Author: Fang Wang

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Preprints

Prediction of survival for severe Covid-19 patients with three clinical features: development of a machine learning-based prognostic model with clinical data in Wuhan

• Downloaded 24,622 times
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  • Site-wide: 428
  • In epidemiology: 77
• Year to date:
  • Site-wide: 4,350
• Since beginning of last month:
  • Site-wide: 5,744

Clinical characteristics of the recovered COVID-19 patients with re-detectable positive RNA test

• Downloaded 21,161 times
• Download rankings, all-time:
  • Site-wide: 503
  • In infectious diseases: 186
• Year to date:
  • Site-wide: 15,271
• Since beginning of last month:
  • Site-wide: 16,985

Sex differences in clinical findings among patients with coronavirus disease 2019 (COVID-19) and severe condition

• Downloaded 6,311 times
• Download rankings, all-time:
  • Site-wide: 2,308
  • In respiratory medicine: 9
• Year to date:
  • Site-wide: 29,185
• Since beginning of last month:
  • Site-wide: 24,490

Cross-species transcriptomic and epigenomic analysis reveals key regulators of injury response and neuronal regeneration in vertebrate retinas

• Downloaded 4,699 times
• Download rankings, all-time:
  • Site-wide: 3,435
  • In neuroscience: 214
• Year to date:
  • Site-wide: 10,034
• Since beginning of last month:
  • Site-wide: 10,340

Spatial drivers and pre-cancer populations collaborate with the microenvironment in untreated and chemo-resistant pancreatic cancer

• Downloaded 2,190 times
• Download rankings, all-time:
  • Site-wide: 10,301
  • In cancer biology: 236
• Year to date:
  • Site-wide: 5,430
• Since beginning of last month:
  • Site-wide: 3,079

Initial Study of Human Genetic Contribution to COVID-19 Severity and Susceptibility

• Downloaded 1,928 times
• Download rankings, all-time:
  • Site-wide: 12,508
  • In genetic and genomic medicine: 59
• Year to date:
  • Site-wide: 64,539
• Since beginning of last month:
  • Site-wide: 53,538

Molecular and cellular phenotypic differences distinguish murine syngeneic models from human tumors

• Downloaded 1,808 times
• Download rankings, all-time:
  • Site-wide: 13,719
  • In cancer biology: 258
• Year to date:
  • Site-wide: 99,371
• Since beginning of last month:
  • Site-wide: 65,722

SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors in vitro

• Downloaded 1,269 times
• Download rankings, all-time:
  • Site-wide: 23,650
  • In immunology: 881
• Year to date:
  • Site-wide: 25,775
• Since beginning of last month:
  • Site-wide: 27,912

scBERT is a Large-scale Pretrained Deep Langurage Model for Cell Type Annotation of Single-cell RNA-seq Data

• Downloaded 1,269 times
• Download rankings, all-time:
  • Site-wide: 23,654
  • In bioinformatics: 2,902
• Year to date:
  • Site-wide: 3,052
• Since beginning of last month:
  • Site-wide: None

An Antioxidant Enzyme Therapeutic for COVID-19

• Downloaded 1,268 times
• Download rankings, all-time:
  • Site-wide: 23,693
  • In biochemistry: 513
• Year to date:
  • Site-wide: 48,520
• Since beginning of last month:
  • Site-wide: 29,695

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells

• Downloaded 1,260 times
• Download rankings, all-time:
  • Site-wide: 23,919
  • In immunology: 858
• Year to date:
  • Site-wide: 39,022
• Since beginning of last month:
  • Site-wide: 35,770

Next generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM

• Downloaded 1,229 times
• Download rankings, all-time:
  • Site-wide: 24,890
  • In genetics: 978
• Year to date:
  • Site-wide: 153,610
• Since beginning of last month:
  • Site-wide: 175,339

Single-cell copy number lineage tracing enabling gene discovery

• Downloaded 1,102 times
• Download rankings, all-time:
  • Site-wide: 29,374
  • In bioinformatics: 2,998
• Year to date:
  • Site-wide: 138,667
• Since beginning of last month:
  • Site-wide: 182,207

