wide: 126,422
• Since beginning of last month:
  • Site-wide: 83,071

Balanced chromosomal rearrangements offer insights into coding and noncoding genomic features associated with developmental disorders

• Downloaded 1,192 times
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  • Site-wide: 30,387
  • In genetic and genomic medicine: 192
• Year to date:
  • Site-wide: 11,997
• Since beginning of last month:
  • Site-wide: 14,618

CTCF looping is established during gastrulation in medaka embryos

• Downloaded 974 times
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  • Site-wide: 41,560
  • In genomics: 3,169
• Year to date:
  • Site-wide: 118,483
• Since beginning of last month:
  • Site-wide: 209,647

Chromosome-length genome assembly and structural variations of the primal Basenji dog (Canis lupus familiaris) genome

• Downloaded 966 times
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  • Site-wide: 42,101
  • In genomics: 3,255
• Year to date:
  • Site-wide: 48,992
• Since beginning of last month:
  • Site-wide: 34,089

Limited evidence for parallel evolution among desert adapted Peromyscus deer mice

• Downloaded 934 times
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  • Site-wide: 44,290
  • In evolutionary biology: 1,762
• Year to date:
  • Site-wide: 127,411
• Since beginning of last month:
  • Site-wide: 160,326

MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface.

• Downloaded 930 times
• Download rankings, all-time:
  • Site-wide: 44,599
  • In cell biology: 1,792
• Year to date:
  • Site-wide: 75,790
• Since beginning of last month:
  • Site-wide: 49,808

A Transferable Model For Chromosome Architecture

• Downloaded 866 times
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  • Site-wide: 49,812
  • In biophysics: 1,582
• Year to date:
  • Site-wide: 146,661
• Since beginning of last month:
  • Site-wide: 179,019

Hi-C yields chromosome-length scaffolds for a legume genome, Trifolium subterraneum

• Downloaded 858 times
• Download rankings, all-time:
  • Site-wide: 50,475
  • In genomics: 3,709
• Year to date:
  • Site-wide: 61,400
• Since beginning of last month:
  • Site-wide: 51,538

Exploring Chromosomal Structural Heterogeneity Across Multiple Cell Lines

• Downloaded 845 times
• Download rankings, all-time:
  • Site-wide: 51,714
  • In biophysics: 1,667
• Year to date:
  • Site-wide: 120,135
• Since beginning of last month:
  • Site-wide: 161,125

Somatic structural variant formation is guided by and influences genome architecture

• Downloaded 724 times
• Download rankings, all-time:
  • Site-wide: 65,007
  • In genomics: 4,502
• Year to date:
  • Site-wide: 103,686
• Since beginning of last month:
  • Site-wide: 50,293

Predicting A/B compartments from histone modifications using deep learning

• Downloaded 691 times
• Download rankings, all-time:
  • Site-wide: 69,480
  • In bioinformatics: 6,903
• Year to date:
  • Site-wide: 6,283
• Since beginning of last month:
  • Site-wide: 18,725

Juicebox.js provides a cloud-based visualization system for Hi-C data

• Downloaded 603 times
• Download rankings, all-time:
  • Site-wide: 83,060
  • In bioinformatics: 7,556
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 59,557

De Novo Prediction of Human Chromosome Structures: Epigenetic Marking Patterns Encode Genome Architecture

• Downloaded 531 times
• Download rankings, all-time:
  • Site-wide: 97,262
  • In biophysics: 3,502
• Year to date:
  • Site-wide: 164,165
• Since beginning of last month:
  • Site-wide: 202,017

A chromosome-length genome assembly and annotation of blackberry (Rubus argutus, cv. Hillquist)

• Downloaded 509 times
• Download rankings, all-time:
  • Site-wide: 102,194
  • In genomics: 6,344
• Year to date:
  • Site-wide: 30,711
• Since beginning of last month:
  • Site-wide: 8,221

Desert Dingo (Canis lupus dingo) genome provides insights into their role in the Australian ecosystem.

• Downloaded 396 times
• Download rankings, all-time:
  • Site-wide: 131,279
  • In genomics: 7,165
• Year to date:
  • Site-wide: 173,642
• Since beginning of last month:
  • Site-wide: 65,661

De novo chromosome-length assembly of the mule deer (Odocoileus hemionus) genome

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 136,716
  • In genomics: 7,391
• Year to date:
  • Site-wide: 97,160
• Since beginning of last month:
  • Site-wide: 71,090

Clean lighting leads to decreased indoor air pollution and improved respiratory health in rural Uganda

• Downloaded 300 times
• Download rankings, all-time:
  • Site-wide: 159,951
  • In epidemiology: 6,504
• Year to date:
  • Site-wide: 147,499
• Since beginning of last month:
  • Site-wide: 90,602

Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues

• Downloaded 288 times
• Download rankings, all-time:
  • Site-wide: 163,480
  • In genomics: 8,280
• Year to date:
  • Site-wide: 53,567
• Since beginning of last month:
  • Site-wide: 169,039

A chromosome-length assembly of the Hawaiian Monk seal (Neomonarchus schauinslandi) confirms genomic stability in the Pinnipeds and a prolonged history of "genetic purging"

• Downloaded 260 times
• Download rankings, all-time:
  • Site-wide: 171,966
  • In genomics: 8,535
• Year to date:
  • Site-wide: 54,025
• Since beginning of last month:
  • Site-wide: 70,126

A Chromosome-length Assembly of the Black Petaltail (Tanypteryx hageni) Dragonfly

• Downloaded 93 times
• Download rankings, all-time:
  • Site-wide: 208,661
  • In genomics: 9,456
• Year to date:
  • Site-wide: 110,149
• Since beginning of last month:
  • Site-wide: 35,791

Proximity-dependent recruitment of Polycomb Repressive Complexes by the lncRNA Airn

• Downloaded 80 times
• Download rankings, all-time:
  • Site-wide: 211,062
  • In genomics: None
• Year to date:
  • Site-wide: 40,792
• Since beginning of last month:
  • Site-wide: 3,939