Engineering acetyl-CoA metabolic shortcut for eco-friendly production of polyketides triacetic acid lactone in Yarrowia lipolytica

• Downloaded 1,011 times
• Download rankings, all-time:
  • Site-wide: 33,427
  • In bioengineering: 608
• Year to date:
  • Site-wide: 50,341
• Since beginning of last month:
  • Site-wide: 62,001

SCMarker: ab initio marker selection for single cell transcriptome profiling

• Downloaded 965 times
• Download rankings, all-time:
  • Site-wide: 35,785
  • In bioinformatics: 3,609
• Year to date:
  • Site-wide: 142,490
• Since beginning of last month:
  • Site-wide: 163,290

Optimizing mevalonate pathway for squalene production in Yarrowia lipolytica

• Downloaded 708 times
• Download rankings, all-time:
  • Site-wide: 56,180
  • In bioengineering: 1,091
• Year to date:
  • Site-wide: 61,108
• Since beginning of last month:
  • Site-wide: 50,941

Latent periodic process inference from single-cell RNA-seq data

• Downloaded 671 times
• Download rankings, all-time:
  • Site-wide: 60,664
  • In bioinformatics: 5,554
• Year to date:
  • Site-wide: 143,121
• Since beginning of last month:
  • Site-wide: 184,407

Asymmetric Pendrin Homodimer Reveals its Molecular Mechanism as Anion Exchanger

• Downloaded 635 times
• Download rankings, all-time:
  • Site-wide: 65,273
  • In biophysics: 3,999
• Year to date:
  • Site-wide: 3,454
• Since beginning of last month:
  • Site-wide: 6,314

Targeted stimulation of an orbitofrontal network disrupts decisions based on inferred, not experienced outcomes

• Downloaded 579 times
• Download rankings, all-time:
  • Site-wide: 73,345
  • In neuroscience: 9,962
• Year to date:
  • Site-wide: 142,298
• Since beginning of last month:
  • Site-wide: 107,529

Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription

• Downloaded 555 times
• Download rankings, all-time:
  • Site-wide: 77,250
  • In molecular biology: 2,214
• Year to date:
  • Site-wide: 77,288
• Since beginning of last month:
  • Site-wide: 38,254

A negative feedback model to explain regulation of SARS-CoV-2 replication and transcription

• Downloaded 543 times
• Download rankings, all-time:
  • Site-wide: 79,361
  • In bioinformatics: 6,926
• Year to date:
  • Site-wide: 128,005
• Since beginning of last month:
  • Site-wide: 128,854

A Novel Primer Probe Set for Detection of SARS-CoV-2 by Sensitive Droplet Digital PCR

• Downloaded 516 times
• Download rankings, all-time:
  • Site-wide: 84,320
  • In infectious diseases: 4,502
• Year to date:
  • Site-wide: 77,333
• Since beginning of last month:
  • Site-wide: 123,312

Effects of Short-time Exposure to Atrazine on miRNA Expression Profiles in the Gonad of Common Carp (Cyprinus Carpio)

• Downloaded 434 times
• Download rankings, all-time:
  • Site-wide: 101,897
  • In genetics: 3,887
• Year to date:
  • Site-wide: 144,095
• Since beginning of last month:
  • Site-wide: 146,785

The photoreceptor UVR8 mediates the perception of both UV-B and UV-A wavelengths up to 350 nm of sunlight with responsivity moderated by cryptochromes

• Downloaded 403 times
• Download rankings, all-time:
  • Site-wide: 109,320
  • In plant biology: 2,730
• Year to date:
  • Site-wide: 156,376
• Since beginning of last month:
  • Site-wide: 156,361

Mitochondrial DNA and their nuclear copies in parasitic wasp Pteromalus puparum: A comparative analysis in Chalcidoidea

• Downloaded 396 times
• Download rankings, all-time:
  • Site-wide: 111,276
  • In genomics: 6,281
• Year to date:
  • Site-wide: 125,179
• Since beginning of last month:
  • Site-wide: 132,730

Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals the potential mechanism of action of miltefosine

• Downloaded 393 times
• Download rankings, all-time:
  • Site-wide: 111,842
  • In microbiology: 7,708
• Year to date:
  • Site-wide: 77,062
• Since beginning of last month:
  • Site-wide: 67,641

Folate deficiency facilitates coordination of KDM6A with p53 in response to DNA damage

• Downloaded 370 times
• Download rankings, all-time:
  • Site-wide: 118,065
  • In bioinformatics: 9,358
• Year to date:
  • Site-wide: 111,183
• Since beginning of last month:
  • Site-wide: 111,850

Chromatin profiling reveals genome stability heterogeneity in clinical isolates of the human pathogen Aspergillus fumigatus

• Downloaded 366 times
• Download rankings, all-time:
  • Site-wide: 119,044
  • In molecular biology: 3,406
• Year to date:
  • Site-wide: 103,397
• Since beginning of last month:
  • Site-wide: 100,024

Neural Sources Underlying Visual Word Form Processing as Revealed by Steady State Visual Evoked Potentials (SSVEP)

• Downloaded 364 times
• Download rankings, all-time:
  • Site-wide: 119,822
  • In neuroscience: 17,136
• Year to date:
  • Site-wide: 102,537
• Since beginning of last month:
  • Site-wide: 97,169

PRL-1 is required for neuroprotection against olfactory CO2 stimulation in Drosophila

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 120,185
  • In neuroscience: 16,801
• Year to date:
  • Site-wide: 165,342
• Since beginning of last month:
  • Site-wide: 131,762

Ab initio Spillover Compensation in CyTOF Data

• Downloaded 354 times
• Download rankings, all-time:
  • Site-wide: 122,462
  • In bioinformatics: 9,597
• Year to date:
  • Site-wide: 136,623
• Since beginning of last month:
  • Site-wide: 133,656

Hedgehog pathway inhibitors significantly reduce the formation of heterotopic ossification in a direct trauma/burn mouse model

• Downloaded 338 times
• Download rankings, all-time:
  • Site-wide: 126,971
  • In pharmacology and toxicology: 937
• Year to date:
  • Site-wide: 73,884
• Since beginning of last month:
  • Site-wide: 83,357

HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming

• Downloaded 316 times
• Download rankings, all-time:
  • Site-wide: 133,406
  • In cancer biology: 4,589
• Year to date:
  • Site-wide: 30,170
• Since beginning of last month:
  • Site-wide: 46,961

Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses

• Downloaded 313 times
• Download rankings, all-time:
  • Site-wide: 134,071
  • In neuroscience: 20,860
• Year to date:
  • Site-wide: 68,663
• Since beginning of last month:
  • Site-wide: 18,111

Targeting uncoupling of copy number and gene expression in cancers

• Downloaded 305 times
• Download rankings, all-time:
  • Site-wide: 136,548
  • In cancer biology: 3,841
• Year to date:
  • Site-wide: 178,800
• Since beginning of last month:
  • Site-wide: 178,738

NF-kB-repressed Sirt3 mediates testicular cholesterol metabolism and cytoskeleton assembly by P450scc/SOD2 deacetylation

• Downloaded 239 times
• Download rankings, all-time:
  • Site-wide: 156,214
  • In developmental biology: 4,203
• Year to date:
  • Site-wide: 61,600
• Since beginning of last month:
  • Site-wide: 28,814

Differential Gene Expression Analysis and Cytological Evidence Reveal a Sexual Stage of an Amoeba with Multiparental Cellular and Nuclear Fusion

• Downloaded 220 times
• Download rankings, all-time:
  • Site-wide: 161,330
  • In developmental biology: 4,076
• Year to date:
  • Site-wide: 128,647
• Since beginning of last month:
  • Site-wide: 133,794

IFN-λ4 may contribute to HCV persistence by increasing ER stress and enhancing IRF1 signaling

• Downloaded 214 times
• Download rankings, all-time:
  • Site-wide: 162,917
  • In cancer biology: 4,710
• Year to date:
  • Site-wide: 172,535
• Since beginning of last month:
  • Site-wide: 151,570

Seasonal Variation in the Internet Searches for Cancer Recurrence: An Infodemiological Study

• Downloaded 213 times
• Download rankings, all-time:
  • Site-wide: 163,264
  • In cancer biology: 4,733
• Year to date:
  • Site-wide: 156,407
• Since beginning of last month:
  • Site-wide: 135,897

Early detection of sublexical and lexical processing in beginning readers: evidence from Steady-State Visual Evoked Potentials (SSVEPs)

• Downloaded 212 times
• Download rankings, all-time:
  • Site-wide: 163,484
  • In neuroscience: 24,278
• Year to date:
  • Site-wide: 33,023
• Since beginning of last month:
  • Site-wide: 69,961

Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin

• Downloaded 186 times
• Download rankings, all-time:
  • Site-wide: 170,017
  • In microbiology: 12,208
• Year to date:
  • Site-wide: 103,424
• Since beginning of last month:
  • Site-wide: 155,754

Evaluate the risk in conventional IVF frozen human blastocysts undergoing PGT using a new quantification method for parental contamination testing (qPCT)

• Downloaded 152 times
• Download rankings, all-time:
  • Site-wide: 177,695
  • In sexual and reproductive health: 117
• Year to date:
  • Site-wide: 28,073
• Since beginning of last month:
  • Site-wide: 39,501

Draft Genome of Cochliopodium minus (Amoebozoa): Insights into Its Complex Sexual Behavior, Across Domain Gene Acquisitions and Metazoan Type Signaling

• Downloaded 150 times
• Download rankings, all-time:
  • Site-wide: 178,083
  • In genomics: 8,272
• Year to date:
  • Site-wide: 41,358
• Since beginning of last month:
  • Site-wide: 62,516

Delayed implantation induced by letrozole in mice

• Downloaded 144 times
• Download rankings, all-time:
  • Site-wide: 179,068
  • In developmental biology: 4,401
• Year to date:
  • Site-wide: 115,648
• Since beginning of last month:
  • Site-wide: 181,120

New Insights on the Evolutionary Relationships Between the Major Lineages of Amoebozoa

• Downloaded 142 times
• Download rankings, all-time:
  • Site-wide: 179,515
  • In evolutionary biology: None
• Year to date:
  • Site-wide: 30,642
• Since beginning of last month:
  • Site-wide: 48,326

Hantaan virus replication is promoted via AKT activated mitochondria OXPHOS

• Downloaded 141 times
• Download rankings, all-time:
  • Site-wide: 179,584
  • In pathology: 1,061
• Year to date:
  • Site-wide: 30,806
• Since beginning of last month:
  • Site-wide: 62,210

Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration

• Downloaded 107 times
• Download rankings, all-time:
  • Site-wide: 184,753
  • In developmental biology: None
• Year to date:
  • Site-wide: 42,641
• Since beginning of last month:
  • Site-wide: 7,182

Elevated FAM84B promotes cell proliferation via interacting with NPM1 in esophageal squamous cell carcinoma

• Downloaded 104 times
• Download rankings, all-time:
  • Site-wide: 185,103
  • In cancer biology: 5,383
• Year to date:
  • Site-wide: 44,065
• Since beginning of last month:
  • Site-wide: 153,194

Omics of an enigmatic marine amoeba uncovers unprecedented giant viruses gene trafficking and provides insights into its complex life cycle

• Downloaded 75 times
• Download rankings, all-time:
  • Site-wide: 188,214
  • In genomics: None
• Year to date:
  • Site-wide: 61,454
• Since beginning of last month:
  • Site-wide: 54,686

Aspergillus fumigatus FhdA transcription factor is important for mitochondrial activity and codon usage regulation during the caspofungin paradoxical effect

• Downloaded 55 times
• Download rankings, all-time:
  • Site-wide: 189,573
  • In microbiology: None
• Year to date:
  • Site-wide: 80,948
• Since beginning of last month:
  • Site-wide: 21,027